Clinical trials: PCOS (Polycystic Ovary Syndrome)
Polycystic Ovary Syndrome (PCOS), Obesity & Overweight
A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese
This clinical study examines whether tirzepatide can improve ovarian dysfunction in premenopausal women with polycystic ovary syndrome (PCOS) who are overweight or have obesity.
- Trial name
- PERIODS (NCT07326111)
- Testing
- Tirzepatide as an adjunct to lifestyle intervention
- Where
- 2 sites in Germany
- Volunteers
- 198 people
- Sponsor
- University of Bonn
Infertility
HRT Versus MOS for Endometrial Preparation Prior to FET in Non PCOS Patients
Evaluation of endometrial preparation using either hormonal therapy or ovarian stimulation prior to frozen-thawed embryo transfer (FET) in patients without polycystic ovarian syndrome (PCOS)
- Trial name
- NCT02330757
- Testing
- Estradiol valerate, Sequential Clomiphene citrate and Gonadotropin
- Where
- 2 sites in Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University
Polycystic Ovarian Syndrome (PCOS), Infertility
Theta Healing-Based Intervention in Women With Polycystic Ovary Syndrome
This randomized controlled study aims to evaluate the effect of a Theta Healing-based intervention on fertility concerns, self-compassion, and body image in women diagnosed with Polycystic Ovary Syndrome (PCOS).
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Infertility, Psychological Stress
- Trial name
- NCT07630441
- Testing
- Theta Healing-Based Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ankara Medipol University
Polycystic Ovary Syndrome, Anovulation
Short-term Structured Exercise Training Program Plus Diet Intervention in Patients With Polycystic Ovary Syndrome (PCOS)
Clomiphene citrate (CC) is the first-line therapy for infertile women with polycystic ovary syndrome (PCOS). Unfortunately, at least 20% of PCOS results are not responsive to CC.
- Trial name
- NCT01004068
- Testing
- SET-diet plus clomiphene, Clomiphene citrate, Structured exercise program plus hypocaloric diet
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- University Magna Graecia
Polycystic Ovary Syndrome
Letrozole or Combined Clomiphene Citrate Metformin as a First Line Treatment in Women With Polycystic Ovarian Syndrome
The purpose of this study is to compare and determine the efficacy of letrozole administration to that of combined metformin and Clomiphene in infertile women with polycystic ovary syndrome (PCOS) not treated before with any…
- Trial name
- PCO (NCT01679574)
- Testing
- Letrozole, Clomiphene, Metformin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
PCOS, Hyperandrogenism
Ultrasound Three-dimensional Characterization of Ovarian Morphology in Women With Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders occurring in women of reproductive age. PCOS is considered a syndrome of ovarian dysfunction that is characterized by the heterogeneous clinical…
- Trial name
- NCT02402413
- Testing
- Ultrasound, Determination of concentrations of androgens, Three dimensional ultrasound probe
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Infertility
Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneuploidy Rate and Developmental Potential
A single centre randomised controlled trial investigating the influence of a novel prematuration system (PMS) using a phosphodiesterase-3 inhibitor for in-vitro maturation of oocytes - pilot study.
- Trial name
- NCT00822874
- Testing
- prematuration culture
- Where
- Belgium
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Polycystic Ovary Syndrome (PCOS)
Effects of a Specific Dietary Program on Overweight/Obese Women With Polycystic Ovary Syndrome: A Multicenter, Prospective, Randomized Controlled Clinical Study
The goal of this clinical trial is to investigate the effects of a specific dietary program on overweight or obese patients with polycystic ovary syndrome (PCOS) through a multicenter, randomized, controlled, prospective study…
- Trial name
- NCT07350889
- Testing
- Specific dietary intervention group, Conventional intervention
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xuanwu Hospital, Beijing
Polycystic Ovary
Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome
The aim of this study is to compare the hormonal, metabolic and clinical effects of metformin and liraglutide in infertile women with PCOs.
- Trial name
- NCT05965908
- Testing
- liraglutide, Metformin
- Where
- Egypt
- Volunteers
- 183 people
- Sponsor
- Beni-Suef University
Polycystic Ovary Syndrome
Women With Polycystic Ovary Syndrome Have Increased Plasma Chitotriosidase Activity
In the present study, serum chitotriosidase activity and its relationship with insulin resistance were determined in patients with Polycystic Ovary Syndrome (PCOS).
- Trial name
- NCT01382576
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Polycystic Ovary Syndrome, Adolescent Behavior
Adolescent Polycystic Ovary Syndrome on a Low-carbohydrate Diet
The aim of the study was to investigate the changes in the clinical and biochemical parameters of adolescents on a low-carbohydrate diet in relation to their PCOS phenotype in the 3rd trimester.
- Conditions
- Polycystic Ovary Syndrome, Adolescent Behavior, Diet Habit
- Trial name
- PCOS (NCT06429618)
- Testing
- Low carbonhydrate diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Hyperandrogenism, Polycystic Ovary Syndrome
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone…
- Conditions
- Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
- Trial name
- CRM008 (NCT03068910)
- Testing
- Micronized progesterone, Spironolactone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Polycystic Ovary Syndrome, Overweight and Obesity
Research of Exenatide for Overweight/Obese PCOS Patients With IGR
Compare the therapeutic effects of exenatide, metformin and their combination for 3 months on reproductive and metabolic improvements of overweight/obese PCOS patients with impaired glucose regulation.
- Conditions
- Polycystic Ovary Syndrome, Overweight and Obesity, Disorder of Glucose Regulation
- Trial name
- NCT03352869
- Testing
- Exenatide, Metformin
- Where
- China
- Volunteers
- 183 people
- Sponsor
- RenJi Hospital
IVM, PCOS (Polycystic Ovary Syndrome)
Low vs. Air Oxygen Concentration CAPA-IVM Culture of Cumulus-oocyte Complexes
IVM with a pre-maturation step, known as capacitation IVM (CAPA-IVM), has demonstrated enhanced maturation of human oocytes in vitro and successful live births.
- Trial name
- NCT06087354
- Testing
- The way of Cumulus-oocyte complexes (COC) CAPA-IVM culture condition
- Where
- Vietnam
- Volunteers
- 20 people
- Sponsor
- Mỹ Đức Hospital
Polycystic Ovary Syndrome
71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women
An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies.
- Trial name
- 17b-ACO (NCT01372293)
- Testing
- oral contraceptive pill
- Volunteers
- 49 people
- Sponsor
- Federal University of Rio Grande do Sul
Infertility, Female
Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome
Polycystic ovary syndrome accounts for the vast majority of anovulatory symptoms and hyperandrogenism in women. The diagnosis of Polycystic ovary syndrome has life-long implications, with increased risk for infertility, metabolic…
- Trial name
- NCT03135301
- Testing
- letrozole plus metformin, letrozole
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Polycystic Ovary Syndrome
Incretin Effect in PCOS Women
This study investigates the incretin effect in women with polycystic ovary syndrome (PCOS) before and after removal of their insulin resistance by metformin.
- Trial name
- NCT01892254
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Insulin Sensitivity
Insulin Sensitivity and Testosterone Response to Aerobic Exercise Versus Added Sugar Elimination in Polycystic Ovary Syndrome Women
the aim of this study is to investigate the effect of aerobic exercise versus the effect of added sugar elimination on the insulin sensitivity and testosterone levels in females with polycystic ovarian syndrome via measuring the…
- Trial name
- NCT07139275
- Testing
- aerobic exercise, added sugar elimination, aerobic exercise and added sugar elimination
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Polycystic Ovarian Syndrome (PCOS)
Time Restricted Feeding Model in Women With Polycystic Ovary Syndrome
This study aims to evaluate the effects of a 16:8 time-restricted feeding (TRF) model on anthropometric, metabolic, and hormonal parameters in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT06807775
- Testing
- Dietary Intervention (time-restricted feeding model (16:8)), Dietary Intervention (energy restricted dietary intervention)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hyperandrogenism,, Polycystic Ovary Syndrome,
Presentations of Hyperandrogenic Phenotypes in Taiwanese Women
STUDY QUESTION: Which of the four abnormally elevated androgen groups (total testosterone [TT], androstenedione [A4], free androgen index [FAI], or dehydroepiandrosterone-sulfate [DHEA-S]) present with an unfavorable metabolic…
- Conditions
- Hyperandrogenism,, Polycystic Ovary Syndrome,, Metabolic Syndrome,, Insulin Resistance,
- Trial name
- NCT01940666
- Where
- Taiwan
- Volunteers
- 649 people
- Sponsor
- Taipei Medical University WanFang Hospital
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