Clinical trials: Oxygen Disorders
COPD
Pathogenesis and Outcomes of Sleep Disordered Breathing in Chronic Obstructive Pulmonary Disease (COPD)
This research is being conducted to examine the effects of nasal insufflation of warm and humidified air through a small nasal cannula on sleep, breathing pulmonary function, and daytime exercise capability.
- Trial name
- NCT01764165
- Testing
- Oxygen, High flow of room air
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
COVID-19
Awake Prone Position for Early Hypoxemia in COVID-19
Prone positioning is a well studied and validated treatment for severe acute respiratory distress syndrome (ARDS), however there are no randomized studies on the use of prone positioning in the non-intubated patient.
- Trial name
- APPEX-19 (NCT04344587)
- Testing
- Self-prone position recommendation, Usual care
- Where
- 13 sites in United States, Spain
- Volunteers
- 305 people
- Sponsor
- Boston University
Vascular Diseases, Myocardial Ischemia
Assessment of Oxygen Changes in the Heart With Cardio-vascular Magnetic Resonance Imaging
The ability of a new SSFP-based BOLD MRI sequence to assess myocardial oxygenation changes in response to coronary flow changes induced by adenosine and increased CO2-partial pressure will be examined in healthy volunteers and…
- Trial name
- NCT00693758
- Testing
- adenosine, modified end-tidal forcing system, arm cuff occlusion
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Hypoxia, Altitude, Exercise
Oxygen Transport in Normobaric vs. Hypobaric Hypoxia
1) Oxygen Transport in Normobaric versus Hypobaric Hypoxia. 2) The purpose of this study is to examine acute responses in arterial and muscle tissue oxygenation during incremental exercise in normobaric versus hypobaric hypoxia.
- Trial name
- NCT03335917
- Testing
- Hypoxia, Exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Acute Ischemic Stroke Patients
Evaluation of rSO2 Between Frontal Lesion Area and Normal Area of Brain by NIRSITX Using NIRS in Acute Ischemic Stroke Patients.
The clinical trial is for acute ischemic stroke patients measuring cerebral oxygen saturation (rSO2) values using pulse oximeter of near-infrared spectroscopy in the frontal lesion area and normal area of brain.
- Trial name
- fNIRS (NCT06250608)
- Testing
- Pulse oximeter, NIRSITX
- Where
- 2 sites in South Korea
- Volunteers
- 35 people
- Sponsor
- OBELAB, Inc.
Oxidative Stress
Saturation Targets and Resuscitation in Preterm Trial
The purpose of this research project is to determine if use of optimized target oxygen strategy during delivery room resuscitation can reduce oxidative stress in premature newborns.
- Trial name
- STARTPreterm (NCT03115463)
- Testing
- Titration of oxygen during neonatal resuscitation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Apnea
Different Flow Rates on Gas Exchange in Children During Apnea
Background: Children desaturate rapidly during apnea following anesthetic induction. The optimal apneic oxygenation flow rate and its effect on CO2 accumulation remain unclear.
- Trial name
- NCT06659887
- Testing
- nasal cannula
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Yasser S Mostafa, MD
Prolonged Mechanical Ventilation
Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation
This project will conduct a series of analysis of physiological and clinical data on tracheostomy patients who receive prolonged mechanical ventilation, hoping to find out the different manifestations of patients through the…
- Trial name
- NCT05634135
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Taiwan University Hospital
One-Lung Ventilation, Hypoxemia During Surgery
Oxygen Reserve Index in One-Lung Ventilation During Elective Thoracic Operations
The investigators' goal is to perform an observational cohort study investigating the use of oxygen reserve index (ORi) in patients undergoing elective thoracic surgery and one-lung ventilation (OLV).
- Conditions
- One-Lung Ventilation, Hypoxemia During Surgery, Oxygen Reserve Index, Perfusion Index
- Trial name
- NCT05050552
- Testing
- Masimo Radical-7 Pulse CO-Oximeter
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Trakya University
Traumatic Brain Injury, Transfusion
HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial
Most trauma deaths are related to traumatic brain injury (TBI). Although the management of patients has improved, mortality remains unacceptably high, and half of survivors of moderate and severe TBI are left with major…
- Trial name
- HEMOTION (NCT03260478)
- Testing
- Red Blood Cells Transfusion
- Where
- 33 sites in Brazil, Canada and 2 more
- Volunteers
- 742 people
- Sponsor
- CHU de Quebec-Universite Laval
COPD (Chronic Obstructive Pulmonary Disease)
Effect of Rehabilitation on the Respiratory Signal in Patients With COPD and Exercise-Induced Desaturation
The aim is to study the effect of SSOT during a 3-week in-patient pulmonary rehabilitation programme. Further aim is to analyse exercise endurance, distinguishing between those exercising whilst breathing air at 760m "normoxia"…
- Trial name
- NCT07107828
- Testing
- Ambient air, Oxygen, Altitude
- Where
- Kyrgyzstan
- Volunteers
- 52 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Colitis, Ulcerative
Hyperbaric Oxygen Therapy for Ulcerative Colitis Flares
Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with recurrent mucosal inflammation. Clinically, the disease is characterized by bloody diarrhea, abdominal pain, and constitutional symptoms such as…
- Trial name
- HBO-UC (NCT03494764)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 8 sites in United States
- Volunteers
- 39 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Multiple Myeloma
Study of Hyperbaric Oxygen Therapy in Addition to Standard Growth Factor Support for Hematopoietic Progenitor/Stem Cell Mobilization
The purpose of this study is to evaluate the safety and efficacy of hyperbaric oxygen therapy (HBOT) as a therapeutic option in mobilizing stem cells for autologous stem cell transplant.
- Trial name
- NCT01449539
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Arkansas
Upper Gastrointestinal Bleeding
HFNC Versus Conventional Oxygen Therapy in Prolonged Upper Gastrointestinal Endoscopy in the ICU
Conventional supplemental oxygen therapy (COT) during upper gastrointestinal (UGI) endoscopy via nasal catheter is considered the standard practice in maintenance of oxygenation and prevention of hypoxia.
- Trial name
- NCT06350864
- Testing
- High-flow nasal cannula (HFNC), Conventional nasal oxygen therapy (COT), Upper gastrointestinal endoscopy (UGE) including gastroscopy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Stage II Grade B Periodontitis
Active Oxygen Gel vs Chlorhexidine Gel in Stage II Grade B Periodontitis
This randomized controlled clinical trial will evaluate the effectiveness of locally delivered active oxygen gel and chlorhexidine gel as adjuncts to scaling and root planing in the treatment of stage II grade B…
- Trial name
- NCT07840716
- Testing
- Active oxygen gel, Chlorhexidine gel
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Bronchiolitis, Chronic Bronchitis
Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard
to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.
- Trial name
- NCT00642447
- Testing
- helium:oxygen mixture
- Where
- Iran
- Volunteers
- 23 people
- Sponsor
- Baqiyatallah Medical Sciences University
Fetal Hypoxia, Fetal Distress
Trans-Abdominal Fetal Pulse Oximetry - EFS-IDE
The Lumerah System, developed and manufactured by Raydiant Oximetry, Inc., is a non-invasive fetal pulse oximeter that measures fetal arterial oxygen saturation using safe, non-invasive, transabdominal near-infrared spectroscopy.
- Conditions
- Fetal Hypoxia, Fetal Distress, Fetal Conditions, Fetal Complications
- Trial name
- NCT06405984
- Testing
- Fetal Oxygenation Measurements
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Raydiant Oximetry, Inc.
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Automated Oxygen Titration During Walking in Patients With COPD
Purpose: to evaluate the immediate effect of automated oxygen titration compared to usual fixed-dose oxygen treatment during exercise in patients with COPD on long-term oxygen treatment.
- Trial name
- NCT04123730
- Testing
- Fixed-dose compared to variable oxygen flow supplementation during walking
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Hvidovre University Hospital
Chronic Heart Failure, Central Sleep Apnea
Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure.
The aims of this study are to 1) determine the optimal levels of O2 flow which prevent nocturnal O2 desaturation while minimizing periods of hyperoxia during the course of nocturnal oxygen therapy (NOXT) in heart failure patients…
- Trial name
- HO2F (NCT03254212)
- Testing
- Titration of nocturnal oxygen needs to prevent desaturations
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Laval University
Coronary Occlusion, Acute Coronary Syndrome
Hemoglobin Based Oxygen Therapeutics in Elective Percutaneous Coronary Revascularization
The test compound and subject of this clinical trial is the haemoglobin-based oxygen carrier, HBOC-201 (Hemopure). HBOC-201, initially developed as an alternative to red blood cells for surgical patients, has the ability to…
- Trial name
- NCT00479895
- Testing
- Hemoglobin Based Oxygen Carrier-201 (HBOC-201, Hemopure)
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Biopure Corporation
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.