Clinical trials: PCT
Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Blasts 5 Percent or More of Bone Marrow Nucleated Cells
Inotuzumab Ozogamicin and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory CD22+ B-cell Acute Lymphoblastic Leukemia
This phase Ib/II trial studies side effects and best dose of inotuzumab ozogamicin and how well it works when given together with vincristine sulfate liposome in treating patients with CD22 positive (+) B-cell acute lymphoblastic…
- Conditions
- Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Blasts 5 Percent or More of Bone Marrow Nucleated Cells, Blasts 5 Percent or More of Peripheral Blood White Cells, CD22 Positive
- Trial name
- NCT03851081
- Testing
- Inotuzumab Ozogamicin, Quality-of-Life Assessment, Vincristine Sulfate Liposome
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Sepsis
Use of Procalcitonin, a Blood Test to Guide Antibiotic Therapy for Sepsis in Adults
Trial design: Randomised controlled, two-arm, parallel, clinical trial to assess the efficacy and safety of sequential daily procalcitonin assessments to guide de-escalation of empirical antibiotic therapy in adult patients with…
- Trial name
- PROCALBAN (NCT05955612)
- Testing
- Procalcitonin measurement
- Where
- Bangladesh
- Volunteers
- 532 people
- Sponsor
- University of Oxford
Essential Hypertension.
Inflammatory Response to Salt in Essential Hypertension
Salt is a main environmental risk factor involved in atherosclerotic complications and in the high risk of a variety of cardiovascular (CV) diseases including hypertension, left ventricular hypertrophy (LVH), chronic kidney…
- Trial name
- NCT01665534
- Testing
- High salt intake
- Volunteers
- 32 people
- Sponsor
- Carmine Zoccali
Sepsis, Pre-Eclampsia
Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.
Procalcitonin is a protein consisting of 116 amino-acids which can rapidly rise under inflammatory conditions and sepsis. More than 20 years ago it has been shown that dipeptidylpeptidase-4 (DPP-4) cleaves procalcitonin from the…
- Conditions
- Sepsis, Pre-Eclampsia, Granulomatosis With Polyangiitis, Microscopic Polyangiitis
- Trial name
- NCT05703802
- Testing
- Procalcitonin-variants ELISA-Assay
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Fever
Procalcitonin in Fever of Unknown Etiology
The purpose of this study is to determine whether new blood test (procalcitonin) can help to reduce unnecessary use of antibiotics in patients with unexplained fever.
- Trial name
- NCT00398775
- Testing
- antibiotic discontinuation
- Where
- Singapore
- Volunteers
- 90 people
- Sponsor
- Changi General Hospital
Infection
PCT and Clinical Algorithm for Determination of Duration of Antibiotics
Patients in the ICU whose infection is resolving will be randomized to standard duration of antibiotics compared to duration determined by a combination of a procalcitonin value and a simple evaluation of clinical status.
- Trial name
- NCT01572831
- Testing
- PCT and clinical algorithm for stopping abx
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Fraser Health
Sepsis
Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial)
MODIFY is a randomized, open-labeled, and prospective study that will be conducted in multiple Intensive Care Units (ICUs) and departments of Internal Medicine across Greece.
- Trial name
- MODIFY (NCT05909683)
- Testing
- Change of antimicrobials based on BCID2 and Reveal Rapid AST tests. Stop of antimicrobials based on PCT results., Standard of Care
- Where
- 15 sites in Greece
- Volunteers
- 190 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Bacterial Infections, Children, Only
Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels
Recently, it has been seen that investigations from saliva samples could be an alternative to those from blood samples. Saliva collection is a simple, non-invasive, cost-effective, and relatively easy method, making it…
- Conditions
- Bacterial Infections, Children, Only, Procalcitonin, Saliva
- Trial name
- NCT06354205
- Testing
- Sliva Procalcitonin
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Ege University
Sepsis
Procalcitonin in Diagnosis of Bacterial Infections in Young Infants
A diagnostic accuracy study investigating the accuracy of procalcitonin in diagnosing invasive bacterial infections in your infants.
- Trial name
- NCT03509727
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- Belfast Health and Social Care Trust
Diabetic Foot Ulcers (DFUs), Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer)
Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound Healing
This study is a prospective, randomized controlled trial designed to evaluate the effectiveness of Miro3D Wound Matrix plus Standard of Care (SOC) compared to SOC alone in treating Wagner Grade 1 diabetic foot ulcers (DFUs) and…
- Trial name
- STRIDDDE (NCT06939686)
- Testing
- Miro3D Wound Matrix, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Reprise Biomedical, Inc.
Infection
NEWS2+Procalcitonin Association in Patients With Infection and Its Significance in Oncological Patients
This observational study aims to evaluate the prognostic significance of the combination of a clinical score (specifically, a score obtained through the measurement of multiple parameters such as blood pressure, body temperature…
- Trial name
- NCT06761118
- Where
- Italy
- Volunteers
- 1,041 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sepsis, Osteoporotic Hip Fracture
Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW)
Hip fracture is a common injury in older adults and is often associated with serious complications, longer hospital stays, and increased risk of death.
- Conditions
- Sepsis, Osteoporotic Hip Fracture, Hip Fracture
- Trial name
- MDW (NCT07350785)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Acute Kidney Injuries
the Percent of AKI Occurred in Patient With Comorbidities Undergoing Colonoscopy
observation the percent AKI in patient with comorbidities undergoing colonoscopy
- Trial name
- NCT06743815
- Volunteers
- 113 people
- Sponsor
- Assiut University
Ventilator Acquired Pneumonia
Procalcitonin Versus Serum Zinc for Diagnosis of Ventilator-Associated Pneumonia in ICU Patients
Ventilator-associated pneumonia (VAP) is a common and serious infection among mechanically ventilated ICU patients. Early diagnosis remains challenging because clinical and radiological findings may lack specificity.
- Trial name
- PROZINC-VAP (NCT07696897)
- Testing
- Serum Procalcitonin Measurement, Serum Zinc Measurement
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Sohag University
Sepsis, Procalcitonin
Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
The timely use of antibiotics can reduce morbidity and mortality associated with bacterial infections, particularly in the intensive care unit setting (ICU).
- Conditions
- Sepsis, Procalcitonin, Antimicrobial Stewardship
- Trial name
- ProPICU (NCT03440918)
- Testing
- Procalcitonin-Guided Antimicrobial Stewardship, Baseline Antimicrobial Stewardship
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Vanderbilt University Medical Center
Pneumonia
Procalcitonin at Zero and 24 Hours as a Prognostic Factor in Patients With Pneumonia
Procalcitonin levels checked initially and at 24 hours will correlate with disease severity, morbidity, and mortality. Patients who have a higher procalcitonin level initially and at 24 hours will likely have higher qSOFA scores…
- Trial name
- NCT03711227
- Testing
- Procalcitonin lab test
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- Corewell Health South
Sepsis
Procalcitonin-Guided Antimicrobial Discontinuation
The current study aims to validate the diagnostic use of PCT assessing its capability to individualize and shorten the duration of antibiotic therapy in critically ill patients with suspected or confirmed sepsis.
- Trial name
- NCT00250666
- Testing
- PCT measurement
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University Hospital, Geneva
Intraventricular Hemorrhage, Intracerebral Hemorrhage
The Natural History of Procalcitonin in Hemorrhagic Stroke
Approximately 12% of strokes in the United States are hemorrhagic.1 Hemorrhagic stroke can lead to multiple complications including fever that is not infectious.
- Trial name
- NCT01498705
- Testing
- Procalcitonin level
- Where
- United States
- Sponsor
- CAMC Health System
Acute Myeloid Leukemia, Blasts 20 Percent or More of Bone Marrow Nucleated Cells
Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome
This phase I/II trial studies the side effects and how well cladribine, idarubicin, cytarabine, and quizartinib work in treating patients with acute myeloid leukemia or high-risk myelodysplastic syndrome that is newly diagnosed…
- Conditions
- Acute Myeloid Leukemia, Blasts 20 Percent or More of Bone Marrow Nucleated Cells, High Risk Myelodysplastic Syndrome, Recurrent Acute Biphenotypic Leukemia
- Trial name
- NCT04047641
- Testing
- Cladribine, Cytarabine, Idarubicin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University