Clinical trials: Oxidative Stress Induction
Endotoxemia, Inflammation
The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia
Excessive inflammation, production of free radicals and vascular injury are considered the main contributors to the development of organ dysfunction in patients with severe infections and sepsis.
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome, Sepsis
- Trial name
- NCT00916448
- Testing
- Atazanavir, E. coli endotoxin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hemodynamics, Oxidative Stress
Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients
To explore the effect of induction and maintenance of anesthesia with etomidate on hemodynamics and oxidative stress in diabetic patients.
- Conditions
- Hemodynamics, Oxidative Stress, Anesthesia
- Trial name
- NCT02202239
- Testing
- midazolam, Penehyclidine Hydrochloride Injection, Etomidate
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
Oxidative Stress
Drinking Effect of Electrolyzed Alkaline Reduced Water on Oxidative Stress and Fatigue After Intense Exercise
The goal of this clinical trial is to test the drinking effect of electolyzed alkaline reduced water (ARW) generated from alkaline ionizer (CGM MWPI-2101) on oxidative stress and fatigue after high-intensity exercise in healthy…
- Trial name
- NCT05673395
- Testing
- Electrolyzed alkaline reduced water generator
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kyu Jae Lee
Advanced Stage Cancer
Melatonin In Reduction of Chemotherapy-Induced Toxicity (MIRCIT) Trial
Meta-analysis of previous studies have shown that melatonin is a beneficial adjutant for reducing chemotherapy-induced toxicity; however no randomized, double-blind, placebo controlled trials have been conducted.
- Trial name
- MIRCIT (NCT01706627)
- Testing
- 10 mg Melatonin, 20 mg Melatonin
- Where
- 2 sites in Thailand
- Volunteers
- 175 people
- Sponsor
- Khon Kaen University
Alcoholic Hepatitis
N-Acetylcysteine in Severe Acute Alcoholic Hepatitis
Acute alcoholic hepatitis (AAH) is the most severe form of alcoholic liver disease (ALD) and is associated with a high risk of dying in the short term.
- Trial name
- NCT00962442
- Testing
- N-Acetylcysteine
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- Erasme University Hospital
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Post-Exercise Recovery
Effect of Chickpea Protein Hydrolysate Supplementation on Muscle Damage and Inflammatory Plasma Markers During a Football Tournament: A Randomized, Placebo-Controlled Crossover Trial
This randomized, placebo-controlled crossover study evaluated the safety and potential beneficial effects of a beverage containing chickpea protein hydrolysate in football players.
- Trial name
- PROVERDE (NCT07765719)
- Testing
- Chickpea Protein Hydrolysate Beverage
- Where
- Spain
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Instituto de la Grasa
Metabolic Syndrome, Obesity, Metabolically Benign
Oxidative Stress, Inflammation, and Lipoprotein in Metabolic Syndrome
Obesity is associated with general low grade inflammation and, consequently, of oxidative stress that affects properties and functionality of lipoproteins. Metabolic syndrome exacerbate low grade inflammation.
- Trial name
- NCT03553381
- Testing
- hypocaloric balanced diet
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- roberta cazzola
Oxidative Stress, Inflammation
Probiotic Sport Study
We investigate the impact of a probiotic-based dietary supplement on oxidative stress and endotoxemia before and after strenuous exercise.
- Conditions
- Oxidative Stress, Inflammation, Endotoxemia
- Trial name
- NCT01474629
- Testing
- probiotic-based dietary supplement
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Green Beat
Muscle Damage
The Effect of New Zealand Blackcurrant (NZBC) Supplementation on Recovery Following Strenuous Exercise
The study aims to examine the effect of a New Zealand blackcurrant (NZBC) supplement on markers of muscle damage and recovery following strenuous resistance exercise.
- Trial name
- CurraNZ_MD (NCT05010057)
- Testing
- New Zealand blackcurrants (NZBC)
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Bipolar Disorder
The Effect of N- Acetylcysteine on Inflammatory and Oxidative Stress Biomarkers
Background: . Bipolar disorders and tobacco use disorder are top of the causes of disability and mortality worldwide Objective: The aim of this study was to evaluate N-acetyl-cysteine (NAC) as an adjunctive treatment in patients…
- Trial name
- nac (NCT02420418)
- Testing
- N-acetyl-cysteine (NAC)
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Alcoholism
A Study of Pleiotropic Pioglitazone Effects on the Alcoholic Lung (APPEAL Study)
This study is a single center, open-label, randomized clinical trial to determine the effect of pioglitazone (PIO) treatment on alveolar macrophage immune function, redox stress, and NADPH oxidase expression in outpatient…
- Trial name
- APPEAL (NCT03060772)
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Emory University
Inflammatory Response, Oxidative Stress
Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation
The aim of this research project is to explore the acute impact of specific foods and beverages, which have been shown to be associated with inflammatory processes, mainly in epidemiological studies, on inflammatory and oxidative…
- Conditions
- Inflammatory Response, Oxidative Stress, Oxidative Stress Induction
- Trial name
- NCT05242978
- Testing
- Nutrition
- Where
- Austria
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Periodontitis (Stage 3), Smoking
Determination of RNA/DNA Damage Associated With Oxidative Stress in Periodontitis Patients
This study looked at whether a type of gum disease called Stage III periodontitis and cigarette smoking are linked to higher levels of "oxidative stress." Oxidative stress can damage DNA and RNA, which are important parts of our…
- Trial name
- NCT07279896
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Zehra Hasgül
Cardiotoxicity, Breast Cancer
Dietary Restriction to Prevent Cardiotoxicity in Breast Cancer Patients
The goal of this clinical trial is to compare a dietary intervention with a regular diet in patients with early breast cancer undergoing anthracycline based chemotherapy.
- Trial name
- PROTECT-COR (NCT06622954)
- Testing
- Protein- and Calorie restriction
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Erasmus Medical Center
Non-communicable Diseases (NCD), Addiction to Opioids
Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants
The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident.
- Conditions
- Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders
- Trial name
- CHANCE (NCT07558187)
- Where
- 5 sites in Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Preeclampsia
Thiol/Disulphide Homeostasis and Preeclampsia
Objective: To evaluate serum evaluate thiol/ disulfide levels in preeclampsia and address its relationship with its severity. Methods: This prospective study will include 50 pregnancies complicated with preeclampsia and 50…
- Trial name
- thiols&PE (NCT03927014)
- Testing
- thiol/disulfide levels
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Performance Recovery, Exercise-induced Inflammation
S-Acetyl Glutathione and Performance Recovery in Soccer
Soccer players display elevated inflammatory and oxidative stress markers combined with reduced soccer specific performance over a 72-hour period.
- Conditions
- Performance Recovery, Exercise-induced Inflammation, Exercise-induced Oxidative Stress
- Trial name
- NCT07690124
- Testing
- 200 mg S-Acetyl Glutathione, 500 mg S-Acetyl Glutathione
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Pigmentation, Oxidative Stress
A Study to Evaluate the Ability of Sunscreen Products to Modulate the Effects of Deep UVA +/- HEV Blue Light Induced Pigmentation and Biomarkers of Cutaneous Oxidative Stress
To assess the level of sub pigmentation following an acute exposure to a Deep Ultraviolet A and high energy Blue Light wavelengths (380-420 nm).
- Trial name
- NCT07695753
- Testing
- Sunscreen application #1, Sunscreen application #2
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Kidney Failure
Urinary Marker for Oxidative Stress in Human Cisplatin- Induced Renal Injury
We previously reported early measurement of urinary MDA might be a useful marker for the prediction of CDDP-induced renal damage in rat.
- Trial name
- NCT00310739
- Where
- Japan
- Sponsor
- Hamamatsu University