Clinical trials: POAG
Glaucoma
Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin Tartrate
This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently…
- Trial name
- NCT06730516
- Testing
- Latanoprost (Xalatan), Brimonidine 0.2 %
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Primary Open Angle Glaucoma, Cataract
Safety and Efficacy of Three Variants of Canaloplasty With Phacoemulsification to Treat Glaucoma and Cataract
It is a comparative study of Safety and Efficacy of Three Variants of Canaloplasty: ab-externo, ab-interno and minicanaloplasty. Combined With Phacoemulsification to Treat Glaucoma and Cataract.
- Trial name
- NCT02908633
- Testing
- canaloplasty and phacoemulsification
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Military Institute od Medicine National Research Institute
Glaucoma, Open-Angle, Ocular Hypertension
Evaluate Efficacy and Safety of PA5108 Ocular Implants in Primary Open Angle Glaucoma or Ocular Hypertension
The goal of this clinical trial is to determine the dose of PA5108 Ocular Implant that is effective and safe for the reduction of intraocular pressure in adult patients with open-angle glaucoma or ocular hypertension, compared to…
- Trial name
- NCT06964191
- Testing
- PA5108 Ocular Implant low dose, PA5108 Ocular Implant, high dose, Latanoprost 0.005% Ophthalmic Solution
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- PolyActiva Pty Ltd
OAG - Open-Angle Glaucoma, OHT - Ocular Hypertension
Study Comparing the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density and Visual Acuity
The purpose of this research study is to compare the effect of Latanoprostene Bunod and Timolol on eye pressure and blood vessels of the back of the eye.
- Trial name
- NCT03931317
- Testing
- Latanoprostene bunod 0.024% QD, Timolol maleate 0.5% BID
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Primary Open Angle Glaucoma
Multimodal Morpho-functional Study in Glaucoma Patients-Citicoline Oral Solution
A prospective, multicentre, randomized, blinded, masked study that involves the enrollment of 60 patients affected by open angle glaucoma (OAG).
- Trial name
- NCT05315206
- Testing
- Citicoline
- Where
- 2 sites in Italy
- Volunteers
- 29 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Glaucoma
Evaluate the Efficacy and Safety of Glaucoma Implant in Primary Open Angle Glaucoma
The objective of this study is to evaluate the efficacy and safety of glaucoma device in the treatment of primary open-angle glaucoma.
- Trial name
- NCT05892185
- Testing
- GELA, XEN
- Volunteers
- 20 people
- Sponsor
- Mingche Biotechnology CO., LTD
Primary Open Angle Glaucoma
A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma
The purpose of this research study is to assess the ability of AMDX- 2011P to identify amyloid deposits in the retina of participants with Primary Open Angle Glaucoma (POAG).
- Trial name
- NCT06223048
- Testing
- AMDX-2011P
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Amydis Inc.
Open Angle Glaucoma, Pigmentary Glaucoma
Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma
The Investigators will investigate the efficacy of combining the standalone iStent infinite and iDose that are minimally invasive surgical and drug depot options are a safe and effective alternative to filtering surgery for…
- Conditions
- Open Angle Glaucoma, Pigmentary Glaucoma, Pseudoexfoliation Glaucoma
- Trial name
- POAG (NCT07228221)
- Testing
- iStent infinite trabecular micro-bypass system model iS3, iDose TR (Travoprost intracameral Implant) 75mcg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jonathon Myers
Primary Open Angle Glaucoma, Ocular Hypertension
Study of the Safety and Efficacy of ATS907 in Subjects With Primary Open Angle Glaucoma (POAG) and Ocular Hypertension
This randomized dose-ranging study will evaluate the safety, tolerability, and preliminary efficacy (reduction in intraocular pressure) of multiple dose levels of ATS907, vehicle, or latanoprost in subjects with primary open…
- Trial name
- NCT01520116
- Testing
- Stage 1 - ATS907 - Dose 1, Stage 1 - ATS907 - Dose 2, Stage 1 - ATS907 - Dose 3
- Where
- 5 sites in United States
- Volunteers
- 180 people
- Sponsor
- Altheos, Inc.
Glaucoma, Open Angle Glaucoma (OAG)
Long-term Safety and Efficacy of a Modified Suprachoroidal Silicone Tube (SST) Shunt
The goal of this observational study is to evaluate the long-term safety and efficacy of a modified suprachoroidal silicone tube (SST) shunt in treating patients with primary open-angle glaucoma (POAG) and pseudo-exfoliative…
- Conditions
- Glaucoma, Open Angle Glaucoma (OAG), POAG, Ocular Hypertension
- Trial name
- NCT06691555
- Testing
- Suprachoroidal silicone tube (SST) shunt
- Where
- Georgia
- Volunteers
- 66 people
- Sponsor
- Davinci LTD
Ocular Hypertension
Efficacy Comparison of Xalatan and Azopt on POAG and OH
Prostaglandin analogs (PGAs) represent a new class of active ocular hypotensive agents and possess a unique mechanism of action.
- Trial name
- NCT01084902
- Testing
- Latanoprost, Brinzolamide
- Volunteers
- 130 people
- Sponsor
- Peking University First Hospital
Glaucoma, Intraocular Pressure
Impact of Home Intraocular Pressure Telemonitoring on Intraocular Pressure Control and Glaucoma Progression
The goal of this clinical trial is to conduct a study randomizing glaucoma patients to home intra-ocular pressure (IOP) telemonitoring combined with Smart phone-based intervention (Management Paradigm I) or Smart phone-based…
- Conditions
- Glaucoma, Intraocular Pressure, Primary Open Angle Glaucoma
- Trial name
- NCT05940623
- Testing
- Home IOP telemonitoring with smart phone-based intervention, Standard care and smart phone-based intervention
- Where
- Hong Kong
- Volunteers
- 142 people
- Sponsor
- The University of Hong Kong
OAG - Open-Angle Glaucoma, OHT - Ocular Hypertension
Effects of Netarsudil and Timolol on Retinal Blood Vessel Density and Visual Acuity
The purpose of this research study is to compare the effect of Netarsudil and Timolol on eye pressure and blood vessels of the back of the eye.
- Trial name
- NCT04064918
- Testing
- Netarsudil 0.02% QD, Timolol maleate 0.5% BID
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Subjects With Primary Open-angle Glaucoma (POAG)
Prospective Evaluation of Open-angle Glaucoma Subjects on Two Topical Hypotensive Medication Treated With Two iStents
The purpose of this study is to assess efficacy and safety of two iStents for the reduction of intraocular pressure associated with primary open-angle glaucoma.
- Trial name
- NCT01252888
- Testing
- iStents
- Where
- Armenia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Glaukos Corporation
Glaucoma, Primary Open Angle, Ocular Hypertension
Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
The purpose of this study is to compare the efficacy and tolerance of generic travoprost with its brand name formulation. In this open label, randomized, crossover study, the primary outcome will be intraocular pressure and the…
- Trial name
- NCT02796560
- Testing
- Brand name travoprost, Generic travoprost
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Université de Sherbrooke
Cataract, Glaucoma
High Frequency Deep Sclerotomy (HFDS) ab Interno a Combination Surgical Intervention Using Cataract Surgery to Lower IOP
Objective: To compare intraocular pressure lowering effect of combined sclerotomy ab interno with phacoemulsification and phacoemulsification alone, in primary or secondary open angle glaucoma patients.
- Conditions
- Cataract, Glaucoma, POAG
- Trial name
- HFDS_abinterno (NCT02312362)
- Testing
- Combined sclerotomy ab interno and phaco, Phacoemulsification with IOL implantation
- Where
- 5 sites in Egypt, Germany and 2 more
- Volunteers
- 108 people
- Sponsor
- Oertli Instrumente AG
Primary Open Angle Glaucoma or Ocular Hypertension
Effect of Rhopressa on Intraocular Pressure (IOP) in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Post-SLT
The purpose of this study is to collect data about how Rhopressa affects IOP in patients who have had an SLT procedure in both eyes.
- Trial name
- NCT06865144
- Testing
- Netarsudil ophthalmic solution 0.02%, Artificial tears
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- East Coast Institute for Research
Primary Open Angle Glaucoma, Ocular Hypertension
Efficacy of the Brand-name Latanoprost and One of Its Generic Version in Primary Open Angle Glaucoma and Ocular Hypertension
The purpose of this study is to evaluate and compare efficacy and tolerability of the brand-name latanoprost and one of its generic version in subjects with primary open angle glaucoma or ocular hypertension.
- Trial name
- NCT02047630
- Testing
- Generic latanoprost, Brand-name latanoprost
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- CHU de Quebec-Universite Laval
Glaucoma, Open-Angle, Ocular Hypertension
Corneal Versus Conjunctival Delivery Using a Delivery Device
Compare the antihypertensive efficacy of three methods for installing Xalatan
- Trial name
- NCT00143429
- Testing
- Xalatan
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Glaucoma, Open-Angle, Ocular Hypertension
A Study of 0.03% Bimatoprost in the Treatment of Primary Open Angle Glaucoma and Ocular Hypertension
This study will evaluate 0.03% bimatoprost in the treatment of primary open angle glaucoma and ocular hypertension.
- Trial name
- LOTUSDI (NCT02020512)
- Testing
- 0.03% Bimatoprost
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Allergan