Clinical trials: PFS
Healthy Volunteer
A Bioequivalence Study of Subcutaneous (SC) Lebrikizumab Administered by Needle and Syringe or by Prefilled Syringe With Needle Safety Device (PFS-NSD)
This study will assess the bioequivalence in healthy participants between a high-concentration formulation of lebrikizumab withdrawn from a vial and administered SC as a single injection by a needle and syringe, and a…
- Trial name
- NCT02486809
- Testing
- Lebrikizumab
- Where
- 4 sites in United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Malignant Neoplasms of Mesothelial and Soft Tissue, Rhabdomyosarcoma, Pelvic
Study of Doxorubicin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Intraoperative Brachytherapy for Unresectable or Refractory Pelvic and Abdominal Rhabdomyosarcoma and Undifferentiated Sarcomas in Children
The goal of this clinical research study is to find the highest tolerable dose of heated doxorubicin that can be given to patients during surgery with abdominal tumors. The safety of this drug will also be studied.
- Conditions
- Malignant Neoplasms of Mesothelial and Soft Tissue, Rhabdomyosarcoma, Pelvic, Rhabdomyosarcoma, Abdominal
- Trial name
- NCT03111069
- Testing
- Abdominal Surgery, Doxorubicin, Intra-Operative Radiation
- Sponsor
- M.D. Anderson Cancer Center
Gastric Cancer Metastatic to Lung, Lung Cancer
Study for Patients With Lung Metastatic Advanced Gastric Cancer and NSCLC Treated With Apatinib
The primary end point was progression-free survival (PFS), secondary end points included duration of locoregional control (LRC), overall survival (OS), quality of life and safety.
- Trial name
- NCT03629691
- Testing
- lung cavitation
- Volunteers
- 187 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Recurrent IDH1/2 Mutated Glioma
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation
Glioma are the most commun frequent brain tumour. Mutation of Isocitrate DeHydrogenase IDH1 or IDH2 genes affect 40% of gliomas, mostly grade II and III gliomas.
- Trial name
- AGIR (NCT03666559)
- Testing
- Azacitidine
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Newly Diagnosed Peripheral T-cell Lymphoma
Treatment of Newly Diagnosed Peripheral T-cell Lymphoma
The purpose of this study is to evaluate the efficacy and safety of Apatinib Combined With CHOP Regimen(cyclophosphamide, vincristine, epirubicin, prednisone in the treatment of newly diagnosed peripheral T-cell lymphoma.
- Trial name
- NCT03631862
- Testing
- Apatinib, CHOP Regimen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhengzhou University
Cancer
Circulating Tumor Cells (CTC) in Cancer
This observational study with circulating tumor cells (CTC) count, isolation and analysis at several time points during disease progression is to investigate the role and biology of CTCs and clusters of CTCs in different cancer…
- Trial name
- NCT04520672
- Testing
- Blood samples, Samples from tumor draining vessels
- Where
- 2 sites in Switzerland
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Extensive-Stage Small-Cell Lung Cancer
To Evaluate the Efficacy of Durvalumab + Anlotinib in Terms of OS and PFS.
This is an open-label, randomised, multicenter, Phase II study. This study is planned to enroll 90 eligible patients to receive durvalumab combined with up to 4 cycles of etoposide and platinum-based chemotherapy (EP).
- Trial name
- NCT04985851
- Testing
- durvalumab + anlotinib, Durvalumab
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shanghai Chest Hospital
Glioblastoma
A Explore Study of Bevacizumab Combined With Conventional Therapy in Glioblastoma
This is a single-center, open-label, single arm study to explore whether potential image biomarkers correlate with efficacy of bevacizumab combined with conventional therapy in newly diagnosed glioblastoma.
- Trial name
- NCT01939574
- Testing
- Chemoradiation Therapy, Adjuvant Therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shandong Cancer Hospital and Institute
ORR, PFS
A Single-Arm Study on the Efficacy of Sequential Chemoradiotherapy Followed by Surgery in Adult Nasal and Paranasal Sinus Rhabdomyosarcoma
Given the rarity of nasal and paranasal sinus rhabdomyosarcoma (SNRMS), there is a lack of literature on systemic treatment models for adult SNRMS, let alone prospective clinical studies.
- Conditions
- ORR, PFS, OS
- Trial name
- NCT07449949
- Testing
- VMAT
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis
Comparison of PK and Tolerability of MSB11022 Administered by AI or PFS
The primary objective of this study is to demonstrate equivalence of the pharmacokinetic (PK) profile of MSB11022 administered by either an auto-injector (AI) or a pre-filled syringe (PFS) as single subcutaneous (s.c.) injection…
- Conditions
- Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis
- Trial name
- NCT04018599
- Testing
- 40 mg MSB11022
- Where
- 2 sites in United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Fresenius Kabi SwissBioSim GmbH
Graves' Disease, Graves Disease
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves' Disease
The main purpose of this study is to look at how efgartigimod affects thyroid function in adults with Graves' Disease (GD). The study will also check whether efgartigimod is safe and well tolerated.
- Trial name
- VitaliThy (NCT07570316)
- Testing
- Efgartigimod PH20 SC
- Where
- 35 sites in United States, Georgia and 1 more
- Volunteers
- 230 people
- Sponsor
- argenx
Metastatic Breast Cancer
Vinorelbine/Carboplatin Versus Gemcitabine/Carboplatin in Metastatic Breast Cancer
Development of an active second-line treatment option for metastatic breast cancer patients previously pre-treated with anthracyclines and taxanes in neoadjuvant, adjuvant or palliative settings.
- Trial name
- NCT04143906
- Testing
- Vinorelbine, Gemcitabine, Carboplatin
- Volunteers
- 200 people
- Sponsor
- Shandong Cancer Hospital and Institute
Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ]), Neoadjuvant Therapy
Neoadjuvant Apatinib Combined With Sintilimab and Perioperative SOX Versus Neoadjuvant Sintilimab Combined With Perioperative SOX for Intestinal Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
This study aims to compare the efficacy and safety of neoadjuvant apatinib combined with sintilimab and perioperative SOX chemotherapy versus neoadjuvant sintilimab combined with perioperative SOX chemotherapy in locally advanced…
- Conditions
- Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ]), Neoadjuvant Therapy, Adjuvant Chemotherapy, pCR Rate
- Trial name
- NCT06925243
- Testing
- Neoadjuvant apatinib combined with sintilimab and perioperative SOX, Neoadjuvant sintilimab combined with perioperative SOX
- Where
- 4 sites in China
- Volunteers
- 682 people
- Sponsor
- Zuoyi Jiao
Cervical Cancer
The Efficacy of Lymph Node Dissection for Stage IIICr of Cervical Cancer(CQGOG0103)
This is an national, prospective, multicenter and randomized clinical study designed to determine if patients with stage IIICr of cervical cancer have longer PFS and/or OS with lymph node dissection before CCRT when compared to…
- Trial name
- NCT04555226
- Testing
- Lymph node dissection, Standard chemoradiation±pembrolizumab, Chemoradiation± pembrolizumab
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Chongqing University Cancer Hospital
Locally Advanced Cervical Cancer
Comparing the Efficacy of Surgery Staging and Image Staging of Locally Advanced Cervical Cancer
The study is a domestic multicenter, prospective, non-randomized controlled concurrent trial. It will be assessed whether surgery staging on locally advanced cervical cancer is superior to image staging for improving…
- Trial name
- NCT05378087
- Testing
- Concurrent chemoradiation, Open/minimally invasive para-aortic lymph node dissection followed by concurrent chemoradiation
- Where
- China
- Volunteers
- 1,956 people
- Sponsor
- Chongqing University Cancer Hospital
Non Small Cell Lung Cancer, Immune Checkpoint Inhibitors
Impact of Pretreatment Emotional Distress on Survival and the Predictive Role of Peripheral Biomarkers in Immunotherapy Response Among Gastroesophageal and Lung Cancer Patients
This is the prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response…
- Conditions
- Non Small Cell Lung Cancer, Immune Checkpoint Inhibitors, Inflammation, Cancer, Treatment-Related
- Trial name
- NCT06629714
- Testing
- Exposure: emotional distress status
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Anhui Medical University
Phase 1
PK, Safety and Tolerability Study of AVT02 (Adalimumab) Pre-filled Syringe (PFS) vs, AVT02 Autoinjector (AI)
This study has been designed as a multicentre, randomised, open label study of AVT02 in healthy adult subjects. The study will assess the PK, safety and tolerability of AVT02 in Pre-Filled Syringe compared to AVT02 in…
- Trial name
- NCT03983876
- Testing
- Adalimumab
- Where
- 2 sites in New Zealand
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Alvotech Swiss AG
Piriformis Syndrome
Comparative Effects of PIR and PFS on Pain, Hip ROM, and Disability in Piriformis Syndrome
This randomized clinical trial evaluates the effectiveness of Post-Isometric Relaxation (PIR) and Post-Facilitation Stretching (PFS) for managing pain, improving hip abduction and internal rotation, and enhancing functional…
- Trial name
- PIR-PFS RCT (NCT07255053)
- Testing
- Post Isometric Relaxation (PIR), Post Facilitation Stretching (PFS)
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Faisalabad
Diabetic Macular Edema (DME), Neovascular Age-Related Macular Degeneration (nAMD)
Study to Evaluate an 8 mg Aflibercept (EYLEA®) Prefilled Syringe (PFS)
Regeneron Pharmaceuticals developed a single-dose pre-filled syringe (PFS) to deliver 8 mg aflibercept. The PFS is a convenient device that contains the study medication that will be injected in your study eye.
- Trial name
- NCT05989126
- Testing
- aflibercept 8 mg PFS
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Regeneron Pharmaceuticals
Spondylitis, Ankylosing
Extension in AS: Sustainability of Benefits, Safety and Tolerability
This 3-year extension study aims at making available the treatment with secukinumab in prefilled syringes (PFS) to patients with ankylosing spondylitis who took part in phase III study CAIN457F2305, defined as "core study", as…
- Trial name
- MEASURE 1 ext (NCT01863732)
- Testing
- Secukinumab
- Where
- 56 sites in United States, Belgium and 12 more
- Volunteers
- 274 people
- Sponsor
- Novartis Pharmaceuticals