Clinical trials: Overweight and Obese Women
Obesity
Effects of High-intensity Exercise With Hypoxia and Taurine Supplementation on Metabolic and Mitochondrial Parameters
The prevalence of obesity in Brazil is one of the highest in Latin America. As an inflammatory disease, obesity needs to be treated, and one of the best interventions is exercise.
- Trial name
- NCT06579508
- Testing
- Cycle ergometer
- Where
- 2 sites in Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Kidney Diseases, Diabetic Nephropathies
First-In-Human Study of GFB-024 in Healthy Overweight and Obese Participants, and Participants With Type 2 Diabetes
GFB-024 is intended for use in patients with kidney disease such as diabetic nephropathy. This study is the first time GFB-024 has been used in humans.
- Conditions
- Kidney Diseases, Diabetic Nephropathies, Diabetes Complications, Diabetes Mellitus
- Trial name
- NCT04880291
- Testing
- GFB-024
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Goldfinch Bio, Inc.
Obesity, Aging
Effect of Age and Weight Loss on Inflammation and Iron Homeostasis
The purpose of this study is to evaluate the effect of aging and weight loss on iron status and immune response in obese women. Iron deficiency and immune impairment are two of the numerous complications of obesity.
- Trial name
- HEP (NCT01636635)
- Testing
- Calorie Restriction
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tufts University
Obesity
Evaluation of a Health at Every Size vs a Behavioral Weight Loss Approach for Obese Women
For over four decades the medical literature has observed a relationship between obesity and poorer health outcomes. The causal mechanisms of these poorer outcomes however are unclear.
- Trial name
- NCT00769717
- Testing
- Wellness-Centered (HUGS), Weight-Centered (LEARN)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Reading Hospital and Medical Center
Obesity, Weight Loss
Bitter Taste and Weight Loss in Women
Individual food preferences are not considered in designing weight-loss therapies. This project will determine if short-term weight-loss is improved by matching participants with diets that reflect their genetically-determined…
- Trial name
- NCT01856660
- Testing
- Low-Carbohydrate Diet, Low-fat Diet
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Obesity
Effect of Nutritional Counseling on Health Outcomes in Female Workers Wih Obesity at Adam Malik Hospital
The goal of this quasi-experimental study is to determine whether nutritional counseling can improve health outcomes in female workers with obesity at Adam Malik Hospital in Medan.
- Trial name
- ECHO-OFEM (NCT06621589)
- Testing
- Nutritional Counseling
- Where
- Indonesia
- Volunteers
- 97 people
- Sponsor
- RS H Adam Malik
Obesity
Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women
Obesity disproportionately impacts sexual minority women. Behavioral weight loss programs are the gold standard treatment for mild to moderate obesity.
- Trial name
- NCT05775497
- Testing
- Behavioral weight loss intervention (Online; Rx Weight Loss), Minority stress intervention, Social support intervention
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- The Miriam Hospital
Obesity, Sarcopenia
Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes
The aim of TIMEDIAB is to demonstrate that early TRE (eTRE) combined to late (afternoon) exercise will outperform eTRE combined to morning exercise on muscle function as primary endpoint, and glucose homeostasis as secondary…
- Conditions
- Obesity, Sarcopenia, Post Menopause, Type 2 Diabetes
- Trial name
- TIMEDIAB (NCT07075133)
- Testing
- Antidiabetic diet (control), eTRE diet, Physical activity in the morning
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Obesity
Effect of Hydroxychloroquine Sulphate in Healthy Lean Females
The effect of an acute administration of hydroxychloroquine sulphate will be investigated on hedonic food intake, appetite related sensations and gastrointestinal hormone release in healthy female subjects.
- Trial name
- PLAQHV (NCT04005768)
- Testing
- Hydroxychloroquine Sulphate
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Polycystic Ovary Syndrome
Study of Pharmacodynamics of LIK066 in Overweight and Obese Women With Polycystic Ovary Syndrome
The purpose of the study was to evaluate whether LIK066 can be developed for the treatment of polycystic ovary syndrome (PCOS) in overweight and obese women.
- Trial name
- PCOS (NCT03152591)
- Testing
- LIK066
- Where
- 5 sites in United States, Germany
- Volunteers
- 29 people
- Sponsor
- Novartis Pharmaceuticals
Hiv, HIV Infections
Changes in Weight, Body Composition and Metabolic Parameters After Discontinuing Dolutegravir or Tenofovir Disproxil
Randomized controlled parallel open-label study in persons living with HIV. The aim is to study weight changes in patients switching from a dolutegravir and tenofovir disoproxil containing regimen to either a dolutegravir or…
- Conditions
- Hiv, HIV Infections, HIV Lipodystrophy, Osteoporosis
- Trial name
- AVERTAS-2 (NCT04903847)
- Testing
- Dolutegravir/Lamivudine 50 MG-300 MG Oral Tablet [DOVATO], Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate 100 MG-300 MG-300 MG Oral Tablet [DELSTRIGO]
- Where
- 5 sites in Denmark
- Volunteers
- 126 people
- Sponsor
- Thomas Benfield
Time Restricted Feeding, Renal Insufficiency, Chronic
Effects of TRF on Obese Patients With CKD Stage 3-4
Obesity is associated with glomerular hyperfiltration leading to renal impairment and is a risk factor for the progression of kidney disease.Weight loss can reduce proteinuria and improve eGFR.Intermittent fasting is safe and…
- Conditions
- Time Restricted Feeding, Renal Insufficiency, Chronic, Obesity
- Trial name
- NCT05037747
- Testing
- Time-restricted feeding(TRF)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Type 2 Diabetes, Depression
Learning to BREATHE: A Randomized Controlled Trial to Lower Diabetes Risk in Adolescent Girls
Type 2 diabetes is a chronic disease that puts people at risk for major health problems like heart disease. Type 2 diabetes is the most common type of diabetes in adults.
- Conditions
- Type 2 Diabetes, Depression, Obesity
- Trial name
- NCT02218138
- Testing
- Learning 2 BREATHE, Colorado Blues
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Obesity
Health After Birth Intervention Trial
This trial is to assess the feasibility of a larger, definitive RCT and determine the clinical effectiveness of an NHS 1:1 programme versus a modified programme with a low carbohydrate dietary intervention (as per Feinman and…
- Trial name
- HABIT (NCT05137691)
- Testing
- Adapted NHS weight management 1:1 programme, NHS 1:1 weight management programme
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Obesity
A Resistance Training Program for Black Women: Project F.I.R.E.
This study will utilize a randomized control trial design, with participants randomly assigned to a theoretically-based culturally tailored intervention or standard of care group.
- Trial name
- NCT05733260
- Testing
- Exercise
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Auburn University
Maternal Obesity Complicating Pregnancy, Birth,or Puerperium, Child Malnutrition
Addressing the Double Burden of Malnutrition in Guatemala
Globally, populations are experiencing increases in the double burden of malnutrition, commonly defined as maternal overweight/obesity and child stunting in the same household.
- Trial name
- NCT06750120
- Testing
- Family food ration, Optimal weight counseling, Enhanced Usual Care
- Where
- Guatemala
- Volunteers
- 1,532 people
- Sponsor
- Brigham and Women's Hospital
Neurologic Disorder, Adiposity
Childhood Adiposity and Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes (CONCEPTT Kids)
This is a follow-up study of children born to mothers who participated in the CONCEPTT Trial. CONCEPTT (a multicentre randomized controlled trial of continuous glucose monitoring (CGM) in women with Type 1 diabetes during…
- Trial name
- NCT04098679
- Where
- 4 sites in Canada
- Volunteers
- 174 people
- Sponsor
- University of Calgary
Female Infertility, Obesity
Effect of the Glycemic Index of Diet on Metabolic and Reproductive Parameters in Overweight and Obese Infertile Women
Infertility has been currently recognized as a disorder related to obesity. Among several metabolic changes associated with obesity, insulin resistance appears to be linked to hormonal disorders that affect reproductive system.
- Trial name
- NCT02416960
- Testing
- Low Glycemic Index Diet Group, Conventional Diet Group
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Insulin Resistance, Obesity
The Effects of Orange Juice on Insulin Sensitivity and Plasma Lipids
The aim of this study is primarily to investigate the ability of antioxidants found in orange juice (OJ) to increase the body's sensitivity to the hormone insulin.
- Trial name
- NCT01201603
- Testing
- orange juice
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Polycystic Ovary, Obesity
Polycystic Ovary Syndrome and BETATROPHIN
This is an original study giving an information about the association body mass index, polycystic ovary syndrome and betatrophin.
- Trial name
- NCT04448730
- Testing
- serum marker levels
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Hatice Akkaya
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