Clinical trials: PLATELET AGGREGATION
Cardiometabolic Health
Effect of Differently Fed Farmed Gilthead Sea Bream Consumption
The trial was a double-blind randomized dietary intervention study with a 1:1 allocation ratio, conducted in accordance with the Declaration of Helsinki.
- Trial name
- NCT05417191
- Testing
- Conventional fish, Enriched fish
- Where
- Greece
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Platelet Aggregation Inhibitors, Hydroxymethylglutaryl-coa Reductase Inhibitors
The Compliance of DAPT and Statins on Clinical Outcomes in Percutaneous Coronary Intervention Patients
A nationwide retrospective cohort study. To investigate the real world medication compliance and the relation with clinical outcomes.
- Conditions
- Platelet Aggregation Inhibitors, Hydroxymethylglutaryl-coa Reductase Inhibitors, Compliance, Medication, Adherence, Medication
- Trial name
- CPPCI (NCT03785509)
- Testing
- DAPT, Statin
- Where
- South Korea
- Volunteers
- 47,291 people
- Sponsor
- Samsung Medical Center
Coronary Disease, Cerebral Infarction
The Study on Profile and Genetic Factors of Aspirin Resistance (ProGEAR Study)
The purpose of this study is to determine the clinically meaningful definition and prevalence of aspirin resistance based on data linking aspirin-dependent laboratory tests to recurrent vascular events in cardiovascular patients…
- Conditions
- Coronary Disease, Cerebral Infarction, Ischemic Attack, Transient
- Trial name
- NCT00250380
- Where
- 23 sites in Japan
- Volunteers
- 583 people
- Sponsor
- Ministry of Health, Labour and Welfare, Japan
Cardiovascular Disease
The Effect of Processed Tomato Products on CVD Risks
The primary working hypothesis is that consuming processed tomatoes frequently/daily will favorably improve endothelium and platelet function disease-risk biomarker profiles in adult men and women compared to consuming no or…
- Trial name
- TOMATO (NCT00937742)
- Testing
- Tomato products
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Penn State University
Angina, Unstable
Pilot Study on Shear-induced Platelet Aggregation in Acute Coronary Syndromes
The purpose of this study is to determine whether shear-induced platelet aggregation is able to discriminate first acute coronary syndrome (ACS) from recurrent ACS
- Trial name
- REACS (NCT00299143)
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cardiovascular Disease
Monocentric Registry to Investigate the Role of Platelet Function, Platelet Genetics, Proteomics and Metabonomics in Heart Disease
Molecular targets on platelets are pivotal for the development of new pharmacological substrates for platelet inhibition and to better understand the impact of platelet-mediated inflammatory processes for the progression of heart…
- Trial name
- TuePIC (NCT01417884)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Tuebingen
Coronary Artery Disease, Myocardial Infarction
Aspirin Response in High Risk Patients With Coronary Artery Disease
Previous studies indicate that patients with cardiovascular disease have a variable response to aspirin. Despite treatment with aspirin a large number of patients suffer a myocardial infarction.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Diabetes Mellitus, Renal Insufficiency, Chronic
- Trial name
- NCT01383304
- Where
- Denmark
- Volunteers
- 906 people
- Sponsor
- University of Aarhus
Platelet Aggregation, Spontaneous, Vascular Thrombosis
The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation
The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design
- Trial name
- EASI (NCT05967741)
- Testing
- Erythritol, Aspartame
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Unstable Angina, NSTEMI
Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition
The purpose of this study is to evaluate the efficacy (reduction of major ischemic events at 6 and 12 months of follow-up) of a tailored clopidogrel therapy in patients with UA/NSTEMI undergoing PCI with stent implantation and…
- Trial name
- DANTE (NCT00774475)
- Testing
- comparison of different dosage of clopidogrel, doubled therapy
- Where
- Italy
- Volunteers
- 442 people
- Sponsor
- University of Florence
Kidney Replacement Disorder
Anticoagulation and Activation - Comparison in Continuous Renal Replacement Therapy
Actual clinical practice predominantly makes use of heparin (systemically) or citrate regionally as anticoagulation in the extracorporeal circulation for renal replacement therapy.
- Trial name
- NCT01276392
- Where
- Germany
- Sponsor
- Klinik für Anästhesiologie
Atrial Fibrillation
Impact of Dabigatran and Phenprocoumon on ADP Induced Platelet Aggregation in Patients With Atrial Fibrillation
The aim of this study is to evaluate whether Dabigatran itself reduces ADP induced platelet aggregation measured by MEA as compared to Phenprocoumon after a two-week treatment with either agent.
- Trial name
- Dabi-ADP-1 (NCT01339819)
- Testing
- Dabigatran, Phenprocoumon
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Drug Resistance
Aspirin and Clopidogrel Resistance Study
Resistance to antiplatelet drugs (aspirin, clopidogrel) is a recognized phenomenon with a prevalence from 17% to 35%. Resistance as detected by in vitro tests such as Multiple Electrode Aggregometry (MEA) has been shown to…
- Trial name
- NCT01039480
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- University Hospital, Basel, Switzerland
Atrial Fibrillation, Atrial Appendage
AntiPlatelet theraPy stratEgy followiNg Left Atrial appenDAGe closurE
The APPENDAGE study is a phase 4 multicentre randomized opened clinical trial comparing 2 different antithrombotic strategies following left atrial appendage closure (LAAC) in patients with non valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Atrial Appendage, Anticoagulants, Stroke
- Trial name
- APPENDAGE (NCT04796714)
- Testing
- Double antiplatelet therapy, Aspirin, Brain MRI
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Diabetes Mellitus, Type 2, Vascular Diseases
Effect of Thiazolidinedione Treatment Vascular Risk Markers
The purpose of this study is to examine the effects of two diabetes medications, rosiglitazone and pioglitazone, on markers of vascular disease in subjects with type 2 diabetes.
- Trial name
- NCT00571506
- Testing
- Rosiglitazone, Pioglitazone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arkansas
Vascular Disease, Coronary Artery Disease Risk Factors Multiple
Safety Study of PZ-128 in Subjects With Multiple Coronary Artery Disease Risk Factors
This study is a Phase I, intravenous, single-dose escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PZ-128 (pepducin inhibitor of PAR1) in subjects with vascular disease or who have 2…
- Trial name
- NCT01806077
- Testing
- PZ-128
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Tufts Medical Center
Thrombocytopathy
Platelet Function in Minimal Extracorporeal Circulation in CABG
Rationale: Cardiac surgery with extracorporeal circulation (ECC) triggers platelets. Minimal extracorporeal circulation system (minimal-ECC) has several advantages compared with conventional ECC amongst less platelet activation.
- Trial name
- ECCTEG (NCT01935245)
- Testing
- Mini extracorporeal circulation, Conventional extracorporeal circulation
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Platelet Thrombus
Anti-Inflammatory and Anti-Coagulant Effects of Salmon Polar Lipids
Inflammation is a normal immune response to tissue healing. However, uncontrolled and unresolved inflammation can initiate and further induce several chronic manifestations that contribute to chronic disorders such as…
- Trial name
- NCT03866265
- Testing
- Food Grade Extract of Salmon Polar Lipids (FGE-Salmon-PLs)
- Where
- Ireland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Pulmonary Arterial Hypertension
A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension
This is a multi-center, open-label study for eligible participants who were actively participating in the BPS-314d-MR-PAH-302 double-blind study (NCT01908699) at the time the study was concluded.
- Trial name
- BEAT OLE (NCT03657095)
- Testing
- Esuberaprost
- Where
- 45 sites in United States, Israel
- Volunteers
- 112 people
- Sponsor
- Lung Biotechnology PBC
Diabetes, Hypertension
Effects of Dengzhanxixin Capsule on Platelet Function in Individuals at High Risk for Cardiovascular Disease
The main objective of this clinical trial is to evaluate whether the antiplatelet efficacy of the Dengzhanxixin capsule is better than that of placebo in individuals at high-risk for atherosclerotic cardiovascular disease (ASCVD).
- Conditions
- Diabetes, Hypertension, Hypercholesterolemia
- Trial name
- FUTURE (NCT05459519)
- Where
- China
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Heart Disease
Arachidonic Acid-induced Platelet Aggregation Rate in Patients With Stable CAD Treated With Ticagrelor Monotherapy
This study was a feasibility trial that was designed to provide preliminary observations and generate hypotheses for future studies.
- Trial name
- NCT02219412
- Testing
- ticagrelor, Aspirin
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Yong Huo