Clinical trials: Oxidative Stress Induction
Healthy
Oxidative Stress as an Acute Exercise-induced Mechanism of Stem and Progenitor Cell Mobilization
It is already known from literature that exercise mobilizes stem and progenitor cells into the peripheral blood. However, the exact mechanisms thereof remain to be fully elucidated.
- Trial name
- EISMO (NCT03747913)
- Testing
- Antioxidative supplementation
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Oxidative Stress, Redox Imbalance
Oxidative Stress and Antioxidant Enzyme Activities in Elite Female Turkish Cross-Country Skiers
This study is designed to investigate oxidative stress and antioxidant defense biomarkers in elite female cross-country skiers compared with sedentary women.
- Conditions
- Oxidative Stress, Redox Imbalance, Exercise-Induced Physiological Stress
- Trial name
- NCT07181889
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Duvenciler Anadolu Lİsesi
Barrett's Esophagus, Gastroesophageal Reflux Disease
Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition
The purpose of this study is to elucidate mechanisms whereby oxidative stress induced by acute reflux esophagitis: 1) activates p38 to regulate proteins that control the G1/S cell cycle checkpoint, and 2) activates HIFs (hypoxia…
- Trial name
- NCT02579460
- Testing
- Cessation of Acid Suppressing Medications
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dallas VA Medical Center
Oxidative Stress
SIMOX - Induction of Oxidative Stress
The purpose of the study is to investigate if use of simvastatin is associated with the level of oxidative stress in humans. The association is examined by comparing changes in oxidative stress in a group treated with simvastatin…
- Trial name
- SIMOX (NCT02256254)
- Testing
- Simvastatin
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Severe Alcoholic Hepatitis
Metadoxine as a Therapy for Severe Alcoholic Hepatitis
The purpose of this study is to determine whether metadoxine is effective for improve survival and reduced oxidative stress in patients with severe alcoholic hepatitis.
- Trial name
- NCT02161653
- Testing
- Prednisone plus Metadoxine, Pentoxifylline plus Metadoxine
- Where
- Mexico
- Volunteers
- 135 people
- Sponsor
- Hospital General de Mexico
Muscle Damage
Recovery Kinetics Following Eccentric Exercise
The aim of this study will be to investigate the recovery kinetics of neuromuscular fatigue, muscle microtrauma indicators, performance and oxidative stress factors after three different exercise induced muscle damage (EIMD)…
- Trial name
- NCT04733911
- Testing
- 75 eccentric contractions, 150 eccentric contractions, 300 eccentric contractions
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Tardive Dyskinesia
Melatonin Treatment for Tardive Dyskinesia in Schizophrenia
This is a double-blind, randomized, placebo-controlled trial of melatonin as an add-on therapy to antipsychotics will be performed to examine the effects of melatonin on tardive dyskinesia symptoms and cognitive deficits in 120…
- Trial name
- NCT01391390
- Testing
- Melatonin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing HuiLongGuan Hospital
Smoking Cessation, Oxidative Stress
ESTxENDS Trial- Substudy on Oxidative Stress Induced by Electronic Nicotine Delivery Systems (ENDS) Measured in EBC
--> This is a substudy of the main ESTxENDS trial (NCT03589989). Oxidative stress outcomes should be considered secondary outcomes of the main smoking cessation outcome formulated in NCT03589989.
- Trial name
- ESTxENDS (NCT03612453)
- Testing
- ENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
- Where
- Switzerland
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Bern
Tracheal Intubation, Extracorporeal Membrane Oxygenation
Mechanism of Nitric Oxide on Ventilator-induced Diaphragm Dysfunction with Extracorporeal Membrane Lung Assistance
The goal of this clinical trial is to explore the effect of NO treatment on diaphragm function after mechanical ventilation with ECMO assistance.
- Conditions
- Tracheal Intubation, Extracorporeal Membrane Oxygenation, Nitric Oxide, Ventilator-induced Diaphragmatic Dysfunction
- Trial name
- NCT06660784
- Testing
- Nitric Oxide
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhongnan Hospital
Opioid Addiction
MEDiterranean Diet-driven Detoxification of OPioid Addicted patiEnts (MED-DOPE)
The MED-DOPE (MEDiterranean diet-driven Detoxification of OPioid addicted patiEnts) study is a randomized controlled trial that aims to investigate the role of a nutritional intervention based on the principles of Mediterranean…
- Trial name
- MED-DOPE (NCT07022782)
- Testing
- A nutritional intervention based on the principles of Mediterranean diet
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristidis Veskoukis
Myotonia
Cardiovascular Consequences of NIV Withdrawal in Patients With Myotonic Dystrophy
Background: Myotonic dystrophy lead to highly heterogeneous, multisystemic symptoms including myotonia, progressive muscle weakness, cardiac conduction defects, cataract, metabolic dysfunction, and excessive daytime somnolence.
- Trial name
- NCT00745238
- Testing
- withdrawal of non-invasive ventilation
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Grenoble
Systemic Inflammation, Cardiopulmonary-bypass
Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase
Study should demonstrate that alkaline phosphatase reduces the incidence and extent of acute kidney injury after cardiopulmonary bypass (CPB) as defined by the AKIN criteria.
- Trial name
- APPIRED-III (NCT03050476)
- Testing
- RESCAP®
- Where
- 21 sites in Australia, Austria and 9 more
- Volunteers
- 1,250 people
- Sponsor
- Alloksys Life Sciences B.V.
Pregnancy Complications, Endothelial Dysfunction
Oxidative Stress and Endothelial Function in Pregnancy Complications
Pregnancy complications like pre-eclampsia (PE), pregnancy induced hypertension (PIH), intra-uterine growth restriction (IUGR) and preterm labor (PTL), (i.e.
- Trial name
- ENDOPREG (NCT02603913)
- Where
- Belgium
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Alcoholic Fatty Liver Disease
The Efficacy of Tocotrienol Rich Fraction for Liver Protection in Adult Patients With Alcoholic Fatty Liver Disease (AFLD)
This clinical study aims to explore the potential liver-protective effects of palm tocotrienol-rich fraction (a form of Vitamin E) in adults with alcoholic fatty liver disease (AFLD).
- Trial name
- NCT07466485
- Testing
- Palm Tocotrienol Rich Fraction (TRF), Refined, bleached, and deodorised (RBD) palm olein
- Where
- Malaysia
- Volunteers
- 26 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Nicotine Dependence, Cigarette Smoking
Lemongrass (Cymbopogon Citratus) on Nicotine Dependence, Cotinine Levels, and Related Biomarkers in Adult Smokers
The goal of this clinical trial is to learn whether lemongrass (Cymbopogon citratus) inhaler and liquid vapor interventions affect nicotine dependence and related biological and behavioral outcomes in adult smokers.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Tobacco Use Disorder, Psychological Stress
- Trial name
- CCIVS (NCT07366294)
- Testing
- Lemongrass Inhaler, Lemongrass Liquid Vapor, Lemongrass Inhaler and Liquid Vapor
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Titin Andri Wihastuti
Healthy Volunteer
Evaluation of Astaxanthin Properties on Anti-fatigue
Ten young, healthy, physically active male college students were crossed over for AST or placebo supplements randomized into placebo or AST trials and orally consumed placebo or AST (28 mg/d) supplements for four days.
- Trial name
- NCT06593535
- Testing
- Astaxanthin (AST trial)
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Schizophrenia, Drug Induced Movement Disorder, Unspecified
Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics
D2 dopaminergic receptor blockers, used to treat schizophrenia, can lead to the onset of movement disorders. Drug-induced movement disorders encompass several syndromes.
- Conditions
- Schizophrenia, Drug Induced Movement Disorder, Unspecified, Oxidative Stress
- Trial name
- NCT03790345
- Testing
- Pyridoxine, Cobalamin
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara
Oxidative Stress Induction, Laryngeal Cancer
Oxidative Stress and Inflammation Biomarkers in Surgically Treated Patients With Laryngeal Cancer
A experimental interventional prospective study will include patients with squamocellular carcinoma of the larynx surgically treated at the tertiary referral center.
- Conditions
- Oxidative Stress Induction, Laryngeal Cancer, Interleukins, Pain Management
- Trial name
- NCT05857202
- Testing
- Analgesics, Opioid, Analgesics, Non-Narcotic
- Where
- 2 sites in Serbia
- Volunteers
- 100 people
- Sponsor
- Clinical Centre of Serbia
Type 1 Diabetes Mellitus
Vitamin C and Liraglutide Effects on Hypoglycemia-induced Oxidative Stress, Inflammation and Endothelial Dysfunction in Type 1 Diabetes.
To investigate the effect of liraglutide on vascular injury induced hypoglycemia in patients with type 1 diabetes mellitus. The vascular damage is evaluated at investigating the changes of endothelial function
- Trial name
- DIAB-01 (NCT02109315)
- Testing
- Vitamine C, Liraglutide 6 mg
- Where
- Spain
- Sponsor
- Anna Cruceta
Exercise-induced Inflammation, Exercise-induced Oxidative Stress
Polyphenols, Exercise, and Metabolomics
Nutrasorb is a newly developed food product (see www.nutrasorb.com). This study will use the Nutrasorb soy protein product that is matrixed with polyphenols from blueberries and green tea extract, and test for efficacy as a…
- Conditions
- Exercise-induced Inflammation, Exercise-induced Oxidative Stress, Exercise-induced Immune Dysfunction
- Trial name
- NCT01775384
- Testing
- Nutrasorb
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Appalachian State University