Clinical trials: PERIPHERAL VASCULAR DISEASE
Peripheral Artery Disease
Walking Impairment Questionnaire in PAD
Purpose is to test and validate a new questionnaire (the WELCH questionnaire) to estimate walking capacity in patients with claudication
- Trial name
- WELCH (NCT01114178)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 340 people
- Sponsor
- University Hospital, Angers
Multiple Myeloma
Escalating Doses of Thalidomide in Conjunction With Bortezomib and HIgh Dose Melphalan for BSCT
The primary objective of this study is to: Determine the maximum tolerated dose of thalidomide used in conjunction with dose-intense melphalan, bortezomib and autologous (syngeneic) HSC support in the salvage therapy of patients…
- Trial name
- Thal/Mel/Vel (NCT01242267)
- Testing
- Thalidomide+Melphalan +Bortezomib+stem cell transplant
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Hackensack Meridian Health
Sarcopenia, Body Composition
CT Body Composition as Predictor of Exercise Therapy Outcome in Peripheral Arterial Disease
Supervised exercise therapy (SET) is the recommended first treatment for patients with leg artery disease (peripheral arterial disease, PAD) causing pain when walking.
- Conditions
- Sarcopenia, Body Composition, Sarcopenic Obesity, Peripheral Arterial Disease
- Trial name
- COMPOSE-PAD (NCT07433309)
- Testing
- SET physiotherapy, CT scan
- Volunteers
- 128 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Ischemic Stroke, Peripheral Artery Disease
Diabetic Artery Obstruction: is it Possible to Reduce Ischemic Events With Cilostazol?
Investigation of the clinical efficacy and safety of dual antiplatelet therapy with clopidogrel and cilostazol versus clopidogrel alone in preventing ischemic vascular events in patients with type 2 diabetes and symptomatic…
- Conditions
- Ischemic Stroke, Peripheral Artery Disease, Diabetes Mellitus, Type 2
- Trial name
- DORIC (NCT02983214)
- Testing
- Clopidogrel, Cilostazol
- Where
- Greece
- Volunteers
- 826 people
- Sponsor
- University of Ioannina
Peripheral Arterial Disease
Ticagrelor and Peripheral Arterial Disease
This is an interventional study assessing the effectiveness of Ticagrelor on the reduction of thrombus burden using optical coherence tomography in patients undergoing peripheral artery stenting.
- Trial name
- NCT02407314
- Testing
- Percutaneous Peripheral Intervention, Optical Coherence Tomography, Ankle Brachial Index
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Arkansas Heart Hospital
Dyslipidemia, Atherosclerosis
Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT)
Dyslipidaemia is characterized by low plasma levels of high-density lipoprotein cholesterol (HDL-c), elevated triglycerides and an increase in low density lipoprotein (LDL-c) particles, and has been unequivocally established as a…
- Trial name
- NASCIT (NCT00712049)
- Testing
- simvastatin, Nicotinic Acid
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Raynaud Disease, Scleroderma, Systemic
Laser Speckle Contrast Imaging for Cutaneous Microvascular Dysfunction Detection in Systemic Sclerosis.
The aim of the study is to determine if postocclusive hyperemia of palmar and dorsal face of the hand with Laser speckle contrast imaging discriminate between patients with systemic sclerosis, subjects with primary Raynaud's…
- Trial name
- SPECIES (NCT01743612)
- Testing
- laser speckle contrast imaging, Cooling
- Where
- 2 sites in France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Diabetic Neuropathies, Distal Peripheral Sensory Neuropathy
Diabetic Neuropathy Screening Study 1.1 + Substudy 1.2-1.3-1.4
The overall objective of this project is to describe the prevalence of and risk factors to diabetic neuropathy in a representative cohort of diabetes patients and to investigate pathophysiological conditions in those patients…
- Conditions
- Diabetic Neuropathies, Distal Peripheral Sensory Neuropathy, Diabetic Foot, Foot Deformities
- Trial name
- DANES (NCT05043636)
- Testing
- Vagus, HeartsTrends, Sudoscan
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Peripheral Vascular Disease
Effects of Paclitaxel on Intimal Hyperplasia
This is a single, one time, limited dose infusion of Paclitaxel, that will potentially prevent recurrent stenosis secondary to intimal hyperplasia when compared to the control group at 10 months.
- Trial name
- Pac1 (NCT01454778)
- Testing
- Paclitaxel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Patrick Kelly
Breast Cancer, Chronic Myeloproliferative Disorders
Campath-1H + FK506 and Methylprednisolone for GVHD
RATIONALE: Alemtuzumab, tacrolimus, and methylprednisolone may be an effective treatment for graft-versus-host disease caused by a donor stem cell transplant.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00109993
- Testing
- alemtuzumab, methylprednisolone, tacrolimus
- Where
- 6 sites in United States
- Volunteers
- 34 people
- Sponsor
- Case Comprehensive Cancer Center
Chronic Limb Threatening Ischemia
Referrals for CLTI: Qualitative Study
The goal of this qualitative study is to explore the experiences of patients who have been diagnosed with chronic limb-threatening ischaemia (CLTI).
- Trial name
- NCT05659004
- Testing
- Qualitative interview
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Hull
Peripheral Arterial Disease, Angina
Ranolazine Versus Placebo Effects on Exercise Tolerance in Patients With Heart Disease and Peripheral Arterial Disease
After 6 weeks of maximal Ranolazine therapy, tissue hemoglobin desaturation kinetics will change compared to placebo in patients with chronic angina and peripheral arterial disease.
- Trial name
- NCT00657514
- Testing
- Ranolazine
- Where
- 3 sites in United States
- Sponsor
- Colorado Prevention Center
Critical Limb Ischemia
Registry of First-line Treatments in Patients With Critical Limb Ischemia
The principal research question is which treatment modality between open surgical, endovascular and conservative therapy is the most effective in terms of limb salvage, survival and reinterventions in patients with critical limb…
- Trial name
- CRITISCH (NCT01877252)
- Testing
- Surgical revascularization, Endovascular revascularization, No vascular intervention
- Where
- Germany
- Volunteers
- 1,200 people
- Sponsor
- St. Franziskus Hospital
Meningioma, Glioblastoma
Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures
This pilot clinical study evaluates the safety and imaging performance of panitumumab-IRDye800 (pan800), a fluorescent, EGFR-targeted imaging agent - in patients undergoing neurosurgical resection of intracranial lesions.
- Conditions
- Meningioma, Glioblastoma, Acoustic Neuroma, Brain Cancer
- Trial name
- NCT07493447
- Testing
- Panitumumab-IRDye800
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eben Rosenthal
Deep Vein Thrombosis, Iliac Vein Thrombosis
Anticoagulant Plus Antiplatelet Therapy Following Iliac Vein Stenting
To evaluate the efficacy and safety of combination of anticoagulant and antiplatelet therapy on the patency of iliac vein at 12-month post stenting in patients with acute proximal DVT and ipsilateral iliac vein stenosis who…
- Conditions
- Deep Vein Thrombosis, Iliac Vein Thrombosis, Iliac Vein Obstruction, Iliac Vein Stenosis
- Trial name
- NCT04694248
- Testing
- Rivaroxaban, Aspirin
- Where
- China
- Volunteers
- 172 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Fabry Disease
Prevalence and Characteristics of Fabry Disease (FD) in Patients With Stroke or Small Fiber Neuropathy
FD is pan-ethnic. Its reported annual incidence of 1 in 100,000 may underestimate the true prevalence of the disease. Indeed, recently, in addition with affected males FD developing a "classic" phenotype, " cardiac variant " and…
- Trial name
- FABRY (NCT03230149)
- Testing
- Measurements of the alpha-GAL enzyme activity
- Where
- France
- Volunteers
- 379 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Limping
High Resolution IR Imaging for Diagnosis in the Acute Limping Child - ThermLimp
A variety of different diseases may cause a limp in a child, and in younger children it is particularly challenging to isolate the area affected.
- Trial name
- Thermlimp (NCT03312348)
- Testing
- Infrared imaging
- Volunteers
- 30 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Peripheral Arterial Disease
Smartstep Smartphone PAD
The study aim is to evaluate the effectiveness of a coached, smartphone-enabled exercise program versus physician directed exercise therapy (usual care).
- Trial name
- SMARTSTEP (NCT03479255)
- Testing
- Smartphone-enabled structured exercise therapy (SE-SET), Standard exercise therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Emory University
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
Monoclonal Antibody Therapy Before Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoid Malignancies
This phase I trial studies the side effects and best dose of monoclonal antibody therapy before stem cell transplant in treating patients with relapsed or refractory lymphoid malignancies.
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma
- Trial name
- NCT01678443
- Testing
- indium In 111 anti-CD45 monoclonal antibody BC8, yttrium Y 90 anti-CD45 monoclonal antibody BC8, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Fred Hutchinson Cancer Center
Stroke, Complex Regional Pain Syndrome
Contrast Compression Therapy for Post-Stroke Complex Regional Pain Syndrome
This study aims to evaluate the effectiveness of contrast compression therapy as an adjunct to conventional rehabilitation in patients diagnosed with complex regional pain syndrome (CRPS) following stroke.
- Conditions
- Stroke, Complex Regional Pain Syndrome, Hemiplegia
- Trial name
- NCT07062913
- Testing
- Conventional Rehabilitation, Contrast Compression Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Meltem Gunes Akinci
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