Clinical trials: Oxygen Therapy; Heart Surgery
Cerebral Hypoxia
Feasibility Trial to Maintain Normal Cerebral Oxygen Saturation in High-Risk Cardiac Surgery
Using the brain and the heart as index organs, perioperative interventions to optimize cerebral oxygen saturation and cardiac contractility in high-risk patients undergoing cardiac surgery should have a beneficial systemic effect…
- Trial name
- Tête-à-coeur (NCT01432184)
- Testing
- strategies to reverse decrease in rSO2
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Montreal Heart Institute
Hypoxemic Acute Respiratory Failure
High Flow Nasal Oxygen Therapy for Hypoxemy After Cardiac Surgery
The main objective of this study is to evaluate the gas exchange (ventilation-perfusion ratio) with the system Optiflow® compared to facial mask among patients having an acute respiratory failure after cardiac surgery.
- Trial name
- Optiflow (NCT01617252)
- Testing
- Optiflow / Facial mask
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Nantes University Hospital
Cardiac Surgery, Blood Transfusion
Personalized Blood Transfusion Protocol for Cardiac Patients
This study compares two accepted ways of deciding when adults recovering from open-heart surgery should receive a blood transfusion in the intensive care unit.
- Conditions
- Cardiac Surgery, Blood Transfusion, Anemia, Cardiopulmonary Bypass
- Trial name
- PerP (NCT07671469)
- Testing
- Demand-Informed Transfusion Decision Rule
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Yan Mia Min
Transposition of the Great Vessels, Hypoplastic Left Heart Syndrome
Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)
The purpose of the Oxy-CAHN study is to improve the monitoring capabilities of newborn infants recovering from congenital heart surgery.
- Conditions
- Transposition of the Great Vessels, Hypoplastic Left Heart Syndrome, Oxygen Consumption Based Assessment of Hemodynamics
- Trial name
- Oxy-CAHN (NCT02184169)
- Testing
- General Electric Healthcare E-COVX Gas Monitoring Module for VO2 Measurments, Edwards Continuous SVO2 Catheter and Monitoring System - 4.5 fr
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Boston Children's Hospital
Congenital Heart Disease
Transfusion Strategies in Pediatric Cardiothoracic Surgery
The purpose of this study is to determine the best red blood cell(hemoglobin) level for infants and children following surgical repair of particular heart defects.
- Trial name
- NCT00350220
- Testing
- transfusion strategy, Low Hb transfusion group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Rochester
Cardiac Disease, High Risk Sex
The Effects of Individualized Oxygen Dynamic on Prognosis of Patients With High-risk Cardiac Surgery
Anesthesia-related factors have been linked to poor perioperative outcomes. Our observational study suggested that the cumulative duration of a triple-low state [intraoperative low mean arterial pressure (MAP), low bispectral…
- Trial name
- NCT03103633
- Testing
- mean artery pressure, bispectral index, Brain oxygen saturation
- Where
- China
- Volunteers
- 286 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Cognitive Dysfunction, Postoperative, Cognitive Dysfunction
Assessment of Brain Oxygen Drops During Surgery and Related Risk Factors for Cognitive Problems After Heart Surgery
This study examines whether decreases in brain oxygen levels during cardiac surgery are linked to postoperative cognitive dysfunction and identifies other factors that may increase the risk of cognitive impairment.
- Conditions
- Cognitive Dysfunction, Postoperative, Cognitive Dysfunction, Cardiac Surgery
- Trial name
- NCT07361068
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Coronary Artery Disease, Heart Valve Diseases
Spectroscopic Assessment of Intramyocardial Oxygen Saturation Feasibility During Open-heart Surgery
This traditional feasibility study aims to capture preliminary safety and effectiveness information on a near-final Investigational Device design to adequately plan the forthcoming pivotal study.
- Trial name
- NCT05479968
- Testing
- Spectrocor device
- Where
- Finland
- Volunteers
- 15 people
- Sponsor
- Spectrocor
Congenital Heart Defect
Prospective Evaluation of Changes in Tissue Oxygen Saturation in Brain and Kidney in Children Admitted to Intensive Care in the Postoperative Period of Cardiac Surgery
It is estimated that the incidence of congenital heart disease varies between 0.5 and 1% of live births, 5,000 new cases per year currently in France These are serious diseases that can be life-threatening to more or less short…
- Trial name
- NCT02884973
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiac Complications, Cardiopulmonary Bypass
Fenoldopam and Splanchnic Perfusion During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) for cardiac operations may be accompanied by different patterns of visceral underperfusion. This could result in clinical patterns of lactic acidosis but in the most severe cases there is the risk for…
- Trial name
- NCT00747331
- Testing
- Fenoldopam mesilate
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Policlinico S. Donato
Pediatric Congenital Heart Surgery
Predictive Value of the FORE-SIGHT™ Monitor for Hemodynamic Deterioration
The postoperative period after congenital heart surgery in children can be a very critical episode, where it is of utmost importance to closely monitor the circulation in these patients.
- Trial name
- NCT01706497
- Testing
- Cerebral tissue oxygen saturation monitoring, blinded
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- KU Leuven
Blood Transfusion, Cardiac Surgery
Brain Tissue Oxygen Saturation and Blood Transfusion in Cardiac Surgery
In cardiac operations under cardiopulmonary bypass(CPB), monitoring of brain tissue oxygen saturation with infrared spectrophotoscopy leads to a reduction of the number of packed red cell(PRC) transfusions during the period of…
- Trial name
- INVOS (NCT00879463)
- Testing
- Brain tissue oxygen saturation monitoring, Transfusion according to the anesthesiologist's judgement
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Larissa University Hospital
Cardiac Surgery Requiring Cardiopulmonary Bypass
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury.
- Trial name
- VO2-EPOC (NCT06930443)
- Testing
- Oxygen consumption measurement
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University Hospital
Intensive Care Unit
Effect of Ketamine Assisted Analgesia on Oxygen Supply and Oxygen Consumption in Patients After Cardiac Surgery
After cardiopulmonary bypass heart surgery, with the rewarming of body temperature, the metabolic capacity of the body is enhanced, the microcirculation is opened, and tissue perfusion is increased.
- Trial name
- NCT04906915
- Testing
- Ketamine
- Where
- China
- Volunteers
- 112 people
- Sponsor
- First People's Hospital of Chenzhou
Sepsis, Post Cardiac Surgery Low Output Syndrome Requiring Inotropic/Vasopressor Therapy
Comparison of Central Venous Oxygen Saturation Measurements by Non-invasive Mespere Venous Oximeter and Central Venous Catheter
The intent of this study is to validate the venous blood oxygenation measurements of the Mespere VA Oximeter compared to the saturations measured by venous blood sampling through an inserted central vein catheter, which is…
- Conditions
- Sepsis, Post Cardiac Surgery Low Output Syndrome Requiring Inotropic/Vasopressor Therapy, Cardiogenic Shock Post Myocardial Infarction, Hypoxemic Respiratory Failure.
- Trial name
- NCT01788956
- Testing
- Mespere Venous Oximeter, Co-Oximeter
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mespere Lifesciences Inc.
Bypass Complications, Disorder of Blood Gas
Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.
- Trial name
- NCT01698853
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Surgery--Complications, Cardiac Valve Disease
Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement
This is a randomized clinical trial, double-blind, placebo-controlled study with the goal to assess the influence of using N-AcetylCysteyn (NAC) for prevention of AKI (Acute Kidney Injury) in post operatory of valve replacement…
- Conditions
- Surgery--Complications, Cardiac Valve Disease, Acute Kidney Injury, Oxygen Radical Damage
- Trial name
- NCT03440268
- Testing
- N Acetyl Cysteine
- Where
- Brazil
- Volunteers
- 154 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes Mellitus (D003920), Cardiac Surgical Procedures (D006348)
Cerebral-tissue Oxygen Balance Affected by Diabetes Mellitus
The brain has high oxygen extraction, thus the regional cerebral tissue oxygen saturation (rSO2) is lower than the central venous oxygen saturation (ScvO2).
- Conditions
- Diabetes Mellitus (D003920), Cardiac Surgical Procedures (D006348), Near-Infrared (D019265)
- Trial name
- NCT03668301
- Volunteers
- 148 people
- Sponsor
- Szeged University
Oxygen Therapy; Heart Surgery
High-Flow Aerosol Generation Study
The study will be measuring aerosol generated from the point of tracheal extubation after cardiac surgery in patients who then receive either high-flow nasal oxygen therapy (HFNT) or standard low-flow oxygen therapy, who have…
- Trial name
- NCT05384275
- Testing
- High Flow Nasal Therapy
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Hypotension,Controlled
Correlation Analysis of the Effects of Management Pressure Goals and Control Volume Goals in Patients in Spinal Surgery
The investigators study 160 patients undergoing spinal surgery.Participants will be randomly divided into study group and control group.The study group will receive controlled hypotension by nitroglycerin and be divided into 3…
- Trial name
- NCT03917004
- Testing
- Nitroglycerin
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Liang Bing