Clinical trials: Ozone Therapy
White Spot Lesion of Tooth
Fluoride Varnish, Ozone, Octenidin and WSLs in Orthodontic Patients
Objectives: to assess the efficiency of four prophylactic protocols on white spot lesions during orthodontic treatment: 1. professional mechanical tooth cleaning (PMTC)+fluoride varnish, 2.
- Trial name
- NCT04992481
- Testing
- PMTC, fluoride varnish, gaseous ozone therapy
- Volunteers
- 150 people
- Sponsor
- Pomeranian Medical University Szczecin
Dentin Sensitivity
The Desensitizing Treatment Effects of the Laser and Ozone on Dentin Hypersensitivity: In-vivo Comparison
The goal of this split mouth clinical trial is to compare clinical efficacy of diode laser and gas ozone in the treatment of dentine hypersensitivity (DHS) of non-carious-cervical lesion.
- Trial name
- NCT05853523
- Testing
- Gas ozone, Diode laser and desensitized gel
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- University of L'Aquila
Endometriosis, Ozone Therapy
Ozone Therapy for Women With Endometriosis
To evaluate the action of ozone therapy as an adjuvant treatment in patients with endometriosis. Secondary Objective: To evaluate the efficacy of ozone therapy for pelvic analgesia in women with endometriosis; To compare the…
- Conditions
- Endometriosis, Ozone Therapy, Thermography
- Trial name
- NCT07035522
- Testing
- Ozone therapy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Paraná
Ozone-therapy (O3), Periodontitis
Ozone-therapy in Non-surgical Periodontal Therapy
Non-surgical periodontal therapy is a widely adopted procedure for the treatment of periodontitis, particularly in its moderate to severe stages.
- Conditions
- Ozone-therapy (O3), Periodontitis, Antimicrobial Ozone Therapy
- Trial name
- PD-OZONE (NCT07202312)
- Testing
- Ozone-therapy after non-surgical therapy
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Carpal Tunnel Syndrome
Ozone Therapy in Patients With Carpal Tunnel Syndrome
ESWT (Extracorporeal Shock Wave Therapy), which has been used in the treatment of musculoskeletal diseases in recent years, has come to the agenda as a new treatment method in Carpal Tunnel Syndrome.
- Trial name
- NCT06469931
- Testing
- range of motion exercises, Extracorporeal shock wave therapy, ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Firat University
Osteo Arthritis Knee
Evaluation of the Effect of Different Doses of Ozone Therapy on Pain and Function of Patients With Knee Osteoarthritis
This study is designed as a randomized clinical trial that will be conducted in Hazrat Rasool Akram Hospital in Tehran. Patients with knee osteoarthritis were selected based on the study entry criteria and written consent was…
- Trial name
- NCT06088706
- Testing
- Intra-articular injection of ozone
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Ahmad Nazari
Impingement Syndrome
Comparison of Mobilization and Ozone Therapy in Impingement Syndrome
Studies investigating the efficacy of the Mulligan technique and ozone therapy in patients with shoulder impingement syndrome are limited in the literature.
- Trial name
- NCT06474897
- Testing
- Ozone therapy, Mulligan Mobilization
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Firat University
Corneal Endothelial Cell Loss, Ozone Therapy
Effect of Systemic Ozone Therapy on Corneal Endothelium
This study evaluates the safety of systemic ozone therapy on the corneal endothelium, a vital non-renewable tissue that maintains corneal transparency.
- Trial name
- OZON-CORNEA (NCT07718100)
- Testing
- Systemic Ozone Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Pain, Chronic
Ozone Therapy in Patients With Diabetic Neuropathy
Diabetic neuropathies are the most prevalent chronic complications of diabetes mellitus. The early recognition and appropriate management of neuropathy in the patient with diabetes is important for patient's quality of life and…
- Trial name
- NCT05000463
- Testing
- Ozone, Convtrol group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia
Ozone Treatment in Paresthesia (Numbness, Tingling) Secondary to Chemotherapy-induced Peripheral Neuropathy
The goal of this phase II/III randomized clinical trial is to evaluate the effect of adding rectal ozone therapy to the usual management of patients with paresthesia (numbness and/or tingling) due to chemotherapy-induced…
- Conditions
- Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling
- Trial name
- OzoParQT (NCT06706544)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
TMJ Disc Disorder
Comparison Between Different Concentrations of Ozone Gas as an Intra-articular Injection for Treatment of Internal Derangement of Tempromandibular Joint
The intra-articular injection is considered the first line of minimally invasive treatment of joint disease as it has an analgesic, antimicrobial effect and an immune system stimulating action as it is one of the most powerful…
- Trial name
- NCT07523451
- Testing
- Patients will be treated with 2ml ozone oxygen mixture with concentration 6 micron/ml, Patients will be treated with 2ml ozone oxygen mixture with concentration 12 micron/ml
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Chronic Inflammatory Gingival Enlargement, Gingival Enlargement
Wound Healing After Gingivectomy
Gingival enlargement caused by chronic inflammation may require surgical intervention when non-surgical periodontal therapy is insufficient.
- Conditions
- Chronic Inflammatory Gingival Enlargement, Gingival Enlargement, Gingival Hyperplasia
- Trial name
- OZONE-GING (NCT07517328)
- Testing
- Gaseous ozone application, Gingivectomy/gingivoplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ataturk University
Oral Mucositis, Chemotherapy-induced Oral Mucositis
Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis
Oral mucositis is a frequent and often debilitating complication of radiotherapy and chemotherapy, particularly in patients treated for head and neck cancers.
- Conditions
- Oral Mucositis, Chemotherapy-induced Oral Mucositis, Head and Neck Neoplasms
- Trial name
- OZOMUC (NCT07491536)
- Testing
- Gas Ozone Therapy, Biomimetic Oral Care Regimen
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Pavia
Knee Osteoarthritis
Investigating the Impact of Ex Vivo Ozone Injection on Synovial Fluids in Patients Diagnosed With Knee Osteoarthritis
The objective of this study is to examine the effect of varying ozone doses on the levels of pro-inflammatory cytokines in synovial fluid collected from individuals with knee osteoarthritis.
- Trial name
- NCT05824052
- Testing
- Ozone injection
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Uskudar State Hospital
Ulcer, Scleroderma
Ozone Therapy in the Treatment of Digital Ulcers in Patients With Systemic Sclerosis
Digital ulcers (DUs) in scleroderma result from recurrent Raynaud's phenomenon (RP) and microtrauma with high impact on quality of life, management of DUs is a great challenge for clinicians.
- Trial name
- NCT02733978
- Testing
- the ozone generator device (Human Pro medic, German)
- Volunteers
- 50 people
- Sponsor
- Assiut University
COVID
Indirect Endovenous Systemic Ozone for New Coronavirus Disease (COVID19) in Non-intubated Patients
Systemic medical ozone has proved to help in several viral diseases, chronic obstructive pulmonary disease and chronic inflammation process.
- Trial name
- OzonoCOVID19 (NCT04359303)
- Testing
- Systemic indirect endovenous ozone therapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Javier Hidalgo Tallón
VAS and JOA Scores, Adverse Reaction Rates
Combined Therapy for Cervical Disc Herniation
This study mainly explores the efficacy and safety of low-temperature plasma radiofrequency ablation combined with ozone injection and collagenase in the treatment of cervical disc herniation.The primary outcomes included the…
- Conditions
- VAS and JOA Scores, Adverse Reaction Rates, Clinical Efficacy at 1 Month and 6 Months
- Trial name
- NCT06995066
- Testing
- collagenase injection into the epidural space
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Nanchong Central Hospital
Plantar Fascitis
Comparison of the Effectiveness of Local Ozone Injection and Dextrose Prolotherapy Injection in Chronic Plantar Fasciitis
The aim of our study was to investigate the effect of local ozone injection and dextrose prolotherapy applications on pain and foot functions to compare the efficacy and to evaluate the thickness of the plantar fascia.
- Trial name
- NCT05984121
- Testing
- Local ozon injections, Local dextroz prolotherapy injections, Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ahi Evran University Education and Research Hospital
Periodontitis
Effects of Ozone Therapy as an Adjunct to Periodontal Treatment
This randomized, placebo controlled, split-mouth clinical study trial evaluates the effects of Ozone therapy on clinical and biochemical parameters. Total of 20 participants completed the study .
- Trial name
- NCT03652558
- Testing
- Ozone application with the Ozonytron XL device
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Systemic Sclerosis
Effect of Ozone Therapy for the Treatment of Digital Ulcer in Patients With SSc
Functionality in patients with SSc? Systemic Sclerosis (SSc) is a chronic connective tissue disease characterized by microvascular involvement, immunological dysfunction, extracellular matrix deposition in the skin and internal…
- Trial name
- NCT04826419
- Testing
- ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Pamukkale University