Clinical trials: Oxytocin
Autism Spectrum Disorders
A Randomized, Controlled Trial of Intranasal Oxytocin as an Adjunct to Behavioral Therapy for Autism Spectrum Disorder
This 3-year study is a trial of cognitive behavioral therapy (CBT), with or without oxytocin (OT) augmentation, in young adults with autism spectrum disorders.
- Trial name
- NCT01914939
- Testing
- Oxytocin, Social Skills focused CBT, Stress management/relaxation training
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- Massachusetts General Hospital
Female, Borderline Personality Disorder
Reactivity of Patients With Borderline Personality Disorder to an Ecological Interpersonal Stress
Use lay language. According to the World Health Organization 1 death by suicide occurs every 40 seconds, leading suicide prevention to one of the public health priority.
- Trial name
- ROI (NCT03602521)
- Testing
- Interpersonal stress
- Where
- France
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Osteoarthritis, Knee, Healthy
Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects
This is a study of participants that will receive an intravenous (IV) infusion of oxytocin (naturally occurring hormone that is made in the brain).
- Trial name
- NCT04431206
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia, Oxytocin
Oxytocin MEG Study
The specific aim of this proposal is to investigate the neurophysiological mechanisms of oxytocin's (OT) prosocial effects in patients with schizophrenia and healthy subjects using magnetoencephalography.
- Conditions
- Schizophrenia, Oxytocin, Magnetoencephalography (MEG), Social Cognition
- Trial name
- MEG (NCT02568709)
- Testing
- Oxytocin, Saline Nasal Spray
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Comparison of Intranasal Oxytocin Effects Using Co-administration With a Vasoconstrictor
This study aims to dissociate direct from indirectly mediated effects of intranasal oxytocin administration by using treatment with or without prior intranasal administration of a vasoconstrictor to reduce peripheral increases in…
- Trial name
- NCT04134663
- Testing
- vasoconstrictor and oxytocin treatment
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Oxytocin
Influence of Oxytocin on Neurophysiological Responses to Live Faces
Previous research has indicated that direct eye gaze compared to averted gaze, elicits a higher skin conductance response (SCR), and a more pronounced left frontal cortex activity than right frontal cortex activity (resulting in…
- Trial name
- NCT03272321
- Testing
- Oxytocin
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Prader-Willi Syndrome
Follow-up of Prader Willi Syndrome Infants Treated by Oxytocin and Comparison With Not-treated Infants.
The objective of this study is to collect data on tolerance and effects of early treatment with oxytocin in children with Prader Willi Syndrome aged from 3 to 4 years and to compare these infants with not treated age-matched…
- Trial name
- OT2SUITE (NCT03081832)
- Testing
- Oxytocin, Control
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Toulouse
Stimulant Use & Co-occuring Opioid Use Disorders
Stimulant Oxytocin Study
This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with…
- Trial name
- SOS (NCT03016598)
- Testing
- Intranasal oxytocin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Premature Birth
Preterm Infants' Weight Gain Following Massage Therapy
The specific aims of this study are: 1) to replicate the data that following ten days of massage therapy, preterm infants show greater daily weight gain and are discharged from the hospital earlier than the controls, thus…
- Trial name
- NCT00029198
- Testing
- massage
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of Miami
Prader-Willi Syndrome
Oxytocin Intranasal Administrations in Children With Prader-Willi Syndrome Aged From 3 to 12 Years
Positive results in preclinical and clinical studies in adults and infants with Prader-Willi syndrome lead investigators to set up a new study in children with Prader-Willi syndrome.
- Trial name
- Oxyjeune (NCT03114371)
- Testing
- Oxytocin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Idiopathic Infertility
Nasal Oxcytocin During IUI
Placebo-controlled study. Application of nasal oxytocin (8 IU) during intrauterine insemination in 86 patients.
- Trial name
- Oxy (NCT00805662)
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Maternal Obesity During Childbirth, Labor; Arrested Active Phase
Impact of Maternal BMI on Plasma Levels of Oxytocin During Labor Augmentation
The aim of this study is to examine the associations between maternal BMI and levels of oxytocin in maternal plasma during augmentation with oxytocin during first stage of labor in term pregnancy.
- Trial name
- NCT04093479
- Testing
- blood samples
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Linkoeping University
Irritable Mood
Dose Response Relationship of Oxytocin on Irritability in Youths
The proposed study is a randomized, double-blind proof of concept (PoC) study on the neural impact of intranasal oxytocin (OXT) administration for adolescents (age 14 to 18), demonstrating a clinically significant level of…
- Trial name
- NCT03863288
- Testing
- Functional MRI (fMRI), Oxytocin Intranasal Spray 8 International Unit (8IU), Oxytocin intranasal spray 24 International Unit (24IU)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Nebraska
Mood Disorder, Disruptive Behavior Disorders
Oxytocin on Irritability/Emotional Dysregulation of Disruptive Behavior and Mood Disorders
Irritability and emotional dysregulation are recognized as serious aspects of psychopathology seen in in pediatric psychiatric patients.
- Trial name
- NCT02824627
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Nebraska
In Vitro Fertilisation (IVF) Treatment
Effect of Oxytocin and Vasopressin Antagonists on Uterine Contractions
The main purpose of this clinical research trial was to evaluate the effects of barusiban and atosiban compared to placebo on luteal phase uterine contractions in oocyte donors supplemented with progesterone.
- Trial name
- OVANCON (NCT00587327)
- Testing
- Barusiban, Atosiban
- Where
- 5 sites in Belgium, Czechia and 1 more
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Breastfeeding, Exclusive, Breastfeeding
After Caesarean Section Oxitocin Breast Massage Anthropometric Characteristics of the Newborn
Background: Delays in breastfeeding and milk release after cesarean section may negatively affect the early initiation of breastfeeding and the mother's breastfeeding self-efficacy.
- Trial name
- OM (NCT06242886)
- Testing
- Oxytocin massage, and Breast massage
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Halic University
Autism Spectrum Disorders
Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors
The purpose of this research study is to learn about the effects of supplemental intranasal oxytocin as a treatment for improving social difficulties in children and adolescents with autism.
- Trial name
- SOARS-B (NCT01944046)
- Testing
- double Blind Oxytocin Nasal Spray, Open Label intranasal oxytocin
- Where
- 7 sites in United States
- Volunteers
- 290 people
- Sponsor
- Linmarie Sikich
Stress Disorders, Post-Traumatic
The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD)
This study is designed to test the hypothesis that a single administration of intranasal oxytocin within 6 hours post-trauma facilitates the physiological recovery for the trauma, thereby preventing the development of Post…
- Trial name
- NCT01039766
- Testing
- Oxytocin
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Postpartum Hemorrhage
Carbetocin Versus Oxytocin Plus Sublingual Misoprostol in the Management of Atonic Postpartum Hemorrhage
The objective of this study is to compare the effectiveness and safety of carbetocin vs. oxytocin plus sublingual misoprostol in the management of atonic postpartum hemorrhage (PPH)after vaginal delivery.
- Trial name
- NCT03870503
- Testing
- oxytocin, oxytocin plus misoprostol, Carbetocin
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Aswan University Hospital
Missed Abortion
Oxytocin Effectiveness in First Trimester Dilatation and Curettage
The aim of this study is to investigate the impact of oxytocin on perioperative blood loss during the D\&C procedure, as well as to assess early and late complications associated with it's use.
- Trial name
- NCT06469203
- Testing
- Oxytocin, Sodium Chloride 0.9% Inj
- Volunteers
- 160 people
- Sponsor
- Assuta Ashdod Hospital