Clinical trials: PAD - Peripheral Arterial Disease
Atherosclerotic Peripheral Arterial Disease, Hemoglobin A1c Protein, Human
Novel Risk Factors and Localization of Peripheral Arterial Disease
Background: .Atherosclerotic peripheral arterial disease (PAD) is associated with a high risk of mortality, coronary events and stroke. The distal localization is frequently associated with amputation.
- Conditions
- Atherosclerotic Peripheral Arterial Disease, Hemoglobin A1c Protein, Human, Guadeloupe
- Trial name
- GWADAOMI (NCT07233356)
- Where
- Guadeloupe
- Volunteers
- 123 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Arterial Occlusive Disease, Intermittent Claudication
Safety and Efficacy of Express LD to Treat Stenosed or Occlusive Atherosclerotic Disease in Iliac Arteries
To obtain additional data on safety and efficacy of the Express stent implantation in the treatment of stenosed or occlusive atherosclerotic disease (de novo or restenotic lesions) in the iliac arteries (common or external).
- Conditions
- Arterial Occlusive Disease, Intermittent Claudication, Atherosclerotic Disease, Thrombosis
- Trial name
- MELODIE (NCT00352222)
- Testing
- stent implantation
- Where
- 10 sites in Belgium, Canada and 3 more
- Volunteers
- 150 people
- Sponsor
- Boston Scientific Corporation
Peripheral Arterial Disease
The PQ Bypass Pivotal IDE Intra-arterial Stent Graft Study
The primary objective of the TORUS 2 IDE Clinical Study is to evaluate the safety and effectiveness of the TORUS Stent Graft System in the treatment of obstructive atherosclerotic lesions of the native SFA or the superficial…
- Trial name
- TORUS2 (NCT04130737)
- Testing
- TORUS Stent Graft System
- Where
- 32 sites in United States
- Volunteers
- 188 people
- Sponsor
- Endologix
Peripheral Arterial Disease, Critical Limb Ischemia
ACPs in Severe PAD/CLI by Direct Intramuscular Injection
Study title: A Study of Blood-Borne Autologous Angiogenic Cell Precursors Therapy in Patients with Critical Limb Ischemia ( ACPs-CLI ) Principle Investigator: Assoc.Prof. Pramook Mutirangura,M.D.
- Trial name
- NCT00523731
- Testing
- Angiogenic Cell Precursors (ACPs) or Vescell TM
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- TheraVitae Ltd.
Intermittent Claudication
Clinical Trial for GNX80 in Intermittent Claudication
This is a Phase 4, randomized clinical trial to evaluate whether GNX80 vs. placebo, prescribed for 6 months to patients with Intermittent Claudication(IC) would lead to an improvement in the walking distance.
- Trial name
- NCT05400395
- Testing
- GNX80
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- SK Chemicals Co., Ltd.
Peripheral Arterial Disease
Effect of Lower Leg Heating and Transcutaneous Electrical Nerve Stimulation on Exercise Capacity in Patients With PAD
Peripheral arterial disease (PAD) is characterized by poor circulation in the lower extremities that often provokes claudication (leg pain, numbness, and heaviness) with physical exertion.
- Trial name
- NCT03462472
- Testing
- Lower leg heating, Lower leg transcutaneous electrical nerve stimulation (TENS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Salisbury University
Peripheral Artery Disease
Paclitaxel-coated Balloons in Femoral Indication to Defeat Restenosis
The aim of the study is correlating efficacy of the treatment to the proportion of paclitaxel-dose supplied by the catheter. Forty-five patients each will be treated by paclitaxel-coated or uncoated conventional balloon catheters…
- Trial name
- PACIFIER (NCT01083030)
- Testing
- Percutaneous transluminal angioplasty (PTA), DCB
- Where
- 3 sites in Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital, Saarland
Chronic Limb Threatening Ischemia
Can a Dedicated Chronic Limb-threatening Ischaemia (CLTI) Clinic Improve Patient Self-reported Quality of Life
CLTI is the most severe form of peripheral arterial disease. Patients with the condition require investigation and management (typically in the form of revascularisation surgery) to salvage the limb.
- Trial name
- NCT05613907
- Testing
- CLTI Clinic
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Peripheral Arterial Disease
Short-term Perfusion Angiography Pilot Study (SPA)
The Short term Perfusion Angiography (SPA) study is designed to collect 2D Perfusion data from Critical Limb Ischemia (CLI) endovascular (interventional) procedures for information on device performance in a real-world setting.
- Trial name
- SPA (NCT03054636)
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- Volcano Corporation
Intermittent Claudication
Safety, Efficacy, and Pharmacokinetics (PK) Study of Trans Sodium Crocetinate (TSC) in Patients With Intermittent Claudication
The purpose of this study is to evaluate the safety and pharmacokinetics of multiple, once-daily, intravenous doses of trans sodium crocetinate (TSC).
- Trial name
- NCT00725881
- Testing
- Trans sodium crocetinate (TSC), 0.9% normal saline
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Diffusion Pharmaceuticals Inc
Peripheral Artery Disease, Intermittent Claudication
Rivaroxaban 2.5 mg BID and Aspirin for Intermittent Claudication in PAD Patients
This trial is evaluating if rivaroxaban 2.5 mg BID and aspirin 100 mg OD compared to aspirin alone improves on intermittent claudication distance in PAD patients.
- Trial name
- NCT04853719
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- 2 sites in Brazil
- Volunteers
- 88 people
- Sponsor
- Science Valley Research Institute
Peripheral Arterial Disease
Atherectomy Followed With a Drug Coated Balloon in the Treatment of Long Femoropopliteal Lesions
The study is a prospective, multicenter, randomized pilot study to evaluate the clinical outcome of the plaque atherectomy system followed by the UltrafreeTM drug coated balloon catheter versus the drug coated balloon in patients…
- Trial name
- NCT05868564
- Testing
- Atherectomy+Drug-coated balloon, Drug-coated balloon
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Peripheral Arterial Disease
Fuzzy Wale Compression Stockinet to Promote Healing Following Transtibial Amputation for Peripheral Arterial Disease
The objective of this study is to determine if using Fuzzy Wale compression stockinet can assist in reducing the healing time and decrease costs in transtibial amputation patients as compared to standard of care treatment…
- Trial name
- NCT06308562
- Testing
- Fuzzy Wale Compression Stockinet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Peripheral Arterial Disease
Study of NMB Drug Ejecting Balloon for Peripheral Arteries
The purpose of this study is to demonstrate the Safety and effectiveness of the use of NMB's drug ejecting balloon for the treatment of de novo and restenotic lesions in peripheral arterial disease.
- Trial name
- NCT01646801
- Testing
- NMB Balloon Catheter
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- N.M.B. Medical Applications Ltd
Peripheral Arterial Disease
Hypoxic Exercise in Lower Extremity Artery Disease
The aim of this randomized controlled trial is to: Phase I: To explore, in a first pilot phase, the adequate combination of hypoxia severity and exercise intensity in patients with symptomatic lower extremity artery disease…
- Trial name
- NCT03506607
- Testing
- Exercise in hypoxia 1500m, Exercise in hypoxia 2500m, Exercise in normoxia
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Peripheral Artery Disease, Access Site Complication
BIOTRONIK 4French for AMBulatory Peripheral Intervention
BIOTRONIK 4French for AMBulatory peripheral intervention. A multicenter, controlled trial comparing 4French versus 6French femoral access for endovascular treatment of lower-extremity peripheral artery disease in an ambulatory…
- Conditions
- Peripheral Artery Disease, Access Site Complication, Outpatient Treatment
- Trial name
- BIO4AMB (NCT03044002)
- Testing
- Biotronik 4 French Portfolio, 6 French Portfolio
- Where
- 5 sites in Austria, Belgium and 2 more
- Volunteers
- 821 people
- Sponsor
- Biotronik AG
Diabetic Foot Ulcer
Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.
The goal of this clinical trial is to learn if using perinatal tissue allografts improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT06437028
- Testing
- Dual-layer perinatal tissue allograft, Three-layer fenestrated perinatal tissue allograft, Standard of care
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Samaritan Biologics
Critical Limb Ischemia
Efficacy and Safety of Umbilical Cord Blood Injection for Critical Limb Ischemia
The purpose of this study is to determine whether treatment with umbilical cord blood stem cells will improve blood flow to the most severely affected leg of a participant with medically refractory and non-surgical peripheral…
- Trial name
- NCT01019681
- Testing
- Cord blood stem cell injection
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Richard Burt, MD
Coronary Artery Disease (CAD), Peripheral Arterial Disease (PAD)
Rivaroxaban Plus Aspirin in Patients With Chronic Coronary Syndrome and High Ischemic Risk
Registry to describe the impact in terms of effectiveness and safety of the combination treatment of rivaroxaban 2.5 mg twice daily with aspirin on clinical outcomes and practices in a real-life Dutch patient population that are…
- Trial name
- NCT04753372
- Testing
- Rivaroxaban 2.5 MG [Xarelto]
- Where
- 12 sites in Netherlands
- Volunteers
- 645 people
- Sponsor
- Maatschap Cardiologie Zwolle
Peripheral Arterial Disease, Popliteal Artery Stenosis
Vessel Deformations and Restenosis After Stenting of the Popliteal Artery
The femoro-popliteal (FP) artery is the most frequently treated vascular segment in patients with symptomatic peripheral artery disease (PAD), for which endovascular therapy became an established treatment option during the last…
- Trial name
- FIRESTEP (NCT04700371)
- Testing
- Interwoven stent, Laser-cut stent
- Sponsor
- Kantonsspital Aarau
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