Clinical trials: Oxidative Stress, completed
Oxidative Stress
Safety and Tolerability of Antioxidant (AT-001)for Reducing Brain Oxidative Stress
The purpose of this study is to determine the safety, bioavailability, and effectiveness of an organic yeast-selenium compound in reducing brain oxidative stress.
- Trial name
- NCT01731093
- Testing
- AT-001
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Alltech Life Sciences Inc.
Type 2 Diabetes, Oxidative Stress
Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes
Oxidative stress has been implicated in the development and complications of diabetes. Hyperglycemia and insulin resistance or insufficiency in diabetes can cause oxidative stress by excessive reactive oxygen species and can…
- Trial name
- NCT00845130
- Testing
- ascorbic acid (Vitamin C)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- In-Young Choi, Ph.D.
Fenofibrate/Simvastatin Comparison
Randomized Comparative Efficacy and Safety Study of Intermittent Simvastatin and Fenofibrate in Hemodialysis
Sixty chronic hemodialysis patients were randomly assigned to receive fenofibrate 100 mg (group 1, n = 30) or simvastatin 20 mg (group 2, n = 30) three times/week after their dialysis session.
- Trial name
- NCT02886299
- Testing
- Fenofibrate, Simvastatin
- Volunteers
- 60 people
- Sponsor
- Cairo University
Temporomandibular Disorder, Oxidative Stress
Evaluation of Oxidative Stress and Inflammation Markers in Temporomandibular Disorders
Background: The occurrence of many diseases has been associated with oxidative stress and disruption of antioxidant mechanisms. Temporomandibular Joint(TMJ) Disorders are also thought to develop with the onset of the destructive…
- Conditions
- Temporomandibular Disorder, Oxidative Stress, Inflammation
- Trial name
- NCT05985733
- Testing
- Biochemical analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Oxidative Stress, Dyslipidemias
Effects of Octacosanol During Taekwondo Training
Taekwondo players undergo rapid reductions of body weight prior to their competition in order to gain a size advantage over the opponent.
- Trial name
- NCT03557476
- Testing
- Octacosanol
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Kosin University
Inflammatory Response, Oxidative Stress
Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation
The aim of this research project is to explore the acute impact of specific foods and beverages, which have been shown to be associated with inflammatory processes, mainly in epidemiological studies, on inflammatory and oxidative…
- Conditions
- Inflammatory Response, Oxidative Stress, Oxidative Stress Induction
- Trial name
- NCT05242978
- Testing
- Nutrition
- Where
- Austria
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Oxidative Stress, Inflammation
Probiotic Sport Study
We investigate the impact of a probiotic-based dietary supplement on oxidative stress and endotoxemia before and after strenuous exercise.
- Conditions
- Oxidative Stress, Inflammation, Endotoxemia
- Trial name
- NCT01474629
- Testing
- probiotic-based dietary supplement
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Green Beat
Intestinal Failure
Effect of Parenteral Nutrition With n-3 PUFAs on Patients With Intestinal Failure
Randomized, double-blind, controlled clinical trial to evaluate the effect of parenteral nutrition (PN) supplemented with lipid emulsions containing 0.1-0.2 g omega 3 polyunsaturated fatty acids (n-3 PUFA)/kg body weight/day for…
- Trial name
- NCT03869957
- Testing
- Intervention group
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Aging, Muscle Damage
Eccentric Exercise and Oxidative Stress
The purpose of the present investigation is to compare the responses and adaptations of young and elderly individuals to repeated eccentric exercise in regards to muscle function and redox homeostasis in a side-by-side comparison.
- Conditions
- Aging, Muscle Damage, Oxidative Stress
- Trial name
- NCT01728675
- Testing
- Exercise
- Where
- Cyprus
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- European University Cyprus
Oxidative Stress, Cardiovascular Diseases
Effect of Oral Intake of Bacopa Monneiri on Vascular Oxidative Stress
Bacoxy_I study aims to evaluate the efficacy of a standardized Bacopa monnieri extract, Bacopa-400®, on vascular oxidative stress.
- Conditions
- Oxidative Stress, Cardiovascular Diseases, Bacopaside II, Bacopa Monnieri
- Trial name
- Bacoxy_I (NCT06355167)
- Testing
- Bacopa monnieri
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Oxidative Stress, Morbid Obesity
A Comparison of the Effects of Desflurane and TIVA on Antioxidant System in Morbidly Obese Patients
With the development of technology, the safety of anesthesia devices and the progression of monitoring techniques affect the anesthetic management.
- Trial name
- OxSys (NCT03814577)
- Testing
- Total Antioxidant Status, Total Oxidant Status, Bispectral Index
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Inonu University
Diabetic Peripheral Neuropathy (DPN)
Thymoquinone as an add-on Therapy for the Management of Patients With Diabetic Peripheral Neuropathy
The goal of this clinical trial is to evaluate the efficacy of thymoquinone as an adjuvant treatment with pregabalin in the management of diabetic peripheral neuropathy for both sexes older than 18 years.
- Trial name
- TQDPN (NCT07313111)
- Testing
- stander treatment pregabalin, thymoquinone
- Where
- Iraq
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Hashimoto Thyroiditis, Autoimmune Thyroiditis
Effects of Low-Level Laser Therapy on Oxidative Stress Levels
Hashimoto's thyroiditis (HT) is the most commonly observed inflammatory and autoimmune disease of the thyroid gland. Recent evidence has suggested that low-level laser therapy (LLLT) can improve thyroid function and reduce levels…
- Conditions
- Hashimoto Thyroiditis, Autoimmune Thyroiditis, Thyroiditis, Thyroid Diseases
- Trial name
- NCT04754607
- Testing
- Low Level Laser Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul Medipol University Hospital
Polycystic Ovary Syndrome, Dental Caries
Oxidative Stress in Polycystic Ovary Syndrome With Periodontal Disease and Dental Caries Lesions
This study evaluates the oxidative stress parameters in females with polycystic ovary syndrome (PCOS) and clinically healthy. Because of the fact that both oral disease included periodontitis and dental caries, and metabolic…
- Trial name
- NCT03594968
- Testing
- polycystic ovary syndrome
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Pre-Eclampsia, Early Onset Preeclampsia
Early Onset Preeclampsia and Nectin-4
Early-onset Preeclampsia (PE) is a pregnancy disorder which may present with adverse pregnancy outcomes. Nectin-4 is an adhesion molecule mainly expressed in placenta.
- Conditions
- Pre-Eclampsia, Early Onset Preeclampsia, Oxidative Stress, Immunologic Diseases in Pregnancy
- Trial name
- NCT05098691
- Testing
- serum marker levels
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Hatice Akkaya
Heart Failure, Cardiomyopathies
The Impact of Zinc Supplementation on Left Ventricular Function in Nonischemic Cardiomyopathy
Heart failure affects over 5.3 million Americans and, while other cardiovascular diseases have enjoyed a reduction in mortality rates over the last decade, the mortality from heart failure continues to rise[1].
- Trial name
- NCT00696410
- Testing
- Zinc Acetate
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Michigan
Schizophrenia, Oxidative Stress
Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia
Schizophrenia is a devastating mental disorder with a prevalence of approximately 1% worldwide. While effective in reducing positive symptoms, current treatments have limited effects on cognitive and social cognition/processing…
- Trial name
- NCT03788759
- Testing
- Alpha-lipoic acid
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
Aging, Oxidative Stress
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and…
- Conditions
- Aging, Oxidative Stress, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04351113
- Testing
- MITO-AO, PB-125, Passive Leg Movement (PLM)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Joel Trinity
Advanced Stage Cancer
Melatonin In Reduction of Chemotherapy-Induced Toxicity (MIRCIT) Trial
Meta-analysis of previous studies have shown that melatonin is a beneficial adjutant for reducing chemotherapy-induced toxicity; however no randomized, double-blind, placebo controlled trials have been conducted.
- Trial name
- MIRCIT (NCT01706627)
- Testing
- 10 mg Melatonin, 20 mg Melatonin
- Where
- 2 sites in Thailand
- Volunteers
- 175 people
- Sponsor
- Khon Kaen University
Sleep Apnea Syndromes
Sleep Apnea and Oxidative Stress and Nitric Oxide
Background: Previous studies present contradictory data concerning obstructive sleep apnea syndrome (OSAS), lipid oxidation and nitric oxide (NO) bioavailability.
- Trial name
- NCT00547937
- Testing
- nasal continuous positive airway pressure (CPAP) therapy
- Where
- Spain
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
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