Clinical trials: Overweight and Obese Adults
Obesity
Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes
This is a 56-week randomized, open-label, controlled study evaluating the efficacy and safety of the HDM1005 compared to tirzepatide in adults with obesity but without diabetes.
- Trial name
- NCT07521631
- Testing
- HDM1005 dose level 1, HDM1005 dose level 2, HDM1005 dose level 3
- Where
- China
- Volunteers
- 372 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Cancer, Prevention Harmful Effects
Social Contextual Influences on Physical Activity
The goal of this study is to learn why some black and Latino men and women choose not to exercise very often. Researchers also want to learn more about any social and environmental factors that may affect the way an exercise…
- Trial name
- NCT01195337
- Testing
- PA Prescription Plan, Pedometer, Newsletters
- Where
- United States
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Obesity
Investigating the Prevalence and Risk Factors for Sarcopenia Amongst Adults Seeking Treatment for Obesity
Sarcopenia, a condition where individuals lose muscle mass and strength, is associated with poorer health and function. While aging is a well-known cause of sarcopenia, obesity is increasingly recognised as a significant factor.
- Trial name
- NCT07541677
- Where
- Singapore
- Volunteers
- 160 people
- Sponsor
- Singapore General Hospital
Physical Activity, Sedentary Lifestyle
Project Step: Evaluating Deposit Contracts and Daily Feedback to Promote Walking in Overweight and Obese Adults
The purpose of this study is to test whether deposit contracts, wherein individuals invest their own money with the study to serve as the incentive, with or without daily feedback about progress help individuals to increase step…
- Conditions
- Physical Activity, Sedentary Lifestyle, Obesity, Overweight
- Trial name
- NCT03566277
- Testing
- Self-monitoring, Incentives, Feedback
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Drexel University
Obesity or Overweight
Obesity Treatment Using an Internet-delivered Intervention Based on the Diabetes Prevention Program in Mexican Adults
In Mexico, 7 out of 10 adults are overweight or obese. The diseases associated with these conditions (diabetes, cardiovascular disease and some cancers) are those that impact the most on the disability-adjusted life years of…
- Trial name
- DPPON-MEX (NCT03629301)
- Testing
- ID-DPP group, Wait-list Group
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Universidad de Sonora
Obesity, Insufficient Sleep
Project SHINE (Sleep Health INitiative for Equity): Culturally Informing a Sleep Extension Intervention for African American Adults
The proposed research aims to reduce obesity-related health disparities by promoting healthy lifestyle behaviors among African Americans (AAs), given the high disease burdens associated with low physical activity, insufficient…
- Trial name
- NCT06226077
- Testing
- sleep extension intervention, contact control intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Minnesota
Intermittent Fasting, Overweight
Monitoring During Different Intermittent Fasting Protocols in Non-Obese Adults
LIMITFOOD is a randomized clinical intervention study that investigates the effects of two different intermittent fasting protocols compared to a control group on the health of normal- and overweight adults.
- Conditions
- Intermittent Fasting, Overweight, Time Restricted Feeding
- Trial name
- LIMITFOOD (NCT04732130)
- Testing
- Time-Restricted Feeding, Alternate Day Fasting
- Where
- Switzerland
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Philipp Gerber
Obesity
Behavioral Self-Regulation
The purpose of this pilot study is to determine whether incorporating self-regulation training using daily weighing is efficacious within a behavioral weight loss program specifically targeting young adults.
- Trial name
- NCT00488228
- Testing
- self-regulation
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- The Miriam Hospital
Haemophilia, Cardiovascular Disease
Cardiovascular Disease (CVD) in Haemophilia
Life expectancy of hemophilia patients has improved considerably during the past decades and is approaching that of the general population.
- Trial name
- NCT01303900
- Where
- 6 sites in Netherlands, United Kingdom
- Volunteers
- 750 people
- Sponsor
- UMC Utrecht
Obesity, Overweight
Effects of Betahistine Hydrochloride in Overweight Women
This study will evaluate the effects of a drug called betahistine on appetite and food intake in overweight women. Betahistine has been used for many years to treat vertigo (dizziness).
- Conditions
- Obesity, Overweight, Overnutrition
- Trial name
- NCT00459992
- Testing
- Betahistine Hydrochloride
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Type 2 Diabetes Mellitus (T2DM), Obesity
A Study to Learn How Different Amounts of PF-06954522 Are Tolerated and Act in Adults With Type 2 Diabetes Mellitus
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple escalating oral doses of PF-06954522 in adult participants with inadequately controlled type 2 diabetes…
- Trial name
- NCT06279234
- Testing
- Rosuvastatin, Midazolam, Omeprazole
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity, Dietary Intervention
Effects of Boron and Mediterranean Diets on Gut Microbiota and Metabolic Health
This study investigated the effects of a boron-rich diet compared with a Mediterranean-style diet (Smart Alternative Food Formulation; SAFF) on obesity-related outcomes in adults.
- Conditions
- Obesity, Dietary Intervention, Gut Microbiota, Cardiometabolic Risk Factors
- Trial name
- BOR-SAFF (NCT07156097)
- Testing
- Mediterranean-style Diet (SAFF), Boron-rich Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dicle University
Diabetes Mellitus, Type 2 Diabetes
Improving Glycemic Control Using a Virtual Weight Control Program and Continuous Glucose Monitoring
This study is a randomized clinical trial with the primary aim examining the efficacy of a novel integrated solution of a digitally delivered behavioral weight management program tailored for diabetes utilizing a continuous…
- Conditions
- Diabetes Mellitus, Type 2 Diabetes, Obesity
- Trial name
- VITAL-CGM (NCT05935514)
- Testing
- WW Intervention, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 152 people
- Sponsor
- Pennington Biomedical Research Center
Overweight Subject, Healthy Subjects
A Drug-Drug Interaction Study of HDM1002 and Metformin, Empagliflozin, Midazolam, Valsartan, and Warfarin
The purpose of this study is to characterize the drug-drug intereaction of HDM1002 and metformin, empagliflozin, midazolam, valsartan, and warfarin in overweight/obese adult subjects.
- Trial name
- NCT07331389
- Testing
- Metformin, Empagliflozin, Midazolam
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Obesity, Bariatric Surgery
Swap Anesthetic Versus Continuous Desflurane in Adults Undergoing Bariatric Surgery
This randomized, parallel-group, non-inferiority clinical trial aims to evaluate whether an anesthetic swap strategy consisting of sevoflurane followed by desflurane 30 minutes before the end of surgery is non-inferior to…
- Trial name
- SWAP (NCT07748247)
- Testing
- Desflurane, Sevoflurane-Desflurane
- Where
- Chile
- Volunteers
- 82 people
- Sponsor
- Clínica Dávila
Obesity
Determinants of Post-Exercise Eating Patterns
This study examines potential physiological and psychological determinants of food intake in response to exercise. Specifically, beyond measuring actual food consumption and physiological markers typically assessed during…
- Trial name
- DEEP (NCT03643315)
- Testing
- Exercise and Meal (EX), No-Exercise and Meal (NEX)
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Overweight, Obesity
Evaluation of a New Orange-Based Beverage Enriched With Polyphenols in Adult Humans
The purpose of this study is to evaluate the effects of a new orange juice-based beverage enriched in fiber and selected phenolic compounds (mainly flavanones) on features of metabolic syndrome and cardiovascular disease risk…
- Trial name
- BIONAOS (NCT01290250)
- Testing
- Orange juice based beverage enriched in polyphenols
- Where
- Spain
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- The Coca-Cola Company
Psoriasis, Metabolic Syndrome
Comparison of Secukinumab 300 mg Combined With a Lifestyle Intervention to Secukinumab Alone for the Treatment of Moderate to Severe Psoriasis Patients With Concomitant Metabolic Syndrome
This study was a randomized, open-label, parallel-group, active comparator controlled study with two treatment arms designed to answer the question whether the combination of Secukinumab with lifestyle intervention could…
- Trial name
- METABOLYX (NCT03440736)
- Testing
- Secukinumab, Life-style intervention
- Where
- 75 sites in Germany
- Volunteers
- 781 people
- Sponsor
- Novartis Pharmaceuticals
Overweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2)
Real-World Two-Year Weight Loss Outcomes With Breath Biofeedback
The goal of this retrospective observational study is to evaluate the real-world durability of weight loss among adults with overweight or obesity who used the Key to Health breath-biofeedback mHealth program.
- Conditions
- Overweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2), Obesity & Overweight
- Trial name
- NCT07430618
- Testing
- Breath acetone biofeedback device with mHealth program
- Where
- Canada
- Volunteers
- 11,524 people
- Sponsor
- University of British Columbia
Overweight and/or Obesity
A Study to Learn How Different Amounts of the Study Medicine Called PF-08656795 Are Tolerated and Act in Adults With Overweight or Obesity
This study will look at how different amounts of the study medicine, called PF-08656795, are tolerated and act in adults with overweight or obesity.
- Trial name
- NCT07876518
- Testing
- PF-08656795
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Pfizer