Clinical trials: Ozone Therapy
Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder
Gene and Molecular Pathways of Ozone Treatment Response in Gynecological Tumor Patients With Chronic Pelvic Pain Secondary to Cancer Treatment
Gynecological cancers, including those affecting the ovaries, uterus, and cervix, represent a significant health burden for women.
- Conditions
- Chronic Pelvic Pain Syndrome (CPPS), Radiation-Induced Disorder, Radiotherapy Side Effects, Side Effect of Chemotherapy
- Trial name
- OzoGynEpigen (NCT06816095)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Bernardino Clavo, MD, PhD
Lumbar Herniated Disc
The Effect of Ozone Therapy for Lumbar Herniated Disc
The purpose of this study is to assess the efficacy (vs. placebo) of ozone infiltration and its effectiveness in comparison with micro discectomy in the treatment of lumbar herniated disc with criteria for surgery.
- Trial name
- NCT00566007
- Testing
- Discectomy/ micro discectomy, Ozone therapy, Oxygen therapy
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Kovacs Foundation
Acute Ischemic Cerebrovascular Disease
A Clinical Study on Ozone Autohemotherapy for the Treatment of Acute Ischemic Stroke
Clinical studies applying ozonated autohemotherapy to treat acute cerebrovascular diseases have validated the safety and efficacy of this treatment, as well as explored its mechanism of action.
- Trial name
- NCT06525792
- Testing
- Oxygen, Ozone, Standard therapy
- Where
- China
- Volunteers
- 62 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Corona Virus Infection
Ozone Therapy in the Prevention of COVID-19 Infection
Coronavirus has already infected 4,673,809 people and killed 312,646 people worldwide, and no specific treatment or a vaccine against it has yet proven to be effective.
- Trial name
- NCT04400006
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people
- Sponsor
- Marmara University
Open Wound of Palate Without Complication, Pain, Postoperative
The Effect of Ozone Therapy on Pain Perception After Free Gingival Graft Surgery in Patients With Mucogingival Defects
Gaseous ozone (O3-triatomic oxygen) is the third-strongest oxidizing agent worldwide. It influences the cellular and the humoral immune system, by stimulating the proliferation of immunocompetent cells and the synthesis of…
- Conditions
- Open Wound of Palate Without Complication, Pain, Postoperative, Free Gingival Grafts, Mucogingival Defects
- Trial name
- NCT05291715
- Testing
- Ozone generator device (Ozone DTA-APOZAa-enterprize CO9-Taiwan, R.0.C)
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Omaima Mossad Mahmoud AL-Sherbini
Carpal Tunnel Syndrome (CTS)
Efficacy of Ozone Therapy and Splint in Carpal Tunnel Syndrome
This study will investigate the effectiveness of repeated ozone therapy combined with splint therapy for carpal tunnel syndrome (CTS).CTS patients will be split into two groups: ozone plus splint and splint only.
- Trial name
- NCT06649461
- Testing
- ozone injections, Splint
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Selcuk University
Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029.
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms who have been referred to the Dr.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity, Chronic Pain, Delayed Wound Healing
- Trial name
- EPOOzo-2 (NCT07325851)
- Testing
- Ozone Therapy
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Bernardino Clavo, MD, PhD
Knee Osteoarthritis
Effects of Platelet-Rich Plasma and Ozone Therapy in Knee Osteoarthritis
Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered.
- Trial name
- NCT06631456
- Testing
- PRP injection, Ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Myofascial Pain Syndrome, Myofascial Trigger Point Pain
The Effectiveness of Ozone (O2-O3) Injections in the Treatment of Myofascial Pain Syndrome
Ozone (O2-O3) has been used as a supportive therapy in various musculoskeletal diseases such as lumbosacral disc herniation, knee osteoarthritis, meniscus injury, shoulder pathologies.The aim of this study is to investigate the…
- Trial name
- NCT04885881
- Testing
- Ozone therapy, Lidocaine injection group
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Endodontic Treatment
Disinfection Effect of Gaseous Ozone
The current study aimed to investigate the effect of gaseous ozone in disinfection the root canals of primary teeth. Thirty-six primary molars of 36 completely healthy patients (aged 5-10) were included in the study.The included…
- Trial name
- NCT06470126
- Testing
- 2.5% NaOCl group: The interventions performed in the study are root- canal therapies and disinfection procedure of these therapies., 0.9% sterile saline solution combined with 80 seconds: The OzonyTronX® interventions performed in the study are root- canal therapies and disinfection procedure of these therapies., 2.5% NaOCl with 80 seconds OzonyTronX®:The interventions performed in the study are root- canal therapies and disinfection procedure of these therapies.
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ankara University
Pulmonary Disease, Chronic Obstructive
Evaluate the Effects of the Drug (SB-656933-AAA) on the Body After a Single Dose in Subjects Who Have Inhaled Ozone
A study to evaluate the effect of SB-656933-AAA on the body after a single dose in subjects who have been challenged with ozone.
- Trial name
- NCT00551811
- Testing
- SB-656933-AAA
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Peri-implant Mucositis
Ozoral Pro and Ozoral Gel vs Chlorhexidine Gel 1% for the Management of Peri-implant Mucositis Sites.
This is a randomized controlled clinical trial (RCT) with a split-mouth design. After signing the informed consent, patients satisfying the inclusion criteria will undergo supragingival and subgingival professional oral hygiene…
- Trial name
- NCT05254275
- Testing
- Ozoral Pro and Ozoral gel administration, Curasept chlorhexidine gel 1%
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Orofacial Pain, Temporomandibular Joint Disorders
Ozone Therapy for Masticatory Muscle Pain (OTMMP)
This study investigates the efficacy of bio-oxidative ozone application in the treatment of TMD of muscular origin.
- Trial name
- OTMMP (NCT02997410)
- Testing
- Ozone, Dental treatment with occlusal splint
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Knee Osteoarthritis
Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis Compared With Hyaluronic Acid
Knee osteoarthritis is a very common pathology, characterized by pain, stiffness and functional deficit. The various therapeutic options used include anti-inflammatory drug treatment, physiokinesitherapy, minimally invasive…
- Trial name
- NCT04426721
- Testing
- Ozone, Hyaluronic Acid
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Humanitas Clinical and Research Center
Extraction of the Lower Third Molars
Influence of Ozone Therapy on Postoperative Pain Relief in the Surgical Treatment of Lower Third Molars: Randomized Controlled Trial
Patients will undergo a split-mouth protocol which includes: a control group: in which the extraction of the lower third molar will be performed according to the standard protocols of the structure.
- Trial name
- NCT05949476
- Testing
- ozone therapy
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Azienda Ospedaliera Ordine Mauriziano di Torino
Periodontitis, Residual Periodontal Pocket
Adjunctive Ozone Therapy for Residual Periodontal Pockets
Patients with residual periodontal pockets following non-surgical periodontal therapy remain at risk for disease progression and may require further periodontal surgery.
- Conditions
- Periodontitis, Residual Periodontal Pocket, Periodontal Pocket, Stage III Periodontitis
- Trial name
- OZPOCKET (NCT07604636)
- Testing
- Scaling and Root Planing, Gaseous Ozone Application
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ataturk University
Heart Failure and Reduced Ejection Fraction
The Effect of Ozone Treatment on Coronary Flow Reserve in Patients With Heart Failure Having Reduced Ejection Fraction
The goal of this clinical trial is to determine the effect of ozone treatment in heart failurte with reduced ejection fraction. The main questions it aims to answer are: Does ozone treatment have beneficial effects in heart…
- Trial name
- NCT07134972
- Testing
- Ozone treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ekrem Bilal Karaayvaz
Lumbar Herniated Disc
Ozone Therapy in Patients on Waiting List for Surgery Due to Disc Herniation: Prospective, Post-authorization Study
The main objective of this study is to estimate the cost-effectiveness of ozone therapy in patients on the waiting list for surgery due to disc herniation.
- Trial name
- O3HDCIRUGIA (NCT03282695)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Bernardino Clavo, MD, PhD
SARS-CoV-2 Respiratory Failure
Blood Ozonization in Patients With SARS-CoV-2 Respiratory Failure
Aim. The emerging outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread worldwide.
- Trial name
- CORMOR (NCT04388514)
- Testing
- Medical Ozone procedure
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine