Clinical trials: PCOS (Polycystic Ovary Syndrome)
Polycystic Ovary Syndrome
Letrozole Dose Increments in PCOS Patients Resistant to Letrozole
Objectives: To study the effect of Letrozole dose increments on ovulation rate and endometrial thickness as a primary outcomes in patients with polycystic ovary syndrome who previously resistant to letrazole conventional dose…
- Trial name
- NCT06403488
- Testing
- Letrozole 2.5mg
- Where
- 2 sites in Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Polycystic Ovary Syndrome
Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS
Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women of reproductive age and despite decades of research the etiology the disorder is not known.
- Trial name
- PULSE (NCT01482286)
- Testing
- Metformin, Dietary Restriction, Exercise Training
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Pennington Biomedical Research Center
Polycystic Ovary Syndrome (PCOS)
Investigation of the Effectiveness of Spinal Stabilization Exercises Added to Aerobic Exercise in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a multisystemic disorder with metabolic and endocrine implications, commonly observed in women of reproductive age and characterized by hyperandrogenism, ovulatory dysfunction, and polycystic…
- Trial name
- NCT07871851
- Testing
- Aerobic Exercise, Spinal Stabilization Exercise
- Volunteers
- 20 people
- Sponsor
- Inonu University
Polycystic Ovary Syndrome
Cardiovascular Risk Markers in Polycystic Ovary Syndrome (PCOS)
Women with polycystic ovary syndrome (PCOS) are more often overweight or obese and are more insulin resistant than women without the condition and may be at greater risk of developing cardiovascular disease.
- Trial name
- CS (NCT01195168)
- Where
- 2 sites in Ireland
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- The Adelaide and Meath Hospital
Polycystic Ovary Syndrome
The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists
Background: Brown adipose tissue (BAT) is a type of fat in the body. It may prevent weight gain, improve insulin sensitivity, and reduce fatty liver. Researchers want to see if BAT helps the body burn energy.
- Trial name
- NCT03049462
- Testing
- Mirabegron, B Complex Plus Vitamin C Tablets
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Polycystic Ovary Syndrome
Adipose Expression of Leptin, Adiponectin and IL-6 and Plasma Levels of Adipocytokines in Women With and Without Polycystic Ovary Syndrome (PCOS)
The purpose of the study was to investigate adipose expression and plasma levels of different adipocytokine, which may play a role in the pathophysiology of PCOS.
- Trial name
- NCT01088061
- Where
- Denmark
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Polycystic Ovary Syndrome
Changes in Pregnancy in Egyptian Women With History of Recurrent Miscarriage
Introduction: Elevated levels of androgen and insulin-resistant have been implicated in recurrent miscarriage in women with PCOS.
- Trial name
- NCT04960982
- Testing
- blood test
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Polycystic Ovary Syndrome
Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome is a frequent cause of abnormal menses and infertility. It has also been related to cardiovascular disease.
- Trial name
- NCT00679679
- Testing
- Metformin
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Privado de Cordoba, Argentina
Polycystic Ovary Syndrom, Metformin
PCOS Patients' Immune Alterations
In this study, the investigators will include PCOS patients and healthy women who meet the trial criteria from the clinical research centers of 3 hospitals, introduce the content of this study to participants, and invite…
- Conditions
- Polycystic Ovary Syndrom, Metformin, Immune Function
- Trial name
- NCT06325969
- Testing
- Detect the immune function of peripheral blood samples
- Where
- China
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Polycystic Ovary Syndrome
Vaginal Progesterone Supplementation in Women With PCOS Undergoing Ovulation Induction With Letrozole
Aromatase inhibitors such as letrozole are hypothesized to maintain normal hypothalamic/ pituitary feedback mechanisms and in the case of OI (ovulation induction) in women with PCOS, may act to increase follicular sensitivity to…
- Trial name
- NCT03440359
- Testing
- Progesterone Vaginal Gel 8%, Letrozole Oral Tablet, pelvic ultrasound
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Eastern Virginia Medical School
Pre Diabetes, Polycystic Ovary Syndrome
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
There is a growing need to develop pharmacologic interventions to improve metabolic function in women with polycystic ovary syndrome (PCOS).
- Conditions
- Pre Diabetes, Polycystic Ovary Syndrome, Obesity Android
- Trial name
- SAXAPCOS (NCT03480022)
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Woman's
Polycystic Ovary Syndrome
Study to Assess the Effect of Metformin Supplementation on IVF Outcome in Patients With Polycystic Ovarian Syndrome.
This study was performed to investigate the effects of metformin on controlled ovarian stimulation (COS), in vitro fertilization (IVF) outcomes, pregnancy outcomes, and comparison of serum and follicular fluid cytokines and…
- Trial name
- NCT03086005
- Testing
- Metformin
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Chung-Hoon Kim
Polycystic Ovary Syndrome
APA on Sleep Quality in Women With PCOS
Women with polycystic ovary syndrome (PCOS) appear to have an increased frequency of sleep problems. The aim of this study was to explore the effect of auricular point acupressure (APA) pressure on sleep quality in women with…
- Trial name
- NCT06009172
- Testing
- Auricular point acupressure (APA)
- Where
- China
- Volunteers
- 88 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Polycystic Ovary Syndrome
Berberine Phytosome for Signs and Symptoms of Polycystic Ovary Syndrome (PCOS)
This multicenter, randomized, controlled clinical trial aims to evaluate the effectiveness of berberine phytosome supplementation in improving signs and symptoms associated with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07465575
- Testing
- Berberine Phytosome (Sophy®), Lifestyle Advice
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Polycystic Ovary Syndrome
The University of Michigan PCOS Intervention Using Nutritional Ketosis
The goal of this proposal is to pilot test our existing very-low carbohydrate diet intervention, adapted for women with PCOS.
- Trial name
- NCT03987854
- Testing
- diet and lifestyle program
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Michigan
Voice Change
Voice Analysis in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to one in five reproductive-aged women. It is associated with clinical and/or biochemical hyperandrogenism, oligomenorrhea, and polycystic appearance of…
- Trial name
- NCT06085170
- Testing
- Acoustic Analysis by MDVP
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Minia University
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Obese
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
Girls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss…
- Trial name
- RESTORE (NCT05819853)
- Testing
- Semaglutide Injectable Product (Wegovy and/or Ozempic)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Polycystic Ovary Syndrome, Anovulation
LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents
PCOS is a complex disease that is diagnosed by the presence of two of the following three: oligo/anovulation, clinical and/or biochemical hyperandrogenism, or polycystic ovaries by ultrasound .
- Trial name
- NCT04325295
- Testing
- Laparoscopic ovarian drilling, Recombinant FSH (rFSH)
- Volunteers
- 200 people
- Sponsor
- Assiut University
Polycystic Ovary Syndrome, Hyperinsulinism
Effects Of Combined Cryolipolysis And High Intensity Interval Training On Insulin Resistance And Body Composition In Polycystic Ovarian Patients
this study will be carried to investigate the effect of cryolipolysis and high intensity interval training on insulin resistance and body composition in pco women
- Trial name
- NCT04744896
- Testing
- cryolipolysis(3 max cool shaping), Treadmill (jkexer focus 8020A)
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity & Overweight, Diabetes Mellitus, Type 2
Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks
This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects…
- Conditions
- Obesity & Overweight, Diabetes Mellitus, Type 2, Hypertension, Non-alcoholic Fatty Liver Disease (MASLD)
- Trial name
- NCT07884903
- Testing
- No intervention; observational assessment only
- Where
- China
- Volunteers
- 25,974 people
- Sponsor
- Shanxi Bethune Hospital
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