Clinical trials: Oxygen Disorders
Respiratory Distress Syndrome, Preterm Pregnancy
Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
The aim of this study is to see if giving less invasive surfactant administration (LISA) during high-flow nasal cannula (HFNC) oxygen treatment reduces the need for invasive ventilation in babies with breathing problems born 2-6…
- Conditions
- Respiratory Distress Syndrome, Preterm Pregnancy, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT06421506
- Testing
- Less invasive surfactant administration during high flow nasal cannula treatment
- Where
- United Kingdom
- Volunteers
- 245 people
- Sponsor
- King's College Hospital NHS Trust
Nervous System Diseases, Respiratory Tract Diseases
Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU)
Oxygen administration is a common practice in intensive care units, although concern is growing about oxygen toxicity. The aim of the study is to access whether a rigorous maintenance of a state of normal oxygenation in…
- Conditions
- Nervous System Diseases, Respiratory Tract Diseases, Cardiovascular Diseases, Immune System Diseases
- Trial name
- OXYGEN-ICU (NCT01319643)
- Testing
- Oxygen
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- University of Modena and Reggio Emilia
Bronchiolitis
Safety Study of Home Oxygen Therapy for Children With Acute Bronchiolitis
Home oxygen therapy is considered an appropriate and relatively safe option for children with chronic respiratory problems such as chronic lung disease of prematurity, but the use of home oxygen therapy for children with acute…
- Trial name
- NCT00677066
- Testing
- Home oxygen therapy
- Where
- Australia
- Volunteers
- 44 people
- Sponsor
- Princess Margaret Hospital for Children
Traumatic Brain Injury, Post-concussive Syndrome
Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.
The purpose of this study is to determine whether sildenafil (Viagra®) is effective in improving cerebral blood flow and cerebrovascular reactivity inpatients who have persistent symptoms at least 6 months after a traumatic brain…
- Trial name
- NCT01762475
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Infants, Difficult Airway
Oxygen Insuflation and ArterialDesaturation During Tracheal Intubation in Children
Infants (0-1 yr.) with anticipated difficult airways will be enrolled in the study. Specifically, we will include infants with cleft palate, Pierre Robin, Treacher Collins, trisomy 21, or similar congenital malformations.
- Trial name
- NCT01664234
- Testing
- laryngoscopy with oxygen, laryngoscopy without oxygen
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Medical University of Vienna
Breast Cancer, Upper Extremity
Arm Exercise Capacity and Maximal Oxygen Consumption With Breast Cancer
Breast cancer is the most common type of cancer among women worldwide. The incidence rate has reached approximately 16%. According to 2016 data from the Ministry of Health, the incidence of breast cancer in Turkey is 46.8 per…
- Conditions
- Breast Cancer, Upper Extremity, Oxygen Consumption, Healthy
- Trial name
- NCT06018038
- Testing
- Arm Exercise Capacity, Peak Oxygen Consumption (VO2peak), Muscle oxygenation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cephalalgia
Protocol to Ease Acute Cephalalgia in Emergency-department
The purpose of this study is to determine if the use of a therapeutic and global protocol to relieve cephalalgia is helpful in the emergency department of Grenoble University Hospital.
- Trial name
- PEACE (NCT02236442)
- Testing
- Recommendation to use global headache treatment protocol
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Grenoble
Chronic Liver Disease and Cirrhosis
Impact of Home-Based Aerobic and Resistance Training in Chronic Liver Disease: a Randomized Control Trial
The goal of this clinical trial is to evaluate whether home-based exercise interventions, including aerobic exercise (AE) and a combination of aerobic and resistance exercise (ARE), can improve physical and health-related…
- Trial name
- NCT06892366
- Testing
- Home-Based Aerobic Exercise Program, Home-Based Aerobic and Resistance Exercise (ARE) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Hacettepe University
COVID-19 Acute Respiratory Distress Syndrome
Prognostic Value of PtcO2 in Patients With COVID-19
Five percent of patients with COVID-19 progressed to respiratory failure and required ICU admission, such patients often have abnormal oxygen tolerance.
- Trial name
- NCT05682612
- Testing
- outcome, Subtype of COVID-19
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Trauma, Wounds and Injuries
Restrictive vs. Liberal Oxygen Therapy for Trauma Patients
The objective of this trial is to investigate whether treatment with oxygen in the early phases after a trauma plays a role in recovery.
- Trial name
- TRAUMOX (NCT03491644)
- Testing
- Titrated Oxygen, Liberal Oxygen
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Male Infertility
A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0
The purpose of this study is to determine if elevations in oxidative stress, as measured by oxidation-reduction potential (ORP), can distinguish between semen samples from men with abnormal semen parameters from those with normal…
- Trial name
- NCT02839447
- Testing
- Diagnostic
- Where
- 6 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aytu BioPharma, Inc.
Chronic Obstructive Pulmonary Disease
Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease
Maximal consumption of oxygen (VO2max) during exercise is used in patients with chronic obstructive pulmonary disease (COPD) to stratify perioperative risk.
- Trial name
- NCT01294033
- Testing
- Fractional inspired oxygen (FiO2) 0.21, Fractional inspired oxygen 0.28
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Covid19
Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Hypoxemia
Of the many treatments proposed for COVID-19, few directly address the severe hypoxia among COVID-19 patients. Interim results from our single-center, non-randomized clinical trial (NCT04332081) suggest that hyperbaric oxygen…
- Trial name
- NCT04619719
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Legacy Health System
Critical Illness
Oxygen Consumption in Critical Illness
Many serious illnesses are characterised by a lack of oxygen delivery to the body's tissues. This can be due to problems with the circulation, such as when the heart fails to pump blood efficiently or if the blood pressure is…
- Trial name
- NCT02163109
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Chronic Obstructive Pulmonary Disease
Mitochondrial Derived Reactive Oxygen Species on Cardiovascular Health in Chronic Obstructive Pulmonary Disease (COPD)
Cardiovascular health is a critical problem in patients with chronic obstructive pulmonary disease (COPD). Existing literature suggests oxidative stress from the mitochondria c driving some of the poor health outcomes in COPD.
- Trial name
- NCT05605548
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Type2diabetes
The Effects of Upper Extremity Aerobic Exercise Training in Patients With Type 2 Diabetes
Type 2 diabetes (T2DM) is a metabolic disease characterized by chronic hyperglycemia that occurs as a result of any disorder in insulin secretion or insulin activity.
- Trial name
- NCT06132334
- Testing
- Upper extremity aerobic exercise training, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Chronic Obstructive Pulmonary Disease
Home High Flow Oxygen to Reduce Acute Exacerbation of COPD
The objective of the study is to evaluate the efficacy of home High Flow Oxygen for the reduction of severe exacerbation following admission for a severe exacerbation of COPD or death against standard oxygen therapy.
- Trial name
- HIFAE (NCT05196698)
- Testing
- High Flow Oxygen Therapy, Long-term oxygen therapy
- Where
- France
- Volunteers
- 406 people
- Sponsor
- University Hospital, Rouen
Diabetes, Periodontitis
Hyperbaric Oxygen Therapy as Adjunctive Therapy to Scaling and Root-planing in the Management of Periodontitis in Patients With Type 2 Diabetes
Diabetes and Periodontitis are both prevalent diseases affecting millions of Americans. Periodontitis is prevalent among Diabetics.
- Trial name
- NCT02671136
- Testing
- Hyperbaric Oxygen therapy, Conventional Wound Therapies
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Loma Linda University
Infant, Premature, Stress, Psychological
Personalized Music Therapy for Preterm Infants
Preterm infants in the Neonatal Intensive Care Unit (NICU) face environmental and clinical stressors that may affect physiological stability and development.
- Trial name
- NCT07295106
- Testing
- Personalized Music Therapy (PMT), Quiet Rest
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fabrizio Faina
Vitiligo Vulgaris
Mitochondrial Network Modulation Approach Using Hyperbaric Oxygen (HBO) Therapy and Nb-UVB for Treating Vitiligo
Vitiligo affects approximately 1 to 2% of the global population and significantly impacts people's quality of life. Achieving the best treatment outcomes for vitiligo involves addressing the autoimmune inflammatory response for…
- Trial name
- MitOxyVit (NCT07557693)
- Testing
- OXYGENE MEDICINAL LIQUIDE AIR PRODUCTS MEDICAL
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
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