Clinical trials: PJI
Periprosthetic Hip Infection
Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Hip Infection: a Microdialysis Study
This study aims to use the technique of microdialysis to analyse the intraarticular space of the hip joint after removal of a periprosthetic joint infection affected endoprosthesis and implantation of an antibiotic-containing…
- Trial name
- PJI_H_MD (NCT07299591)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bonn
Prosthetic Joint Infection
PCA Administration in Prosthetic Joint Infection
Determine if dietary protocatechuic acid (PCA) will affect health biomarkers in patient undergoing revision surgery for a knee prosthetic joint infection
- Trial name
- NCT06591741
- Testing
- Oral PCA
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Dr. Dean Reeves Clinic
Lynch Syndrome, FAP
Hereditary Colorectal and Associated Tumor Registry Study
After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample.
- Conditions
- Lynch Syndrome, FAP, Hereditary Diffuse Gastric Cancer, Juvenile Polyposis Syndrome
- Trial name
- NCT00633607
- Testing
- Research Registry
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Pittsburgh
Periprosthetic Joint Infections
Laser Disinfection in Periprosthetic Joint Infection
The eradication of biofilms from infected implants is still an unsolved challenge. The high-energy light beam of an Er:YAG laser causes rapid heating and explosive ablation of tissue.
- Trial name
- NCT06440564
- Testing
- Er:YAG Laser irradiation
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Periprosthetic Knee Infection
Analysis of Pharmacological Aspects Regarding Infection Free Survival After Surgical Treatment of a Periprosthetic Knee Infection: a Microdialysis Study
This study aims to use the technique of microdialysis to analyse the intraarticular space of the knee joint after removal of a periprosthetic joint infection affected endoprosthesis and implantation of an antibiotic-containing…
- Trial name
- PJI_K_MD (NCT07299565)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bonn
Periprosthetic Infection
"Debridement PhagE AnTibiotics for PJI"
Total joint replacement (TJR) has revolutionized care provided for patients suffering from disabling joint pain. Unfortunately, periprosthetic joint infection (PJI) remains a devastating complication and the leading cause of…
- Trial name
- DePHEAT-PJI (NCT07698002)
- Testing
- The investigational product specifically targeting P. aeruginosa (DP-QB-PSA-005) and that targeting S. aureus (DP-QB-STA-005), each formed of a mixture of 5 bacteriophages.
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Prosthetic Infection
Rifabutin Versus Rifampicin for Treatment of Staphylococcal PJI Treated With DAIR
Rifampicin, is key in the treatment of staphylococcal PJIs. Rifabutin has a better profile of tolerance than rifampicin regarding the risk of interaction with concomitant medications and liver disorders.
- Trial name
- RIFAMAB (NCT04672525)
- Testing
- Rifabutin, Rifampicin
- Where
- 30 sites in France
- Volunteers
- 436 people
- Sponsor
- Tourcoing Hospital
Dactinomycin Adverse Reaction, Bone and Joint Infection
Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin
Daptomycin is an antibiotic from the family of cyclic lipopeptides, bactericide, concentration-dependent. Its spectrum concerns Gram-positive bacteria.
- Trial name
- NCT04414137
- Testing
- Description of eosinophilic pneumonia due to daptomycine
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Periprosthetic Knee Infection
Antibiotic Elution After Two-stage Knee Revision
The goal of this observational study is to monitor the eluted antibiotic concentrations of gentamicin and vancomycin by a static knee cement spacer in patients being treated for periprosthetic infections of the knee.
- Trial name
- NCT06944184
- Testing
- Intraarticular microdialysis
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bonn
PJI
Infection Consortium Study#1
In this study, the Sponsor wants to evaluate the performance and accuracy of the PJI Panel compared to the currently used multiple-criterion scoring systems for the diagnosis of PJI.
- Trial name
- NCT06153446
- Testing
- Synovasure® Comprehensive Infection Panel
- Where
- United States
- Volunteers
- 810 people
- Sponsor
- Zimmer Biomet
Prosthetic-joint Infection
Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis (Sonic)
This retrospective study is to analyse microbiological cultures from the sonication fluid of the explanted prothesis to detect bacteria in the biofilm on the implant surface and to investigate whether the number of bacteria in…
- Trial name
- Sonic (NCT05265598)
- Where
- Switzerland
- Volunteers
- 176 people
- Sponsor
- University Hospital, Basel, Switzerland
Prosthesis-Related Infections
PCA Loading Time Before Knee Prosthetic Joint Infection Revision
Proof of principle pilot study of the effect of dietary nutritional loading of protocatechunic acid (PCA) on the health and welfare of individuals with prosthetic joint infection (PJI), as measured by standard biomarkers
- Trial name
- NCT06591728
- Testing
- Oral PCA
- Volunteers
- 10 people
- Sponsor
- Dr. Dean Reeves Clinic
Periprosthetic Joint Infection (PJI)
A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants
This is a Phase 1/2, randomized, controlled, open-label, proof-of-concept study to evaluate the safety and tolerability, local and systemic PK profiles of TNP-2092 administered via IA injection on the basis of vancomycin IV and…
- Trial name
- NCT06889701
- Testing
- TNP-2092 for injection, Vancomycin Hydrochloride for Injection (IA), Vancomycin Hydrochloride for Injection (IV)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- TenNor Therapeutics Inc.
Prosthetic Joint Infection
Bacteriophage Therapy in Patients With Prosthetic Joint Infections (PJI)
This is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.
- Trial name
- ACTIVE2 (NCT05269134)
- Testing
- Bacteriophage
- Where
- 10 sites in United States
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Prosthetic Joint Infection
Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation
Study Type Prospective, single-arm, open-label, multicenter (3 to 5 sites), interventional trial. Primary Study Objective The objective of the study is to determine the safety profile of local antibiotic irrigation for the…
- Trial name
- NCT03721328
- Testing
- vancomycin hydrochloride and tobramycin sulfate
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Osteal Therapeutics, Inc.
Revision Total Hip Arthroplasty (RTHA), Revision Total Knee Arthroplasty
CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee
The goal of this clinical trial is to compare two types of skin preparation solutions (chlorhexidine gluconate-alcohol solution and povidone-iodine solution) that help eliminate harmful bacteria on the skin at the time of surgery…
- Trial name
- CLEANJoint (NCT05828810)
- Testing
- Chlorhexidne Gluconate-Alcohol Skin Preparation, Poviodine-iodine Skin Preparation
- Where
- 3 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Sunnybrook Health Sciences Centre
PJI
Results of Silver-coated Resection Prostheses in the Treatment of Periprosthetic Knee Infections with Bone Deficiency
The goal of this observational study is to evaluate the infection control and mid-term survival of silver-coated articulated megaprosthetic and knee arthrodesis implants in PJI patients with bone stock deficiency and treated with…
- Trial name
- MEGAPJI (NCT06806449)
- Where
- 3 sites in Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Periprosthetic Joint Infection
Clinical Validation of CD Diagnostics Synovasure PJI ELISA Test and Synovasure PJI Lateral Flow Test for Detection of Periprosthetic Joint Infection in Synovial Fluid
To demonstrate the tests' performance when compared to the detection of PJI using the Musculoskeletal Infection Society (MSIS) criteria-based definition of PJI for diagnosing PJI.1 This criteria-based definition of PJI places…
- Trial name
- NCT02868736
- Testing
- Synovasure PJI Lateral Flow test and Synovasure PJI ELISA Test
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- CD Diagnostics
Periprosthetic Joint Infection (PJI)
Periprosthetic Joint Infection Bubble Study
Patients with an infected knee replacement will receive their standard of care surgical treatment of the infection, with and without additional ultrasound microbubble treatment (randomly divided 50/50 in the active and control…
- Trial name
- PJI (NCT07599865)
- Testing
- Ultrasound-triggered microbubble destruction with antibiotics
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Acute Leukemia, Adenomatous Polyposis
Familial Investigations of Childhood Cancer Predisposition
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll.
- Conditions
- Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma, AML
- Trial name
- SJFAMILY (NCT03050268)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- St. Jude Children's Research Hospital