Clinical trials: POAG
Primary Open Angle Glaucoma, Primary Angle Closure Glaucoma
Malay Glaucoma Eye Study II Navigation, Mobility and Reading Ability in Primary Glaucoma
With the improvement of health system, the life span of Asians has increased tremendously especially in Malaysia. As an early preparation to be an 'aging country' in 2023, Malaysia needs to prepare infrastructure and policy to…
- Trial name
- MaGESII (NCT04736264)
- Testing
- Visual rehabilitation module: navigation and mobility, Visual rehabilitation module: exercise, Visual rehabilitation module: reading
- Where
- Malaysia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Glaucoma, Open-Angle, Ocular Hypertension
A 6-Week Safety and Efficacy Study of Travatan Compared to Xalcom in Subjects With Open-Angle Glaucoma(OAG) or Ocular Hypertension(OHT)
To compare the safety and IOP-lowering efficacy of TRAVATAN and XALCOM in subjects with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00051155
- Testing
- Travoprost (0.004%), Latanoprost (0.005%)/Timolol (0.5%)
- Where
- United States
- Sponsor
- Alcon Research
Primary Open-angle Glaucoma
Efficacy and Tolerability of Preservative-free 0.0015% Tafluprost in Glaucoma Patients
The aim of this work is to evaluate efficacy and tolerability of preservative containing 0.0015% tafluprost and preservative-free 0.0015% tafluprost.
- Trial name
- NCT03104621
- Testing
- Benzalkonium chloride (BAK), 0.0015% tafluprost
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Glaucoma, Open-Angle, Glaucoma
Exercise Intervention in Primary Open-angle Glaucoma
EYE-FIT is a randomized clinical trial with a two-arm parallel design aimed at assessing the impact of performing a structured and supervised physical training program on the different variables associated with glaucoma…
- Trial name
- EYE-FIT (NCT05704777)
- Testing
- Exercise, Control
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- Universidad de Granada
Open-Angle Glaucoma, Ocular Hypertension
Phase 3 Study Comparing IOP Lowering in OAG or OH in Japanese Subjects C-01-98
The purpose of this study is to evaluate safety and efficacy of two different IOP lowering medications after twelve months of treatment in Japanese subjects.
- Trial name
- NCT00047593
- Testing
- IOP Lowering Medications
- Where
- 3 sites in United States
- Sponsor
- Alcon Research
Primary Open Angle Glaucoma, Ocular Hypertension
A Comparative Confirmatory Study of STN1012600 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
To investigate whether the IOP lowering efficacy of STN1012600 ophthalmic solution 0.002% is non-inferior to that of latanoprost 0.005% in subjects with POAG or OHT after treatment for 4 weeks.
- Trial name
- NCT05495061
- Testing
- STN1012600 ophthalmic solution 0.002%, Latanoprost ophthalmic solution 0.005%
- Where
- 44 sites in Japan
- Volunteers
- 325 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Glaucoma
Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery?
The investigators hypothesize that intracameral Triesence during glaucoma surgery will provide lower intraocular pressure through better control of ocular inflammation, thus leading to a more successful filtering procedure.
- Trial name
- NCT00853905
- Testing
- Triesence, balanced salt solution BSS
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Wills Eye
Ocular Hypertension, Primary Open Angle Glaucoma
Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AKB-9778 Ophthalmic Solution
The purpose of this Phase 1b study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AKB-9778 ophthalmic solution (eye drops) administered for 7 days in adults.
- Trial name
- NCT04284514
- Testing
- AKB-9778 Ophthalmic Solution
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Aerpio Therapeutics
Glaucoma, Glaucoma, Open-Angle
Prevalence of Glaucoma and Normative Data of Ocular Biometry in Elderly Population in Bangkok
The BANMOP eye study is an ophthalmic subproject of the Bangkoknoi Model Project (BANMOP), a community-based initiative integrating electronic health databases with population surveys to sup-port context-specific health promotion…
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Suspect, Glaucoma, Angle-Closure
- Trial name
- BANMOP (NCT07763288)
- Where
- Thailand
- Volunteers
- 1,470 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Primary Open Angle Glaucoma
Effect of Metformin on Visual Function in Patients With Glaucoma
The purpose of this study is to determine whether Metformin could prevent the progression of glaucoma in a safe and effective manner.
- Trial name
- NCT04155164
- Testing
- Metformin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Primary Open Angle Glaucoma, Ocular Hypertension
Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP)
Main objective is to compare the ability of Latanoprost 0.005% preservative-added ophthalmic solution versus Tafluprost 0.0015% preservative-free ophthalmic solution, both given once a day at the evening, in reducing 24-hour…
- Trial name
- SAF-24H-IOP (NCT01162603)
- Testing
- Goldmann and Perkins applanation tonometry, TAFLUPROST 0.0015% EYEDROPS, LATANOPROST 0.005% EYEDROPS
- Where
- 2 sites in Greece, Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Glaucoma
Functional Brain Changes of Primary Open-angle Glaucoma Patients
Structural and functional brain changes of primary open-angle glaucoma patient will be examined with fMRI. POAG patients and control group were examined with 3.0T magnetic resonance imaging.
- Trial name
- NCT02570867
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Qing Zhou
GLAUCOMA 1, OPEN ANGLE, D (Disorder), Cataract
Comparison of Visual Outcomes and Patient Satisfaction in Mild to Moderate Glaucoma Patients Undergoing Cataract Surgery With EDOF Versus Monofocal IOLs
Cataract is the leading cause of reversible vision loss, while glaucoma remains the primary cause of irreversible blindness, often impairing contrast sensitivity (CS), glare tolerance, and dark adaptation.
- Trial name
- NCT07436871
- Testing
- Cataract surgery (Monofocal intraocular lens implantation), cataract surgery (Extended depht of focus intraocular lens implantation)
- Volunteers
- 74 people
- Sponsor
- OMIQ Research
Open Angle Glaucoma
Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons…
- Trial name
- NCT05104294
- Testing
- Optical Coherence Tomography- Angiography, Photopic negative response
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Benha University
To See the Safety and Efficacy of the Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma Patients
The Effectiveness of Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma
Outpatient department of cmch, ceitc,cimch POAG patients enrolled for the study.
- Trial name
- NCT04205201
- Testing
- Drugs, Investigational
- Where
- 2 sites in Bangladesh
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chittagong Medical College
Primary Open Angle Glaucoma, Hypertension Ocular
Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion.
Glaucoma is among the leading causes for blindness in the western world. Elevated intraocular pressure (IOP) has been identified as the most important risk factor.
- Trial name
- GME (NCT02300818)
- Testing
- Pulsed Electromagnetic Field Therapy, Seawater eyedrops
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American Society Of Thermalism And Climatology Inc
Ocular Hypertension, Primary Open Angle Glaucoma
Glaucoma Adherence Study, Spain
The purpose of this study is to evaluate adherence to DuoTrav® when reinforced by the use of the Travalert™ Dosing Aid.
- Trial name
- GAS (NCT00680329)
- Testing
- Travoprost 0.004%/timolol 0.05% fixed combination eye drops (DuoTrav), Travalert Dosing Aid
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Alcon Research
Primary Open Angle Glaucoma
Surgical Approaches in Treating Uncontrolled Glaucoma in Black African and African-Caribbeans
The aim is to perform a randomised feasibility trial preceding a large prospective randomised controlled trial (RCT) comparing three surgical methods - trabeculectomy with Mitomycin C (MMC), primary Baerveldt tube with MMC and…
- Trial name
- PEACE (NCT02989207)
- Testing
- Trabeculectomy, Baerveldt tube surgery, mitomycin-C
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Primary Open Angle Glaucoma, Ocular Hypertension
Effect of Epigallocatechin-Gallate on Inner Retinal Function in Ocular Hypertension and Early Glaucoma
The present study attempts to evaluate the potential beneficial effects of a flavonoid, the epigallocatechingallate, on retinal ganglion cell function, evaluated by pattern electroretinogram, in subjects with ocular hypertension…
- Trial name
- NCT00476138
- Testing
- Epigallocatechin-gallate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Glaucoma, Open-Angle
Valuation of the Antioxidant and Neuroprotective Effects of CoQ10-MINIACTIVES® (COQUN® OS) in Patients Affected by Primary Open Angle Glaucoma
This is a randomized, double blind study with competitive enrolment, aimed to enroll a total of 70 patients with a diagnosis of primary open angle glaucoma (POAG).
- Trial name
- NCT04038034
- Testing
- CoQ10- MINIACTIVES
- Where
- 2 sites in Italy
- Volunteers
- 70 people
- Sponsor
- VISUfarma SpA