Clinical trials: PCOS (Polycystic Ovary Syndrome)
Polycystic Ovary Syndrome, Androgen Excess
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2
Polycystic ovary syndrome (PCOS) affects 10% of all women, and it usually co-exists with high levels of sex hormones called androgens, such as testosterone.
- Conditions
- Polycystic Ovary Syndrome, Androgen Excess, Metabolic Disease
- Trial name
- REFUEL PCOS (NCT05647356)
- Testing
- Bicalutamide 50 mg
- Where
- Ireland
- Volunteers
- 16 people
- Sponsor
- Royal College of Surgeons, Ireland
Polycystic Ovary Syndrome, PCOS
Obstetric Outcomes in Women With PCOS
The aim of the study is to investigate body composition in newborn children of women with PCOS and controls and to investigate adverse obstetric outcomes in pregnant women with PCOS.
- Trial name
- NCT01983202
- Where
- Denmark
- Volunteers
- 1,248 people
- Sponsor
- Odense University Hospital
PCOS, NAFLD
Lifestyle Changes in PCOS with OSA and NAFLD
Complain of obstructive sleeping apnea and fatty liver is common in PCOS women so lifestyle changes are recommended
- Conditions
- PCOS, NAFLD, OSA
- Trial name
- NCT06591169
- Testing
- diet restriction and exercise, diet restriction
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
PCOS (Polycystic Ovary Syndrome)
Letrozole and Cabergoline Versus Letrozole Alone in Ovulation Induction
Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorders in women of reproductive age. According to the World Health Organization (WHO) estimation revealed over 116 million women (3.4%) are affected by PCOS…
- Trial name
- NCT07168837
- Testing
- Letrozole tablets
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Healthy, PCOS
In Vitro Maturation of Human Eggs
CCRM Fertility, a global pioneer in fertility treatment, research and science, is seeking participants for a new study on in vitro maturation (IVM).
- Conditions
- Healthy, PCOS, PCOS (Polycystic Ovary Syndrome), Ovarian Reserve
- Trial name
- NCT06633120
- Testing
- IVM
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Colorado Center for Reproductive Medicine
PCOS
Effect of Laparoscopic Ovarian Drilling on Outcomes of in Vitro Fertilisation in Clomiphene-resistant Women With Polycystic Ovary Syndrome
the polycystic ovarian syndrome is associated with an ovulation and infertility. recently the laparoscopic ovarian drilling has been used as surgical treatment for ovulation in women with polycystic ovarian syndrome, although its…
- Trial name
- NCT03527979
- Testing
- IVF/ICSI
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Polycystic Ovary Syndrome, Resistance, Insulin
Effects of Myo-inositol in Women With Polycystic Ovary Syndrome
The study will be carried out at the hospital of the medical school of sao paulo (HC-FMUSP) and the goal is to compare the effects of the administration of myo-inositol in relation to the effects of metformin in women with…
- Conditions
- Polycystic Ovary Syndrome, Resistance, Insulin, Glucose Intolerance
- Trial name
- NCT04892186
- Testing
- Myo-inositol, Metformin
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Polycystic Ovary Syndrome
Molecular Basis of PCOS in Oocytes and Surrounding Cells
Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age that is characterized by elevated androgen levels, ovulatory dysfunction and polycystic ovarian morphology (PCOM).
- Trial name
- NCT04493788
- Testing
- Blood test, ultrasound and egg retrieval
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Polycystic Ovary Syndrome, Berberine
Berberine and Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is the most frequent endocrine disease in female reproductive-age. Recently, increasing evidence has shown that natural plant-based products may play a role in PCOS management.
- Trial name
- NCT04932070
- Testing
- Berberine
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes
IVM - Fresh ET (THE SAIGON PROTOCOL) Versus IVF - FET in PCOS Women
Assisted Reproductive Technologies (ART) aim to increase success rates while minimizing patient risks. For women with high AFC or PCOS, conventional IVF carries a high risk of OHSS (Ho et al., 2019).
- Conditions
- Polycystic Ovary Syndrome (PCOS), In Vitro Maturation of Oocytes, Fresh Embryo Transfer
- Trial name
- SAIGON-PTC (NCT07171970)
- Testing
- IVM-Fresh (No gonadotropin + Fresh embryo transfer), IVF-FET (GnRH-Antagonist - Agonist Trigger - Frozen embryo transfer)
- Where
- Vietnam
- Volunteers
- 600 people
- Sponsor
- Mỹ Đức Hospital
Gene Abnormality
Endometrial Heparin-binding Epidermal Growth Factor Expression
Women with PCOS comprise a majority of fertility clinic attendees. Unfortunately, a high failure rate following fertility treatment was observed especially in obese women due to implantation failure.
- Trial name
- NCT04175002
- Testing
- utrogestan
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
PCOS, Obesity
Ketogenic Diet in PCOS With Obesity and Insulin Resistance
The purpose of the VLCKD randomized clinical trial is to demonstrate the superiority of very low calorie ketogenic diet with respect to the standard low calorie diet in reducing body weight and insulin resistance in obese and…
- Conditions
- PCOS, Obesity, Insulin Resistance
- Trial name
- VLCKD (NCT04801173)
- Testing
- Very low calorie ketogenic diet, Low calorie standard diet
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Female Infertility, Polycystic Ovary Syndrome
Vitamin D Supplementation and Improvement of PCOS Therapy and IVF Outcomes in Infertile Saudi Women
This randomized double-blinded-controlled clinical trial consists of two protocols as follow: protocol 1: evaluation of the therapeutic effects of Vitamin D3 supplement when given alone and in combination with an…
- Conditions
- Female Infertility, Polycystic Ovary Syndrome, Pathologic Processes, Vitamin D Deficiency
- Trial name
- NCT05106712
- Testing
- Vitamin D3, Clomiphene Citrate, Letrozole
- Volunteers
- 700 people
- Sponsor
- Umm Al-Qura University
Polycystic Ovary Syndrome
Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
Hypothesis The overall hypothesis is that non-obese (BMI <30) women with PCOS have high luteinising hormone (LH) and cortisol pulse frequency and amplitude and that repeated low-frequency EA restore these alterations and induce…
- Trial name
- PCOSLFEA (NCT00921492)
- Testing
- Low-frequency electro-acupuncture (EA), Meeting a therapist - attention control
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Göteborg University
Infertility Treatment, Pregnancy Rates
Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation Rate
Women who meet the study requirements will be enrolled and randomly assigned by a computer system to receive either pioglitazone 30 mg daily or a placebo starting from the second day of their menstrual period for the same…
- Trial name
- NCT07462065
- Testing
- Clomiphene Citrate., Pioglitazone (PIO) + Clomiphene citrate
- Where
- Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- PAEC General Hospital, Islamabad
Polycystic Ovary Syndrome (PCOS), Anovulatory Infertility
Clomiphene Citrate Alone Versus Clomiphene Plus Metformin as First Line Approach for the Treatment of Anovulation in Infertile Patients With Polycystic Ovary Syndrome
This study will compare the effectiveness of clomiphene citrate alone with clomiphene citrate combined with metformin for treating anovulation and infertility in women with polycystic ovary syndrome (PCOS).
- Trial name
- CC-MET PCOS T (NCT07872501)
- Testing
- Clomiphane citrate + Metformin, clomiphene citrate alone
- Where
- Pakistan
- Volunteers
- 218 people
- Sponsor
- Independent University Hospital, Pakistan
Polycystic Ovary Syndrome
Prevalence of Pregnancy in Polycystic Ovary Syndrome
Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age, with a prevalence of approximately 5-10%.
- Trial name
- NCT03157921
- Testing
- transvaginal ultrasound, Hormonal levels
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Infertility, PCOS
Metformin in Patients With PCOS and Predictors of Poor Ovarian Response Ongoing In-vitro Fertilization
Metformin should be administered with caution and could be potentially dangerous in infertile patients with PCOS who show a poor ovarian response and are undergoing gonadotropin-based ovarian stimulation.
- Conditions
- Infertility, PCOS, Prognosis for Poor Response
- Trial name
- NCT01208740
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- University Magna Graecia
Polycystic Ovary Syndrome, Hyperinsulinism
Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome
OBJECTIVES: I. Determine whether reduction of serum insulin levels by metformin increases ovulatory response to clomiphene citrate in women with polycystic ovary syndrome.
- Trial name
- NCT00005104
- Testing
- clomiphene citrate, metformin
- Where
- 6 sites in United States, Italy
- Volunteers
- 99 people
- Sponsor
- National Center for Research Resources (NCRR)
Polycystic Ovary Syndrome
Acupuncture for Polycystic Ovarian Syndrome
This is a randomized control trial of acupuncture for women with polycystic ovary syndrome. The study is triple-blinded.
- Trial name
- NCT00602940
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Virginia
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