Clinical trials: Oxygen
Trauma, Hemorrhagic Shock
Phase 2c Dose Comparison Study of MP4OX in Trauma
MP4OX is being developed as an ischemic rescue therapy to perfuse and oxygenate tissues at risk during hemorrhagic shock. MP4OX is a pegylated hemoglobin-based colloid designed to improve perfusion and target delivery of oxygen…
- Conditions
- Trauma, Hemorrhagic Shock, Lactic Acidosis
- Trial name
- NCT01973504
- Testing
- MP4OX, Control
- Where
- 31 sites in Australia, Belgium and 9 more
- Sponsor
- Sangart
Hypoxemia, Procedural Sedation
The Effectivity of End-tidal CO2 and Oxygen Reserve Index (ORI) Monitoring in Sedation
Endoscopic procedures are commonly performed using sedation. As drug-induced respiratory depression is a major cause of sedation-related morbidity, pulse oximetry has been established as standart practice .
- Conditions
- Hypoxemia, Procedural Sedation, Hypercapnia, Apnea
- Trial name
- NCT04793178
- Testing
- Oxygen Reserve Index, Masimo Corporation, USA.
- Volunteers
- 200 people
- Sponsor
- Yuksek Ihtisas Hospital
Oxygen Saturation, Percutaneous Coronary Intervention
Effects of Pilates Breathing Versus Diaphragmatic Breathing on Oxygen Saturation and Heart-Rate Variability in Post-Percutaneous Coronary Intervention Patients
Percutaneous Coronary Intervention (PCI) is a common procedure used to restore coronary blood flow in patients with coronary artery disease.
- Trial name
- NCT07872098
- Testing
- Pilates Breathing, Diaphragmatic breathing
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Middle Ear Barotrauma
Effects of Hyperbaric Oxygen Therapy on Middle and Inner Ear Functions
The goal of this observational study is to measure the effect of hyperbaric oxygen therapy on middle ear pressure in order to predict the risk factors for middle ear barotrauma also, to assess its effects on hearing functions of…
- Trial name
- HBOT (NCT06209021)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Obstructive Pulmonary Disease
High Flow Nasal Oxygen Versus Usual Care in COPD Pulmonary Rehabiliation
To compare the effects of high flow nasal oxygen with usual care during an outpatient 6-week pulmonary rehabilitation program after hospitalization for COPD exacerbation.
- Trial name
- NCT03940040
- Testing
- Usual care, High flow nasal oxygen
- Where
- Singapore
- Volunteers
- 22 people
- Sponsor
- Changi General Hospital
Overweight and Obesity, Insulin Sensitivity
Does Hyperbaric Oxygen Therapy Lead to a Sustained Increase in Insulin Sensitivity?
In a recent series of studies performed by our group, we have shown that exposure to hyperbaric oxygen (HBOT) leads to an increase in insulin sensitivity in male subjects and that this improvement can be measured in all men, not…
- Trial name
- HOTAIR3 (NCT02136615)
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Oxygen Saturation
Accuracy Performance Verification of the INVOS™ PM7100 System in Adults
Prospective, observational, post-market, verification study to ensure compliance to the ISO 80601-2-85:2021 standard
- Trial name
- NCT06581835
- Testing
- Observational
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Electrical Stimulation
Effect of Femoral Quadriceps Muscle Length on Fatigue Induced by Neuromuscular Electrical Stimulation
This study aims To investigate the effects of Quadriceps femoris muscle length on neuromuscular fatigue induced by NMES, muscle performance, discomfort and peripheral oxygen extraction.
- Trial name
- NCT05905406
- Testing
- Electrical estimulation
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome
A Randomized Study to Investigate the Effect of Intravenous Imatinib on the Amount of Oxygen in the Lungs and Blood of Adults With COVID-19 Needing Mechanical Ventilation and Supportive Care.
The COVID-19 pandemic has led to an increase in the number of patients admitted to intensive care units (ICU) with acute respiratory distress syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome, Covid19, ARDS
- Trial name
- IMPRESS COVID (NCT04953052)
- Testing
- Imatinib Mesylate
- Where
- 8 sites in India
- Sponsor
- Exvastat Ltd.
Respiratory Insufficiency, Fasting
Non-inferiority of Continuing Oral Intake Versus Fasting in Patients With Acute Respiratory Failure
Fasting in intensive care is mainly studied in mechanically ventilated patients or those in the weaning phase. Recent research challenge the common assumption of fasting and suggests that continuing enteral nutrition before…
- Conditions
- Respiratory Insufficiency, Fasting, Dysphagia, Swallowing Disorder
- Trial name
- JEUN-TUBE (NCT06510972)
- Testing
- Oral intake continuation strategy, Fasting strategy
- Where
- 14 sites in France
- Volunteers
- 754 people
- Sponsor
- University Hospital, Tours
Wounds and Injuries
Tissue Perfusion and Blood Flow Monitoring Technology
The purpose of this study is to investigate the safety and efficacy of an optical device designed and developed to quantitatively monitor blood flow velocity of wound sites.
- Trial name
- WoundImager (NCT01139567)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- CW Optics, Inc.
Respiratory Distress Syndrome in Premature Infants, Very Low Birth Weight Baby
Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation
This study hopes to determine whether nitric oxide along with oxygen during the first 20 minutes of life in infants needing help with breathing will reduce the percentage and total exposure to oxygen during that time frame.
- Trial name
- iNO (NCT01220687)
- Testing
- iNO, Nitrogen
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Oklahoma
Bronchiolitis
Monitoring OXYgen in Infants Hospitalized With Bronchiolitis: A Best Practices Trial (The MOXY Trial)
In infants hospitalized with bronchiolitis, a common infection in the lungs caused by a virus, it is uncertain on how to best monitor their oxygen levels.
- Trial name
- NCT01646606
- Testing
- Intermittent oxygen monitoring, Continuous oxygen monitoring
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- The Hospital for Sick Children
Pulmonary Resection, Oxygen Therapy
Comparing The Outcome Of High Flow Oxygen Versus Conventional Oxygen In Extubated Patients After Lung Resection.
Conventional oxygen therapy (COT) is the main supportive treatment administered to patients postoperative after planned extubation and has conventionally been delivered using nasal prongs, cannula or masks.
- Trial name
- NCT05511636
- Testing
- Oxygen therapy
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pulmonary Disease, Chronic Obstructive
Erythrocytes Membrane Stability in COPD Patients in Long-Term Home Oxygen Therapy
Chronic Obstructive Pulmonary Disease (COPD) patients in Long-Term Home Oxygen Therapy (LTOT) have a reduction in airflow that is not totally reversible.
- Trial name
- NCT02732444
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
NIRS
The Systemic and Brain Oxygen Stauration Change During Bronchoscopy
Bronchofiberoscopy is a widespread invasive intervention in clinical practice with a number of diagnostic and therapeutic indications. The Clinic of Pulmonary Medicine in Debrecen carries out nearly 2000 examinations a year.
- Trial name
- BFNIRS (NCT04002609)
- Testing
- oxygen
- Where
- Hungary
- Volunteers
- 92 people
- Sponsor
- University of Debrecen
Cardiac; Arteriosclerosis, Aortic Valve Disease
The Association Between Delivered Oxygen and Cerebral Impact During the Use of Cardiopulmonary Bypass.
Investigating the connection between delivered oxygen index and cerebral impact with COx (cerebral oximetry index) och cerebral injury markers during the routine use of cardiopulmonary bypass.
- Trial name
- NCT05620875
- Testing
- Cerebral injury markers, Cerebral oximetry index
- Where
- Sweden
- Volunteers
- 106 people
- Sponsor
- Uppsala University
COVID-19
Investigation of the Muscle Oxygenation in Patients With Post COVID-19 Syndrome
More than 60% of patients infected with COVID-19 have long-term symptoms. These symptoms are associated with common ground-glass opacities on computed tomography scans and chest radiographs.
- Trial name
- NCT05957575
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Gazi University
Pneumonia, Pleural Effusion
Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation
The objective of this study is to assess whether there is a difference between a care protocol with the use of incentive spirometry (Voldyne ®) and another with the application of NIV (non invasive ventilation with single-level…
- Conditions
- Pneumonia, Pleural Effusion, Atelectasis
- Trial name
- NCT01416519
- Testing
- Continuous Positive Airway Pressure (CPAP) facial mask, Assisted deep inspiration technique
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Santa Casa de Votuporanga
Long COVID, Long COVID-19 Syndrome
Quality of Life After Hyperbaric Oxygen Therapy in Post-COVID Patients
Post-Covid syndrome, also known as long Covid, is a clinical condition in which patients experience long term symptoms after Covid-19 infection. Treatment options for post-Covid are not effective.
- Conditions
- Long COVID, Long COVID-19 Syndrome, Long Covid19, Long Covid 19
- Trial name
- QoL COVID HBOT (NCT06159309)
- Testing
- Hyperbaric oxygen therapy
- Where
- 6 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Rutger Lalieu