Clinical trials: PAD - Peripheral Arterial Disease
Diabetic Foot
Induced Wound Healing by Application of Expanded Bone Marrow Stem Cells in Diabetic Patients With Critical Limb Ischemia
Diabetic foot patients with chronic limb ischemia and without the option for surgical or interventional revascularization were recruited and randomized to the transplant groups or the control group within this clinical trial.
- Trial name
- NCT01065337
- Testing
- tissue repair cells (TRC), bone marrow stem cells (BMC)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ruhr University of Bochum
Diabetic Foot Ulcer, Peripheral Arterial Disease
A Non-significant Risk Clinical Study of Therapeutic Ultrasound for Patients With Diabetic Foot Ulcers.
This study is evaluating whether a therapeutic ultrasound device can improve blood flow to the leg with diabetic foot ulcer (DFU).
- Conditions
- Diabetic Foot Ulcer, Peripheral Arterial Disease, Wound; Foot
- Trial name
- Dulcet (NCT05145439)
- Testing
- VibratoSleeve Therapeutic Ultrasound Device
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vibrato Medical, Inc.
Peripheral Arterial Occlusive Disease Fontaine Stage IIa
Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication
The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited.
- Trial name
- NCT05111379
- Where
- Estonia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Peripheral Arterial Disease (PAD), Intermittent Claudication
Home-based Exercise Therapy for Patients With PAD
Cardiovascular disease represents a considerable economic burden to society and effective preventive measures are necessary. Patients with peripheral arterial disease (PAD) have a severe impairment of functional ability, namely…
- Trial name
- WalkingPAD (NCT04749732)
- Testing
- WalkingPad plus Psychological Intervention - PsyWPad Group, WalkingPad plus Virtual Assistant - CyberWPad Group, WalkingPad group - Paper WPad Group
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Centro Hospitalar do Porto
Peripheral Arterial Disease
Polestriding Versus Walking for Subjects With Poor Leg Circulation
The purpose of this study is to compare the effects of polestriding (walking with poles) and traditional walking on physical endurance in subjects with poor circulation in their legs.
- Trial name
- NCT00719355
- Testing
- Walking with poles, Walking exercise
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- University of Illinois Chicago
Intermittent Claudication, Critical Limb Ischemia
Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp)
This trial was designed to challenge the wide held view that polytetrafluoroethylene (PTFE) performs better than Dacron for above knee femoropopliteal bypass.
- Trial name
- NCT00300690
- Testing
- 6 mm Uni-graft® (B-Braun), 6 mm Gore-Tex® (WL Gore)
- Volunteers
- 400 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Chronic Total Occlusion of Artery of the Extremities
Treatment of Calcific Total Occlusions in Peripheral Artery Disease
Prospective, multi-center, non-randomized, open label, clinical study intended to provide data to demonstrate safety and performance of the SoundBite Crossing System XS Peripheral.
- Trial name
- CaTO-PAD (NCT05551780)
- Testing
- SoundBite Crossing System
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 130 people
- Sponsor
- SoundBite Medical Solutions, Inc.
Peripheral Arterial Disease, Peripheral Bypass Surgery
Pilot Study to Asses the Function and Patency of Polyester-Coated Composite Bypasses From Autologous Varicose Veins
If patients need to undergo bypass surgery, either an autologous vein can be used as bypass or, if there are no suitable veins are available, a prosthetic graft can be implanted.
- Conditions
- Peripheral Arterial Disease, Peripheral Bypass Surgery, Bypass From Autologous Varicose Vein, External Graft Support
- Trial name
- PROVENA (NCT00460291)
- Testing
- Implantation of the ProVena vein graft during bypass surgery
- Where
- 11 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Peripheral Artery Disease
Predicting Outcomes of PAD Patients Undergoing Endovascular Intervention With CTA
Lower extremity peripheral artery disease (PAD), the third leading cause of atherosclerotic cardiovascular morbidity following coronary artery disease and stroke, affect 200 million people worldwide and is associated with high…
- Trial name
- NCT03974880
- Where
- China
- Volunteers
- 480 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Intermittent Claudication, Peripheral Arterial Disease
Randomized Phase IIb Trial of DVC1-0101
DVC1-0101 is a gene therapy medicine to treat peripheral arterial disease (PAD) based on recombinant F-gene-deleted, non-transmissible Sendai virus (rSeV/dF) expressing human fibroblast growth factor-2 (FGF-2) gene.
- Trial name
- NCT02276937
- Testing
- DVC1-0101
- Where
- 4 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Kyushu University
Androgen Receptor Abnormal, Insulin-Like Growth Factor I Deficiency
AR, IGF-IR, IR and Peripheral Artery Disease
Peripheral artery Disease (PAD) is a major cardiovascular disease that can impair quality of life (QoL). It affects more often male patients and its pathophysiology is not completely known.
- Conditions
- Androgen Receptor Abnormal, Insulin-Like Growth Factor I Deficiency, Insulin Receptor, Defect in
- Trial name
- ANIMALPAD (NCT04710186)
- Testing
- arterial reconstructive open surgery
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Catanzaro
Peripheral Artery Disease
Zilver® PTX® in China
The objective of this study is to evaluate the Zilver® PTX® Drug-Eluting Peripheral Stent for treatment of lesions of the above-the-knee femoropopliteal artery in a Chinese patient population.
- Trial name
- NCT02171962
- Testing
- Zilver® PTX® Drug-Eluting Peripheral Stent
- Where
- 9 sites in China
- Volunteers
- 178 people
- Sponsor
- Cook Group Incorporated
Peripheral Arterial Disease
Safety and Efficacy Study of a New Intermittent Pneumatic Compression Device to Treat Patients With Peripheral Arterial Disease (PAD) Stage II
The purpose of this study is to evaluate the safety and efficacy of new intermittent pneumatic compression device on initial claudication distance in patients with Peripheral Arterial Disease stage II
- Trial name
- NCT00762086
- Testing
- AngioPress Intermittent pneumatic compression (IPC) Device, Medications and Standard walking exercises
- Where
- 4 sites in Germany, Israel
- Volunteers
- 67 people
- Sponsor
- Mego Afek Ltd.
Peripheral Arterial Disease
The Cre8™ BTK Post Market Clinical Follow-up Study
Cre8™ BTK is a CE marked drug eluting stent, integrally coated with i-Carbofilm, loaded with formulated Sirolimus for the treatment of infrapopliteal peripheral artery disease.
- Trial name
- NCT05616156
- Testing
- Cre8™ BTK
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- CID S.p.A.
Femoral Artery Stenosis, Popliteal Artery Stenosis
IN.PACT Admiral Drug-Coated Balloon vs. Standard Balloon Angioplasty for the Treatment of Superficial Femoral Artery (SFA) and Proximal Popliteal Artery (PPA)
The purpose of the study is to demonstrate the safety and efficacy of the IN.PACT Admiral drug-coated balloon (DCB) in comparison to any standard balloon for treatment of peripheral arterial disease (PAD) in the superficial…
- Conditions
- Femoral Artery Stenosis, Popliteal Artery Stenosis, Femoral Artery Occlusion, Popliteal Artery Occlusion
- Trial name
- INPACT SFA II (NCT01566461)
- Testing
- Drug-Coated Balloon (DCB), PTA Balloon: Balloon Angioplasty
- Where
- 2 sites in United States
- Volunteers
- 331 people
- Sponsor
- Medtronic Endovascular
Obesity, Peripheral Arterial Disease
Lower Extremity Venous Hemodynamics in Obese Patients Without Clinically Significant Venous Disease
This research project is investigating the relationship between body weight and function of the leg veins using a special non-invasive technique known as venous plethysmography.
- Trial name
- NCT00554541
- Testing
- Ankle Brachial Index Venous physiologic study
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Atherosclerosis
Study Comparing Legflow Versus Bare Balloon Angioplasty for Treatment of Atherosclerotic Disease
A randomized multicentric study for endovascular treatment of patients with obstructive disease in the SFA (superficial femoral artery) and in the popliteal artery.
- Trial name
- NCT02710656
- Testing
- Legflow® balloon, Standard PTA
- Where
- 9 sites in Belgium, France and 1 more
- Volunteers
- 130 people
- Sponsor
- Cardionovum GmbH
Peripheral Arterial Disease, Intermittent Claudication
Telehealth Exercise Training in Peripheral Arterial Disease - TEXT-PAD
Peripheral arterial disease is a common, under-treated and under-researched issue. The vast majority of these patients often have multiple issues which can be improved with targeted behavioural change interventions.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Behavior, Health, Exercise Intervention
- Trial name
- NCT05260567
- Testing
- Exercise and Lifestyle Change
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Northumbria University
Peripheral Artery Disease, Intermittent Claudication
Motivating Physical Activity With Behavioural interVention and Electrical Stimulation Remotely in Intermittent Claudication
Peripheral Arterial Disease (PAD) is a common vascular disease which commonly causes limb pain and reduced exercise tolerance termed Intermittent Claudication (IC).
- Trial name
- MAvERIC (NCT06114732)
- Testing
- Walking exercise behaviour change intervention + TENS
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Glasgow Caledonian University
Peripheral Artery Disease, Coronary Artery Disease
Diagnosis and Treatment of CAD in Severe PAD After Lower Extremity Revascularization
Peripheral artery disease, lack or blood flow to the legs, has a high prevalence in the Veteran population. In patients with severe peripheral artery disease that requires an endovascular or surgical intervention for lower leg…
- Trial name
- CAD in sPAD (NCT06387355)
- Testing
- Coronary computed topography (CT) angiography with FFR-CT
- Where
- 7 sites in United States
- Sponsor
- VA Office of Research and Development
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