Clinical trials: PARKINSON DISEASE (Disorder)
Parkinson's Disease, Mild Cognitive Impairment
Training of Psychosocial Skills Based on Cognitive Behavioural Therapy for Patients With Parkinson's Disease
Patients with Parkinson's disease (PD) will be trained using a cognitive behavioral group-training-program to reduce stress and augment quality of life.
- Trial name
- CBT (NCT02048605)
- Testing
- Psycho-social CBT based training, Unspecific group training
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Parkinson Disease
Pilot Randomized Controlled Trial of Telemedicine for Individuals With Parkinson Disease in a Rural Population
To eliminate barriers (such as travel and cost) to specialized Parkinson disease (PD) care, two movement disorder specialists at the University of Rochester will be providing telemedicine visits for patients with PD who reside in…
- Trial name
- Tele-PD (NCT00668551)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Rochester
Parkinson Disease
A Late Phase II Clinical Trial of KDT-3594 in Patients With Parkinson's Disease
This trial is a late phase II, multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy, safety, and pharmacokinetics of KDT-3594 administered at escalating doses ranging from 0.25…
- Trial name
- NCT06722729
- Testing
- KDT-3594
- Where
- Japan
- Volunteers
- 178 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Parkinson Disease
Vestibulopathy, Imbalance, and Gait Disturbances in Parkinson Disease
This study investigates whether vestibular (inner ear) dysfunction is a cause for poor balance in Parkinson Disease (PD), and whether inner ear stimulation with a small device may improve balance.
- Trial name
- VEST (NCT05446194)
- Testing
- Non invasive neuromodulation device pattern 1, Non invasive neuromodulation device pattern 2
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Michigan
Parkinson's Disease
An Evaluation of the Pharmacokinetics and Pharmacodynamics of AP09004 in Patients With Parkinson's Disease
The purpose of this study is to evaluate blood level profiles of multiple oral doses of AP09004 vs. active control and to determine its safety and efficacy in Parkinson's patients.
- Trial name
- NCT00918177
- Testing
- AP09004, Carbidopa/Levodopa, immediate release
- Where
- 7 sites in Israel
- Volunteers
- 72 people
- Sponsor
- Intec Pharma Ltd.
Parkinson's Disease
How Does STN-DBS Influence Emotional Conflict Decision in Parkinson's Disease: a EEG Study
A large body of evidence points to impairment in the decoding of emotional stimuli in Parkinson's disease (PD). These changes seem to be related to dysfunction of the mesocorticolimbic projections leading to dysfunction of the…
- Trial name
- DBS-EMOTION (NCT02786680)
- Testing
- stroop test in condition DBS off, stroop test in condition DBS on
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parkinson's Disease, Restless Leg Syndrome
A Single Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Ropinirole 0.25 mg Tablets Und Fasted Conditions
The objective of this study was to assess the single dose bioequivalence of Roxane's Ropinirole Tablets, 0.25 mg to ReQuip Tablets, 0.25 mg (GlaxoSmithKline) under fasting conditions using a single-dose, randomized, 2-treatment…
- Trial name
- NCT00673088
- Testing
- Ropinirole Hydrochloride
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Parkinson Disease, Apathy
Methylphenidate for Apathy in Veterans With Parkinson's Disease
Apathy is one of the most common behavioral symptoms of Parkinson's disease. Patients with apathy show diminution in motivation and goal-directed behaviors, which is a fundamental aspect of human functioning, affecting dependency…
- Trial name
- MAV-PD (NCT05669170)
- Testing
- Psychosocial intervention, Methylphenidate
- Volunteers
- 60 people
- Sponsor
- Ralph H. Johnson VA Medical Center
Parkinson Disease
Impact of Subthalamic Nucleus Deep Brain Stimulation on Pain in Parkinson Disease
Pain is a common symptom of Parkinson's disease (PD) but the physiology remains poorly understood. Recent work suggests that subthalamic nucleus deep brain stimulation (STN-DBS) could make a profit on the pain in PD.
- Trial name
- NCT02885194
- Testing
- Laser-Evoked potential
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease
Sensor-supported Classification of Gait Patterns in Everyday Movement of Patients With Parkinson's Disease
Within this study we conduct long-term measurements on Parkinson patients using a three sensor IMU setup: one sensor is located at the wrist, one sensor at the belt/ in the pocket and one sensor is worn as a pendant.
- Trial name
- PD-GPC (NCT04054856)
- Testing
- Body Sensor Network
- Where
- Germany
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Parkinson Disease
The Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Depression in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients with depression.
- Trial name
- PD-D-taVNS (NCT07679529)
- Testing
- Active Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson Disease
Combining VNS With PT Interventions for Individuals With PD
The purpose of this study is to evaluate the combined effects of non-invasive neuromodulation (specifically transauricular Vagus Nerve Stimulation) with exercise interventions to improve physical function and quality of life in…
- Trial name
- VNS-PT-PD (NCT05871151)
- Testing
- taVNS, Exercise
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Wolff-Parkinson-White Syndrome, Sudden Cardiac Death
Stress ECG Test for the Evaluation of the Risk of Sudden Cardiac Death in a Paediatric Cohort With WPW Pattern
Patients with preexcitation are at risk for sudden cardiac death. The pathogenesis is a rapid antegrade conduction of atrial fibrillation over the accessory pathway to the ventricle resulting in ventricular fibrillation.
- Conditions
- Wolff-Parkinson-White Syndrome, Sudden Cardiac Death, Risk Stratification
- Trial name
- NCT03207373
- Testing
- Stress test (ECG)
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Christian Balmer
Parkinson Disease
Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study
The PASS-PD study is set out to screen individuals from the general population with an increased risk for the development of Parkinson's Disease (PD) and to investigate this highly enriched cohort longitudinally for five year.
- Trial name
- PASS-PD (NCT04724941)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Alzheimer Dementia, Parkinson Disease
Assessment of Empathetic Process by Scanpath Study of an Artwork
Analysis of gaze patterns during social cognition tasks and standardised exploration of a specific artwork, between elderly subjects without cognitive disorders and subjects with neurodegenerative diseases such as Fronto-Temporal…
- Conditions
- Alzheimer Dementia, Parkinson Disease, Fronto-Temporal Dementia
- Trial name
- EYE-EMPATH (NCT04665622)
- Testing
- Eye-Tracking / Neuropsychological evaluations
- Where
- Monaco
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Princesse Grace
Parkinson Disease
Evaluation of the Safety of Electrical Spinal Cord Stimulation in Parkinson's Patients Presenting With Painful Camptocormia
Camptocormia is defined by abnormal flexion of the trunk, not fixed, present when standing and walking, resolves when lying down and often complicated by lower back pain.
- Trial name
- CAMPTOSTIM (NCT06291051)
- Testing
- Electrical spinal cord stimulation
- Where
- 4 sites in France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Rouen
Parkinson Disease, Autonomic Nervous System Diseases
Biomarkers of Risk of Parkinson Disease
This study (https://pdrisk.ninds.nih.gov) will determine if people who have risk factors for Parkinson disease (PD) have biomarkers (objective ways to measure a disease process) that show that the disease process is actually…
- Conditions
- Parkinson Disease, Autonomic Nervous System Diseases, Pure Autonomic Failure
- Trial name
- NCT00775853
- Testing
- 6-[18F]Fluorodopamine, 6-[18F]Fluorodopa, 13N-Ammonia
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease
Kick Out Parkinson's Disease- Karate Intervention
The benefits of exercise for general health and wellbeing in older adults are well-established. Balance exercises such as tai chi and yoga, along with resistance training, can improve or maintain physical function in older adults…
- Trial name
- NCT03555695
- Testing
- Karate Classes, Pre-Intervention Focus Group, Post-Intervention Focus Group
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Rush University Medical Center
Parkinson Disease
Influence of Emotions on Decision-making in Parkinson's Disease
Parkinson's disease mainly affects the dopaminergic neurons of the Substancia nigra, which project on the striatum. Neuronal death within this structure leads to a decrease in dopamine levels.
- Trial name
- NCT03342339
- Testing
- cognitive examination, viewing of video, Iowa Gambling Task
- Where
- 2 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation (DBS) Data Base Study
The primary goal of this study is to evaluate and compare outcomes, trends, and effectiveness of both awake and asleep Deep Brain Stimulation (DBS) surgical treatments, target selection, targeting accuracy and outcomes in…
- Trial name
- NCT01909531
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix