Clinical trials: Overweight and Obese Adults
Metabolic Syndrome, Obesity
The Effect of a Diet- and Exercise- Related Weight Control Intervention Program on Obesity in Adult Aged 40 and Over
The purpose of this study is to assess study subjects' adherence to different weight control intervention programs and the effect of intervention programs on physical and biochemical examinations, physical fitness, food intake…
- Trial name
- NCT01040546
- Testing
- Individualized education, Grouped education
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- China Medical University Hospital
Healthy Volunteers
Effects of Two Virtual HIFCT Programs in Adults With Abdominal Obesity
It is estimated that by 2030 one in five women and one in seven men will be obese, equivalent to more than 1 billion people around the world.
- Trial name
- HIFCT-V (NCT05619874)
- Testing
- HIFCT-S, HIFCT-P
- Where
- Colombia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Obesity Type 2 Diabetes Mellitus, Obesity (Disorder)
Dietary Insights and Nutrition Experiences in Adults on GLP-1 Therapy - A Study on Diet Quality Changes in Adults on GLP-1 Therapy
The DINE-GLP1 study aims to understand how people on GLP-1 therapy change their eating habits and what kind of dietary support they need.
- Trial name
- DINE-GLP1 (NCT07313384)
- Testing
- GLP-1 Therapy
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of South Carolina
Type 2 Diabetes Mellitus
Exercise Intensity, Glycemic Control and Abdominal Fat in People With Type 2 Diabetes: A Pilot Study
Body fat is an important risk factors for type 2 diabetes. However, not all body fat is the same. Research suggests that fat stored in the abdomen is most harmful. This is known as intra-abdominal fat.
- Trial name
- NCT01144078
- Testing
- Traditional Intensity Exercise, High Intensity Interval Exercise
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Alberta
Osteoporosis, Sarcopenia
Skeletal Maturation and Endocrine Health in Young Adults
Diseases which can be the result of poor lifestyle choices in adult life, such as osteoporosis, obesity or poor muscle mass (sarcopenia) can also be driven by heritable genetic factors.
- Conditions
- Osteoporosis, Sarcopenia, Obesity, Cardiovascular Diseases
- Trial name
- EPIPEAK (NCT06509776)
- Where
- 9 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Holbaek Sygehus
Obesity, Overweight
Pounds Off Digitally (POD): The Use of Podcasting and Mobile Media to Promote Weight Loss
Overweight and obesity play a role in both cancer incidence and survival rates. Many people have found attending weight loss support groups to be time-intensive.
- Trial name
- POD (NCT01139255)
- Testing
- Podcasting + mobile media
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Abdominal Obesity, Postprandial Lipemia
Alternating Energy Intake and Blood Fat Content After a Meal
Increasing evidence suggests that meal timing affects metabolic health. For example, intermittent fasting (IF) may have positive effects on plasma glucose and lipid levels, insulin sensitivity, and blood pressure.
- Conditions
- Abdominal Obesity, Postprandial Lipemia, Lipid Metabolism, Glucose Metabolism
- Trial name
- NCT04894526
- Testing
- Alternating Energy Intake, Regular Energy Intake
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Weight Management, Treatment Of Obesity
A Trial In Diabetic Patients To Assess Effect Of CE-326,597 On Glucose Control And Body Weight
Study of whether the investigational drug CE-326,597 improves glucose control and results in body weight loss in patients with type 2 diabetes
- Trial name
- NCT00542009
- Testing
- CE-326,597 100 mg QD, CE-326,597 50 mg QD, CE-326,597 25 mg QD
- Where
- 54 sites in United States, Bulgaria and 5 more
- Volunteers
- 252 people
- Sponsor
- Pfizer
Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesis
Obesity and glucose intolerance or overt diabetes are increasing at an alarming rate in the population, and are bound to become a public health issue and a major cause of disability, loss of independence and high social costs in…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes Mellitus Type 2 in Nonobese, Obesity
- Trial name
- NCT05755321
- Testing
- Skin biopsy
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Metabolic Syndrome, Metabolic Endotoxemia
Alleviation Of Metabolic Endotoxemia In Adults With Metabolic Syndrome With Milk Fat Globule Membrane
Metabolic syndrome (MetS) adults (n = 24; 18-65 y) will be enrolled to complete a 2-arm, double-blind, randomized controlled, crossover trial.
- Trial name
- NCT03860584
- Testing
- MFGM-enriched full-fat dairy milk, Soy phospholipid/lecithin milk
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Obesity, Colorectal Cancer
Time-Restricted Eating and Mindfulness-Based Stress Reduction to Reduce the Risk of Early-Onset Colorectal Cancer
The goal of this clinical trial is to evaluate the feasibility of remote time-restricted eating (TRE) and mindfulness-based stress reduction (MBSR) interventions and the preliminary effect on EOCRC-related markers.
- Conditions
- Obesity, Colorectal Cancer, Microbial Colonization, Time Restricted Feeding
- Trial name
- MBSR&TRE (NCT06022887)
- Testing
- TRE, MBSR
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Lisa Tussing-Humphreys
Obesity, Vitamin D3 Deficiency
Vitamins D and K Effects on Vascular Function in Obese Adults.
A prospective, randomized, placebo-controlled, double-blind study that aims to evaluate the effects of combined vitamin D3 and K2-MK7 supplementation on vascular function, sympathetic tone, metabolic biomarkers and inflammatory…
- Trial name
- NCT05689632
- Testing
- Vitamin D3 + K2-MK7, Vitamin D3
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Pedro Ernesto
Nutrition Disorders, Hypertension
Assessment of Progranulin and FAM19A5 Protein Blood Levels in Metabolic Syndrome
The main objective of the study is to assess the serum levels of progranulin and FAM19A5 protein in adults with metabolic syndrome.
- Conditions
- Nutrition Disorders, Hypertension, Dyslipidemias, Glucose Intolerance
- Trial name
- PROG-FAM (NCT04451616)
- Testing
- Blood sample collection, Hair sample collection, Urine sample collection
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Chronic Insomnia, Overweight/Obesity
Cognitive Behavioral Therapy for Insomnia as an Adjunct to Time-restricted Eating on Weight Loss in Adults With Overweight or Obesity and Chronic Insomnia
Obesity (being overweight due to excess body fat) is a common health condition that increases the risk of developing problems such as diabetes, high blood pressure, and heart disease.
- Trial name
- NCT07770516
- Testing
- Flexible Time-restricted eating group (FTRE), Flexible Time-restricted eating plus cognitive behavioural therapy for insomnia group (CBTI+FTRE)
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Body Weight Changes, Overweight and Obesity
Body Weight-Based Interval Training in Sedentary Overweight and Obese Adults
Body-weight based interval training (IT) performed 3 times per week will lead to reductions in abdominal adiposity and reduce overall body fat percentage in overweight and obese sedentary adults more effectively than moderate…
- Conditions
- Body Weight Changes, Overweight and Obesity, Physical Activity
- Trial name
- NCT03524521
- Testing
- Interval Training, Standard of Care
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity and Overweight
Intermittent Carbohydrate Restriction in Cardiometabolic Health
Metabolic conditions, such as heart disease, type 2 diabetes, and metabolic syndrome, are among the leading causes of disability and mortality worldwide.
- Trial name
- NCT06684834
- Testing
- 5:2 carbohydrate restriction, Early time-restricted carbohydrate intake
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bath
Gout, Obesity (BMI>30)
Mazdutide for Weight Management and Gout in Adults With Obesity
This is a single-arm, open-label, pre-post controlled study to evaluate the effect of Mazdutide on the annualized flare rate (AFR) in adults with obesity and gout.
- Conditions
- Gout, Obesity (BMI>30), Hyperuricemia, Metabolic Syndrome
- Trial name
- NCT07824895
- Testing
- Mazdutide
- Volunteers
- 30 people
- Sponsor
- Hongwei Jiang
Overweight, Obesity
A Study to Compare Two Different Forms of PF-07081532 in Adults Who Are Overweight or Obese
The purpose of this study is to compare the amount of PF-07081532 in blood after taking two different forms of PF-07081532. This study is seeking participants who are at least 18 years of age and are overweight and/or obese.
- Trial name
- NCT05677867
- Testing
- Formulation A (PF-07081532 20 mg plus 60 mg), Formulation B (PF-07081532 80 mg)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
A Drug-Drug Interaction Study to Examine the Impact of Itraconazole and Cyclosporine on PF-07081532 Pharmacokinetics in Overweight or Obese Adults
This is a Phase 1, open-label, fixed-sequence, 3-period study to evaluate the effect of multiple doses of itraconazole and a single dose of cyclosporine on the single-dose PK of PF-07081532 in otherwise healthy, overweight or…
- Trial name
- NCT05745701
- Testing
- PF-07081532, Cyclosporine, Itraconazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Weight Loss
Feasibility of a Campaign Intervention Compared to a Standard Behavioral Weight Loss Intervention in Overweight and Obese Adults
The purpose of this study is to examine the feasibility of a campaign intervention for weight management compared to a standard behavioral weight loss intervention in overweight and obese adults.
- Trial name
- NCT01803737
- Testing
- Standard Behavioral Weight Loss Intervention (SBWL), Campaign Intervention (CI)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Pittsburgh