Clinical trials: Oxygen Disorders
Prostatic Neoplasms
Transrectal Tumour Oxygen - US Army
Prostate cancer is now the most commonly diagnosed tumor among men in the United States. Most patients have tumors that are confined to the prostate gland at diagnosis and are suitable for treatment with surgery or radiotherapy…
- Trial name
- NCT00160979
- Testing
- Pre-treatment tumour oxygen measurements
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University Health Network, Toronto
Anemia, Critical Illness
Oxygen Extraction-guided Transfusion in Critically Ill Patients
Anemia is common in intensive care unit (ICU) patients and often appears early in the ICU course. The optimal management red blood cells RBC transfusion in critically ill patients remains controversial and clinical studies in…
- Trial name
- NCT03767127
- Where
- Italy
- Volunteers
- 177 people
- Sponsor
- Università degli Studi di Ferrara
Pulmonary Disease
Effect of Different Oxygen Concentration on Postoperative Pulmonary Complications After Pulmonary Reexpansion
To evaluate the effect of 80% inspiratory oxygen fraction (FiO2) and 30% FiO2 on the incidence of pulmonary complications after pulmonary reexpansion following one-lung ventilation and 2-hour postoperative within the first 7 days…
- Trial name
- NCT06202586
- Testing
- low FiO2, high FiO2
- Where
- China
- Volunteers
- 300 people
- Sponsor
- RenJi Hospital
Postmenopausal Diabetes
Effects of Different Exercise Training Dose on Exercise Performance and Noninvasively Estimated Muscle Oxygen Extraction in Diabetic Postmenopausal Women
The purpose of this study is specifically to investigate (1) the exercising muscle oxygenation response in diabetic postmenopausal women; (2) the dose-response of different physical activity interventions on skeletal muscle…
- Trial name
- NCT00905203
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Fiberoptic Bronchoscopy
50% Nitrous Oxide and 50% Oxygen (MEOPA) Conscious Sedation Versus Placebo in Fiberoptic Bronchoscopy
Fiberoptic bronchoscopy may generate pain, anxiety or cough and dyspnea. It may then induce discomfort and then run down its yield.
- Trial name
- NCT00392522
- Testing
- 50% Nitrous Oxide and 50% Oxygen (MEOPA)
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Hospices Civils de Lyon
Gynecologic Cancer, Cervical Cancer
A Pilot Study of Quantitative Tumor Oxygen Measurements in Cervical Cancer
This research is studying the level of oxygen in tumors during the brachytherapy procedure.
- Trial name
- NCT03970083
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Blood Pressure, Respiration
Verification Protocol for the Cloud DX Vitaliti Continuous Vital Signs Monitor (VERDICT-2)
The VERDICT-2 verification study will examine the accuracy of the Cloud DX Vitaliti Continuous Vital Signs Monitor (Model: CVSM-1A) in an ambulatory context with healthy participants.
- Conditions
- Blood Pressure, Respiration, Pulse Rate, Oxygen Saturation
- Trial name
- VERDICT-2 (NCT05886153)
- Testing
- Vitaliti Continuous Vital Sign Monitor Model CVSM-1A
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Chronic Obstructive Pulmonary Diseases
The Role of Ambulatory Oxygen in Improving the Effectiveness of Pulmonary Rehabilitation for COPD Patients
Pulmonary rehabilitation (PR) is an exercise program tailored for patients with chronic lung disease that is a core part of the management of patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT02707770
- Testing
- Pulmonary Rehabilitation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College Healthcare NHS Trust
Lung Disease Chronic
Postural Drainage With and Without Aerobic Training on Chronic Suppurative Lung Disease
This will be a randomized controlled trial Patients will be divided into two groups randomly. Both groups will receive postural drainage as baseline treatment thrice a week for two weeks.
- Trial name
- NCT05771766
- Testing
- Postural Drainge and aerobic training, Postural Drainage
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Opioid Use Disorder
Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering
The aims of this study are to 1) explore the efficacy of hyperbaric oxygen therapy (HBOT) applied at two different pressures compared to sham treatment in relieving signs and symptoms (both physical and psychological) of opioid…
- Trial name
- NCT05924022
- Testing
- Hyperbaric Oxygen Treatment Full, Hyperbaric Oxygen Treatment Partial Pressure
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington State University
Anemia
Erythropoietin Alfa in Elderly Subjects With Unexplained Anemia
The primary objective of this study is to assess the ability of epoetin alfa to raise hemoglobin (Hb) levels in elderly outpatients with unexplained anemia.
- Trial name
- NCT00954486
- Testing
- Epoetin alfa
- Where
- 3 sites in United States
- Sponsor
- Stanford University
Postoperative Complications, Orthopedic Disorder
PaO2 and Lung Function After Orthopedic Surgery
Hypoxia and reduced oxygen partial pressure is commonly occurring after abdominal surgery. This study aims to investigate whether similar changes also occur after orthopedic surgery in the form of upper limb surgery.
- Trial name
- NCT05227573
- Testing
- Orthopedic surgery
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
Cardiovascular Disease
Study of Non-Invasive Regional Oxygen Saturations in Pediatric Patients Undergoing Cardiac Catheterization
The purpose of this study is to validate the Nonin Near-infrared spectroscopy (NIRS) device to measure regional oxygen saturation in a cohort of children with cardiovascular disease undergoing cardiac catheterization.
- Trial name
- NCT00939224
- Testing
- Model 7600 Regional Oximeter System
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Nonin Medical, Inc
Myocardial Ischemia
The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart
Ischemia reperfusion injury may be attenuated by HO-1 induction. Our previous data confirmed strong HO-1 induction in peripheral blood cells following heme arginate infusion in healthy humans.
- Trial name
- NCT02314780
- Testing
- Heme arginate 3mg/kg, Heme arginate 1mg/kg
- Where
- Austria
- Volunteers
- 31 people
- Sponsor
- Martin Andreas, M.D.
Noninvasive Ventilation, Covid19
Predictors of Non-invasive Respiratory Support Failure in COVID-19 Pneumonia
The main objective of the current study is to search predictors of non-invasive respiratory support failure, like high -flow oxygen system (HFO) and pressure systems, Bilevel positive airway pressure (BiPAP) and continuous…
- Conditions
- Noninvasive Ventilation, Covid19, Distress; Respiratory Syndrome, Adult
- Trial name
- RUTIROX (NCT05094661)
- Testing
- BiPAP, CPAP
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Germans Trias i Pujol Hospital
Single Ventricle Heart Disease After Fontan Surgery
Pharmacokinetic/Pharmacodynamic Study of Udenafil in Adolescents
To determine the pharmacokinetic profile and safety of udenafil in adolescents with Fontan physiology and to assess the short-term pharmacodynamic effect of udenafil on pharmacodynamic measures of exercise capacity, ventricular…
- Trial name
- NCT02201342
- Testing
- Udenafil
- Where
- 6 sites in United States, Canada
- Volunteers
- 36 people
- Sponsor
- Mezzion Pharma Co. Ltd
Sickle Cell Disease
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia
MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease.
- Trial name
- MitoQ (NCT04109820)
- Testing
- MitoQ
- Where
- 5 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cardiovascular Disease
Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery
To evaluate the efficacy of Hemolink™ in combination with Intraoperative Autologous Donation (IAD) versus control (IAD alone) in facilitating avoidance of allogeneic RBC transfusion during and following primary CABG surgery
- Trial name
- NCT00038454
- Testing
- Hemolink (hemoglobin raffimer IV solution)
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Hemosol
Neonatal Respiratory Distress, Very Low Birth Weight Infant
Evaluation of the Impact of SpO2 Averaging Time on Performance of an Automatic FiO2 Control System: a Randomized Study
The aim of the study is to determine the preferred oximeter averaging setting during automated control of FiO2 (A-FiO2) in infants receiving respiratory support and supplemental oxygen.
- Trial name
- NCT05274386
- Testing
- Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 4to6 s, Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 10 s, Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 16 s
- Where
- Czechia
- Volunteers
- 10 people
- Sponsor
- Czech Technical University in Prague
Ulcerative Colitis
The Efficacy of Hyperbaric Oxygen-assisted Treatment for ASUC and Refractory IBD
The Department of Gastroenterology plans to conduct a randomized controlled study on the efficacy analysis of hyperbaric oxygen-assisted treatment for acute severe ulcerative colitis and refractory inflammatory bowel disease.
- Trial name
- NCT07257588
- Testing
- Administration of methylprednisolone sodium succinate, Hyperbaric Oxygen Therapy
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Xijing Hospital of Digestive Diseases
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