Clinical trials: PERIODONTAL DISEASE
Peri-implantitis, Peri-Implant Health
Reconstructive Therapy for Peri-implantitis Using Tuberosity Bone with or Without Electrolytic Cleaning: a Randomized Clinical Trial
This study aims to evaluate the effectiveness of two surgical approaches for managing peri-implantitis, a condition characterized by inflammation and bone loss around dental implants.
- Conditions
- Peri-implantitis, Peri-Implant Health, Peri-Implantational Loss, Peri-Implantation Loss
- Trial name
- NCT06708247
- Testing
- Standard Peri-implant Reconstructive Surgery, Electrolytic Cleaning with Peri-implant Reconstructive Surgery
- Where
- Lithuania
- Volunteers
- 31 people
- Sponsor
- Vilniaus Implantologijos Centro (VIC) Klinika
Cystectomy, Segmental Growing of Alveolar Tissue
Study of Collagen Membrane in Guided Bone Regeneration
The main purpose of this study is to investigate the efficacy of Hypro-Sorb® F, a bilayered bioabsorbable membrane in inducing bone regeneration in different dental procedures requiring GBR.
- Conditions
- Cystectomy, Segmental Growing of Alveolar Tissue, Sinus Lift, Root Amputation and Apicoectomy
- Trial name
- GBR (NCT00454038)
- Testing
- HYPRO SORB F
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Edentulous Jaw, Missing Teeth
The Effect of a Suturing Technique on the Gingival Tissues Around Dental Implants
There is general agreement that a thick zone of the keratinized tissues around implants promotes accurate prosthetic procedures, permits oral hygiene maintenance, resists recession, and enables esthetic blending with surrounding…
- Conditions
- Edentulous Jaw, Missing Teeth, Gingival Diseases
- Trial name
- NCT06496776
- Testing
- Choukroun's technique
- Where
- Syria
- Volunteers
- 14 people
- Sponsor
- Damascus University
Gingival Recession
Evaluation of Cyanoacrylate as an Alternative to Sutures in Free Gingival Graft Stabilization
Free gingival graft (FGG) is a widely used periodontal plastic surgery technique for treating gingival recession, increasing keratinized gingiva width, and enhancing peri-implant soft tissues.
- Trial name
- NCT06821984
- Testing
- FGG secured using cyanoacrylate tissue adhesive without sutures.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Chronic Periodontitis, Coronary Artery Disease
Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further.
- Conditions
- Chronic Periodontitis, Coronary Artery Disease, miRNA
- Trial name
- NCT04583085
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Gingival Recession
MCAF and EMD With and Without CTG Wall Technique for the Treatment of Class III and IV Gingival recessions-a Randomized Control Trial
Research is to compare and evaluate the clinical outcomes of the Connective tissue graft wall technique with modified coronally advanced flap to improve root coverage and clinical attachment levels in Miller's class III and IV…
- Trial name
- NCT06525285
- Testing
- Connective tissue graft wall technique
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontal Pocket, Impacted Third Molar Tooth
Evaluation of Two Different Grafting Techniques After Mandibular Impacted Third Molar Surgery
This study evaluates the effectiveness of using Mineralized Plasmatic Matrix and β-tricalcium phosphate that placed to extraction socket as a graft material in terms of periodontal damage occurred in the distal aspect of the…
- Conditions
- Periodontal Pocket, Impacted Third Molar Tooth, Impacted Teeth With Abnormal Position
- Trial name
- NCT04366635
- Testing
- Impacted third molar surgery, Application of mineralised plasmatic matrix, Application of β-tricalcium phosphate
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Furcation Defects
Effect of Two Irrigation Protocols Applied Prior to Furcation Repair
Perforations are mishaps that might occur during the course of endodontic treatment mainly due to iatrogenic factors. However, they might also occur due to extensive decay of dentinal structure.
- Trial name
- NCT06757660
- Testing
- Furcation Repair
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Peri-Implantitis, Periodontitis
Macrophage Markers in Periodontal and Peri-implant Health and Disease
Macrophage surface markers (CD80, CD163 and CD206) will be evaluated in periodontally healthy gingiva, healthy peri-implant mucosa, and periodontitis and peri-implantitis lesions.
- Trial name
- NCT05242354
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biruni University
Periodontitis
The Influence of Porcelain Fused to Metal ( PFM) and Zirconia Crowns on Periodontal Health
Investigate the influence of the crown tye Porcelain fused to metal or Zirconia on periodontal health.
- Trial name
- NCT02461823
- Testing
- Zirconia crown, Porcelain metal crown
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Tobacco Use, Periodontitis
Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden
Smoking and dual using associated with poor periodontal health.
- Trial name
- NCT03918902
- Testing
- Qestinnaires
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Apical Periodontitis
Effect of Passive Ultrasonic Irrigation Versus Needle Irrigation on Postoperative Pain and Periapical Healing
The aim of this study is to compare the effect of passive ultrasonic irrigation versus needle irrigation on post-operative pain and healing in patients with permanent posterior teeth with apical periodontitis treated in a single…
- Trial name
- NCT02913937
- Testing
- Passive ultrasonic irrigation, Endodontic needle
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Periodontal Diseases
The Influence of Local Antibiotic Therapy on the Outcomes Following Periodontal Regeneration Procedures.
Assessmnet of the influence of local antibiotic therapy on the clinical, radiological, microbiological parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) following periodontal regeneration…
- Trial name
- ANBperio (NCT07027137)
- Testing
- SRP+ANB+SURG, SRP+SURG
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Bialystok
Tooth Loss
3D Analysis of Peri-implant Soft Tissue with Two Different Connection Types
Objectives: assessment of dimensional soft tissues change after single tooth gap implantation with a closed healing approach and using conical and butt-joint implant-abutment connection type.
- Trial name
- NCT06627023
- Testing
- Implant Placement with Conical or Butt-Joint Connection
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Charite University, Berlin, Germany
Periodontitis (Stage 3), Smoking
Determination of RNA/DNA Damage Associated With Oxidative Stress in Periodontitis Patients
This study looked at whether a type of gum disease called Stage III periodontitis and cigarette smoking are linked to higher levels of "oxidative stress." Oxidative stress can damage DNA and RNA, which are important parts of our…
- Trial name
- NCT07279896
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Zehra Hasgül
Osteoporosis, Osteopenia
Periodontal Disease and Post-menopausal Osteoporosis
The aim of this study was to investigate the levels of RANKL and Osteoprotegerin, and their relationship in gingival crevicular fluid of post-menopausal women with osteoporosis/osteopenia and chronic periodontitis simultaneously…
- Conditions
- Osteoporosis, Osteopenia, Periodontal Disease
- Trial name
- NCT02184962
- Where
- Argentina
- Volunteers
- 81 people
- Sponsor
- Universidad Nacional de Córdoba
Periodontitis
Evaluation of the Effects of Immune Cells on Periodontal Healing
Periodontitis is an inflammatory disease with an infectious character, where, as the result of the host response to a dysbiotic microflora, attachment and bone loss occur.
- Trial name
- EMTA (NCT04792372)
- Testing
- Initial periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Biruni University
Peri-implantitis, Soft Tissue Augmentation at Dental Implants
Adjunctive Keratinized Mucosa Augmentation in Peri-Implantitis
This study aims to increase the width and thickness of peri-implant keratinized mucosa (KM) by transferring a properly dimensioned free gingival graft (FGG) from the palatal donor site and to evaluate its effect as an adjunctive…
- Trial name
- NCT07471386
- Testing
- Submucosal debridman + saline irrigation, Free gingival graft surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Edentulism, Tooth Loss
Mandibular Biological Drilling at Different Speeds for Dental Implant Placement
This randomized controlled clinical trial aims to evaluate the effect of different biological drilling speeds (50, 150, and 300 rpm) during implant osteotomy preparation in the mandible on marginal bone level changes and implant…
- Trial name
- NCT07474454
- Testing
- biological drilling at 50 RPM, biological drilling at 150 RPM, biological drilling at 300 RPM
- Volunteers
- 39 people
- Sponsor
- Cairo University
Periodontitis, Type 2 Diabetes Mellitus
Diagnostic Biomarkers Related to Periodontal Disease Activity in Diabetic
The purpose of the study was to monitor the activity of periodontal disease and suggest potential biomarkers related to active periodontal disease in patients with chronic periodontitis (PD) associated or not with type 2 diabetes…
- Trial name
- NCT02220751
- Testing
- non-surgical periodontal therapy + systemic doxycycline, Non-surgical periodontal therapy
- Where
- Brazil
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo