Clinical trials: PAD - Peripheral Arterial Disease
Peripheral Arterial Disease, Hypertension
Strength Training in Walking Tolerance in Intermittent Claudication Patients
Background: Muscle atrophy and reduced leg strength are related to exercise intolerance in patients with intermittent claudication (IC), suggesting that strength training (ST) could improve exercise performance in these patients.
- Conditions
- Peripheral Arterial Disease, Hypertension, Diabetes
- Trial name
- NCT00879697
- Testing
- Walking Training, Strength Training
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- University of Sao Paulo
Cardiovascular Diseases, Metabolic Disease
Vascular Lab Resource (VLR) Biorepository
This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases.
- Conditions
- Cardiovascular Diseases, Metabolic Disease, Peripheral Artery Disease, Carotid Disease
- Trial name
- NCT05628948
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- The Cleveland Clinic
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
Assessment of Superficial Femoral Artery Lesions With FFR From the ACIST Navvus® Catheter
This study is intended to help establish standard procedures for use of FFR in the peripheral arterial system and to evaluate the correlation of post-procedural FFR values and clinical outcomes in Superficial Femoral artery (SFA)…
- Trial name
- FLO THRU (NCT05079906)
- Testing
- Fractional Flow Reserve (FFR), High Definition Intravascular Ultrasound (HD-IVUS)
- Sponsor
- Acist Medical Systems
Peripheral Vascular Disease
Effects of Paclitaxel on Intimal Hyperplasia
This is a single, one time, limited dose infusion of Paclitaxel, that will potentially prevent recurrent stenosis secondary to intimal hyperplasia when compared to the control group at 10 months.
- Trial name
- Pac1 (NCT01454778)
- Testing
- Paclitaxel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Patrick Kelly
Critical Limb Ischemia
Evaluation of the Tissue Genesis® Icellator Cell Isolation System™ to Treat Critical Limb Ischemia
The purpose of this study is to determine the safety and effectiveness of the Tissue Genesis® Icellator Cell Isolation System™ in Critical Limb Ischemia.
- Trial name
- CLI-DI (NCT02234778)
- Testing
- TGI SVF material via intramuscular injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tissue Genesis
Peripheral Artery Disease
Korean Post-market Registry Assessing the Clinical Use and Safety of the Lutonix DCB in Femoropopliteal Arteries
The purpose of the registry is to assess the clinical use and safety of the LUTONIX Drug Coated Balloon Catheter in a heterogeneous patient population in real world clinical practice.
- Trial name
- NCT02717104
- Where
- 16 sites in South Korea
- Volunteers
- 249 people
- Sponsor
- C. R. Bard
Peripheral Arterial Disease Below the Knee, Peripheral Arterial Disease, Rutherford 4 and 5 with Possibility to Improve Vascularization
Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters
Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters ("BTK Multicath Registry") A non-randomized clinical registry This study is designed to obtain preliminary data on clinically…
- Trial name
- NCT06906055
- Testing
- Multicath, Standard of Care (SOC)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Summa Therapeutics, LLC
Intermittent Claudication, Peripheral Vascular Disease
Trial of VLTS-589 in Subjects With Intermittent Claudication
The purpose of this study is to evaluate the safety and tolerability of VLTS-589 compared with placebo, administered bilaterally to the lower extremities, in subjects with intermittent claudication and to determine the effect of…
- Trial name
- NCT00068133
- Testing
- Plasmid based Gene Transfer product-VLTS-589
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Valentis
Peripheral Arterial Disease
BEST SFA Pilot Study - Best Endovascular STrategy for Complex Lesions of the Superficial Femoral Artery
Prospective, multi-center 1:1 randomized trial to compare efficacy and safety of a stent-avoiding (using drug coated balloons) versus a stent-preferred (using drug eluting or interwoven stents) approach for treatment of complex…
- Trial name
- NCT03776799
- Testing
- Stent-avoiding, Stent-based
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Leipzig
Peripheral Artery Disease
Safety and Effectiveness Evaluation of Peripheral Orbital Atherectomy
This is a prospective, single-arm, multi-center study designed to evaluate the safety and efficacy of the Orbital Atherectomy System (OAS) for the treatment of adult Japanese subjects with a de novo symptomatic calcified…
- Trial name
- KAIZEN (NCT05529472)
- Testing
- Peripheral Orbital Atherectomy System (OAS)
- Where
- 12 sites in Japan
- Volunteers
- 81 people
- Sponsor
- Abbott Medical Devices
Ultrasonography, Doppler, Peripheral Arterial Disease
Comparison of Huntleigh Dopplex DMX Digital Doppler Arterial Waveform With the Gold Standard of Ultrasound Duplex Arterial Waveform
NICE guidelines recommend an Ankle brachial pressure index (ABPI) as the primary assessment tool for patients presenting with symptoms or are at a high risk of developing peripheral arterial disease (PAD).
- Trial name
- NCT05373875
- Testing
- Doppler ultrasound
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
Chronic Limb-Threatening Ischemia, Surgery-Complications
Use of CPETarm for Risk Stratification of Patients With CLTI
This is a prospective cohort study of patients undergoing surgery for chronic limb threatening ischaemia. Prior to surgery, patients will undergo CardioPulmonary Exercise testing (CPET) using an arm ergometer.
- Trial name
- NCT06404229
- Testing
- CardioPulmonary Exercise Testing
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Manchester
Hyperlipidemia
Implementation of an Algorithm- and Multi-professional Team-supported Strategy to Improve Lipid Management of Patients With Atherosclerotic Cardiovascular Disease
This is a randomized, controlled, collaborative, multicenter, pilot implementation science study evaluating the hypothesis that algorithm- and multi-professional team-supported lipid management reduces low density…
- Trial name
- OPTIMIZE ASCVD (NCT07334834)
- Testing
- Algorithm- and multi-professional team-supported lipid management, Guideline-directed lipid management by usual care provider
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Colorado Prevention Center
Peripheral Arterial Disease
REVASC-PAD: REstricted VASCular Exercise for Peripheral Arterial Disease - A Feasibility Study at University of Tennessee Medical Center
The purpose of this study is to evaluate the effects of Blood Flow Restriction (BFR) training on walking function, health-related quality of life, and safety among adults with Peripheral Arterial Disease (PAD).
- Trial name
- REVASC-PAD (NCT07223437)
- Testing
- Blood Flow Restriction Cuff System, Low-load Resistance Training, High-load Resistance Training
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Peripheral Arterial Occlusive Disease
Vasovist Magnetic Resonance Angiography (MRA) in Peripheral Arterial Occlusive Disease
This study aims at investigating the diagnostic accuracy of magnetic resonance angiography using the contrast agent Vasovist® in the detection of relevant vascular narrowing of the lower extremity.
- Trial name
- NCT00717639
- Testing
- Diagnostic MR-Angiography
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Heidelberg University
Peripheral Arterial Disease, Peripheral Vascular Diseases
Real World Registry Assessing the Clinical Use of the Bard UltraScore Forced Focus PTA Balloon
The objective of this study is to assess the clinical use of the Bard® UltraScore™ Focused Force PTA balloon in a heterogeneous patient population in a real world, on-label clinical application.
- Conditions
- Peripheral Arterial Disease, Peripheral Vascular Diseases, Arterial Occlusive Diseases
- Trial name
- NCT03193619
- Testing
- PTA (UltraScore Focused Force PTA Balloon)
- Where
- 31 sites in United States
- Volunteers
- 350 people
- Sponsor
- C. R. Bard
Critical Limb Ischemia, Extracellular Matrix Alteration
Matrix Metalloproteinases in Patients With Critical Limb Ischemia Undergoing Surgical Revascularization
In the present study the investigators will evaluate MMPs. serum levels variations in patients affected by critical limb ischemia, before and after lower limb surgical revascularization through venous or prosthetic bypass.
- Conditions
- Critical Limb Ischemia, Extracellular Matrix Alteration, Peripheral Revascularisation
- Trial name
- ROMAMETA (NCT02388867)
- Testing
- Polytetrafluoroethylene (PTFE) bypass grafting., Autogenous vein bypass grafting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Peripheral Arterial Disease(PAD)
Vascular Complications in Patients Undergoing Peripheral Revascularization and Taking SGLT-2 Inhibitors
The study is observational and involves patients (pts) with peripheral arterial occlusive disease (PAD) who have undergone lower limb revascularization procedures.
- Trial name
- NCT07157475
- Testing
- Treatment with SGLT2 inhibitors (flozins)
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Wroclaw Medical University
Critical Limb Ischemia
Evaluation of Safety and Tolerability of Libella Gene Therapy for Critical Limb Ischemia: AAV- hTERT
Using gene therapy to express active telomerase (hTERT) in human cells has the potential to treat many diseases related to aging, including critical limb ischemia (CLI).
- Trial name
- NCT04110964
- Testing
- AAV-hTERT
- Where
- Colombia
- Volunteers
- 5 people
- Sponsor
- Libella Gene Therapeutics
Peripheral Artery Disease, Critical Limb Ischemia
Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinically driven target lesion…
- Trial name
- TANGO-3 (NCT04433572)
- Testing
- Temsirolimus
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Mercator MedSystems, Inc.