Clinical trials: Ozone
Fibromyalgia Syndrome
Effectiveness of Major Ozone Autohemotherapy in the Treatment of Fibromyalgia Syndrome
Patients who were admitted to the Physical Medicine and Rehabilitation (PMR) outpatient clinic of our hospital between January 2017 and December 2020 and were treated with Major ozone autohemotherapy with a diagnosis of…
- Trial name
- NCT05034770
- Testing
- major ozone autohemotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Emine Dundar Ahi, MD
Ozone, Caries
Effectiveness of the Ozone Application in Two-Visit Indirect Pulp Therapy of Permanent Molars With Deep Carious Lesion
The aim of this study was to evaluate the clinical and microbiological effectiveness of the ozone application in two-visit indirect pulp therapy.
- Trial name
- ozone (NCT03693066)
- Testing
- Ozone, chlorhexidine digluconate, Control
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia
Gut Microbiome Profiles in Patients With Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of chemotherapy (CT), often requiring dose reductions or treatment interruptions, which can compromise efficacy of the planned CT…
- Conditions
- Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling
- Trial name
- OzoParQTmicrob (NCT06799351)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
Dental Caries
Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Caries means demineralization with the formation of cavities and pulp symptoms and necrosis as an end result. The acids in the mouth are mainly produced by oral bacteria like Streptococcus mutans from bacterial biofilms adhering…
- Trial name
- NCT00495495
- Testing
- Ozone treatment
- Where
- 3 sites in United States
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Control
Genetic Susceptibility TO Ozone-induced Airway Inflammation in Humans
The principal purpose of this study is to identify hyper-responsive, responsive and non-responsive groups of healthy human subjects based on their airway neutrophilic response to ozone exposure, and to perform micro-array…
- Trial name
- GARBOZ (NCT00840528)
- Testing
- ozone
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Respiratory Depression, Blood Pressure
Cardiopulmonary Responses to Exposure to Ozone and Diesel Exhaust
The US EPA Clean Air Multiyear research program is moving toward a multi-pollutant approach to the assessment of air pollution in response to recommendations by the NRC 2004 and the BOSC in 2005.
- Trial name
- DEPOZ (NCT01874834)
- Testing
- ozone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Myofascial Pain Syndrome, Myofascial Trigger Point Pain
The Effectiveness of Ozone (O2-O3) Injections in the Treatment of Myofascial Pain Syndrome
Ozone (O2-O3) has been used as a supportive therapy in various musculoskeletal diseases such as lumbosacral disc herniation, knee osteoarthritis, meniscus injury, shoulder pathologies.The aim of this study is to investigate the…
- Trial name
- NCT04885881
- Testing
- Ozone therapy, Lidocaine injection group
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Ozone-therapy (O3), Periodontitis
Ozone-therapy in Non-surgical Periodontal Therapy
Non-surgical periodontal therapy is a widely adopted procedure for the treatment of periodontitis, particularly in its moderate to severe stages.
- Conditions
- Ozone-therapy (O3), Periodontitis, Antimicrobial Ozone Therapy
- Trial name
- PD-OZONE (NCT07202312)
- Testing
- Ozone-therapy after non-surgical therapy
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Corona Virus Infection
Ozone Therapy in the Prevention of COVID-19 Infection
Coronavirus has already infected 4,673,809 people and killed 312,646 people worldwide, and no specific treatment or a vaccine against it has yet proven to be effective.
- Trial name
- NCT04400006
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Marmara University
Neck Pain
Therapy With Paravertebral Oxygen-ozone Injections and Topical Cannabidiol and β-Caryophyllene Patch in Neck Pain
The aim of this study is to compare the effectiveness of combined treatment with paravertebral oxygen-ozone injections and topical patches containing Cannabidiol and β-Caryophyllene in patients with neck pain by evaluating the…
- Trial name
- NCT06099171
- Testing
- Cannabidiol and β-Caryophyllene Patch, Oxygen-Ozone Therapy
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Humanitas Clinical and Research Center
Pain, Chronic
Ozone Therapy in Patients With Diabetic Neuropathy
Diabetic neuropathies are the most prevalent chronic complications of diabetes mellitus. The early recognition and appropriate management of neuropathy in the patient with diabetes is important for patient's quality of life and…
- Trial name
- NCT05000463
- Testing
- Ozone, Convtrol group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Asthma
Ozone and Rhinovirus-Induced Disease in Asthmatics
In the U.S., morbidity associated with human rhinovirus (RV) infection represents a major health problem. In asthmatics, up to 80% of asthma exacerbations are associated with upper respiratory infections.
- Trial name
- NCT00013715
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Knee Osteoarthritis
The Effectiveness of Ultrasound Guided Ozone (O2-O3) Injection With Knee Osteoarthritis
Knee ostheoarthritis (KOA) is a common disabling and degenerative disease leading to painful joints, articular stiffness, and decreased function.
- Trial name
- NCT04830423
- Testing
- Medical ozone injection, steroid injection group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Knee Osteoarthritis
Investigating the Impact of Ex Vivo Ozone Injection on Synovial Fluids in Patients Diagnosed With Knee Osteoarthritis
The objective of this study is to examine the effect of varying ozone doses on the levels of pro-inflammatory cytokines in synovial fluid collected from individuals with knee osteoarthritis.
- Trial name
- NCT05824052
- Testing
- Ozone injection
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Uskudar State Hospital
Lipedema, Pain
Effect of Systemic and Local Ozone Therapy in Lipedema
Lipedema is a disease characterized by enlargement of the subcutaneous tissue and is observed only in the female population. Recently, the inflammatory cascade has been suggested to be the initiator of lipoedema and to play a…
- Conditions
- Lipedema, Pain, Activities of Daily Living, Musculoskeletal Ultrasound
- Trial name
- NCT06954870
- Testing
- Ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara Etlik City Hospital
Lumbar Disc Herniation
Post Market Non-Inferiority Study Comparing Triojection® to Discectomy for Lumbar Disc Herniation
The primary objective of this study is to compare the early clinical outcomes following non-surgical treatment with Triojection® to surgical discectomy. Early is defined as less than or equal to 6 months.
- Trial name
- NCT02525120
- Testing
- Triojection, Surgical discectomy
- Where
- 3 sites in Greece, Italy and 1 more
- Volunteers
- 49 people
- Sponsor
- Minimus Spine, Inc
Periodontal Diseases
Effect of Ozone Gel on Treatment of Chronic Periodontitis
To evaluate the efficacy of locally delivered ozone gel as an adjunct to conventional periodontal therapy on selected clinical parameters as well as alveolar bone density (BD) and superoxide dismutase (SOD) activity in patient…
- Trial name
- NCT02066337
- Testing
- scaling and root planing, Ozonated olive oil gel
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Low Back Pain, Failed Back Surgery Syndrome
The Effect of Epiduroscopy and Ozone Therapy in Patients With Failed Back Surgery Syndrome
The aim of this study is to assess the efficacy and safety of ozone therapy (vs. placebo) applied into the epidural space through epiduroscopy in Patients with Failed Back Surgery Syndrome.
- Trial name
- Epiduroscopy (NCT01172457)
- Testing
- Epiduroscopy with oxygen therapy, Epiduroscopy with ozone therapy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Bronchitis
Functional Implications of TNF
The research plan proposes to develop translational studies in humans that will identify host susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone.
- Trial name
- NCT00729131
- Testing
- Etanercept inhibition of ozone-induced airway hyper-responsiveness.
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Rectal Ozone, Neuroprotector
Rectal Ozone as Neuroprotector Post CNS Insult in Children
This study aims to evaluate the efficacy of rectal ozone therapy as a neuroprotective modality in Pediatric acquired brain injury.
- Conditions
- Rectal Ozone, Neuroprotector, CNS, Insult
- Trial name
- NCT07153627
- Testing
- Rectal ozone sessions, Conventional rehabilitation program
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University