Clinical trials: Oxygen Disorders
High Grade Glioma
Trans Sodium Crocetinate (TSC) Study of Intra-tumoral Oxygen Concentration, Safety, and Pharmacokinetics in Patients With High Grade Glioma
The purpose of this study is to evaluate the impact of Trans Sodium Crocetinate (TSC) on oxygen levels in brain tumor tissue in patients with high grade glioma.
- Trial name
- NCT00826930
- Testing
- Trans Sodium Crocetinate (TSC)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Diffusion Pharmaceuticals Inc
Pulmonary Disease, Chronic Obstructive
Six-Minute Walk Test Comparing Helium/Oxygen to Nitrogen/Oxygen for COPD Rehabilitation
The purpose of this study is to evaluate effects of inspired gas mixtures on the distance walked by patients with severe Chronic Obstructive Pulmonary Disease (COPD) during a Six-Minute Walk test.
- Trial name
- rehabilitate (NCT01355809)
- Testing
- Inhalation gas, Inhalation Nitrogen/Oxygen, Inhalation Helium/Oxygen
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- Air Liquide SA
Respiratory Distress Syndrome
Medium vs Low Oxygen Threshold for the Surfactant Administration
The aim of this study will be to assess the better fraction inspired oxygen (FiO2) threshold for the surfactant treatment in preterm infants with respiratory distress syndrome (RDS) randomized to receive exogenous surfactant at…
- Trial name
- NCT04199364
- Testing
- Poractant Alfa 80 mg/mL Intratracheal Suspension
- Volunteers
- 200 people
- Sponsor
- Virgilio Paolo Carnielli
Cardiovascular Disease
ROS Signaling in Endothelial Function
The vascular endothelium (inner lining of cells in blood vessels) normally prevents vasospasm and thrombosis by producing nitric oxide and other regulatory substances.
- Trial name
- NCT01037465
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Boston University
Hypotension, Ischemia
Phase III Study of Hemospan® to Prevent Hypotension in Hip Arthroplasty
The purpose of this study is to determine whether Hemospan is superior to Voluven for preventing hypotensive episodes during the perioperative period (from induction of spinal anesthesia until 6 hours after skin closure), and for…
- Trial name
- NCT00421200
- Testing
- Hemospan (MP4OX), Voluven (HES 130/0.4)
- Where
- 18 sites in Belgium, Czechia and 4 more
- Volunteers
- 375 people
- Sponsor
- Sangart
Type 2 Diabetes Mellitus
Autologous Stem Cell and Hyperbaric Oxygen Therapy in Type 2 Diabetes Mellitus
A prospective, open labeled, randomized controlled clinical trial comparing the benefit of both hyperbaric oxygen therapy and intrapancreatic stem cell infusion to standard medical treatment alone for type 2 diabetes mellitus.
- Trial name
- HOT (NCT01786707)
- Testing
- Autologous stem cells, Hyperbaric oxygen therapy, Insulin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Rodolfo Alejandro
Acute Respiratory Distress Syndrome, Intensive Care
Liberal Oxygenation Versus Conservative Oxygenation in ARDS
No clear recommendation exists for the level of oxygenation of intensive care patients. In Acute Respiratory Distress Syndrome (ARDS), pulsed oxymetry (SpO2) have to be kept between 88 and 95 percent and oxygen alveolar pressure…
- Trial name
- LOCO2 (NCT02713451)
- Testing
- Modulation of Inspired Fraction of Oxygen (FiO2)
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Thoracic, Diseases
The Effect of Two Airway Interventions, During One Lung Ventilation, on Blood Oxygen Content
Patients requiring one lung ventilation (OLV) for open thoracic surgery will be ventilated (breathing performed by a breathing machine) during anesthesia using a lung protective ventilation strategy (small breath volumes at…
- Trial name
- NCT01495936
- Testing
- RM + Positive End Expiratory Pressure, Continuous Positive Airway Pressure
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Right Ventricular Dysfunction
Right Ventricular Echocardiography in caRdiac SurgEry
Postoperative right ventricular (RV) dysfunction increases mortality and risk of cardiac failure after cardiac surgery substantially.
- Trial name
- ReVERSE (NCT03301571)
- Testing
- Change in preload and afterload, Inspired oxygen, Pacemaker mode
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Covid19
Trial Efficacy of Saisei Pharma Dietary Supplements MAF Capsules, 148 mg and M Capsules, 148 mg in Hospitalized COVID-19 Patients
The SaiseiCovUKR clinical study is a multicentric, randomized trial study targeting patients hospitalized with COVID-19 who do not require mechanical ventilation.
- Trial name
- SaiseiCovUKR (NCT04762628)
- Testing
- MAF capsules 148 mg, M capsules 148 mg, Standard of care
- Where
- 2 sites in Ukraine
- Volunteers
- 600 people
- Sponsor
- Saisei Pharma
Acute Kidney Injury, Coronary Artery Disease
Erector Spinae Oxygen Saturation and AKI After OPCAB
Acute kidney injury (AKI) is a frequent and serious complication after cardiac surgery, including off-pump coronary artery bypass (OPCAB).
- Conditions
- Acute Kidney Injury, Coronary Artery Disease, Coronary Artery Bypass, Off-Pump, Postoperative Complications
- Trial name
- NCT07760129
- Testing
- Near-infrared spectroscopy monitoring of erector spinae muscle and renal regional oxygen saturation
- Volunteers
- 138 people
- Sponsor
- Yonsei University
Pulmonary Vascular Disease, Pulmonary Artery Hypertension
High Altitude (HA) Residents With Pulmonary Vascular Diseases (PVD), 6 Minute Walk Distance (6MWD) Assessed at 2840m (HA) With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in participants with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension (PH) who permanently live >2500m…
- Conditions
- Pulmonary Vascular Disease, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT06003244
- Testing
- 6-minute walk distance (6MWD) test, 6-minute walk distance (6MWD) test with supplemental oxygen (3 l/min, nasal)
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University of Zurich
COPD Diagnosed
Evaluation of a Simple Clinical Test to Detect the Risk of Falling in Patients With BPCO and Research for Predictive Factors of Fall Risk.
The risk of falling in increased in patients with Chronic Obstructive Pulmonary Disease. To date, a screening test (the Berg Balance scale, BBS) is used to evaluate this risk but it spends 20 to 30 minutes to complete.
- Trial name
- Equil-BPCO (NCT03152344)
- Testing
- Timed Up and Go
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pulmonary Disease, Chronic Obstructive
Benefits of Liquid Oxygen in COPD Patients Presenting Desaturation During Exercise.
The purpose of this study is analyzed the impact of oxygen adjusted during exercise in COPD patients without conventional for LTOT but with exercise desaturation.
- Trial name
- NCT02273830
- Testing
- oxygen
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- Jtarrega
Atelectasis
Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
The purpose of this study is to determine whether breathing high levels of oxygen during surgery affects oxygen levels after surgery.
- Trial name
- NCT00715741
- Testing
- FiO2 (fraction of inspired oxygen) 0.3 plus PEEP (positive end expiratory pressure) 3 -5 cm water, FiO2 0.3 without PEEP, FiO2 >0.9 with 3-5 cm water PEEP
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Congenital Heart Defect
Prospective Evaluation of Changes in Tissue Oxygen Saturation in Brain and Kidney in Children Admitted to Intensive Care in the Postoperative Period of Cardiac Surgery
It is estimated that the incidence of congenital heart disease varies between 0.5 and 1% of live births, 5,000 new cases per year currently in France These are serious diseases that can be life-threatening to more or less short…
- Trial name
- NCT02884973
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Surgical Complications From General Anesthesia, Cerebral Ischemia
Measurement of the Cerebral Saturation for Assessment of Safety of Epidural Anaesthesia During Abdominal Surgery
Subsequent and non-randomised patients, adult patients qualified for major abdominal surgeries were enrolled
- Conditions
- Surgical Complications From General Anesthesia, Cerebral Ischemia, Anesthesia; Reaction
- Trial name
- NCT03161275
- Where
- Poland
- Volunteers
- 101 people
- Sponsor
- Jagiellonian University
Infant ALL, Congenital Heart Disease
Determining the Effect of Two Different Methods in Children to Maintain Drain Patency After Cardiac Surgery
In this study, it was aimed to determine the effect of the use of milking and sucking methods on bleeding amount, vital signs and oxygen saturation in children with chest and mediastinal drains after cardiac surgery.
- Trial name
- NCT04454294
- Testing
- Control, Experimental Group (Absorption Group), Experimental Group (Milking Group)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Acibadem University
Spinal Cord Injuries
KAFO Orthoses Versus the ABLE Exoskeleton
This randomized crossover study will compare walking with KAFO type orthoses (current standard of care) versus the ABLE Exoskeleton device, during walking in patients with spinal cord injury in a hospital setting.
- Trial name
- NCT04855916
- Testing
- ABLE Exoskeleton, KAFO Orthosis
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- ABLE Human Motion S.L.
Colitis, Ulcerative
Hyperbaric Oxygen Therapy for Ulcerative Colitis Flares
Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with recurrent mucosal inflammation. Clinically, the disease is characterized by bloody diarrhea, abdominal pain, and constitutional symptoms such as…
- Trial name
- HBO-UC (NCT03494764)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 8 sites in United States
- Volunteers
- 39 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.