Clinical trials: PCOS (Polycystic Ovary Syndrome)
Polycystic Ovarian Syndrome, Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome and Cabergoline
Cabergoline prevents ovarian hyperstimulation syndrome in high risk patients by disrupting follicular fluid hormone microenvironmentally altering the follicular fluid levels of insulin like growth hormone -I (IGF-I)…
- Trial name
- NCT01569256
- Testing
- Cabergoline
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanim Womens' Health and Teaching Hospital
Polycystic Ovary Syndrome
The Relationship of PRL and Polycystic Ovary Syndrome (PCOS) in Taiwan's Women
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of reproductive-age women. According to Rotterdam 2003 criteria: at least two of three criteria are met, hyperandrogenism, chronic anovulation, and…
- Trial name
- NCT01117272
- Where
- Taiwan
- Volunteers
- 474 people
- Sponsor
- Taipei Medical University WanFang Hospital
Induction of Ovulation, PCO - Polycystic Ovaries
Sodium-Glucose Co-Transporter-2 Inhibitors as Adjuvant Therapy With Letrozole in Induction of Ovulation in Women With Polycystic Ovarian Syndrome
The aim of the study is to assess the efficacy of adjuvant therapy dapagliflozin, metformin as monotherapy and combination of both in comparison to control group in induction of ovulation with letrozole in women PCOS, focusing…
- Trial name
- SGLT-2/PCOS (NCT07589075)
- Testing
- Metformin 1000 mg Oral Tablet, Dapagliflozin 10 MG Oral Tablet [Farxiga], Combined Dapagliflozin-Metformin 5/1000mg
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Polycystic Ovary Syndrome
Markers and Calculation of Cardiovascular Risk in the Distinct Phenotypes of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder and cause of anovulatory infertility among reproductive aged women.
- Trial name
- NCT01392781
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Infertility
Dosage Optimization for Letrozole Treatment
In a prospective interventional study, 44 Clomiphene resistant infertile patients were selected from Abolfazl Infertility Clinic of Bushehr University of Medical Sciences.
- Trial name
- NCT01315912
- Testing
- Letrozole
- Where
- Iran
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bushehr University of Medical Science
Obesity, Polycystic Ovaries Syndrome
The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome (PCOS)
The first aim of the investigators study, was to investigate the combined effect of diet,physical exercise and orlistat, for 24 weeks, on serum Anti-Müllerian Hormone (AMH) levels in obese women with polycystic ovary syndrome…
- Trial name
- NCT01475019
- Testing
- Orlistat, Sibutramine, Diet and physical exercise
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Aristotle University Of Thessaloniki
Polycystic Ovary Syndrome, Infertility
Inositol in Letrozol Resistant PCOS Women
Polycystic ovary syndrome (PCOS),is a complex neuro-endocrine disorder affecting approximately 5% to 10% of women in reproductive age.Inositols are considered insulin sensitizers, as they modulate the members of insulin signaling…
- Trial name
- NCT07585396
- Testing
- Myoinositol, Metformin
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Kafrelsheikh University
Polycystic Ovary Syndrome, Insulin Resistance
Metformin vs Inositol vs Diet vs Combination Therapy in PCOS
Polycystic ovary syndrome (PCOS) is a common condition that can cause irregular periods, excess male-type hormones, weight gain, and insulin resistance.
- Conditions
- Polycystic Ovary Syndrome, Insulin Resistance, Metabolic Syndrome
- Trial name
- PCOS-COMBO (9) (NCT07380841)
- Testing
- Metformin Hydrochloride, Myo-Inositol, Dietary Restriction
- Where
- Pakistan
- Volunteers
- 192 people
- Sponsor
- Islamabad Medical and Dental College
PCOS
A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS
This study evaluates the effects and biological mechanisms of Dingkundan，Diane-35 and the combination of Dingkundan and Diane-35 in the treatment of polycystic syndrome(PCOS) in adults women.
- Trial name
- NCT03264638
- Testing
- Dingkundan, Dingkundan & Diane-35, Diane-35
- Where
- China
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Aijun Sun
Polycystic Ovary Syndrome
Serum Preptin and Amylin Levels in Polycystic Ovary Syndrome Patients
Preptin and amylin are pancreatic hormones which participate in glucose homeostasis. This study aims to evaluate how serum preptin and amylin levels are altered in polycystic ovary syndrome (PCOS) patients and healthy women based…
- Trial name
- NCT03587415
- Testing
- preptin and amylin level
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Infertility, Polycystic Ovarian Syndrome
Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome
The study null hypothethesis is: intrauterine insemination (IUI) does not improve pregnancy rates in women with polycystic ovary syndrome.
- Conditions
- Infertility, Polycystic Ovarian Syndrome, Intrauterine Insemination
- Trial name
- OSIPS (NCT01675843)
- Testing
- Intrauterine insemination (IUI)
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Mansoura University
Polycystic Ovary Syndrome (PCOS) Women, Insulin Resistance Syndrome
Relationship Between Metformin Treatment, Anemia, and Erythropoietin Levels in Women With Polycystic Ovary Syndrome in Jordan
This prospective longitudinal interventional study aims to evaluate the effects of routine metformin therapy on metabolic, iron-related, erythropoietin, lipid, and hematological parameters in adult women with polycystic ovary…
- Trial name
- Metformin-APO (NCT07759674)
- Testing
- Metformin
- Where
- Jordan
- Volunteers
- 25 people
- Sponsor
- Jerash Private University
Hirsutism, Type 2 Diabetes
Prospective Study of Patients With Hirsutism
Hirsutism is the presence of terminal hairs in a male-like pattern in females, due to elevated male hormone levels. Females with hirsutism are often overweight and have metabolism disturbances as insulin resistance and impaired…
- Conditions
- Hirsutism, Type 2 Diabetes, Polycystic Ovary Syndrome
- Trial name
- NCT00145288
- Where
- Denmark
- Volunteers
- 340 people
- Sponsor
- Odense University Hospital
Insulin Resistance, Oxidative Stress
Alpha Lipoic Acid and Polycystic Ovary Syndrome
The study will recruit 40 subjects with Polycystic Ovary Syndrome (PCOS) as defined by the NIH criteria. The subjects will be pre-screened for insulin sensitivity using fasting insulin and glucose levels and oral glucose…
- Trial name
- NCT00505427
- Testing
- Alpha Lipoic Acid
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Polycystic Ovary Syndrome, Insulin Resistance
The RCT of Acupuncture on PCOS Combined With IR
The objectives of this randomized controlled trial are to compare insulin sensitivity following true acupuncture + placebo metformin (Group 1) vs sham acupuncture + placebo metformin (Group 2) vs sham acupuncture + metformin…
- Trial name
- NCT02491333
- Testing
- true acupuncture, metformin
- Where
- China
- Volunteers
- 342 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Poly Cystic Ovary Syndrome
Efficacy of Vildagliptin Versus Metformin in Patients With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, with insulin resistance playing a central role in its…
- Trial name
- NCT07811011
- Testing
- Metformin, Vildagliptin (Galvus)
- Volunteers
- 70 people
- Sponsor
- Tanta University
Ovarian Hyperstimulation Syndrome
Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS
This a prospective randomized double blind study involving patients at high risk of OHSS development with peak serum E2 levels < 4,000 pg/ml comparing the ongoing pregnancy rates in patients who receive adjuvant hCG 1,000 IU at…
- Trial name
- NCT01815138
- Testing
- hCG
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- UConn Health
PCOS, Obesity
The Gut Microbiome in Women With Polycystic Ovary Syndrome
Testing two different strategies for weight loss intervention and revealing possible changes in composition of gut microbiota, in order to provide more insight in the effect of dietary changes and weight loss treatments on gut…
- Conditions
- PCOS, Obesity, Metabolic Syndrome
- Trial name
- NCT03642600
- Testing
- dietary advice plus myo-inositol and folic acid, dietary advice plus Liraglutide Pen Injector
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Polycystic Ovary Syndrome, Chiglitazar
Chiglitazar/Metformin in Non-obese Women With PCOS
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorders in women of reproductive age, and its prevalence rate is from 9% (NIH criteria) to 18% (Rotterdamcriteria).
- Conditions
- Polycystic Ovary Syndrome, Chiglitazar, Metformin
- Trial name
- NCT06125587
- Testing
- Chiglitazar, Metformin
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Shengjing Hospital
Polycystic Ovary Syndrome (PCOS) With Concurrent Nonalcoholic Fatty Liver Disease (NAFLD)
Evaluation of the Therapeutic Effects of Curcumin on Changes in Lipid, Metabolic, and Hormonal Profiles, Liver Enzyme Activity, and Ultrasonography Morphology of the Liver in Women With Polycystic Ovary Syndrome and Nonalcoholic Fatty Liver Disease: A Double-blind, Placebo-controlled Clinical Trial
Background and Objectives: Polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) commonly co-occur and are associated with insulin resistance, chronic inflammation, and metabolic and hormonal imbalances.
- Trial name
- NCT07278128
- Testing
- Patients (women of reproductive age suffering from non-alcoholic fatty liver with polycystic ovary syndrome) receiving 500 mg curcumin capsules (prepared from the extraction of turmeric in the laborat
- Where
- Iran
- Volunteers
- 74 people
- Sponsor
- Fateme Moshirenia
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