Clinical trials: Oxycontin
Pain
A Study to Evaluate Safety and Efficacy Following Dosing of Oxycodone/Naltrexone for Treatment of Adults With Pain Following Bunionectomy Surgery
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, Phase 3 study to evaluate the efficacy and safety of the administration of multiple doses of Oxycodone Hydrochloride plus Naltrexone…
- Trial name
- NCT02401750
- Testing
- Oxycodone Naltrexone (a), Oxycodone Naltrexone (b)
- Where
- 5 sites in United States
- Volunteers
- 163 people
- Sponsor
- Elite Laboratories, Inc
Low Back Pain
A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain
The primary objective is to assess the efficacy of oxycodone/naloxone controlled-release tablets (OXN) for the management of opioid-induced constipation (OIC) compared with oxycodone controlled-release tablets (OXY) in subjects…
- Trial name
- NCT01427283
- Testing
- Oxycodone/Naloxone controlled-release, Oxycodone HCl controlled-release
- Where
- 149 sites in United States
- Volunteers
- 450 people
- Sponsor
- Purdue Pharma LP
Nausea
Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery
The study aims to compare the incidence of side effects caused by Oxycodone and Hydromorphone.
- Trial name
- NCT02295124
- Testing
- Oxycodone, Hydromorphone
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Opiate Dependence
Remote Observed Dosing to Increase Suboxone Compliance
The goal of this project is to test the feasibility, acceptability, and preliminary efficacy of using remote compliance monitoring in buprenorphine (Suboxone®) treatment for opiate dependence.
- Trial name
- RODISC (NCT01779973)
- Testing
- Remote Observed Dosing
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Arthroplasty, Replacement, Hip
Oxycodone Versus Intravenous Morphine for Postoperative Analgesia After Hip Surgery
The main objective is to demonstrate that postoperative analgesia by IV oxycodone (compared to morphine IV) reduces opioid-related adverse events (nausea, vomiting, pruritus, respiratory depression, urinary retention, allergies…
- Trial name
- NCT01536301
- Testing
- Standard Care morphine hydrochloride, Oxycodone
- Where
- 2 sites in France
- Volunteers
- 246 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Kidney Stones
Visceral Pain From the Upper Urinary Tract - a Trial on the Effect of Morphine and Oxycodone in Patients Undergoing PCNL
The purpose of this study is to investigate the effect of oxynorm versus morphine after operation for kidney stone (PCNL). In addition the relationship between pain symptoms and referred sensory and trophic changes will be…
- Trial name
- NCT00784472
- Testing
- oxycodone, morphine
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- Katja venborg Pedersen
Hip Injuries, Hip Fractures
Is the Rate of Early Mobilisation in Hip Fracture Patients Using Alfentanil Better Than Standard Opioid Analgesia?
Hip fracture injuries are linked with increased morbidity, frailty, and mortality risk. Studies have shown that in hip fracture surgery, early mobilisation confers better pain control, 30-day complication and mortality rates and…
- Conditions
- Hip Injuries, Hip Fractures, Pain, Post Operative Pain
- Trial name
- REHAB (NCT06212622)
- Testing
- Alfentanil, Oxycodone
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Moderate-severe Pain
Safety and Pharmacokinetic Study of ALO-02 in Children Ages 7-17 With Pain
Safety and pharmacokinetics of an abuse-deterrent, extended-release formulation of oxycodone hydrochloride with a sequestered naltrexone core in children 7-17 with moderate-severe pain.
- Trial name
- NCT02680847
- Testing
- ALO-02
- Where
- 16 sites in United States
- Volunteers
- 32 people
- Sponsor
- Pfizer
Postoperative Pain
Sufentanil Sublingual Tablet System for Postoperative Pain Management After Total Knee Arthroplasty
The aim of this study is to assess the effectiveness of Sublingual Sufentanil Tablets System (SSTS, Zalviso ®) to control postoperative pain after total knee arthroplasty in the context of early rehabilitation program.
- Trial name
- NCT04448457
- Testing
- Sufentanil Sublingual Tablet, Oxycodone oral tablet and oxycodone extended-release oral tablet
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Centre Hospitalier Universitaire de Tivoli
Non Cancer Pain
Targin for Non-cancer Pain
To determine the improvement in symptoms of constipation in subjects receiving treatment with oxycodone/naloxone prolonged release tablets (OXN) compared to oxycodone prolonged release tablets (OXY) based on the Bowel Function…
- Trial name
- NCT01918098
- Testing
- Oxycodone/naloxone prolonged release tablets
- Where
- 31 sites in China
- Volunteers
- 230 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Chronic Pain
OTR Tablet 40 mg Fasted-state Bioequivalence Study
This is an open-label, single dose, randomised, cross-over study to confirm the bioequivalence (BE) of OTR tablet 40 mg and OXYCONTIN tablet 40 mg in a fasted state in Chinese subjects with chronic pain
- Trial name
- NCT03398278
- Testing
- Oxycodone Tamper Resistant, OXYCONTIN®
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Pain Control
Opioids Titration Study in Advanced Cancer Patients in Hong Kong
Pain is a common symptom that is experienced by patients with advanced cancer. Whilst mild pain can usually be controlled with simple analgesics, more severe pain may require initiation of opioid analgesics.
- Trial name
- NCT03024515
- Testing
- opioids titration, predefined titration steps
- Where
- Hong Kong
- Volunteers
- 2 people
- Sponsor
- Chinese University of Hong Kong
Opioid Use, Opioid Dependence
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
This study is designed to track brain functional changes in individuals with i) chronic back pain + opioid use (CBP+O) and individuals with ii) chronic back pain + opioid misuse disorder (CBP+mOUD) following a brief drug delay…
- Conditions
- Opioid Use, Opioid Dependence, Opioid-use Disorder, Narcotic Use
- Trial name
- NCT05463367
- Testing
- Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Oxycontin
Oxycodone Concentration in the Blood After Oral Premedication
Oxycodone is an opioid frequently given orally as a premedication prior to any kind of surgery. The initial studies are performed on healthy testpersons and is not given in surgery.
- Trial name
- NCT03386318
- Testing
- Oxycodone
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Lumbar Spine Stenosis, Lumbar Spine Degeneration
OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
- Trial name
- NCT05452694
- Where
- 3 sites in United States
- Volunteers
- 235 people
- Sponsor
- OpalGenix, Inc
Pharmacokinetics
Pharmacokinetics of Oxycodone and PF614 Co-Administered with Nafamostat (PF614-MPAR-101)
A single dose study to assess the pharmacokinetics (PK) of oxycodone, when PF614 is solution is administered alone and with nafamostat as an immediate-release (IR) solution and/or extended-release (ER) capsule prototypes.
- Trial name
- MPAR-101 (NCT05090280)
- Testing
- PF614 solution, Naltrexone Hydrochloride, Nafamostat Mesylate
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Ensysce Biosciences
Healthy
A Study to Characterize the Abuse Liability of Intravenous Oxycodone Alone or in Combination With Intravenous Naltrexone in Healthy, Non-Dependent, Recreational Opioid Users
The main purpose of this study is to simulate if oxycodone and naltrexone combination capsules (ALO-02) were to be tampered with by dissolving and then injecting intravenously for the purpose of getting high.
- Trial name
- NCT01825447
- Testing
- Oxycodone + Naltrexone, Oxycodone
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pain, Postoperative
Comparison of Adverse Drug Reactions Associated for Oxycodone and Morphine in Postoperative Pain After Abdominal Hysterectomy
The objective of this study is compare adverse reactions associated with oxycodone and morphine for the treatment of postoperative pain after abdominal hysterectomy
- Trial name
- NCT02936934
- Testing
- Morphine, Oxycodone
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hospital Civil de Guadalajara
Pain, Postoperative
The Safety and Efficacy of Epidural Oxycodone
There are conflicting results in earlier studies concerning the safety and efficacy of epidural oxycodone. In a study by Bäcklund and colleagues, epidural oxycodone was as effective as intravenous oxycodone, so they did not…
- Trial name
- epioksipanu (NCT02573909)
- Testing
- Oxycodone intravenously, Oxycodone epidurally
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Kuopio University Hospital
Pain, Postoperative
Use of Oxycodone in Bariatric Surgery
There is still no effective treatment for surgical pain, especially visceral pain in bariatric surgery. Oxycodone has great application prospect in patients with obesity, but there are few clinical studies and analgesic effect is…
- Trial name
- NCT05515822
- Testing
- Oxycodone Hydrochloride, Dezocine, Esketamine and Oxycodone
- Volunteers
- 90 people
- Sponsor
- Qiang Fu