Clinical trials: PARKINSON DISEASE (Disorder)
Parkinson's Disease
A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease
This is a multi-center, international, open-label, safety study of ND0612, a solution of levodopa/carbidopa (LD/CD) delivered via a pump system as a continuous SC infusion in subjects with advanced Parkinson's Disease (PD).
- Trial name
- BeyoND (NCT02726386)
- Testing
- ND0612
- Where
- 57 sites in United States, Austria and 7 more
- Volunteers
- 214 people
- Sponsor
- NeuroDerm Ltd.
Parkinson Disease
Effects of Home-based High-speed Bodyweight Resistance Training in Individual With Parkinson's Disease
Exercises that involve increasing the speed of movements are beneficial for individuals with Parkinson's disease (PD) and have the potential to reduce bradykinesia and improve mobility.
- Trial name
- NCT06646523
- Testing
- High-speed bodyweight resistance training, Control group (Bodyweight intervention, usual speed)
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Federal University of Minas Gerais
Parkinson Disease
Safety Study to Autonomic Rehabilitation o Parkinson's Disease
Introduction: The Parkinson is one of the most common degenerative diseases of the central nervous system , mainly characterized by resting tremor , rigidity, akinesia and postural instability , also featuring the autonomic…
- Trial name
- NCT02680522
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Parkinson's Disease
Ascending Dose Tolerability/Safety of SLV308 for the Treatment of Parkinson's Disease
This study is a multicenter, randomized, double-blind, placebo controlled, parallel group study of a seven-week ascending dose period of SLV308 adjunctive to L-dopa treatment in patients with advanced stage Parkinson's disease…
- Trial name
- NCT00134251
- Testing
- SLV308
- Where
- 10 sites in Bulgaria, Malta and 1 more
- Sponsor
- Solvay Pharmaceuticals
Antidepressive Agents
Wuling Powder for the Treatment and Underlying Mechanism of Depressive Symptoms in Patients With Parkinson's Disease
Depression is one of the most important nonmotor features of idiopathic PD（Parkinson's disease ）which may not just interfere with the motor symptoms of PD but can also cause immense personal suffering as well as decreased quality…
- Trial name
- NCT03195231
- Testing
- Wuling Powder
- Volunteers
- 120 people
- Sponsor
- Beijing Hospital
Parkinson's Disease (PD), Healthy Aging
Exoskeleton-Assisted Mobility in Aging and in Parkinson's Disease
This study will evaluate whether a wearable robotic exoskeleton can improve mobility, balance, and walking in healthy older adults and in individuals living with Parkinson's disease, populations at high risk of falls and mobility…
- Trial name
- NCT07567482
- Testing
- Exoskeleton
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Centre intégré de santé et de services sociaux de l'Outaouais
Parkinson Disease, Movement Disorders
Validation of DaTscan for Detection of Parkinson Disease Related Disorders
This investigator initiated trial is designed to measure the accuracy of diagnosis of Parkinson disease through the use of DaTscan. Currently, DaTscan is FDA approved to measure dopamine transporter densities in human tissue.
- Trial name
- NCT02138682
- Testing
- l-123 Ioflupane
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Wisconsin Institute for Neurologic and Sleep Disorders S.C.
Virtual Reality; Rehabilitation; Parkinson's Disease
Virtual Reality-based Interactive Treadmill Gait Training System for Parkinson's Disease
Virtual-reality-based interactive treadmill system will be applied to the Parkinsons' disease patients who can walk (Hoehn and Yahr stage 2 to 4).
- Trial name
- NCT03686462
- Testing
- Virtual reality-based interactive treadmill training, Treadmill training without VR-based interaction
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Seoul National University Hospital
Parkinson Disease, Idiopathic, Freezing of Gait
Vortioxetine for Depressive Symptoms and Freezing of Gait in Parkinson Disease
The present study involves patients with Parkinson Disease (PD) suffering from freezing of gait (FOG) and depressive symptoms. The main aim of the study is evaluating the efficacy of vortioxetine in reducing moderate/severe FOG…
- Conditions
- Parkinson Disease, Idiopathic, Freezing of Gait, Depression Not Otherwise Specified
- Trial name
- NCT06805266
- Testing
- Vortioxetine (tablet)
- Volunteers
- 40 people
- Sponsor
- Marianna Amboni
Parkinson's Disease, Fecal Microbiota Transplantation
Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease With Constipation
Parkinson's disease(PD) may cause the autonomic nervous system's improper functioning, which is responsible for regulating the intestinal tract movement.
- Trial name
- NCT04837313
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou First People's Hospital
Parkinson Disease
Non-motor Symptoms (Depressive Symptoms) of Parkinson's Disease and Their Course Under Pramipexole Treatment
The objective of this PMS study is the evaluation of depressive symptoms measured with Unified Parkinson's Disease Rating Scale (UPDRS) Part I (mentation, behavior and mood) and with Hospital Anxiety and Depression Scale…
- Trial name
- NCT00651183
- Testing
- Pramipexole immediate release
- Where
- 57 sites in Austria
- Volunteers
- 286 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease, Dementia
Using Gait Robotics to Improve Symptoms of Parkinson's Disease
This study evaluates the benefits of exoskeleton-based exercise for improving mood and cognition in people with Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT03583879
- Testing
- Exoskeleton exercise, Standard exercise, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- University of New Brunswick
Parkinson Disease
Effects of Ecological Rythmic-acoustic Stimulation (E-RAS) on Motor Skills in Individuals With Parkinson's Disease
The use of rhythmic auditory stimulation (RAS) has been proven useful in the management of gait disturbances induced by Parkinson's disease (PD).
- Trial name
- NCT03228888
- Testing
- Administration of rhytmic acoustic stimuli for gait training
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Dementia, Neurodegenerative Diseases
Retinal Hyperspectral Imaging in Neurodegenerative Diseases
Hyperspectral retinal imaging is a non-invasive imaging modality in which a series of images of the retina are captured using light of different wavelengths.
- Conditions
- Dementia, Neurodegenerative Diseases, Alzheimer Disease, Parkinson Disease
- Trial name
- NCT07545473
- Testing
- Hyperspectral camera
- Where
- Australia
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Center for Eye Research Australia
Parkinson's Disease
Intraoperative Analysis of Reward and Impulsivity in the Basal Ganglia
This project studies the impulsive side effects of common treatments for Parkinson's Disease. By learning how parts of the brain involved in Parkinson's encode information related to reward and motivation, the investigators will…
- Trial name
- NCT02319694
- Volunteers
- 36 people
- Sponsor
- Duke University
Parkinson's Disease
Riluzole to Treat Parkinson's Disease
This study will evaluate the effects of the drug riluzole on Parkinson's disease symptoms and on dyskinesias (involuntary movements) that develop as a result of long-term treatment with levodopa.
- Trial name
- NCT00013624
- Testing
- IV Levodopa
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Parkinson
Evaluation of a Computer Game Based Rehabilitation System for Assessment and Treatment of Balance and Gait Impairments in Individuals With Parkinson's Disease.
Examining the feasibility and acceptability of the computer game based rehabilitation system for improving balance, gait and executive function in individuals with PD.
- Trial name
- NCT03232996
- Testing
- Computer game based balance and walking rehabilitation for individuals with Parkinson's Disease
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Parkinson s Disease
Primary Parkinsonian Pain: Clinical Association and Phenotype
Among the different types of pain observed in Parkinson's disease, primary parkinsonian pain (PPP) is the most severe, the most difficult to treat, but also the least well characterized and the hardest to describe, not only by…
- Trial name
- PHENOPAIN (NCT07702266)
- Testing
- Online self-administered questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson
Prism Adaptation Treatment of Parkinson's Disease
Subjects diagnosed with Idiopathic Parkinson's Disease, between ages of 40-85 inclusive, who have been referred for gait training.
- Trial name
- NCT02380859
- Testing
- Prism adaptation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Parkinson Disease
The Measurement of Nocturnal Hypokinesia in Parkinson's Disease (PD) Patient Compared With Spouse by Wearable Sensors
To quantitative measurement of nocturnal hypokinesia of Parkinson's disease patients compares with their spouses by using multisite accelerometers for 1 night at their home.
- Trial name
- PD (NCT02352727)
- Where
- Thailand
- Volunteers
- 28 people
- Sponsor
- Chulalongkorn University