Clinical trials: PAD - Peripheral Arterial Disease
Peripheral Arterial Disease
Belgian Trial Investigating the LifeStream Stent in Complex TASC C and D Iliac Lesions
The BELSTREAM Trial investigates the efficacy of the LifeStream Peripheral Stent Graft System in the treatment of iliac stenotic or occlusive lesions (TASC C and D). An expected total of 70 patients will be treated.
- Trial name
- BELSTREAM (NCT03349996)
- Testing
- LifeStream Peripheral Stent Graft System
- Where
- 7 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- ID3 Medical
Chronic Limb-threatening Ischemia, Microtia
the Gut Microbiome and Metabolomics in Chronic Lower extreMities Threatening Ischemia
Intestinal floras and their metabolites are involved in progressing metabolic and cardiovascular diseases. However, currently, articles related to the relationship between intestinal floras and atherosclerosis mainly focus on…
- Trial name
- MMM (NCT06220994)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Peripheral Arterial Disease
Umbilical Cord Mesenchymal Stem Cells Injection for Peripheral Arterial Disease
The purpose of this study is to assess the safety and efficacy of umbilical cord blood mesenchymal stem cells with peripheral arterial disease.
- Trial name
- NCT02287831
- Testing
- umbilical cord mesenchymal stem cells
- Volunteers
- 28 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Critical Limb Ischemia (CLI)
Efficacy, Tolerability and Safety of Intramuscular Injections of PLX PAD for the Treatment of Subjects With Critical Limb Ischemia (CLI) With Minor Tissue Loss Who Are Unsuitable for Revascularization
This will be a randomized, placebo-controlled, parallel group, multicenter, Phase III study.The study aims to evaluate the Efficacy, Tolerability and Safety of Intramuscular Injections of PLX PAD for the Treatment of Subjects…
- Trial name
- NCT03006770
- Testing
- PLX-PAD
- Where
- 57 sites in United States, Bulgaria and 7 more
- Volunteers
- 213 people
- Sponsor
- Pluristem Ltd.
Critical Limb Ischemia
Cost Analysis of Vascular Surgical Techniques
Whilst mortality rates and surgical limitations are widely known and understood for each intervention performed, the cost implications, in UHL, are not known.
- Trial name
- NCT06367803
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- University Hospital of Limerick
Chronic Lower Limb Ischemia, Peripheral Athero Obstructive Disease
Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass Surgery
Chronic lower limb ischemia due to atherosclerosis causes significant morbidity especially in elderly: the prevalence of asymptomatic obstructive peripheral atherosclerosis among 40-74 old is 4-22%.
- Conditions
- Chronic Lower Limb Ischemia, Peripheral Athero Obstructive Disease, Critical Ischemia, Claudication
- Trial name
- finnptx (NCT01450722)
- Testing
- bypass surgery, stent placement, stent placement
- Where
- Finland
- Volunteers
- 400 people
- Sponsor
- Kuopio University Hospital
Peripheral Artery Disease, Severe Intermittent Claudication
Autologous CD34+ Stem Cell Injection for Severe Intermittent Claudication (Leg Pain)
The goal of the study is to determine the safety and possible effectiveness of various doses of autologous (one's own) stem cells, delivered with a needle into the regions of the leg with poor blood flow in patients with blocked…
- Trial name
- NCT00311805
- Testing
- Autologous Stem Cells (CD34+)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Losordo, Douglas, M.D.
Peripheral Arterial Disease (PAD)
Zilver Flex Post-Market Study in Japan
Japanese post market clinical study of the Zilver Flex device.
- Trial name
- NCT02254356
- Testing
- Zilver Flex Bare Metal Stent
- Where
- Japan
- Volunteers
- 239 people
- Sponsor
- Cook Group Incorporated
Hip Osteoarthritis, Muscle Weakness
The Role of Surgical Approach on Residual Limping After Total Hip Arthroplasty
Residual limping after total hip arthroplasty is empirically associated with the use of lateral approach but has been reported in litterature even with the use of posterior approach.
- Conditions
- Hip Osteoarthritis, Muscle Weakness, Muscle Atrophy, Muscle Injury
- Trial name
- HSS (NCT05216666)
- Testing
- Lateral approach, Posterior approach
- Where
- Sweden
- Volunteers
- 580 people
- Sponsor
- Sahlgrenska University Hospital
Arterial Occlusive Disease, Ischemia
Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-1)
To evaluate the safety and efficacy of recombinant human hepatocyte growth factor (HGF) bare plasmid injection for local intramuscular injection in the treatment of patients with severe lower limb hemorrhagic disease (Rutherford…
- Conditions
- Arterial Occlusive Disease, Ischemia, Ulcers, Peripheral Vascular Disease
- Trial name
- NCT04275323
- Testing
- NL003, Normal Saline
- Where
- 13 sites in China
- Volunteers
- 302 people
- Sponsor
- Beijing Northland Biotech. Co., Ltd.
Peripheral Arterial Disease, Angioplasty
Analysis of the Different Strategies for Revascularization of the Lower Limbs by Peripheral Angioplasty
Peripheral arterial disease (PAD) caused by atherosclerosis causes damage to the arteries originating in the aorta (descending) from the iliacs to the extremities of the lower limbs. It causes significant morbidity and mortality.
- Trial name
- NCT05155462
- Testing
- One or two phone call
- Where
- France
- Volunteers
- 330 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Peripheral Artery Disease (PAD)
IV-X Medical Peripheral Intravascular Lithotripsy Study for PAD
To evaluate the safety and performance of the IV-X Medical Intravascular Lithotripsy (IVL) System in adults in order to demonstrate the ability of the IV-X Medical IVL System to safely and effectively deliver IVL treatment…
- Trial name
- HELIX-PAD (NCT07746362)
- Testing
- IV-X Medical IVL System
- Volunteers
- 140 people
- Sponsor
- IVX Medical
Peripheral Arterial Disease, Atherosclerosis
Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With PAD and Claudication
The purpose of this trial is to evaluate the safety and efficacy of sonodynamic therapy (SDT) on reducing atherosclerotic plaques inflammation among patients with symptomatic femoropopliteal peripheral artery disease.
- Conditions
- Peripheral Arterial Disease, Atherosclerosis, Cardiovascular Diseases
- Trial name
- SMART-PAD (NCT03457662)
- Testing
- OMC and pseudo-SDT, OMC and SDT
- Where
- China
- Volunteers
- 32 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Chronic Disease, Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Truway Diagnostic Tools in Primary Care
This study evaluates the effectiveness of Truway Health-sourced portable diagnostic devices, including ultrasound and blood glucose monitors, in early detection of chronic conditions in outpatient primary care settings.
- Conditions
- Chronic Disease, Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight, Hypertension, Cardiovascular Disease Acute
- Trial name
- TruDxPC (NCT07209527)
- Testing
- Truway Portable Ultrasound Device, Truway Blood Glucose Monitor, Standard Oral Hypoglycemic Agent
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Truway Health, Inc.
Peripheral Arterial Disease
Safety and Efficacy Study of Bosentan for Intermittent Claudication in Peripheral Arterial Disease
A prospective study, proof-of concept, randomized, controlled, parallel groups, simple blind was performed in 30 male patients (50-60 years old) with Intermittent Claudication (Rutherford category 1-2) recently diagnosed and…
- Trial name
- CLAU (NCT01738542)
- Testing
- Bosentan, Antiaggregant therapy, Statins
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Getafe
Peripheral Arterial Disease
Angiosome Perfusion After Tibial Bypass
Microcirculation should be assessed before and after tibial bypass surgery by intraoperative fluorescence angiography. According to this, the direct and the indirect angiosomes should be compared according to the individual…
- Trial name
- NCT03012750
- Testing
- Indocyanine Green
- Volunteers
- 40 people
- Sponsor
- University Hospital Erlangen
Peripheral Vascular Disease
Endovascular Atherectomy Safety and Effectiveness Study
The purpose of this study is to evaluate the procedural safety and effectiveness of the Phoenix Atherectomy™ System for the treatment of de novo and restenotic atherosclerotic lesions located in the native peripheral arteries.
- Trial name
- EASE (NCT01541774)
- Testing
- Phoenix Atherectomy System
- Where
- 16 sites in United States, Germany
- Volunteers
- 128 people
- Sponsor
- AtheroMed, Inc
Peripheral Artery Disease
Daily Step-based Exercise Using Fitness Monitors for Peripheral Artery Disease
Peripheral artery disease (PAD) is caused by blockages in the leg arteries. PAD limits patients' walking ability and quality of life. For patients with PAD, home exercise programs can improve walking ability and quality of life.
- Trial name
- EASY FIT (NCT03099369)
- Testing
- Daily Step-based Exercise, Symptom-based Exercise, Fitbit Fitness Monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Peripheral Arterial Disease, Critical Limb Ischemia
Exercise Rehabilitation for Patients With Critical Limb Ischemia After Revascularization
Peripheral arterial disease (PAD) affects more than 200 million people worldwide. This disease occurs with narrowing and occlusion of arteries supplying oxygenated blood to the organs and limbs.
- Trial name
- NCT03839953
- Testing
- Supervised Exercise Program, Best Medical Therapy
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Peripheral Vascular Disease, Peripheral Artery Disease
Prehabilitation for PAD Revascularization Patients
Patients undergoing elective revascularization of their peripheral artery disease will be randomized to a prehabilitation program or usual care prior to their scheduled procedure.
- Trial name
- NCT02767895
- Testing
- Prehabilitation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Michigan
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