Clinical trials: Oxygen Therapy; Heart Surgery, open to volunteers
Cardiac Surgery
Validation and Feasibility of Noninvasive Oxygen Delivery Index Monitoring in Cardiac Surgery Patients
This study will establish the feasibility and preliminary validity of real-time oxygen delivery index (DO₂i) monitoring using noninvasive hemoglobin (SpHb, Masimo) and minimally invasive cardiac output (FloTrac, Edwards) in…
- Trial name
- NCT07573306
- Testing
- SpHb monitor
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Acute Kidney Injury, Coronary Artery Disease
Erector Spinae Oxygen Saturation and AKI After OPCAB
Acute kidney injury (AKI) is a frequent and serious complication after cardiac surgery, including off-pump coronary artery bypass (OPCAB).
- Conditions
- Acute Kidney Injury, Coronary Artery Disease, Coronary Artery Bypass, Off-Pump, Postoperative Complications
- Trial name
- NCT07760129
- Testing
- Near-infrared spectroscopy monitoring of erector spinae muscle and renal regional oxygen saturation
- Volunteers
- 138 people
- Sponsor
- Yonsei University
Doppler-Based Renal Ultrasound, Urinary Oxygen Tension
The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery
This study aims to investigate the predictive value of Doppler-based renal ultrasound and urinary oxygen tension in the development of acute kidney injury after cardiac surgery.
- Conditions
- Doppler-Based Renal Ultrasound, Urinary Oxygen Tension, Acute Kidney Injury, Open Heart Surgery
- Trial name
- NCT07037485
- Testing
- Renal resistive index, Renal Artery Pulsatility Index, Urinary oxygen tension (PUO2)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Cardiac Surgery, Blood Transfusion
Personalized Blood Transfusion Protocol for Cardiac Patients
This study compares two accepted ways of deciding when adults recovering from open-heart surgery should receive a blood transfusion in the intensive care unit.
- Conditions
- Cardiac Surgery, Blood Transfusion, Anemia, Cardiopulmonary Bypass
- Trial name
- PerP (NCT07671469)
- Testing
- Demand-Informed Transfusion Decision Rule
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Yan Mia Min
Congenital Heart Disease (CHD), Cardiopulmonary Bypass
Research on Circulation Management Strategy Based on Oxygen Metabolism Balance After CHD Surgery
The objective is to investigate a goal-oriented postoperative circulation management strategy centered on "oxygen metabolism balance".
- Conditions
- Congenital Heart Disease (CHD), Cardiopulmonary Bypass, Children, Oxygen Delivery
- Trial name
- NCT06747546
- Testing
- "goal-directed" treatment strategy based on oxygen supply and consumption balance, Conventional Treatment group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Children's Hospital of Fudan University
Cardiac Surgery Requiring Cardiopulmonary Bypass
Oxygen Consumption, Hypoperfusion and Organ Injury After Cardio-pulmonary Bypass
The goal of this observational study is to understand how oxygen consumption after heart surgery relates to blood flow problems and organ injury.
- Trial name
- VO2-EPOC (NCT06930443)
- Testing
- Oxygen consumption measurement
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University Hospital
Coronary Artery Disease, Heart Valve Diseases
Spectroscopic Assessment of Intramyocardial Oxygen Saturation During Open-Heart Surgery
The goal of this observational study is to test in the safety and performance of intraoperative myocardial spectroscopic measurement in open-heart surgery patients The main questions it aims to answer are: The Devices can record…
- Trial name
- ECS (NCT06084091)
- Testing
- Myocardial spectrometric measurement
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Spectrocor
Chronic Heart Failure
Non-invasive Ventilation and High-speed Oxygen Therapy Effects on Heart Function - HiFlow-Heart Study
The investigators hypothesize that the airway pressures generated by High Flow Oxygen Therapy could have a beneficial impact in patients with heart failure, particularly by lowering capillary pulmonary arterial pressures.
- Trial name
- HiFlow-Heart (NCT04471129)
- Testing
- HFO/O2C/NIV, NIV/O2C/HFO
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Rouen
Coronary Artery Disease, Anesthesia
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.
- Trial name
- Promise-O2 (NCT04808401)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiac Surgery Subjects
PuO2 in RenalGuard Pilot Study
The PuO2 in RenalGuard (PURE) study is planned as a single center, randomized controlled pilot study comparing renal oxygenation during cardiac surgery with cardiopulmonary bypass (CPB) with or without balanced forced diuresis…
- Trial name
- PURE (NCT06886191)
- Testing
- RenalGuard Therapy
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Cardiac Surgery, Cardiopulmonary Bypass
HEMO-INTEGRA: Integrated Intraoperative Hemodynamic Monitoring During Cardiac Surgery With Cardiopulmonary Bypass - A Pilot Study
HEMO-INTEGRA is a software system that integrates four domains of intraoperative hemodynamic monitoring in a single dashboard during cardiac surgery with cardiopulmonary bypass (CPB): (1) ventricular-arterial coupling (VAC)…
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Hemodynamic Monitoring, Ventricular-Arterial Coupling
- Trial name
- HEMO-INTEGRA (NCT07683299)
- Where
- Colombia
- Volunteers
- 30 people
- Sponsor
- Hernán Darío Castro Arias
Circulatory Failure / Shock State, Fluid Therapy
Metabolic Fluid Responsiveness in Children
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery.
- Trial name
- METAFRIC (NCT07255469)
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bordeaux
Surgery, Post Operative Complications
Enhanced Vitals Monitoring After Major Surgery Trial
The aim of this clinical trial is to examine the feasibility of an enhanced vital sign monitoring solution in-hospital and at-home. This study includes adult patients undergoing inpatient major vascular or abdominal surgery.
- Conditions
- Surgery, Post Operative Complications, Quality of Recovery, General Surgery
- Trial name
- NCT06584825
- Testing
- Enhanced Vitals Monitoring
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- University of British Columbia
Cyanotic Congenital Heart Disease, Right Ventricular Outflow Tract Obstruction
RVOT Stenting Versus Surgical RV-PA Conduit in Cyanotic Adults
This prospective observational cohort study aims to compare clinical and hemodynamic outcomes of percutaneous right ventricular outflow tract stenting versus surgical right ventricle-to-pulmonary artery conduit placement in…
- Trial name
- NCT07866911
- Volunteers
- 30 people
- Sponsor
- Assiut University
Perfusion Index and Cerebral NIRS Trends in Low Cardiac Output Syndrome
Can Perfusion Index and Cerebral Oxygen Saturation Trends Predict Low Cardiac Output in Pediatric Cardiovascular Surgeries
In this prospective, observational study, we aim to investigate whether routinely monitored Perfusion Index (PI) and cerebral oxygen saturation (NIRS) values in pediatric patients aged 0-6 undergoing congenital heart surgery are…
- Trial name
- NCT06759506
- Volunteers
- 40 people
- Sponsor
- Bozyaka Training and Research Hospital