Clinical trials: Overweight , Obesity
Obesity
Cognition and Magnetic Resonance Imaging of Brain Inflammation in Obesity
The rate of obesity in the United States is high and is a risk factor for concurrent cognitive impairment and, in late life, dementias such as Alzheimer's disease.
- Trial name
- NIFOB (NCT04116229)
- Testing
- Oral glucose tolerance test, Cognitive testing, Magnetic resonance imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Postoperative Pain, Pregnancy
Transverse Abdominis Plane (TAP) Block After Cesarean Delivery
Since there have been no published dose-response studies investigating the effective analgesic dose of ropivacaine for use in a TAP block for post-Cesarean delivery analgesia, the investigators propose a study primarily examining…
- Conditions
- Postoperative Pain, Pregnancy, Obesity
- Trial name
- NCT01170702
- Testing
- 0.9% Normal Saline, 0.2% Ropivacaine, 0.5% Ropivacaine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Obesity, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities
The main purpose of this phase 3b study is to evaluate the efficacy and safety of tirzepatide compared with semaglutide in adult participants who have obesity or overweight with weight related comorbidities without Type 2…
- Trial name
- SURMOUNT-5 (NCT05822830)
- Testing
- Tirzepatide, Semaglutide
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 751 people
- Sponsor
- Eli Lilly and Company
Insulin Resistance, Type 2 Diabetes Mellitus
T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
The purpose of this research study is to understand the effects of testosterone and estrogen on the body's response to the hormone insulin.
- Conditions
- Insulin Resistance, Type 2 Diabetes Mellitus, Obesity, Androgen Deficiency
- Trial name
- T-IR (NCT01686828)
- Testing
- Acyline, Testosterone 1.62% gel, Letrozole
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cardiovascular Disease, Obesity
STEP AND GO: A Study of Technology-based Exercise Promotion
The purpose of the study is to test an intervention that uses a mobile game to encourage increased physical activity among adults.
- Conditions
- Cardiovascular Disease, Obesity, Cancer, Diabetes
- Trial name
- NCT01953224
- Testing
- Game-based intervention, Smartphone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Obesity
Effectiveness and Safety Study of LAP-BAND Treatment in Subjects With BMI >/= 30 kg/m2 and < 40 kg/m2
The purpose of this study is to determine whether the LAP-BAND system is safe and effective in subjects with BMI ≥ 30 kg/m2 and < 40 kg/m2.
- Trial name
- NCT00570505
- Testing
- LAP-BAND System
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Apollo Endosurgery, Inc.
Obesity, Vitamin D Deficiency
Vitamin D and Vascular Health in Children
In this study, we will test the central hypothesis that enhancement of vitamin D status in obese and overweight children will improve their vascular health and their cardiovascular disease (CVD) and metabolic syndrome risk…
- Trial name
- NCT01797302
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Overweight and Obesity, Physical Activity
Healthy Mom Zone: A Gestational Weight Gain Management Intervention
The purpose is to establish feasibility of delivering an individually-tailored, behavioral intervention to manage gestational weight gain [GWG] that adapts to the unique needs and challenges of overweight/obese pregnant women…
- Conditions
- Overweight and Obesity, Physical Activity, Weight Change, Body, Eating Behavior
- Trial name
- HMZ (NCT03945266)
- Testing
- Intervention group, Control group
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obesity, Dysglycemia
Metabolic Effects of Betaine Supplementation
Betaine is important in cellular metabolic pathways. Few epidemiologic studies link betaine levels to diabetes and cardiovascular disease. Small human studies suggest benefit for non-alcoholic liver disease.
- Trial name
- NCT01950039
- Testing
- Betaine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Joslin Diabetes Center
Overweight and Obesity
Preventing Weight Gain Among Those Who Decline Behavioral Weight Loss Treatment (STEADY)
The goal of this pilot trial is to pilot test an intervention to help prevent weight gain or produce weight loss among adults with obesity. Participants are asked to self-weigh on a smart scale for one year.
- Trial name
- STEADY (NCT04751656)
- Testing
- Steady Intervention
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Florida
Obesity, Obesity, Morbid
Comparing Anti-XA Levels in Post-Cesarean Patients Undergoing Enoxaparin Thromboprophylaxis
Pregnant and recently postpartum women are at significantly higher risk of developing a blood clot in their arms or legs known as a deep venous thrombosis (DVT) and/or a blood clot in their lungs known as a pulmonary embolism…
- Conditions
- Obesity, Obesity, Morbid, Pregnancy, Complications; Cesarean Section
- Trial name
- NCT02070237
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System
Diabetes, Obesity
A Study to Evaluate the Effect of Lipid Infusion on Toll Like Receptor 4 (TLR4) Signaling
The purpose of this study is to determine whether a lipid infusion can up-regulate toll-like receptor 4 (TLR4) signaling in human subjects
- Trial name
- NCT01740817
- Testing
- Intralipid 20%, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity, Vitamin D Deficiency
Vitamin D Supplementation Reduces Renin-Angiotensin System Activity in Obesity
Hypothesis: Vitamin D supplementation lower renin-angiotensin system activity in obesity. Specific Aim: To investigate whether Vitamin D supplementation in obesity improves the vascular sensitivity to angiotensin II.
- Conditions
- Obesity, Vitamin D Deficiency, Hypertension
- Trial name
- NCT01068418
- Testing
- Vitamin D (cholecalciferol)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Brigham and Women's Hospital
Obesity, Patient Education
Teaching Obesity Treatment Options to Adult Learners Trial
Obesity is the second leading cause of death in the U.S. The treatment of obesity and its related health issues, including cardiovascular disease and diabetes, exceeds $150 billion annually.
- Conditions
- Obesity, Patient Education, Weight Loss
- Trial name
- TOTAL (NCT03856320)
- Testing
- Educational Video
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Prader-Willi Syndrome, Hyperphagia
Oxytocin vs. Placebo for the Treatment Hyperphagia in Children and Adolescents With Prader-Willi Syndrome
The investigators propose a randomized double-blind 8 week treatment trial of intranasal oxytocin (IN-OXT) vs. placebo in 24 subjects aged 5 to 18 years with PWS in order to assess IN-OXT's affect on (1) Eating behaviors (2)…
- Trial name
- OXT-PWS (NCT02629991)
- Testing
- Intranasal Oxytocin (IN-OXT)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Montefiore Medical Center
Overweight, Obesity
STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity
This study will look at the change in participants' body weight from the start to the end of the study. This is to compare the effect on body weight in people taking semaglutide (a new medicine) and people taking "dummy"…
- Trial name
- STEP 6 (NCT03811574)
- Testing
- Semaglutide
- Where
- 28 sites in Japan, South Korea
- Volunteers
- 401 people
- Sponsor
- Novo Nordisk A/S
Dietary Habits, Adiposity
Study of Household Purchasing Patterns, Eating and Recreation
This project examines behavioral and household characteristics associated with food purchasing patterns.
- Conditions
- Dietary Habits, Adiposity, Blood Pressure
- Trial name
- SHoPPER (NCT02073643)
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Morbid Obesity
Effectiveness and Safety Study of LAP-BAND Treatment for Obese Adolescents
The purpose of this study is to determine whether the LAP-BAND system is safe and effective in morbidly obese adolescents.
- Trial name
- NCT00447590
- Testing
- LAP-BAND System
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Apollo Endosurgery, Inc.
Overweight, Obesity
Study of Gelesis100 on Body Weight in Overweight and Obese Subjects With and Without Type 2 Diabetes
This study will asses the decrease in body weight after repeated administration of Gelesis100 in overweight and obese subjects with and without Type 2 Diabetes.
- Trial name
- NCT02307279
- Testing
- Gelesis100
- Where
- 36 sites in United States, Canada and 4 more
- Volunteers
- 436 people
- Sponsor
- Gelesis, Inc.
Obesity, Morbid, Spinal Anesthesia
ED90 for Hyperbaric Bupivacaine in Super Obese Parturients
The aim of this study is to determine the ED90 of hyperbaric intrathecal bupivacaine for the super obese population undergoing cesarean section under a combined spinal epidural technique.
- Conditions
- Obesity, Morbid, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT03781388
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Duke University
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