Clinical trials: Oxidative Stress Induction
Inflammation
LycoRed 40051 Product as a Countermeasure to Exercise Stress
The primary purpose of this study is to determine if 4-weeks ingestion of LycoRed (code 40051) product containing a mixture of tomato extract with carotenoids and phytochemicals by endurance runners attenuates inflammation…
- Trial name
- NCT02369666
- Testing
- LycoRed (code 40051) product
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Muscular Injury
Turmeric and Exercise-Induced Muscle Damage and Oxinflammation
The purpose of this study is to measure the effect of using a turmeric-based supplement for 2-weeks on muscle damage and soreness that occur in the body after 90-minutes of exercise.
- Trial name
- NCT04765527
- Testing
- Turmeric Strength for Joint
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Tourniquet Pain, Ischemia-reperfusion
The Effect of Prolonged ischemıa and anesthetıc Agents on Oxidative Stress
The goal of this observational study is to learn about the relationship between postoperative pain and tourniquet-induced oxidative damage in adults undergoing orthopedic knee arthroscopy surgery.The goal of this observational…
- Conditions
- Tourniquet Pain, Ischemia-reperfusion, Postoperative Pain, Anesthesia
- Trial name
- NCT06942650
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duzce University
Healthy, Athletes
Effects of Maca Supplementation on Badminton-specific Exercise Performance
This study aims to investigate whether a 14-day short-term supplementation of Maca can effectively mitigate oxidative stress and fatigue induced by badminton competition.
- Trial name
- NCT07082985
- Testing
- Maca (Maca trial)
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
STEMI, Oxidative Stress
Correlations Between Oxidative Stress Biomarkers, h-FABP and Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Undergoing Primary PCI
The investigators intend to evaluate Oxidative Stress biomarkers through a. Catalase Activity Assay; b. Lipid Peroxidation Assay; c. SOD Assay; d. Total Antioxidant Capacity Assay; e.
- Conditions
- STEMI, Oxidative Stress, Oxidative Stress Induction, Primary PCI
- Trial name
- OxiSTEMIhFABP (NCT04034940)
- Testing
- Dosing Oxidative stress biomarkers & hFABP in STEMI pPCI patients
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Hypertension
Neural Mechanism of Aldosterone-induced Insulin Resistance
Patients with high aldosterone hormone have higher blood glucose than normal people. This study is being done to understand how aldosterone hormone affects the nerve activity that controls blood flow in the muscles and blood…
- Trial name
- NCT02102243
- Testing
- DEFINITY® infusion, Human Recombinant Regular Insulin infusion, Dextrose infusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wanpen Vongpatanasin
Head and Neck Neoplasms
THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS
Head and neck cancer corresponds to tumors located in the upper aerodigestive tract, such as the oral cavity, pharynx and larynx.
- Trial name
- NCT02241876
- Testing
- N-acetylcysteine
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Campinas, Brazil
Exertion; Excess, Oxidative Stress
Garcinia Mangostana L Rind and Solanum Lycopersicum Fructus Trial to Prevent Exercise-induced Oxidative Stress
Treatments are an administration of a mixed extract of Garcinia mangostana 400mg and Solanum Lycopersicum Fructus 200mg (OKSI(R) POM TR 193324351) and placebo control.
- Trial name
- GMR-RCT-EOS (NCT03899454)
- Testing
- Garcinia-mangostana-L-rind and Solanum-Lycopersicum-Fructus mixture-extract
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitas Negeri Semarang
Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029.
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms who have been referred to the Dr.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity, Chronic Pain, Delayed Wound Healing
- Trial name
- EPOOzo-2 (NCT07325851)
- Testing
- Ozone Therapy
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Bernardino Clavo, MD, PhD
Exercise-induced Inflammation
Effect of 4 Weeks Fish Oil Supplementation on Cycling Performance in Healthy Male Cyclists
Research Plan Eleven trained cyclists have completed 4 cycling performance trials, before and after 4 weeks of fish oil supplementation and before and after 4 weeks of placebo with a 4 week washout between supplementation…
- Trial name
- NCT03205241
- Testing
- n-3 PUFA
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Exercise-induced Oxidative Stress
Physiological Effect of Ataulfo Mango (Manguifera Indica) Beverage in Exercise
The aim of this study is to assess the antioxidant capacity of two mango base beverages (AM1, AM2), against exercise-induced oxidative stress.
- Trial name
- NCT03182543
- Testing
- Mango pulp beverage, Mango pulp and peel beverage, Control beverage
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Ciudad Juarez
Contrast-induced Acute Kidney Injury
Remote Ischemic Preconditioning to Prevent Contrast-Induced Kidney Injury in Diabetic Patients (PRINCES)
This study investigates whether remote ischemic preconditioning (RIPC)-a non-invasive technique involving brief cycles of blood flow restriction to the arm-can prevent contrast-induced nephropathy (CIN) in diabetic patients…
- Trial name
- PRINCES (NCT07179874)
- Testing
- Remote Ischemic Preconditioning
- Volunteers
- 71 people
- Sponsor
- Universidad de Murcia
Oral Mucositis
Low-level Laser Therapy on Inflammatory Mediators During Chemotherapy-induced Oral Mucositis
The aim of the study is to evaluate the effect of low-level laser therapy (LLLT) on the severity of oral mucositis (OM) and inflammatory mediators (pro- and anti-inflammatory cytokines, metalloproteinases and growth factors)…
- Trial name
- LLLTHSCT (NCT02050373)
- Testing
- Low-Level laser
- Volunteers
- 51 people
- Sponsor
- Universidade Federal de Goias
Oxidative Stress, Physical Activity
Effect of the Combination of Pterostilbene Cocrystal With Silybin and Nicotinamide Riboside on Exercise-Induced Oxidative Stress
This study aims to evaluate the effects of the dietary supplement ccPT-SIL-NR, which contains pterostilbene (ccPT), silybin (SIL), and nicotinamide riboside (NR), on oxidative stress markers after a high-intensity exercise…
- Conditions
- Oxidative Stress, Physical Activity, Antioxidant Effect
- Trial name
- PT-SILAOX (NCT07024966)
- Testing
- Pterostilbene-silybin-nicotinamide riboside, Control Group
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Inflammation;Muscle(S), Oxidative Stress Injury
Effect of 8-week Supplementation With Black Chokeberry on Recovery in Highly Trained Rowers
Purpose: To analyze the effects of 8-week supplementation with anthocyanin compounds contained in black chokeberry (Aronia melanocarpa) on indicators of inflammation and oxidative stress.
- Conditions
- Inflammation;Muscle(S), Oxidative Stress Injury, Permeability; Increased
- Trial name
- NCT06133751
- Testing
- black chokeberry (Aronia melanocarpa)
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- Poznan University of Physical Education
Fetal Alcohol Syndrome (FAS)
Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children
The flavonoid epigallocatechin gallate (EGCG) is a modulator of neuronal plasticity useful in other neurodevelopmental diseases.
- Trial name
- Neuro-SAF (NCT02558933)
- Testing
- Epigallocatechin gallate
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Alcoholic Hepatitis
Effect of Omega 5 Fatty Acid as an Adyuvant Treatment to Prednisone in Patients With Severe Alcoholic Hepatitis
In Mexico, alcoholic liver disease is the fourth cause of mortality (INEGI). Patients with severe alcoholic hepatitis have a high mortality at 28 days and 6 months, patients receiving standard therapy with prednisone that are non…
- Trial name
- NCT03732586
- Testing
- Omega 5 fatty acid supplement
- Where
- 2 sites in Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital General Dr. Manuel Gea González
Phenylketonuria
Phenylketonuria, Oxidative Stress, and BH4
The purpose of this study is to see how tetrahydrobiopterin therapy (BH4; also known as sapropterin dihydrochloride or Kuvan) affects measures of oxidative stress and endothelial function in patients with Phenylketonuria (PKU).
- Trial name
- NCT01395394
- Testing
- Kuvan, Meal Challenge
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Alcoholism
Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Alcoholics
This is a randomized, placebo controlled trial of dietary zinc and S-adenosylmethionine (SAMe) in otherwise healthy alcoholic US Veterans.
- Trial name
- ExZACTO (NCT01899521)
- Testing
- Bronchoscopy, Zinc sulfate 220 mg once daily, S-adenosylmethionine 400 mg twice daily
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- VA Office of Research and Development
Nephrotoxicity, Acute Kidney Injuries
Rutin and Ascorbic Acid for Prevention of Vancomycin-Induced Nephrotoxicity in Adult Patients" - a Clinical Trial Protocol Evaluating Whether Combined Rutin/Vitamin C Supplementation Reduces Kidney Toxicity From Vancomycin, Compared to Vitamin C Alone and Control.
Background: Vancomycin, a key antibiotic for MRSA infections, frequently causes nephrotoxicity (kidney damage) via oxidative stress, especially at the higher doses and longer durations now recommended.
- Trial name
- NCT07873372
- Testing
- Rutin + Ascorbic Acid (RUTA C60®), Ascorbic Acid (C-Retard®)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University