Clinical trials: Oxygenation,
ARDS
Effectiveness of Recruitment Maneuvers and Lung Protective Ventilation Strategy in ARDS
The study was designed to comparison the effectiveness of recruitment maneuvers(RM) and lung protective ventilation strategy(LPVS) for patients with moderate to severe ARDS.
- Trial name
- ARDS (NCT05023226)
- Testing
- RM, LPVS
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Asia University
Bronchoscopy
Three Different Oxygenation Strategies in Bronchoscopy Procedures Under Sedation
The purpose of study aims to determine which of the three different oxygenation strategies, including nasal cannula, modified nasopharyngeal cannula, and HFNO groups, is safer in patients undergoing bronchoscopy under sedation.
- Trial name
- NCT05912985
- Testing
- different oxygenation methods
- Where
- Turkey (Türkiye)
- Volunteers
- 252 people
- Sponsor
- Ankara City Hospital Bilkent
Newborn, Preterm
Influence of Premedication Protocols for Neonatal Endotracheal Intubation on Cerebral Oxygenation
The purpose of this study is to examine the influence of premedication drugs Atropin, Fentanyl and Mivacurium and of endotracheal intubation on cerebral oxygenation and cardiac output in term and preterm newborn infants.
- Conditions
- Newborn, Preterm, Intubation
- Trial name
- NCT01427985
- Testing
- Atropine, Fentanyl, Mivacurium
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University of Ulm
Cardiac Arrest, Cardiopulmonary Resuscitation
Cardiac Arrest Extra Corporeal Oxygenation Membrane
French guidelines for Cardio Pulmonary Resuscitation (CPR) consider Extra-Corporeal Life Support (ECLS) as one option in Refractory out-of hospital Cardiac Arrest (ROHCA) patients with a no-flow less than five minutes and absence…
- Conditions
- Cardiac Arrest, Cardiopulmonary Resuscitation, Advanced Cardiac Life Support, Extracorporeal Life Support
- Trial name
- CAREECMO (NCT03352999)
- Testing
- Fast track access to vaECMO
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Abdominal Surgery
Continuous Bupivacaine Infusion Following Colonic Surgery
The primary objective is to evaluate the influence of continuous local anesthetic infiltration on tissue oxygenation after surgical procedures requiring abdominal surgery as a major predictor for wound healing.
- Trial name
- NCT00557843
- Testing
- Bupivacaine, Saline
- Sponsor
- The Cleveland Clinic
AKI, Continuous Renal Replacement Therapy
Renal Physiology During Continuous Renal Replacement Therapy
Approximately 50% of patients in the intensive care unit (ICU) develop acute kidney injury (AKI) and more than 10% need dialysis. There is no treatment for AKI.
- Conditions
- AKI, Continuous Renal Replacement Therapy, Dialysis, Intensive Care
- Trial name
- NCT04114747
- Testing
- Starting at high or low blood pressure
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Genitourinary Syndrome of Menopause
Concomitant Treatment with Topical Hyaluronic Acid and High Concentration Oxygen Therapy (Vaginal Natural Oxygenation Device - VNOD) in the Improvement of Symptoms Related to Genitourinary Syndrome of Menopause in Women with Natural and Oncological Postmenopause: Open-Label, Single-Center, Randomize
The Caress study is a single-center, open-label, randomized controlled trial (RCT) evaluating the efficacy of a combined treatment using topical hyaluronic acid and high-concentration oxygen therapy (Vaginal Natural Oxygenation…
- Trial name
- Caress (NCT06879938)
- Testing
- High-concentration vaginal oxygen therapy (Caress Flow) with topical hyaluronic acid, hyaluronic acid-based gel (Hydeal-D®)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Cerebral Oxygenation
Cerebral NIRS Monitoring During Anesthesia in Neonates and Infants
The brain is a very vulnerable organ, especially in premature babies, newborns and infants. However, during anesthesia, the oxygenation of the brain can only be monitored indirectly and insufficiently.
- Trial name
- NCT04132414
- Testing
- NIRS open
- Sponsor
- Medical University of Graz
Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
To establish whether a pre-hospital advanced physician/ paramedic cardiac arrest team that is ECMO capable can establish ECMO flow within 30 minutes of collapse.
- Conditions
- Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
- Trial name
- SUB30 (NCT03700125)
- Testing
- ECMO resuscitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- Barts & The London NHS Trust
Pulmonary Disease, Chronic Obstructive
Single Portable Pulse-dose-conserving Device vs. Combined Use of Stationary and Portable.
Introduction: Portable oxygen devices simplify and facilitate patient therapy. This study was designed to compare oxygen saturation and patient satisfaction with a portable oxygen concentrator or with a combined system consisting…
- Trial name
- NCT02079753
- Testing
- Inogen, Combination system of a portable and a stationary device.
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- Hospital Son Espases
Placental Oxygenation
Could the Cerebral Oximetry be a Good Technology to Measure Placental Oxygenation?
To assess the potential of the cerebral oximeter to measure placental oxygenation
- Trial name
- NCT01834599
- Testing
- cerebral oximetry
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Lung Transplantation
Heparin-free Extracorporeal Membrane Oxygenation Support During Clinical Lung Transplantation
The aim of this investigation is to compare two different anti-coagulation strategies in clinical lung transplantation where lung implantations are all routinely done on veno-arterial (VA) extracorporeal membrane oxygenation…
- Trial name
- zero-hep (NCT05697692)
- Testing
- Heparin sodium
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
COPD (Chronic Obstructive Pulmonary Disease), Intersitital Lung Disease
MoblO2 to Maintain Oxygenation
Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course.
- Trial name
- SSeifert (NCT07704567)
- Testing
- MoblO2 controls O2 flow, MoblO2 does not control flow
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Minnesota HealthSolutions
COPD, Interstitial Lung Disease
MOBoxy: MoblO2 to Maintain Oxygenation
Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course.
- Trial name
- MOBoxy (NCT07222592)
- Testing
- MoblO2 control
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Jewish Health
Delirium, Acute Kidney Injury
Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury
Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality.
- Conditions
- Delirium, Acute Kidney Injury, Critical Illness, Cognitive Impairment
- Trial name
- INCOGNITOAKI (NCT04722939)
- Testing
- Cerebral oxygenation
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Dr. Gordon Boyd
Heart Failure
Blood Flow Restriction Combined With Aerobic or Resistance Exercise in Heart Failure
The aim of this study is to compare the clinical effects of aerobic and resistance exercise modalities combined with blood flow restriction in patients with stable heart failure, and to determine the most effective, feasible, and…
- Trial name
- NCT07627737
- Testing
- Aerobic Exercise Plus Blood Flow Restriction Resistance Training, Resistance Training Plus Blood Flow Restriction Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Biruni University
Near-Infrared Spectroscopy
Comparison of Intercostal and Quadriceps Femoris Muscle Oxygenation in Women and Men
The differences in physiological responses due to gender during exercise tests have recently begun to be investigated. The oxygen use of respiratory muscles and lower extremity muscles may differ during upper and lower extremity…
- Trial name
- NCT06896838
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Long-term Outcome, Extracorporeal Membrane Oxygenation
Long Term Outcome of Extracorporeal Membrane Oxygenation Patients in China
Outcomes and Long-term Quality-of-life of Patients requiring Extracorporeal Membrane Oxygenation are not known in china. A prospective study survey will be performed to assess the long-term outcome of these patients.
- Trial name
- ECMO (NCT03345758)
- Testing
- outcome
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Southeast University, China
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Intracranial Hypertension
Intracranial Pressure and Brain Function: Effects of Head Down Tilt Upon Brain Perfusion and Cognitive Performance
The aim of the study is to understand the relationship between intracranial pressure regulation, cerebral tissue oxygenation and cognitive functioning.
- Trial name
- IPCog (NCT02976168)
- Testing
- 12° head down tilt
- Where
- Germany
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- DLR German Aerospace Center