Clinical trials: Oxygen Disorders
Prematurity, Oxidative Stress
Trial of a Limited Versus Traditional Oxygen Strategy During Resuscitation in Premature Newborns
Preterm infants are born with immature lungs and often require help with breathing shortly after birth. This traditionally involves administering 100% oxygen.
- Trial name
- NCT01697904
- Testing
- Titration of oxygen during newborn resuscitation in delivery room
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Texas Southwestern Medical Center
Bronchiolitis
Bronchiolitis: Evaluation of Wang's Score as a Predictor of the Duration of Oxygen Therapy in Bronchiolitis
Evaluation of Wang's score as a predictor of the duration of oxygen therapy in bronchiolitis
- Trial name
- NCT03362125
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Rennes University Hospital
Hypoxic-Ischemic Encephalopathy
A Study of a Blood Marker in Newborns With Brain Injury Caused by Lack of Oxygen at Birth
Perinatal asphyxia is a significant health problem with an incidence of 1 to 8 per 1,000 live births and can lead to serious morbidity and mortality during the neonatal period.
- Trial name
- NCT07292220
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mustafa Gürkan
Cerebral Hypoxia, Postoperative Cognitive Dysfunction
The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane
the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .
- Trial name
- NCT01757561
- Testing
- propofol, sevoflurane
- Where
- China
- Volunteers
- 144 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Stroke
High Intensity Interval Training in Chronic Stroke Patients
Stroke is a global health-care problem that is common, serious and disabling. In most countries, stroke is second or third most common cause of death and one of the main causes of acquired adult disability.
- Trial name
- NCT01777113
- Testing
- High intensity aerobic training, High Intensity Strength Training, Mixed Training
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Universita di Verona
Periodontitis
Clinical Effectiveness of Oxygen-Releasing Oral Gel as an Adjunct to Scaling and Root Debridement in Patients With Severe Periodontal Pockets: A Randomized Clinical Trial
The goal of this clinical trial is to learn if adding an oxygen-releasing gel to a deep dental cleaning treatment can improve gum health more than deep cleaning alone, in adults with severe gum disease.
- Trial name
- NCT07840859
- Testing
- Topical oxygen-releasing oral gel, No intervention
- Where
- Malaysia
- Volunteers
- 38 people
- Sponsor
- Universiti Sains Malaysia
Breast Cancers
A Phase II Single-Arm Clinical Study to Explore the Efficacy and Safety of Hyperbaric Oxygen in the Neoadjuvant Treatment of Breast Cancer Patients
The goal of the study is to explore the efficacy and safety of hyperbaric oxygen in the neoadjuvant treatment of breast cancer patients
- Trial name
- NCT06811870
- Testing
- hyperbaric oxygen treatment
- Where
- 2 sites in China
- Volunteers
- 161 people
- Sponsor
- Guangdong Provincial People's Hospital
COPD
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients' SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with hypoxemia/respiratory distress.
- Trial name
- NCT07222410
- Testing
- Closed loop oxygen control, Manual titration
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Fisher and Paykel Healthcare
Effects of High Altitude, Hypoxia
Induced Changes in Ventilatory Responsiveness and Altitude Exposure
The main purpose of this study is to determine if a drug (acetyl-cysteine or ACCY) can increase the amount of oxygen in your body at a high altitude of 11,500 feet.
- Conditions
- Effects of High Altitude, Hypoxia, Inadequate or Impaired Breathing Pattern or Ventilation, Abnormal Blood Oxygen Pressure
- Trial name
- NCT01241513
- Testing
- NAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Stroke
High Flow Oxygen Therapy and Acute Ischemic Stroke
Hypoxemia is common in acute ischemic stroke and associated with neurological deterioration and mortality. However, the benefit of oxygen therapy is controversial.
- Trial name
- NCT03402594
- Testing
- High flow oxygen, Low flow oxygen
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Cardiogenic Shock
Venous Oxygen Saturation During ECMO Support
Extracorporeal veno-arterial membrane oxygenation" (ECMO-VA), are used to manage refractory cardiogenic shocks by replacing the failed "heart-lung" block.
- Trial name
- ECMOxygen (NCT04934566)
- Testing
- ECMO flow
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Healthy, Hypertension
A Validation Study of Selfie Technology for Assessment of Vital Signs
The aim of this study is to compare accuracy of DocMe, a video technology developed by DocMe Health Technologies, with previously validated medical devices used for measurements of heart rate, heart rate variability, respiratory…
- Trial name
- NCT05117762
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- DocMe Technologies Ltd
Heart Defects, Congenital, Adolescent
Rehabilitation of Adolescents and Young Adults With Congenital Heart Diseases
The investigators aim to measure the impact of a rehabilitation program in congenital cardiology in terms of health related quality of life.
- Conditions
- Heart Defects, Congenital, Adolescent, Young Adult
- Trial name
- QUALIREHAB (NCT03690518)
- Testing
- Cardiac rehabilitation
- Where
- 17 sites in France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Montpellier
COVID-19, Endothelial Function
Diagnostics of Coronavirus Disease 2019 Cardiovascular Complications
Aim of this prospective, observational, multi-centered, randomized study is to detect cardiovascular complications in patients after coronavirus infection.
- Conditions
- COVID-19, Endothelial Function, Diastolic Dysfunction, Oxygen Consumption
- Trial name
- NCT05608603
- Testing
- Portable cardiac monitor "CardioQvark", Cardiorespiratory stress test, Analysis of exhaled air using the Compact PTR-MS proton mass spectrometer
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Overdose
Monitoring of Overdose Patients With and Without Supplemental Oxygen in the Emergency Department
This study will compare the data from pulse oximeters to capnographers as they are used to monitor patients who are being observed in the Emergency Department for a suspected overdose of alcohol or other drugs.
- Trial name
- NCT02101424
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hennepin Healthcare Research Institute
Angina
Effect of Oxygen During Percutaneous Coronary Intervention for Pain Relief
Nasal oxygen is widely used as pain relief against ischemic pain during Percutaneous Coronary Intervention (PCI). However, to our knowledge no randomised clinical trials have tested this.
- Trial name
- OXYPAIN (NCT01413841)
- Testing
- Nasal oxygen, Regular nasal air
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Encephalopathy, Hypoxic-Ischemic, Infant, Newborn, Diseases
Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome
Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per…
- Trial name
- ALBINO (NCT03162653)
- Testing
- Allopurinol, Mannitol
- Where
- 12 sites in Austria, Belgium and 10 more
- Volunteers
- 760 people
- Sponsor
- University Hospital Tuebingen
COVID-19
Interest in the Use of Nasal High-Flow Oxygen Therapy (OptiFlow™) in Secondary Transport of COVID-19 Positive Patients
Since the beginning of COVID-19 pandemic situation, several modes of ventilation have been tried to correct the hypoxaemia induced by SARS-CoV-2 virus.
- Trial name
- SAMU83 (NCT05289141)
- Testing
- Use of high flow nasal oxygen therapy, Use of other non-invasive ventilation or high concentration oxygen masks
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Lumbar Disc Herniation, Respiratory Mechanics
Pulmonary Mechanics and Cerebral Oxygenation During Prone Lumbar Disc Surgery
This prospective observational study aims to evaluate the relationship between changes in respiratory mechanics and cerebral oxygenation in adult patients undergoing elective lumbar disc surgery in the prone position under…
- Conditions
- Lumbar Disc Herniation, Respiratory Mechanics, Cerebral Oxygenation
- Trial name
- NCT07862257
- Testing
- Prone Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Coronary Artery Disease, Anesthesia
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.
- Trial name
- Promise-O2 (NCT04808401)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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