Clinical trials: Overweight and Obese Volunteers
Rheumatoid Arthritis
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of AZD9567.
A study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of AZD9567.
- Trial name
- NCT02760316
- Testing
- AZD9567 10 mg, AZD9567 20 mg, AZD9567 40 mg
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity
The Effect of Liraglutide on the GIT
Liraglutide is a glucose-like peptide 1 agonist, currently used as an effective weight-loss treatment. Its mechanism of action has not yet been elucidated.
- Trial name
- LIRHV (NCT04008290)
- Testing
- 0.6 mg Liraglutide
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity
A Study to Characterize Event Related Potential Markers of Attentional Bias Towards Words and Images of Food
GSK is planning to undertake two anti-obesity drug studies in the area of obesity. In addition to assessment by questionnaires, it would be of significant value to incorporate an objective non-interventional measure of cognitive…
- Trial name
- NCT01366508
- Testing
- High calorie lunch, Breakfast
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity
Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures
This study will examine how body metabolism adjusts to small changes in environmental temperature and how it may be related to weight loss.
- Trial name
- NCT00521729
- Testing
- Exposure to Cold Temperature
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity
Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity
This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing…
- Trial name
- NCT01900366
- Testing
- Fat Biopsy
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Obesity, Metabolic Disease
Xla1 Christensenella Minuta, Phase I, Randomized, Partially Placebo-controlled Double-blind Protocol, Evaluating Safety, Tolerability and Impact on the Gut Microbiota in Healthy Volunteers, Overweight and Obese Adults
Xla1 Christensenella minuta, phase I, randomized, placebo-controlled double-blind protocol, evaluating safety, tolerability and impact on the gut microbiota in healthy volunteers, overweight and obese adults.
- Trial name
- CAUSALITY (NCT04663139)
- Testing
- Xla1
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- YSOPIA Bioscience
Obesity, Morbid Obesity
Effects of RM-493 on Energy Expenditure in Obese Individuals
Background: RM-493 is a drug that stimulates parts of the brain that control eating and metabolism. It has helped to reduce body weight and improve insulin sensitivity in lab tests.
- Trial name
- NCT01867437
- Testing
- RM-493
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Healthy Volunteers
A Study of Multiple-ascending Doses of GSBR-1290 in Healthy Overweight/Obese Participants
The purpose of this study is to compare the safety, tolerability, pharmacokinetic (PK), and comparative bioavailability of repeated administration of GSBR-1290 in healthy overweight/obese participants.
- Trial name
- NCT06139055
- Testing
- GSBR-1290 (Capsule/Tablet), GSBR-1290
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Overweight (BMI > 25)
To Evaluate Efficacy and Safety of Proprietary Healthy Diet Combinations for Weight Management in Overweight Volunteers
This is an open-label, four-arm, randomized, controlled clinical study designed to evaluate the efficacy and safety of a structured Weight Management Program (WMP) in overweight and obese adults with a body mass index (BMI) ≥ 23…
- Trial name
- NCT07452757
- Testing
- Arm II, Arm III, Arm IV
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bioagile Therapeutics Pvt. Ltd.
Overweight and Obesity
Safety, Tolerability, and Pharmacokinetics of a Single or Multiple Ascending Doses of CPX101
This randomized, double-blind, placebo-controlled Phase I clinical study was designed to evaluate the tolerability and safety, PK profile, immunogenicity of CPX101 in a single dose in healthy participants and multiple doses in…
- Trial name
- NCT06545162
- Where
- 3 sites in China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Guangzhou Chia Tai Innovative Pharmaceutical Co., Ltd.
Obesity, Normal Physiology
Energy Expenditure Responses to Different Temperatures
Background: The way that the body burns calories is known as energy expenditure. Some studies show that when we are cold, we burn more calories to keep our bodies warm.
- Trial name
- NCT01568671
- Testing
- Room temperatures
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiometabolic Risk, Abdominal Obesity
Characterization of Gut Microbiota Composition and Activity After a Daily Supplementation of 4.5 g/Day of ChitinGlucan Fibre During 3 Weeks in At-cardiometabolic Risk Volunteers
The aim of this study is to demonstrate the beneficial effects on gut microbiota composition and activity of the diary intake of insoluble fiber (extract from Aspergillus Niger) for three weeks.
- Trial name
- FITACHITIN (NCT03773900)
- Testing
- Kiotransine (chitin-glucan from aspergillus niger)
- Where
- France
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Diabetes Type 2, Obesity and Overweight
Gastric Emptying in Healthy Volunteers and GLP-1 Agonist Users
This observational study aims to determine the gastric emptying kinetics assessed by ultrasound in healthy volunteers after a standard breakfast and the state of the stomach after a clear liquid diet for 18 /24 hours in patients…
- Trial name
- aGLP1-GUS (NCT06987669)
- Testing
- Gastric Ultrasound
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Clinica Alemana de Santiago
Healthy, Obesity
The Effect of Bitter Taste Receptor Agonists on The Gastrointestinal Tract, Hunger and Food Intake
In this study, the investigators aimed at evaluating the role of bitter taste receptors in the gastrointestinal tract (GIT). Intragastric or intraduodenal administration of denatonium benzoate (DB) or quinine hydrochloride were…
- Trial name
- NCT02759926
- Testing
- Denatonium benzoate, Quinine hydrochloride, Tap water
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Overweight and Obesity
Predictors of Lorcaserin-Induced Weight Loss
This two-phase study aims to explore ways to predict who will respond well to the weight loss drug lorcaserin and to understand the mechanisms that develop which limit drug efficacy.
- Trial name
- NCT03353220
- Testing
- Belviq
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obesity, Diabetes
Study of the Mechanisms of Metabolic Adaptations to Overfeeding
Obesity results from complex interactions between genetic and environmental factors, and are strongly associated with metabolic complications such as type 2 diabetes mellitus.
- Trial name
- Polynut (NCT02225457)
- Testing
- Hypercaloric diet, polyphenols
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obesity (Disorder), Ventilation Homogeneity
Positional Effects on Lung Ventilation and Perfusion in Obesity
Electrical Impedance Tomography (EIT) is a non-invasive, bedside monitoring tool that provides real-time information on regional ventilation and perfusion.
- Conditions
- Obesity (Disorder), Ventilation Homogeneity, Perfusion, Ventilation Perfusion Mismatch
- Trial name
- NCT07341113
- Testing
- Standardized body positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Koç University
Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM)
Phase 1 Clinical Study of MWN105 Injection in Healthy Chinese Volunteers
This study is a randomized, double-blind, placebo-controlled, single-dose and multiple-dose, dose-escalation phase I clinical trial, aiming to evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic…
- Conditions
- Overweight , Obesity, Type 2 Diabetes Mellitus (T2DM), MASH - Metabolic Dysfunction-Associated Steatohepatitis
- Trial name
- NCT07801313
- Testing
- MWN105
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Obesity, Overweight
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-5817 Injection
The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-5817 when administered subcutaneously (SC) as single and multiple doses in adults who are affected by obesity.
- Trial name
- NCT06934408
- Testing
- HRS-5817 Injection
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Healthy Volunteers, Overweight
First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes
The purpose of this study is to investigate how safe, and how well tolerated, the new study drug NNC0480-0389 is when it is given together with semaglutide.
- Conditions
- Healthy Volunteers, Overweight, Obesity, Diabetes Mellitus, Type 2
- Trial name
- NCT04259801
- Testing
- NNC0480-0389, Semaglutide
- Where
- Netherlands
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S