Clinical trials: Oxygenation,
Tissue Oxygenation
Accuracy Verification of the INVOS PM7100
Prospective, observational, pre-market, verification study to confirm accuracy of the INVOS 7100 system in compliance with ISO 80601-2-85:2021 standard
- Trial name
- NCT07166341
- Testing
- Observational
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Intensive Care (ICU), Respiratory Distress Syndrome (RDS)
Feasibility of Protocolised Analgosedation in ECMO
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care (ICU), Respiratory Distress Syndrome (RDS), Sedation and Analgesia, Extracorporeal Membrane Oxygenation
- Trial name
- ECMO-SED (NCT07580781)
- Testing
- Sedation protocol
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Extracorporeal Membrane Oxygenation Complication
BivaLirudin versUS Heparin in Extracorporeal Membrane Oxygenation
The goal of this open label randomised clinical trial is to compare Bivalirudin versus Heparin for anticoagulation in patients requiring extracorporeal membrane oxygenation support.
- Trial name
- BLUSH (NCT05959252)
- Testing
- Unfractionated heparin, Bivalirudin
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- Sydney Local Health District
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Kinesio Taping, Muscle Oxygenation
The Effect of Kinesio Taping Applied to the Gastrocnemius Muscle on Muscle Oxygenation, Pain Pressure Threshold, and Muscle Mechanical Properties
The aim of this study is to investigate the effects of kinesio taping applied to the gastrocnemius muscle on muscle oxygenation, pain pressure threshold, and mechanical properties of the muscle in healthy young individuals.
- Trial name
- NCT07572201
- Testing
- Kinesio® tape application
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Okan University
Postoperative Pulmonary Complications, Impaired Oxygenation
PEEP Strategies and Mechanical Power in Robotic Surgery
Robotic surgery requires pneumoperitoneum and steep Trendelenburg positioning, which significantly impair respiratory mechanics and increase the risk of postoperative pulmonary complications.
- Conditions
- Postoperative Pulmonary Complications, Impaired Oxygenation, Mechanical Ventilation
- Trial name
- NCT07536464
- Testing
- Fixed PEEP Ventilation, Decremental PEEP Strategy, Incremental PEEP Strategy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Pulmonary Dysfunction, Oxygenation Impairment
Mechanical Power Ventilation in RALP
Robot-assisted laparoscopic radical prostatectomy (RALP) requires steep Trendelenburg positioning and pneumoperitoneum, which adversely affect respiratory mechanics and may lead to impaired postoperative oxygenation.
- Conditions
- Postoperative Pulmonary Dysfunction, Oxygenation Impairment, Robot-Assisted Radical Prostatectomy
- Trial name
- NCT07534553
- Testing
- Mechanical Power-Targeted Ventilation, Standard Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Fracture Related Infection, Hyperbaric Oxygenation
Hyperbaric Oxygen Therapy as Adjunctive Treatment for Fracture-Related Infection
A fracture-related infection (FRI) is a difficult to treat condition in which a bone fracture and surrounding tissues are infected.
- Trial name
- SOLDIER (NCT07535164)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mechanical Power, Postoperative Pulmonary Complications (PPCs)
EIT vs Dynamic Compliance Guided PEEP Titration During Laparoscopic Gynecological Surgery
The goal of this randomized controlled clinical trial is to compare the pulmonary protective effects of two different positive end-expiratory pressure (PEEP) titrating methods in patients with non-injured lungs undergoing…
- Conditions
- Mechanical Power, Postoperative Pulmonary Complications (PPCs), Oxygenation
- Trial name
- TITRANT (NCT07170514)
- Testing
- EIT-guided PEEP titration, Cdyn-guided PEEP titration
- Where
- 3 sites in Hungary
- Volunteers
- 200 people
- Sponsor
- Pest County Flór Ferenc Hospital
Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation Complication
"Continuous Positive Airway Pressure on Venovenous extracorporeaL Membrane Oxygenation for Acute respIratory Distress syndrOme"
The CALMDOWN trial is a prospective, open-label, multicenter, comparative, controlled trial randomizing patients who received near apneic ventilation vs usual care on ECMO (ultra-protective lung ventilation).
- Trial name
- CALMDOWN (NCT06814340)
- Testing
- ECMO + near apneic ventilation, ECMO + ultra-protective lung ventilation
- Where
- 11 sites in France
- Volunteers
- 280 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ıntraoperative Cerebral Oxygenation, Cerebral Oxygenation Monitoring
Comparison of the Effects of Desflurane-Remifentanyl and Propofol-Remifentanyl Anesthesia on Intraoperative Cerebral Oxygenation in Patients Undergoing Laparoscopic Cholecystectomy
Study Population: Patients undergoing elective laparoscopic cholecystectomy under general anesthesia will be included. Study Design: This is an observational study.
- Trial name
- NCT07517146
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Cerebral Oxygenation, Low Flow Anesthesia
The Effect Of Low-Flow And Hıgh-Flow Anesthesıa On Intracranıal Pressure
This prospective randomized study was conducted to evaluate the effects of low-flow and high-flow anesthesia on intracranial dynamics and cerebral oxygenation in patients undergoing laparoscopic hysterectomy in the Trendelenburg…
- Conditions
- Cerebral Oxygenation, Low Flow Anesthesia, Optic Nerve Sheath Diameter Measurement
- Trial name
- NCT07514026
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bursa City Hospital
Extracorporeal Membrane Oxygenation Complication
Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation
The purpose of this study was to evaluate the efficacy and safety of bivalirudin in anticoagulation therapy in patients with extracorporeal membrane oxygenation (ECMO) compared with unfractionated heparin.
- Trial name
- NCT06275555
- Testing
- bivalirudin, unfractionated heparin
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Xiaotong Hou
Delirium - Postoperative, Cerebral Oxygenation
Cerebral Oxygen Consumption Response to Increased Oxygen Supply and Postoperative Delirium in Older Surgical Patients
The goal of this observational study is to learn whether the brain's ability to use oxygen during surgery is associated with postoperative delirium in adults aged 65 years and older undergoing general anesthesia.
- Trial name
- NCT07463586
- Testing
- Intraoperative Cerebral Oxygen Utilization Assessment
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Diabetes Mellitus, Glycemic Control
Effect of Glycemic Control on Intraoperative NIRS and Postoperative Recovery in Diabetic Patients
This prospective observational study aims to evaluate the effect of glycemic control level on intraoperative cerebral oxygenation measured by near-infrared spectroscopy (NIRS) and postoperative recovery in patients with diabetes…
- Conditions
- Diabetes Mellitus, Glycemic Control, Cerebral Oxygenation, Anesthesia
- Trial name
- NIRS-DM (NCT07491185)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ege University
ExtraCorporeal Membrane Oxygenation (ECMO), Cardiac Arrest
Plasma Biomarkers and Platelet Morphology of Extracorporeal CardioPulmonary Resuscitation
Extracorporeal cardiopulmonary resuscitation (ECPR) constitutes a pivotal emergency intervention for cardiac arrest (CA) patients.
- Trial name
- ECPR (NCT07113769)
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Central China Fuwai Hospital of Zhengzhou University
Fascial Plane Block, ICU Length of Stay
Postoperative Analgesia and Ventilation After Cardiac Surgery
Cardiac surgery performed via median sternotomy is associated with significant postoperative pain due to extensive tissue trauma, sternal bone healing, and mediastinal retraction.
- Conditions
- Fascial Plane Block, ICU Length of Stay, Mechanical Ventilation Duration, Oxygenation
- Trial name
- NCT07475884
- Testing
- conventional analgesic regimen, Fascial Plane Blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people
- Sponsor
- Bursa City Hospital
Neonatal Cerebral Oxygenation, Cesarean Section
Effects of Spinal Versus General Anesthesia on Neonatal Cerebral Oxygenation During Cesarean Section
This prospective observational study evaluates and compares the effects of spinal and general anesthesia techniques used during elective cesarean section on neonatal cerebral regional oxygen saturation (crSO₂) during the early…
- Trial name
- NEO-OXY-CS (NCT07477093)
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Akdeniz University Hospital