Clinical trials: PET-CT
Prostate Cancer
Digital PET/CT Using [Ga-68]PSMA vs. [F-18]NaF for Evaluation of Osseous Metastatic Involvement in Prostate Cancer Patients
The purpose of this study is to evaluate a radioactive diagnostic study drug, which is called Gallium-68 Prostate Specific Membrane Antigen ([Ga-68]PSMA) for detection of bone metastasis in patients with prostate cancer.
- Trial name
- NCT05527483
- Testing
- [68Ga]PSMA, Flourine-18 [F-18] Sodium Fluoride (NaF), PET/CT
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University Hospitals Cleveland Medical Center
Pancreatic Cancer
68Ga-FAPI-FS PET/CT and PET/MR in Pancreatic Cancer
This is a preliminary study of 68Ga-FAPI-FS PET/CT or PET/MR in patients with confirmed or suspicious pancreatic cancer. The goal is to determine the safety, biodistribution, and tumor uptake of 68Ga-FAPI-FS.
- Trial name
- NCT05875753
- Testing
- 68Ga-FAPI-FS PET/CT
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Prostate Cancer, Prostate Adenocarcinoma
Multi-modality Imaging (PCa) Using Sodium MRI and PSMA PET in Men Pre-prostatectomy
The study is a non-randomized, prospective trial of men scheduled for radical prostatectomy for treatment of prostate cancer as standard of care and will undergo a series of pre-operative multi-modality imaging studies.
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Neoplasm
- Trial name
- IGPC-5 (NCT04053842)
- Testing
- PET Scan, [18F]PSMA-1007 Injection, Sodium MRI
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Glenn Bauman
Malignant Neoplasm of Oropharynx Stage III, Malignant Neoplasm of Larynx Stage III
Dose Escalation Versus Standard in Laryngopharyngeal Cancers
The primary objective of the study is to establish the safety of using a moderate escalation of radiotherapy dose in advanced/poor prognosis OPC and LH cancers receiving curative radiotherapy.
- Conditions
- Malignant Neoplasm of Oropharynx Stage III, Malignant Neoplasm of Larynx Stage III, Malignant Neoplasm of Hypopharynx Stage III, Malignant Neoplasm of Oropharynx Stage IVa
- Trial name
- INTELHOPE (NCT02757222)
- Testing
- Escalated Dose, Standard Dose
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Tata Medical Center
Prostate Cancer
Prostate MRI and Pylarify PSMA PET/CT
This is a voluntary research study to find out how using technology including advanced magnetic resonance imaging (MRI) and prostate-specific membrane antigen - positron emission tomography (PSMA-PET) scan imaging, in addition to…
- Trial name
- NCT05568537
- Testing
- Pylarify Piflufolastat Flourine-18 (18F-DCFPyL)
- Sponsor
- Corewell Health East
Alzheimer Disease, Dementia
A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese Population
This is a bridging study to visually and quantitatively assess PET images obtained after single application of 300 MBq [18F]florbetaben and PET scanning of patients with Alzheimer disease.
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT05527288
- Testing
- Drug: [18F]florbetaben
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sinotau Pharmaceutical Group
Carcinoma, Sarcoma
PET Imaging of Cancer Patients Using [18F]-SKI-249380, a Radiolabeled Dasatinib-Derivative
This study is the first time that a new experimental drug called [18F]-SKI-249380 is being used in people. [18F]-SKI-249380 is not a therapeutic drug.
- Conditions
- Carcinoma, Sarcoma, Myeloma, Lymphoma
- Trial name
- NCT01916135
- Testing
- [18F]-SKI-249380, PET/CT scan, Blood draws
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Post Traumatic Stress Disorder
A Pilot Study of Deep Brain Stimulation of the Amygdala for Treatment-Refractory Combat Post-Traumatic Stress Disorder
The purpose of this study is to determine whether deep brain stimulation of the basolateral nucleus (BLn) of the amygdala, on both sides of the brain, can safely reduce symptoms of post-traumatic stress disorder (PTSD) in combat…
- Trial name
- ADIP (NCT01658748)
- Testing
- Week 0 Medtronic 3387 electrodes/Activa PC amygdala DBS, Week 12 Medtronic 3387 electrodes/Activa PC amygdala DBS
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Rheumatoid Arthritis
68Ga-BNOTA-PRGD2 PET/CT in Patients With Rheumatoid Arthritis
This is an open-label positron emission tomography/computed tomography ( PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-BNOTA-PRGD2 in rheumatoid arthritis (RA) patients.
- Trial name
- GRGDRA (NCT01940926)
- Testing
- 68Ga-BNOTA-PRGD2
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Natural Killer/T-cell Lymphoma
GELAD-Based Response-Adapted Treatment for Early-Stage Extranodal NK/T-Cell Lymphoma
This prospective, multicenter study evaluates a response-adapted treatment strategy for previously untreated patients with early-stage extranodal NK/T-cell lymphoma of the upper aerodigestive tract.
- Trial name
- NCT07768943
- Testing
- Gemcitabine (GEM), Etoposide Injection, Dexamethasone
- Where
- China
- Volunteers
- 620 people
- Sponsor
- Fudan University
HER2-positive Breast Cancer, Recurrent Breast Cancer
PET/CT in Evaluating Response to Chemotherapy in Patients With Breast Cancer
This phase I trial studies the side effects of positron emission tomography (PET)/computed tomography (CT) in evaluating response to chemotherapy in patients with breast cancer.
- Conditions
- HER2-positive Breast Cancer, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer
- Trial name
- NCT01712815
- Testing
- laboratory biomarker analysis, pharmacological study, questionnaire administration
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Southern California
AD, DM
The Mechanism Study of Diabetic Pancreatic Amyloid Deposition on Cognitive Dysfunction in Alzheimer's Disease
Alzheimer's disease (AD) is closely related to diabetes (DM). DM will aggravate the progression of AD, but the specific mechanism has not yet been clarified.
- Conditions
- AD, DM, PET-CT
- Trial name
- NCT05372458
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Hodgkin Lymphoma
Tailored Therapy for Hodgkin Lymphoma Using Early Interim Therapy PET for Therapy Decision.
Recently published studies demonstrated very high event free survival for patients with a normal interim PET/CT and a high hazard ratio for progression of an interim positive (pathological)study.
- Trial name
- NCT00392314
- Testing
- PET/CT post 2 cycles of chemotherapy
- Where
- Israel
- Volunteers
- 365 people
- Sponsor
- Rambam Health Care Campus
Post-Acute COVID-19, Post-Acute COVID-19 Infection
68Ga-FAPI PET/CT to Detect Ongoing Fibroblast Activity in Post-acute COVID-19
The goal of this observational study is to investigate the role fibroblasts play in the persistent respiratory complaints after a COVID-19 infection.
- Conditions
- Post-Acute COVID-19, Post-Acute COVID-19 Infection, Post-Acute COVID-19 Syndrome, Pulmonary Fibrosis
- Trial name
- FAPI CLIMATE (NCT05981885)
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- University Medical Center Groningen
Atherosclerotic Cardiovascular Disease
Proof of Mechanism Study of MLN1202 on Atherosclerotic Inflammation in Participants With Stable Atherosclerotic Cardiovascular Disease
The purpose of this study is to evaluate the effect of MLN1202 on arterial inflammation in participants with stable atherosclerotic cardiovascular disease (CVD) who are receiving standard-of-care (SOC) therapy.
- Trial name
- NCT02388971
- Testing
- MLN1202
- Sponsor
- Takeda
Gastrointestinal Cancer
Fibroblast Activation Protein Inhibitor PET/CT Imaging in Malignant Tumor of Digestive System
The purpose of this single center prospective study is to assess the value of FAPI PET imaging in predicting early postoperative recurrence of malignant tumor of digestive system and to evaluate the diagnostic performance of FAPI…
- Trial name
- NCT05420558
- Testing
- Fibroblast activation protein inhibitor PET/CT imaging
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongnan Hospital
Breast Cancer
Test - Retest Reproducibility of 18F Fluoroestradiol (FES) PET
This study will formally address the hypothesis that FES-PET/CT measurement of ER expression predicts clinical benefit of first-line endocrine therapy in newly diagnosed ER+ metastatic breast cancer patients and establishes the…
- Trial name
- NCT03065712
- Testing
- F-18 Fluoroestradiol, Computed Tomography, Positron Emission Tomography
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Prostate Cancer, Prostate Cancer Metastatic
Clinical Use of 68Ga PSMA-11 PET/CT in Diagnosing, Staging and Restaging Prostate Cancer
The purpose of this protocol is to provide 68Ga Prostate Specific Membrane Antigen-11 (68Ga PSMA-11) for clinical use in the diagnosis, staging and restaging of prostate cancer using Positron Emission Tomography with Computed…
- Conditions
- Prostate Cancer, Prostate Cancer Metastatic, Prostate Cancer Recurrent
- Trial name
- NCT05002465
- Testing
- 68Ga-PSMA-11, Positron Emission Tomography/Computed Tomography
- Where
- United States
- Sponsor
- Dana Mathews
Parkinson Disease
11C-PIB PET/CT in Patients With Parkinson's Disease and Parkinsonian Dementia Syndromes
To evaluate the potential contribution of amyloid burden, as indexed by 11C-Pittsburgh compound B (PiB) retention, to the progression of cognitive impairments in patients with Parkinson's disease(PD).
- Trial name
- NCT03555292
- Testing
- 11C-PiB
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oriental Neurosurgery Evidence-Based-Study Team
Esophageal Neoplasms
PET-CT Based Radiotherapy in Esophageal Cancer Patients
The purpose of this study is to determine the locoregional control in PET/CT based radiotherapy treatment planning in the treatment of esophageal cancer patients.
- Trial name
- NCT01156831
- Where
- 5 sites in Netherlands
- Volunteers
- 115 people
- Sponsor
- Maastricht Radiation Oncology
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