Clinical trials: Oxygen Disorders
Chronic Obstructive Pulmonary Disease
Bronchodilators and Oxygen Kinetics With Exercise in Chronic Obstructive Pulmonary Disease (COPD) Patients
Hypothesis: The reduction of dynamic hyperinflation and its negative effects on the respiratory system following a bronchodilator could lead to an improvement of cardiac function in terms of increased cardiac output.
- Trial name
- NCT00354354
- Testing
- Combivent
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Queen's University
Heart Failure
EXercise InTervention in Heart Failure
This is a pragmatic, non-inferiority clinical trial, enrolling heart failure patients who will be randomized to a 12-week exercise training program either centre-based or home-based with telemonitoring.
- Trial name
- EXIT-HF (NCT04334603)
- Testing
- Exercise Training Program
- Where
- Portugal
- Volunteers
- 120 people
- Sponsor
- Centro Hospitalar do Porto
Exposure to Man-made Visible Light
Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 3 of 7)
NOTE: This is the third of in total 7 sub-studies related to the Ethics Committee of the Canton of Bern Ref. No. KEK-BE 2016-00674.
- Trial name
- NCT02882542
- Testing
- Visible light exposure
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Bern
Oxygen Deficiency, Coronavirus Infection
Awake Proning in COVID-19 Patients With Hypoxemic Respiratory Failure
The purpose of this study is to retrospectively review clinical data to determine whether awake proning improves oxygenation in spontaneously breathing patients with COVID-19 severe hypoxemic respiratory failure.
- Trial name
- NCT04408222
- Testing
- Awake proning
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Columbia University
Pneumonia, Viral, Corona Virus Infection
Convalescent Antibodies Infusion in COVID 19 Patients
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has become a major concern all over the world.
- Trial name
- NCT04418531
- Testing
- Anti-coronavirus antibodies (immunoglobulins) obtained with DFPP form convalescent patients
- Sponsor
- Piero Luigi Ruggenenti
Sarcopenia, Old Age; Atrophy
Beetroot Juice Resistance Training Older Adults
The present study compared the effects of a nitrate containing beetroot juice supplement (BRJ+Nitrate) vs. a placebo (Control) on total and regional fat free mass, quadriceps muscle strength, lower body mobility, and VO2peak in…
- Trial name
- NCT05460351
- Testing
- BRJ+Nitrate, Control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Amputation, Diabetes Complications
Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking
Amputee gait produces periodic occlusion of residual limb blood vessels. During the stance phase of gait, body weight cause the prosthesis to compresses the soft tissue of the residual limb and occlude blood flow.
- Conditions
- Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
- Trial name
- NCT00985842
- Testing
- Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- VA Office of Research and Development
Morbid Obesity, Surgery
Oxygen Reserve Index: Utility as Early Warning for Desaturation in Morbidly Obese Patients
The Oxygen Reserve Index (ORi) is a reference that could help clinicians with their assessments of normoxic and hyperoxic states by scaling the measured absorption information between 0.00 and 1.00.
- Trial name
- NCT03021551
- Testing
- Rainbow sensor
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Masimo Corporation
Pulmonary Disease, Chronic Obstructive, Hyperoxia
Effective High Aerobic Intensity Endurance Training Regimes in Chronic Obstructive Pulmonary Disease (COPD) Patients
4 times 4 minutes interval training with and without hyperoxia is more effective than low intensity endurance training.
- Trial name
- NCT00658853
- Testing
- 4 times 4 minutes high aerobic intensity one leg cycling
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Norwegian University of Science and Technology
SARS-CoV2, COVID
Prognostication of Oxygen Requirement in Non-severe SARS-CoV-2 Infection
Note that this is a study that is co-sponsored by Medecins Sans Frontieres, Spain, and the University of Oxford. The primary objective of this study is to identify clinical and biochemical prognostic markers in adults with…
- Trial name
- PRIORITISE (NCT04441372)
- Where
- 3 sites in Brazil, India
- Volunteers
- 600 people
- Sponsor
- Medecins Sans Frontieres, Spain
COVID-19
Hyperbaric Oxygen Therapy (HBOT) as a Treatment for COVID-19 (COVID-19) Infection
Patients who meet inclusion criteria will be randomized into treatment vs control group. Treatment groups will undergo Hyperbaric Oxygen Therapy (HBOT) and compared to the control group.
- Trial name
- NCT04343183
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Sponsor
- Ochsner Health System
Respiratory Diseases, Pneumonia
Performance and Safety of the Pneumoscope Device in Adults and Children
Respiratory diseases are associated with high morbidity and mortality worldwide. Proper diagnosis and risk assessment of these conditions are essential for optimal management.
- Conditions
- Respiratory Diseases, Pneumonia, Asthma, Cyanotic Heart Disease
- Trial name
- NCT06373939
- Testing
- Digital lung auscultation, Pulse oximetry measurement, Non invasive body temperature measurement
- Where
- Switzerland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Idiopathic Pulmonary Fibrosis
Effects of an Oxymizer® During Daytime in Patients With Pulmonary Fibrosis (IPF)
This study will investigate the effects of a reservoir nasal cannula (Oxymizer®) compared to a conventional nasal cannula (CNC) in patients with idiopathic pulmonary fibrosis.
- Trial name
- NCT02268981
- Testing
- Oxymizer® compared to CNC
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Hypoxemic Respiratory Failure, Hypoxia
Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia
The aim of this study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen supply and better oxygen control than manually controlled oxygen therapy for patients admitted to the emergency…
- Conditions
- Hypoxemic Respiratory Failure, Hypoxia, Hypoxemia, Respiratory Failure
- Trial name
- O2MATIC-ACUT (NCT04079465)
- Testing
- O2matic
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- Hvidovre University Hospital
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Myocardial Ischemia, Cardiovascular Morbidity
The Effect of Peri-percutaneous Coronary Intervention Oxygenation on Myocardial Protection & Cardiovascular Fitness
Elective percutaneous coronary intervention (PCI) is often associated with myocardial necrosis evidenced by peri-procedural troponin release. This is a surrogate for subsequent cardiovascular events.
- Trial name
- NCT03256175
- Testing
- Percutaneous Coronary Intervention
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Malaya
COVID-19
Evaluation of the Outcome of COVID-19 Patients Discharged Home on Oxygen Therapy
The René Dubos Hospital in Pontoise has set up a home discharge system for oxygen-requiring patients in collaboration with PRADO, a health insurance organization, or private providers.
- Trial name
- COVAMBU (NCT05684575)
- Testing
- Phone satisfaction questionnaire
- Where
- 2 sites in France
- Volunteers
- 151 people
- Sponsor
- Hôpital NOVO
Keratoconus
Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus
Clinical trial to evaluate the safety and feasibility of corneal cross-linking in both eyes on the same day in subjects with keratoconus.
- Trial name
- NCT07629557
- Testing
- Riboflavin Ophthalmic Solutions, UV-A Irradiation System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Glaukos Corporation
Bronchiolitis, Hypoxia
Heated High Flow Oxygen Use in Infants With Bronchiolitis and Hypoxia
Bronchiolitis is a common cold weather seasonal respiratory illness affecting infants and children. Multiple supportive therapies have been tried in infants with bronchiolitis including albuterol, racemic epinephrine, hypertonic…
- Trial name
- HHFNC (NCT01662544)
- Testing
- Oxygen delivery
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Colitis, Ulcerative
Hyperbaric Oxygen Therapy for Ulcerative Colitis Flares
Ulcerative colitis (UC) is a chronic inflammatory bowel disease associated with recurrent mucosal inflammation. Clinically, the disease is characterized by bloody diarrhea, abdominal pain, and constitutional symptoms such as…
- Trial name
- HBO-UC (NCT03494764)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 8 sites in United States
- Volunteers
- 39 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
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