Clinical trials: Oxygen Disorders
Chronic Obstructive Pulmonary Disease, Oxygen/Therapeutic Use
Correction of Exercise-induced Desaturation by Acute Oxygen Supply and Exercise Responses in COPD
In the literature, the effects of acute oxygen administration on exercise tolerance and related symptoms have often appeared to be contradictory.
- Trial name
- RePox-1 (NCT02055885)
- Where
- 2 sites in France
- Volunteers
- 255 people
- Sponsor
- 5 Santé
Acute Viral Bronchitis, Hypoxemic Respiratory Failure
NHF vs. COT in Hypoxemic Pandemic Viral Illness
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
- Conditions
- Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
- Trial name
- HIVI (NCT04750408)
- Testing
- Standard oxygen, Nasal high-flow
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Jens Bräunlich
Pediatric Pneumonia
Effect of Nurse-Directed Therapeutic Positioning in Children With Pneumonia
Pneumonia is a common respiratory infection in children that may cause respiratory distress and impaired oxygenation. This quasi-experimental study aims to evaluate the effectiveness of nurse-directed therapeutic positioning on…
- Trial name
- NCT07913191
- Testing
- Nurse - Directed Side - Lying Positioning, Nurse - Directed Semi-fowler's positioning
- Volunteers
- 150 people
- Sponsor
- University of Baghdad
Aortic Stenosis
Reactive Oxygen Species Following Aortic Valve Replacement
Surgical aortic valve replacement (SVAR) is currently the 'Gold Standard' therapy for patients with severe symptomatic aortic stenosis (AS).
- Trial name
- ROS (NCT02841917)
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Brain Death
ORI and ETCO₂ Relationship With Arterial Blood Gas During Apnea Test
This observational study aims to evaluate the relationship between the Oxygen Reserve Index (ORI) and End-Tidal Carbon Dioxide (ETCO2) values with arterial blood gas parameters in patients undergoing the apnea test for the…
- Trial name
- NCT06983990
- Testing
- No intervention (observational monitoring only)
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Healthy, Hypertension
A Validation Study of Selfie Technology for Assessment of Vital Signs
The aim of this study is to compare accuracy of DocMe, a video technology developed by DocMe Health Technologies, with previously validated medical devices used for measurements of heart rate, heart rate variability, respiratory…
- Trial name
- NCT05117762
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- DocMe Technologies Ltd
Brain Injury, Sequelae
Functional and Anatomical Magnetic Resonance Imaging (MRI) of Chronic Brain Injury and Hyperbaric Oxygen (HBO2) Study Subjects
The purpose of this study is to evaluate Brain MRI (Magnetic Resonance Imaging), and Brain CT (Computed Tomography) Angiogram data in subjects who participate in the "Hyperbaric Oxygen for Chronic Stable Brain Injury" (HYBOBI)…
- Conditions
- Brain Injury, Sequelae, Stroke, Anoxia
- Trial name
- HYBOBI-MRI (NCT01126515)
- Testing
- Magnetic Resonance Imaging, Computed Tomography Angiography
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Intermountain Health Care, Inc.
Heart Failure, Diastolic (HFpEF)
Effect of Short-term Oxygen During CPET in HFpEF
In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients…
- Trial name
- NCT04157660
- Testing
- Oxygen application
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University of Zurich
Branch Retinal Vein Occlusion, Retinal Blood Flow
Assessment of Retinal Vessel Diameters and Red Blood Velocities in Patients With BRVO and Healthy Subjects
Assessment of retinal vessel calibers combined with bidirectional Fourier domain optical coherence tomography (FDOCT) for measurement of retinal blood velocities is a new and sophisticated method for assessing retinal blood flow…
- Conditions
- Branch Retinal Vein Occlusion, Retinal Blood Flow, Retinal Oxygen Saturation
- Trial name
- NCT01746615
- Testing
- Dynamic Vessel Analyzer, Bidirectional Fourier-Domain Optical Coherence Tomography (FDOCT)
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
TBI (Traumatic Brain Injury)
Long Lasting Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Traumatic Brain Injury Patients
To evaluate the cognitive functions of patients who suffered brain injury due to traumatic head injury and were previously treated in a hyperbaric chamber between one and four years after the end of treatment.
- Trial name
- NCT07430150
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
High-flow Nasal Cannula, Exercise Capacity
Exercise Capacity Under Various FiO2 and Oxygen Flow Rates Using HFNC
The purpose of this study is to compare the exercise capacity (6-min walking distance) under the following 4 conditions using High-flow nasal cannula (HFNC); 1.
- Conditions
- High-flow Nasal Cannula, Exercise Capacity, Respiratory Failure
- Trial name
- NCT04471220
- Testing
- High-flow nasal cannula
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- National Hospital Organization Minami Kyoto Hospital
Stroke
Correlating Brain Tissue Oxygen and Regional Cerebral Oximetry
Controversy surrounds the use of regional cerebral oximetry (rSO2) as a measure of true cerebral oxygenation because of extracranial signal contamination and unmeasured confounding of cerebral a:v ratio.
- Trial name
- NCT03128957
- Testing
- IVOS cerebral oximeter, Licox cerebral oxygenation monitor, Cerebral oxygenation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Reflex Sympathetic Dystrophy
Near-infrared Spectroscopic Measurement in Complex Regional Pain Syndrome
Recent clinical investigations have suggested that the cause of abnormal pain in complex regional pain syndrome could be ischemia and inflammation, due to poor blood flow to deep tissues from microvascular pathology.
- Trial name
- NCT01586377
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Respiratory Failure, Hypoxemic Respiratory Failure
Helmet NIV vs. CPAP vs. High-flow Nasal Oxygen in Hypoxemic Respiratory Failure
Multicenter, open label, three-arm randomized trial to assess the effect of helmet noninvasive ventilation vs. helmet continuous positive airway pressure vs.
- Trial name
- HENIVOT2 (NCT05089695)
- Testing
- Noninvasive respiratory support
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Keratoconus
Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus
Clinical trial to evaluate the safety and feasibility of corneal cross-linking in both eyes on the same day in subjects with keratoconus.
- Trial name
- NCT07629557
- Testing
- Riboflavin Ophthalmic Solutions, UV-A Irradiation System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Glaukos Corporation
Idiopathic Pulmonary Fibrosis, Hypoxemia
Study to Evaluate the Effect of GBT440 Administered to Subjects With IPF on Supplemental Oxygen at Rest
This is an open label study in which eligible IPF subjects who are using supplemental oxygen at rest will receive GBT440 orally daily.
- Trial name
- Zephyr (NCT02989168)
- Testing
- GBT440
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 14 people
- Sponsor
- Global Blood Therapeutics
IVH- Intraventricular Hemorrhage, Extreme Prematurity
Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants
This study is being conducted to compare the incidence of preterm infants (up to 28+6 weeks GA) who achieve a peripheral oxygen saturation of 80 percent by 5 minutes of life (MOL) given mask CPAP/PPV with an FiO2 of 1.0 during…
- Conditions
- IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia
- Trial name
- DOXIE (NCT04413097)
- Testing
- Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sharp HealthCare
Infant, Newborn, Diseases, Hypoxia
Environmental or Nasal Cannula Oxygen for Preterm Infants Receiving Oxygen Therapy: a Randomized Cross-over Pilot Study
The purpose of this study is to determine if, in preterm infants < 37 weeks' gestation at birth receiving oxygen without ventilatory/CPAP support, oxygen environment (OE) compared with nasal cannula oxygen (NC), will decrease the…
- Trial name
- ECO (NCT02794662)
- Testing
- Oxygen Environment, Nasal Cannula Oxygen
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Cardiac Disease, Cognitive Dysfunction
Cerebral Oxygen Saturation Monitoring In Cardiac Surgery (COSMICS)
Neurological dysfunction continues to be one of the complications of considerable concern in patients undergoing cardiac surgery.
- Trial name
- COSMICS (NCT04766554)
- Testing
- Cerebral oximetry monitor (The INVOS® Cerebral/Somatic Oximeter) and protocol-based interventions
- Where
- 2 sites in Brazil
- Volunteers
- 326 people
- Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
Interstitial Lung Disease, Acute Respiratory Failure
NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases
The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during acute respiratory failure in…
- Trial name
- IRAPIDPhysio (NCT06182956)
- Testing
- Noninvasive mechanical ventilation, Nasal high-flow oxygen therapy, Continuous positive airway pressure
- Where
- France
- Volunteers
- 18 people
- Sponsor
- ADIR Association
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