Clinical trials: Oxygen Toxicity
Oxygen Toxicity, COPD Bronchitis
Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates
Oxygen therapy is at the heart of the healthcare system. Oxygen flow rates depend on a number of confounding factors confounding factors (target used, skin pigmentation, pulse oximeter used, etc.) The investigators have recently…
- Conditions
- Oxygen Toxicity, COPD Bronchitis, Respiratory Failure
- Trial name
- Interfaces (NCT06646991)
- Testing
- Nasal canula - up to 6 liters per minute, Nasal canula - up to 15 liters per minute, Open oxygen mask
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Laval University
Oxygen Toxicity, COPD Exacerbation
Automated Adjustment of Oxygen on Patient With Acute COPD Exacerbation - FreeO2 HypHop
The aim of this study is to evaluate if automated adjustment of oxygen (with FreeO2 device) can reduce the hospital length of stay for acute exacerbation of COPD with comparison of manual oxygen titration.
- Conditions
- Oxygen Toxicity, COPD Exacerbation, Hyperoxia, Hypoxemia
- Trial name
- FreeO2 HypHop (NCT03835741)
- Testing
- FreeO2, manual titration
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Laval University
Respiratory Insufficiency of Prematurity
Canadian Oxygen Trial (COT)
Study Question: In infants who are born at gestational ages of 23 0/7 to 27 6/7 weeks, does lowering the concentration of supplemental oxygen to target an arterial oxygen saturation by pulse oximetry (SpO2)of 85-89% compared with…
- Trial name
- COT (NCT00637169)
- Testing
- Titration of oxygen therapy
- Where
- 23 sites in United States, Argentina and 4 more
- Volunteers
- 1,201 people
- Sponsor
- McMaster University
Overweight and Obesity, Exertion; Excess
Effects of Ketogenic Diet in Divers Breathing Enriched Air Nitrox
Overweight divers face a challenging activity such as immersions, starting from a higher levels of circulating cytokines and oxidative stress.
- Conditions
- Overweight and Obesity, Exertion; Excess, Oxygen Toxicity
- Trial name
- NCT03114176
- Testing
- Ketogenic Diet
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Padova
Oxygen Toxicity
Northern Survey on Therapeutic Oxygen Prescription
This is a prospective multicenter observational trial. Included patients and attending physician complete a standardized questionnaire.
- Trial name
- NONSTOP (NCT03937622)
- Testing
- 17 items questionaire
- Where
- 2 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Hannover Medical School
Oxygen Toxicity, Pulmonary Injury
Hyperoxia Induced Pulmonary Inflammation and Organ Injury: a Human in Vivo Model
Oxygen is the most commonly administered therapy in critical illness. Accumulating evidence suggests that patients often achieve supra-physiological levels of oxygenation in the critical care environment.
- Conditions
- Oxygen Toxicity, Pulmonary Injury, Acute Lung Injury
- Trial name
- NCT05414370
- Testing
- Liquid oxygen, medical air
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Coronavirus, Pneumonia
Closed-Loop Oxygen to Verify That Healthcare Workers Interventions Decrease During SARS-CoV-2 Pneumonia (COVID-19)
There is a high risk of transmission of COVID-19 to healthcare workers. In a recent cohort, 29% of the patients hospitalized were healthcare workers.
- Conditions
- Coronavirus, Pneumonia, Oxygen Toxicity
- Trial name
- NCT04320056
- Testing
- Standard administration of oxygen flow, Automated oxygen administration - FreeO2
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Laval University
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Hyperbaric Oxygen Therapy in Treating Patients With Radiation Necrosis of the Brain
RATIONALE: Hyperbaric oxygen may increase blood flow and decrease swelling in areas of the brain damaged by radiation therapy. Giving hyperbaric oxygen therapy together with dexamethasone may be an effective treatment for…
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Radiation Toxicity
- Trial name
- NCT00087815
- Testing
- dexamethasone, hyperbaric oxygen, cognitive assessment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Barrett Cancer Center
Hyperbaric Oxygenation, Oxygen Toxicity
Selected Lysosomal Enzyme Activities and the Oxidant-antioxidant Balance in Hyperbaric Oxygen Condition.
The aim of the research project was to investigate the effects of hyperbaric oxygen (HBO) treatment on the redox equilibrium in individuals with different pathological conditions.
- Conditions
- Hyperbaric Oxygenation, Oxygen Toxicity, Antioxidants, Oxidative Stress
- Trial name
- NCT06401941
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Poland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Nicolaus Copernicus University
Oxygen Toxicity
Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 2)
The purpose of this study is to understand how ketogenic food products affect oxygen toxicity in undersea divers. Oxygen toxicity affecting the central nervous system, mainly the brain, is a result of breathing higher than normal…
- Trial name
- NCT05831228
- Testing
- Ketogenic food products
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Oxygen Toxicity, Oxygen Deficiency
Supplementary Oxygen in Surgical and Medical Wards Evaluated by 30-day Mortality
This study evaluates the use and effects of supplementary oxygen in surgical and medical wards on patients admitted to a hospital in the capital region of Denmark.
- Trial name
- SOSAM (NCT03625700)
- Testing
- Oxygen gas
- Where
- Denmark
- Volunteers
- 11,196 people, healthy volunteers welcome
- Sponsor
- Hannibal Troensegaard
Adult and Pediatric Chronic Cerebral Disorders
Oxygen Toxicity of HBOT in Chronic Brain Injury
Hypothesis: That HBOT can be toxic in the low-pressure range.
- Trial name
- NCT00592891
- Testing
- Hyperbaric oxygen therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Paul G. Harch, M.D.
Oxygen Toxicity
Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 1)
The purpose of this study is to understand how ketogenic food products affect oxygen toxicity in undersea divers. Oxygen toxicity affecting the central nervous system, mainly the brain, is a result of breathing higher than normal…
- Trial name
- NCT05801120
- Testing
- Ketogenic food products
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Duke University
Carbon Monoxide Poisoning
Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy
Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome…
- Trial name
- COCARDIOTOX (NCT06549621)
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Brest
Trauma, Oxygen Toxicity
Restrictive Vs. Liberal Oxygen in Trauma
Victims of trauma are often healthy individuals prior to the incident, but acquire numerous complications including sepsis and pulmonary complications and diminished quality of life after trauma.
- Conditions
- Trauma, Oxygen Toxicity, Wounds and Injuries
- Trial name
- TRAUMOX2 (NCT05146700)
- Testing
- Restrictive oxygen, Liberal oxygen
- Where
- 5 sites in Denmark, Netherlands and 1 more
- Volunteers
- 1,508 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bladder Cancer, Cervical Cancer
Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer
RATIONALE: Radiation therapy can cause long-term adverse effects. Hyperbaric oxygen therapy may be effective in lessening gastrointestinal symptoms caused by radiation therapy given for pelvic cancer.
- Conditions
- Bladder Cancer, Cervical Cancer, Colorectal Cancer, Endometrial Cancer
- Trial name
- NCT01087268
- Testing
- questionnaire administration, gastrointestinal complications management/prevention, quality-of-life assessment
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Oxygen Toxicity
Pulmonary Function After Hyperbaric Oxygen Therapy
Patients receiving hyperbaric oxygen therapy (HBOT) for any indication at the Hyperbaric Medicine Unit (University Health Network, Toronto, ON, Canada) from 2016-2021 were recruited to this prospective cohort study.
- Trial name
- NCT05088772
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- University of Toronto
Intraoperative Complications, Respiratory Complication
Lower Inspiratory Oxygen Fraction for Preoxygenation
During the induction period of general anesthesia, surgical patients are inevitably experienced a short period of apnea for endotracheal intubation or other airway manipulation.
- Conditions
- Intraoperative Complications, Respiratory Complication, Oxygen Toxicity, Oxygen Deficiency
- Trial name
- NCT03665259
- Testing
- Pure oxygen group, Lower oxygen group
- Where
- Taiwan
- Volunteers
- 304 people
- Sponsor
- E-DA Hospital