Clinical trials: PAD - Peripheral Arterial Disease
Peripheral Arterial Disease
The DETOUR 2 Clinical Trial
Prospective, single-arm, multi-center, international clinical investigation to evaluate the safety and effectiveness of the PQ Bypass System to access, deliver guidewires, and implant stent grafts for a percutaneous…
- Trial name
- NCT03119233
- Testing
- DETOUR System
- Where
- 34 sites in United States, Germany and 1 more
- Volunteers
- 202 people
- Sponsor
- Endologix
Peripheral Arterial Disease
Sonodynamic Therapy in the Treatment of Perivascular Adipose Tissue on Patients With PAD and Claudication
The purpose of this trial is to evaluate the safety and efficacy of sonodynamic therapy (SDT) in reducing the inflammation of perivascular adipose tissue and increasing peak walking time (PWT) among peripheral artery disease…
- Trial name
- NCT03967730
- Testing
- Sonodynamic therapy(SDT)
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Peripheral Arterial Disease
Angioplasty + SBCV vs. Angioplasty Alone for Femoropopliteal Artery Stenosis
The purpose of this study is to compare balloon angioplasty plus SBCV against balloon angioplasty alone for treatment of stenosis within the femoropopliteal artery.
- Trial name
- SHIELD (NCT02568293)
- Testing
- SBCV, Saline
- Where
- 8 sites in Australia, New Zealand
- Volunteers
- 66 people
- Sponsor
- Symic Vascular
Peripheral Arterial Disease, Peripheral Artery Disease
Impacts of Mitochondrial-targeted Antioxidant on Peripheral Artery Disease Patients
Peripheral artery disease (PAD) is a common cardiovascular disease, in which narrowed arteries reduce blood flow to the limbs, causing pain, immobility and in some cases amputation or death.
- Trial name
- NCT03506633
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Nebraska
Peripheral Artery Disease, Atherosclerosis
SirolimUs CoaTed Balloon for The TrEatment of Below The Knee Arterial Disease
This study aims to conduct a randomized, double blind, randomised controlled multicentre trial of sirolimus drug coated balloon versus standard percutaneous transluminal angioplasty for the treatment of below the knee arterial…
- Conditions
- Peripheral Artery Disease, Atherosclerosis, Arterial Disease of Legs
- Trial name
- FUTURE-BTK (NCT04511247)
- Testing
- MagicTouch PTA Sirolimus drug coated balloon, POBA balloon
- Where
- 20 sites in Singapore, Taiwan and 1 more
- Volunteers
- 219 people
- Sponsor
- Concept Medical Inc.
Peripheral Arterial Disease, Peripheral Vascular Diseases
Safety and Efficacy of Autologous Concentrated Bone Marrow Aspirate for Critical Limb Ischemia - Continued Access
This study will continue to evaluate the performance of the MarrowStim™ PAD Kit to treat subjects with critical limb ischemia (CLI) caused by severe PAD.
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Diseases, Critical Limb Ischemia
- Trial name
- MOBILE-CA (NCT02474121)
- Testing
- Bone marrow concentration device
- Where
- 9 sites in United States
- Sponsor
- Zimmer Biomet
Skin Cancer, Skin Diseases
Multi-modal Quantitative Imaging of the Skin
This clinical trial is about evaluating the suitability of multi-modal imaging technology, which covers virtually the entire body, to evaluate the possibility of screening and early detection of disease.
- Conditions
- Skin Cancer, Skin Diseases, Atopic Dermatitis, Psoriasis
- Trial name
- DermaFlow (NCT06989216)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Peripheral Arterial Disease, Arterial Occlusive Diseases
SIMPADICO - Study of Immune Modulation Therapy in Peripheral Arterial Disease and Intermittent Claudication Outcomes
The purpose of this study is to assess the effects of the Celacade™ system in patients with intermittent claudication.
- Conditions
- Peripheral Arterial Disease, Arterial Occlusive Diseases, Intermittent Claudication
- Trial name
- NCT00111826
- Testing
- Celacade™ system
- Volunteers
- 500 people
- Sponsor
- Vasogen
Peripheral Arterial Disease (PAD)
Paclitaxel-coated Peripheral Stents Used in the Treatment of Femoropopliteal Stenoses
This randomized multi-center study is intended to compare different coatings on stents for treatment of lesions of the above-the-knee femoropopliteal artery.
- Trial name
- XPEDITE (NCT02936622)
- Testing
- Zilver® Paclitaxel-Eluting Peripheral Stent, Zilver® Paclitaxel-Eluting Peripheral Stent with slower-dissolving polymer-free paclitaxel coating, Zilver® Paclitaxel-Eluting Peripheral Stent with higher-dose polymer-free paclitaxel coating
- Where
- 11 sites in Germany, New Zealand
- Volunteers
- 176 people
- Sponsor
- Cook Group Incorporated
Peripheral Artery Disease
Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease
The INTERCEDE randomized trial will establish whether six-months of intermittent pneumatic compression combined with walking exercise improves walking endurance at six-month follow-up, compared to walking exercise + sham…
- Trial name
- INTERCEDE (NCT03871075)
- Testing
- intermittent pneumatic compression, exercise, Health Education
- Where
- 4 sites in United States
- Volunteers
- 211 people
- Sponsor
- Northwestern University
Peripheral Vascular Disease
Multicenter Assessment of the Safety and Efficacy of the Minnow Medical GRST™ Peripheral Catheter System
The objective of this clinical investigation is to evaluate the safety and efficacy of the Minnow Medical GRST™ Peripheral Catheter System in the treatment of de novo lesions in the superficial femoral artery (SFA) or the…
- Trial name
- NCT00881257
- Testing
- GRST Peripheral Catheter System
- Where
- 2 sites in Germany
- Volunteers
- 78 people
- Sponsor
- Vessix Vascular, Inc
Peripheral Arterial Diseases, Superficial Femoral Artery Stenosis
Evaluation of Efficacy of the EPIC™ Self-Expanding Nitinol Vascular Stent
The intent of this clinical registry is to demonstrate the efficacy of the EPIC™ stent in patients with superficial femoral/ popliteal artery disease.
- Trial name
- SUMMIT (NCT01336101)
- Testing
- EPIC™ Self-Expanding Nitinol Vascular Stent
- Where
- 4 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Provascular GmbH
Peripheral Arterial Disease
Major Adverse Limb Events in Patients With Femoro-popliteal and Below-the-knee Peripheral Arterial Disease Treated With Either Sirolimus-coated Balloon or Standard Uncoated Balloon Angioplasty
The SirPAD trial is an academic, investigator-initiated, single-center, randomized, non-inferiority, open-label clinical trial investigating whether the use of sirolimus-coated balloon catheters in patients with peripheral artery…
- Trial name
- NCT04238546
- Testing
- sirolimus-coated balloon catheter, uncoated balloon catheter
- Where
- 2 sites in Switzerland
- Volunteers
- 1,200 people
- Sponsor
- Nils Kucher
Peripheral Arterial Disease
Study to Evaluate the Effect of Simvastatin, Losartan and Pioglitazone on Patients With Peripheral Arterial Disease.
Part A. The purpose of this study is to assess the effects of 6 weeks of treatment with, simvastatin, losartan or pioglitazone compared to placebo on the RNA expression profile of lower extremity peripheral arterial…
- Trial name
- LEAP (NCT00720577)
- Testing
- Simvastatin, Losartan, Pioglitazone
- Volunteers
- 164 people
- Sponsor
- Medtronic Endovascular
Diabetic Foot, Peripheral Arterial Disease
Diagnostic Tools to Establish the Presence and Severity of Peripheral Arterial Disease in People With Diabetes
In the UK there are over 7,000 leg amputations each year because of diabetes. The most important cause of this is poor circulation. The detection of poor circulation in patients with diabetes is difficult.
- Conditions
- Diabetic Foot, Peripheral Arterial Disease, Diabetic Foot Ulcer, Peripheral Vascular Diseases
- Trial name
- DM PAD (NCT05009602)
- Testing
- Toe Brachial Pressure Index (TBPI), Ankle Brachial Pressure Index (ABPI), Exercise Ankle Brachial Pressure Index (ABPI)
- Where
- 17 sites in United Kingdom
- Volunteers
- 604 people
- Sponsor
- Imperial College London
ASCVD
The Cardiovascular Multi-dimensional Observational Investigation of the Use of PCSK9 Inhibitors (cvMOBIUS)
cvMOBIUS is a North American registry of patients with ASCVD aimed at understanding patterns of care in ASCVD while evaluating the real world effectiveness of PCSK9 inhibitors.
- Trial name
- cvMOBIUS (NCT04197453)
- Where
- 164 sites in United States, Canada
- Volunteers
- 752 people
- Sponsor
- Amgen
Critical Limb Ischemia
Evaluating the Effectiveness of Paclitaxel-eluting Balloons for Below-the-knee Angioplasty in Patients With Critical Limb Ischemia
to evaluate the the effectiveness of paclitaxel-eluting balloon for below-the-knee angioplasty in terms of restenosis at 12 months
- Trial name
- NCT01938872
- Testing
- paclitaxel eluting balloon angioplasty in below-the-knee lesions
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ospedale San Donato
Peripheral Arterial Disease
Effect of Evolocumab in Functional Status and LDL Oxidation of Patients With Peripheral Arterial Disease
Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerotic cardiovascular disease (ASCVD) and is associated with increase cardiovascular risk.
- Trial name
- Evol-PAD (NCT04306081)
- Testing
- Evolocumab 140 mg/mL Subcutaneous Injection 1 milliliter (mL) pre-filled injector Pen x 3 for a monthly dose of 420 mg for 6 months.
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Leonardo Clavijo
Peripheral Arterial Disease, Heart Failure
Mind Our Heart Study
Patients with atherosclerotic cardiovascular disease (i.e. peripheral artery disease, ischemic heart failure, myocardial infarction) are randomised to (1) treatment as usual (i.e.
- Conditions
- Peripheral Arterial Disease, Heart Failure, Myocardial Infarction, Atherosclerotic Cardiovascular Disease
- Trial name
- NCT03826836
- Testing
- Mindfulness-based stress reduction
- Where
- 2 sites in Netherlands
- Volunteers
- 240 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Peripheral Arterial Disease, Claudication
Phoenix Post-Approval Registry - Using the Phoenix Atherectomy Systems
The Phoenix Post-Approval Registry is a prospective, multi-center, single arm registry sponsored by Volcano Corporation to evaluate the short and long term performance and clinical outcomes of the Phoenix Atherectomy System.
- Conditions
- Peripheral Arterial Disease, Claudication, Critical Limb Ischemia
- Trial name
- NCT02475200
- Testing
- Atherectomy
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Volcano Corporation
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