Clinical trials: Oxygen Delivery
Infant, Premature
Automated Oxygen Control in Preterms on Non-invasive Ventilation
This randomised controlled trial aims to investigate the effectiveness of closed-loop automated oxygen control (CLAC) in preterm infants receiving non-invasive respiratory support and determine if it reduces the duration of…
- Conditions
- Infant, Premature, Airway Morbidity
- Trial name
- NCT07622563
- Testing
- Closed loop automated oxygen control
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College Hospital NHS Trust
Chronic Obstructive Pulmonary Disease
Effects of Supplemental Oxygen Delivery Via Demand Versus Continuous Flow in Hypoxemic COPD Patients
Oxygen supplementation has been proven to be effective in hypoxemic COPD patients by increasing oxygenation and reducing dyspnea.
- Trial name
- NCT02744170
- Testing
- 1 continuous flow oxygen supplementation, 2 demand delivery liquid oxygen supplementation, 3 demand delivery oxygen supplementation via concentrator
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Oxygen Delivery, Intubation
Environmental Oxygen Levels During Artificial Ventilation and Oxygen Therapy
European Resuscitation Council 2021 Guidelines and Advanced Life Support Provider Courses teach that the oxygen supply must be removed from the patient during defibrillation to the distance of minimum of 1 meter.
- Conditions
- Oxygen Delivery, Intubation, Airway Control, Concentration
- Trial name
- NCT06718361
- Testing
- Oxygen levels measurement (%)
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- David Peran, PhD, FERC
Colorectal Cancer
RADOX' Reduced Abdominal Distension and Oxygen Delivery
The use of laparoscopic surgery is continuing to increase in colorectal resection and expected reach 80% in the next 10 years. Although laparoscopic (keyhole) or minimally invasive surgery can lead to faster recovery it can also…
- Trial name
- RADOX (NCT02045680)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Dr Michael Scott
Cardiac Surgery, Blood Transfusion
Personalized Blood Transfusion Protocol for Cardiac Patients
This study compares two accepted ways of deciding when adults recovering from open-heart surgery should receive a blood transfusion in the intensive care unit.
- Conditions
- Cardiac Surgery, Blood Transfusion, Anemia, Cardiopulmonary Bypass
- Trial name
- PerP (NCT07671469)
- Testing
- Demand-Informed Transfusion Decision Rule
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Yan Mia Min
Oxygen Saturation Targetting in Preterm Ventilated Infants
Comparison of Automated Oxygen Control With and Without Automated Pressure Control in Preterm Ventilated Infants.
This is a cross-over randomized study. Eligible participants are preterm infants born at less than 37 weeks gestation (23+0 to 36+6 weeks), who are receiving conventional mechanical ventilation through an endotracheal tube and…
- Trial name
- CLIO-VG (NCT03865069)
- Testing
- Mode of ventilation (Volume Guarantee)®, Mode of ventilation (Volume control Ventilation)
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Acute Respiratory Failure
Evaluation of Oxygen Therapy Delivery Systems in Hypoxemic Acute Respiratory Failure
The main objective of this study is to evaluate the efficiency of the oxygen therapy delivery system Optiflow® compared to 2 others standard oxygen therapy delivery systems (Ospal®, non invasive ventilation).12 immunocompetent…
- Trial name
- OPTI O2 (NCT01243918)
- Testing
- Oxygen therapy delivery systems
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Nantes University Hospital
Oxygen Supply Absent
Monitoring Free Tissue Transfer Hemodynamics Using NIRS
Free tissue transfer (FTT) is a surgical procedure for repairing cancer resection wounds. Free tissue transfer usually involves taking skin from one area of the body (e.g.
- Trial name
- NCT06661525
- Testing
- Free Flap NIRS
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Infant, Premature, Stress, Psychological
Personalized Music Therapy for Preterm Infants
Preterm infants in the Neonatal Intensive Care Unit (NICU) face environmental and clinical stressors that may affect physiological stability and development.
- Trial name
- NCT07295106
- Testing
- Personalized Music Therapy (PMT), Quiet Rest
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fabrizio Faina
Oxygen Toxicity, Oxidative Stress
Optimized Oxygen Delivery During General Anesthesia in Newborn Infants
An open randomized control trial investigating the delivery of two levels of inspired oxygen to newborn infants during general anesthesia.
- Trial name
- ANOXneo (NCT02698020)
- Testing
- Room-air
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Uppsala University
Asphyxia
Erythropoietin for Infants With Brain Injuries Due to Oxygen Deprivation at Birth
Erythropoietin (Epo) is a hormone normally found in the body that may protect brain cells from damage due to lack of oxygen. This study will evaluate the safety of high-dose Epo in infants who did not get enough oxygen during…
- Trial name
- NCT00491413
- Testing
- epoetin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Prematurity, Oxidant Injury
Use of Blended Oxygen for Delivery Room Resuscitation of Very Low Birth Weight Infants
We propose a preliminary trial to evaluate the safety and efficacy of using more restricted oxygen during resuscitation for VLBW infants than is utilized currently in an effort to reduce the oxidant stress of such treatment, and…
- Trial name
- NCT00369720
- Testing
- Titration of oxygen in delivery room
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Neil Finer
Pneumonia Childhood
A Feasibility Study Evaluating a Novel Mask (Nasal Reservoir Cannula)
This study evaluates the addition of a novel mask (nasal reservoir cannula) to a standard nasal cannula during supplemental oxygenation for the treatment of hospitalized pediatric patients with hypoxemia due to severe pneumonia.
- Trial name
- NCT03929484
- Testing
- Nasal reservoir cannula
- Where
- Uganda
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
Hypoxemic Respiratory Failure
A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula
Our main objective is to collect feasibility data on helmet NIPPV and other clinical elements in to eventually prepare for a full scale randomized trial based on findings of this pilot study.
- Trial name
- NOVA-pilot (NCT04035460)
- Testing
- Helmet, High Flow Nasal Oxygen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baystate Medical Center
Infant, Newborn, Diseases, Other Preterm Infants
Surfactant Positive Airway Pressure and Pulse Oximetry Trial
This study compared the use of continuous positive airway pressure initiated at birth with the early administration of surfactant administered through a tube in the windpipe within 1 hour of birth for premature infants born at 24…
- Conditions
- Infant, Newborn, Diseases, Other Preterm Infants, Infant, Small for Gestational Age, Premature Birth
- Trial name
- SUPPORT (NCT00233324)
- Testing
- Surfactant, Continuous Positive Airway Pressure (CPAP), Supplemental oxygen with target saturation of 85 to 89%
- Where
- 22 sites in United States
- Volunteers
- 1,316 people
- Sponsor
- NICHD Neonatal Research Network
Pre-Term
Cerebral Oxygen Saturation Monitoring During Optimum Cord Management in Preterm Infants
This study will assess the feasibilty measuring cerebral oxygen saturations using a Near Infrared Spectroscopy (NIRS) monitor immediately after delivery of preterm infants.
- Trial name
- COSMIC (NCT06526091)
- Testing
- Cerebral NIRS monitoring at delivery
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College Healthcare NHS Trust