Clinical trials: Oxygen Metabolism
Power, Metabolic Disturbance
Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists
This clinical study evaluates the effect of 500 mg of 2S-hesperidin for 8 weeks on performance (power generated in different metabolic zones), body composition (fat and muscle mass) and biochemical (antioxidant, inflammatory…
- Conditions
- Power, Metabolic Disturbance, Change, Body Weight, Changes Fatty
- Trial name
- HESPERFORMAN (NCT04597983)
- Testing
- 2S-hesperidin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Resting Metabolic Rate
Modulation of Metabolic Rate by Inorganic Nitrate
The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.
- Trial name
- NCT02022176
- Testing
- Glucose Uptake, Resting metabolic rate, Nitrite infusion
- Where
- Sweden
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Diabetic Foot Ulcer, Diabetes
Hyperbaric Oxygen Therapy in Diabetics With Chronic Foot Ulcers and Improvement of Quality of Life
This study evaluated the effect of hyperbaric oxygen therapy (HBOT) on wound healing, inflammation index, glycemic control, amputation rate, survival rate of tissue, bacterial wound cultures, and quality of life (QOL) in diabetic…
- Trial name
- NCT02328508
- Testing
- Hyperbaric oxygen therapy
- Volunteers
- 38 people
- Sponsor
- Chen-Yu Chen
Type 2 Diabetes Mellitus
Acute Effect of Phototherapy With Light Emitting Diode (LED) on Muscle and Pulmonary Oxygen Consumption on Diabetes Mellitus
The purpose of this study is to determine the phototherapy may be adjuvant to exercise to improve muscular efficiency and increase aerobic capacity.
- Trial name
- NCT01889784
- Testing
- Phototherapy through light emitting diode (LED) - 150J, Phototherapy through light emitting diode (LED) - 300J
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aparecida Maria Catai
Healthy Subjects
Interval Training and Resting Metabolism
It has been reported that obese individuals are seated 2 ½ hour more than lean individuals and that non exercise thermo genesis (NEAT) may vary with as much as 2000 Kcal/day between equal size people due to different occupational…
- Trial name
- NEAT (NCT01313468)
- Testing
- 1 x 4 minute interval, 4 x 4 minutes Intervals, Moderate continuous Training
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Cerebral Hypoxia During and/or Resulting From A Procedure
The Effects of Body Mass İndex On İntraabdominal Pressure And Regional Cerebral Oxygen Saturation İn Prone Position
A total of 40 ASA (American Society of Anesthesiology) physical status I-III who underwent lumbar disc hernia repair for one or two levels were included in this prospective study.
- Trial name
- NCT05392478
- Volunteers
- 40 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Etiology of Hyperlactathemia, Early Period After Cardiopulmonary Bypass Surgery
NEW MONITORING IN DIFFERENTIAL DIAGNOSIS OF HYPERLACTATHEMIA IN CARDIOPULMONARY BYPASS SURGERY
Objective: The objective of the study was to investigate a reverse correlation between blood lactate levels and rSO2, and distinguish between hypoxic and non-hypoxic hyperlactatemia seen in the early postoperative period.
- Conditions
- Etiology of Hyperlactathemia, Early Period After Cardiopulmonary Bypass Surgery, Washout Phenomenon
- Trial name
- NCT04706884
- Testing
- Near infrared spectroscopy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Acibadem University
Shock, Hemorrhagic, Shock, Traumatic
Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients
MP4OX is a novel oxygen therapeutic agent specifically developed to perfuse and oxygenate tissue at risk for ischemia and hypoxia.
- Conditions
- Shock, Hemorrhagic, Shock, Traumatic, Acidosis, Lactic
- Trial name
- NCT01004198
- Testing
- MP4OX, Ringers Lactate solution
- Where
- 13 sites in France, Germany and 2 more
- Volunteers
- 51 people
- Sponsor
- Sangart
Diabetes Mellitus, Chronic Ulcers of the Lower Limb
Hyperbaric Oxygen Therapy (HBOT) for Chronic Diabetic Lower Limb Ulcers
The purpose of this study is to determine if HBOT plus standard wound care is more effective than standard wound care alone at preventing the need for major amputation (metatarsal and up) in patients with diabetes mellitus (Type…
- Trial name
- HBOT (NCT00621608)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Canada
- Volunteers
- 107 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Overweight and Obesity
Biking vs. Running: Comparison of EPOC, Substrate Oxidation, Appetite and Energy Intakes in Men With Overweight/Obesity.
The management of obesity involves hygienic and dietary measures that include appropriate nutrition and an increase in physical activity (PA).
- Trial name
- BIKERUN (NCT06082310)
- Testing
- Exercise
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Obesity, Bariatric Surgery Candidate
Effects of Recruitment Manouever on Oxygenation, Oxygen Reserve Index and Postoperative Pulmonary Complications
General anesthesia and mechanical ventilation decrease pulmonar volume; attenuate small airway closure, atelectasis, and increase the rate of hypoxia and postoperative pulmonary complications.
- Trial name
- NCT05705245
- Testing
- recruitment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Balikesir University
Healthy Young Men, Healthy Young Women
Characterization of the Plasma Metallomic Profile to Acute Exercise in Healthy Men and Women (METALEXO)
Among the various trace elements playing a key role in physical performance, iron is probably one of the most studied in the last 30 years.
- Trial name
- METALEXO (NCT05718752)
- Testing
- Maximal incremental exercise test, 30-min submaximal exercise test
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Rennes 2
Parkinson Disease, Effect of Drug
Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease
In recent years, mitochondrial dysfunction and oxidative stress have been implicated in PD pathophysiology. Intermittent hypoxia therapy (IHT) is an upcoming treatment used by elite athletes as well as fragile individuals in…
- Trial name
- TALISMAN (NCT05214287)
- Testing
- Hypoxic Gas Mixture
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Radboud University Medical Center
Obesity
Evaluation of the Effectiveness of Oxygen Reserve Index Monitoring During Pre-oxygenation in Obese Patients
In obese patients, the risk of perioperative complications such as rapid desaturation, atelectasis, difficult mask ventilation, difficult intubation, and hypoxia is higher compared to the normal population.
- Trial name
- ORi (NCT07097662)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Irem Caner
Electroconvulsive Therapy Treated Patients, Obesity
LMA vs High-flow Nasal Oxygen During ECT in Obese Patients
This study aims to compare two oxygenation strategies-laryngeal mask airway (LMA) ventilation and high-flow nasal cannula (HFNC)-during electroconvulsive therapy (ECT) in obese patients.
- Trial name
- NCT07093372
- Testing
- Laryngeal Mask Airway, High-Flow Nasal Cannula
- Volunteers
- 25 people
- Sponsor
- Eulji University Hospital
Obesity & Overweight, Fat Mass
High-Intensity Interval Training in Low Versus Normal Oxygen: Effects on Body Fat and Gut Health in Adults Aged 50-75 With Overweight or Obesity (HYPOXFAT)
Overweight and obesity are major public health challenges worldwide, and their prevalence increases with age, partly because of age-related metabolic and hormonal changes.
- Trial name
- HYPOXFAT (NCT07796971)
- Testing
- Hypoxic High-Intensity Interval Training, Normoxic High-Intensity Interval Training
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Acidosis, Oxidative Stress
Effects of Zeolite + Dolomite on Performance and Acidosis
Purpose: This study investigates the effects of dietary zeolite + dolomite on performance, exercise-induced acidosis, oxidative stress, inflammation and intestinal barrier dysfunction in trained people.
- Conditions
- Acidosis, Oxidative Stress, Inflammation
- Trial name
- NCT01831492
- Testing
- zeolite + dolomite, cellulose
- Where
- Austria
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Green Beat
Overweight and Obese Adults, High Intensity Interval Exercise (HIIE)
Acute Effects of Isoenergetic HIIE vs. MICE on Key Parameters of Fat Mass Loss in Young Females With Overweight or Obesity
Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases.
- Trial name
- COMEFIT (NCT06868862)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Obesity, Obstructive Sleep Apnea (Moderate to Severe)
Heated Humidified High Flow Nasal Cannula Oxygen in Obstructive Sleep Apnea in Adolescents
The research study is being done to test heated humidified high-flow air (HHF), as a treatment for OSA.
- Conditions
- Obesity, Obstructive Sleep Apnea (Moderate to Severe), Central Sleep Apnea
- Trial name
- NCT05354401
- Testing
- HHF
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Liver Cirrhosis, Hepatic Encephalopathy
Cerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy (HE)
We wish to study patients with liver cirrhosis during and 2 weeks after an acute episode of liver coma (hepatic encephalopathy).
- Trial name
- NCT01151475
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus