Clinical trials: PREG1, open to volunteers
Breastfeeding, Breastfeeding Initiation
Birth & Breastfeeding Support Study
The goal of this observational study is to learn about the effects of birth practices such as cesarean section and vacuum assisted birth and diseases such as gestational diabetes and preeclampsia on exclusive breastfeeding.
- Conditions
- Breastfeeding, Breastfeeding Initiation, Breastfeeding Duration, Birth
- Trial name
- BABSS (NCT06844019)
- Where
- Denmark
- Volunteers
- 1,628 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Preeclampsia
Prediction of Chronic Kidney Disease Following Pre-eclampsia: Diagnosis and Early Care
Pre-eclampsia (PE) is a pregnancy-associated syndrome of variable severity, classically defined by the combination of hypertension and proteinuria in a previously non-hypertensive or proteinuric patient.
- Trial name
- PRECEDE (NCT05056701)
- Testing
- annual follow-up during 10 years
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier le Mans
Pregnancy, Preeclampsia (PE)
Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia
The purpose of this study is to learn if giving 17-hydroxyprogesterone caproate (17 OHPC) to mothers with preeclampsia diagnosed before 34 weeks gestation improves mother and baby outcomes.
- Trial name
- PROGRESS (NCT02989025)
- Testing
- 17 OHPC
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Mississippi Medical Center
Preeclampsia Postpartum
Postpartum Low-Dose Aspirin and Preeclampsia
The purpose of this research study is to find out whether women with severe preeclampsia taking low-dose aspirin (LDA) for 3 weeks post-delivery will experience an improvement in endothelial function (measured as flow-mediated…
- Trial name
- NCT03667326
- Testing
- Aspirin tablet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
Preeclampsia, Hypertensive Disorder of Pregnancy
Cardiovascular Protection After Preeclampsia With Enalapril
The purpose of this study is to learn if postpartum women are willing to be randomized to different blood pressure medicines after delivery and how that affects blood pressure in women with hypertensive disorders of pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Hypertension, Gestational Hypertension
- Trial name
- CAPP-E (NCT07222852)
- Testing
- Enalapril, Standard treatment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Preeclampsia, Gestational Hypertension
Exploring the Effect of Discharge Education, Blood Pressure Cuffs, and Postpartum Bracelets to Improve Health Among Newly Diagnosed Gestational Hypertension and Preeclampsia Patients During the Postpartum Period.
This pilot, exploratory qualitative, descriptive study will examine whether standard postpartum discharge education, a free home blood pressure cuff, and an "At-Risk Postpartum" bracelet support self-management among postpartum…
- Conditions
- Preeclampsia, Gestational Hypertension, Postpartum
- Trial name
- NCT07807098
- Testing
- Education, Blood Pressure Cuff, and Visual Cue Bracelet
- Volunteers
- 40 people
- Sponsor
- Memorial Hermann Health System
Preeclampsia (PE)
Prevention of Preeclampsia in Denmark: A National Implementation Study
The goal of this clinical study is to learn if a new first-trimester screening program can better find pregnant women who are at high risk of developing preeclampsia and help prevent the condition with early treatment.
- Trial name
- PREPRED (NCT07485140)
- Testing
- First trimester screening for preeclampsia
- Where
- 3 sites in Denmark
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital at Herlev
Hypertension Disorders in Pregnancy, Gestational Hypertension
Vascular Biomarkers Predictive of the Progression From Hypertensive Disorders in Pregnancy to Preeclampsia in Pregnant Women
Hypertension during pregnancy remains a leading cause of maternal and fetal morbidity and mortality. The frequency (5 to 10% of pregnancies) and potential severity of these diseases, both for the mother and the child, are reasons…
- Conditions
- Hypertension Disorders in Pregnancy, Gestational Hypertension, Pre-Eclampsia
- Trial name
- BIOVASC-PreHTA (NCT04520048)
- Testing
- Determination of the UEMP levels, Aortic central pressure and the carotid-femoral pulse wave velocity, Vascular biomarker assay
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia Postpartum
Aspirin and Preeclampsia
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia.
- Trial name
- NCT04479072
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Chicago
Preeclampsia
NOPE37: Angiogenic Factors for Managing Term Preeclampsia
This study tests the hypothesis that, in women with preeclampsia without severe features, delivery management based on sFlt-1/PlGF would reduce the rate of induction of labor without worsening the rate of progression to…
- Trial name
- NOPE37 (NCT07193680)
- Testing
- Intervention arm: expectant management if sFlt-1/PlGF<38, Standard care: elective delivery at 37 weeks of gestation
- Where
- 23 sites in Spain
- Volunteers
- 750 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Airway Assessment
Ultrasonographical Assessment of Airway Indices in Pregnancy
Clinical and ultrasound indices of airway, in addition to laryngoscopic view will be assessed and compared among three groups of patients: non pregnant, pregnant with normal blood pressure, preeclampsia patients undergoing…
- Trial name
- NCT07423741
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- South Valley University
Preeclampsia, Premature Birth
Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes
Objective: This study aims to investigate the association between maternal serum placental growth factor (PLGF) and nucleosome levels in early pregnancy and adverse pregnancy outcomes, and to evaluate their predictive value for…
- Conditions
- Preeclampsia, Premature Birth, Fetal Growth Restriction, Recurrent Miscarriage
- Trial name
- NCT07841197
- Testing
- Measurement of plasma nucleosome and placental growth factor (PLGF) levels
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Preterm Birth, PPROM
Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth
In this randomized controlled study, the investigators aim to examine if antenatal breastmilk expression (aBME) from week 28 in high-risk pregnancies is a safe and effective method to ensure early access to mother's own milk.
- Conditions
- Preterm Birth, PPROM, Preeclampsia, Previous Preterm Birth
- Trial name
- EXPRESSMOM2 (NCT07191366)
- Testing
- Handstimulation of breast
- Volunteers
- 250 people
- Sponsor
- Odense University Hospital
Hypertension, Postpartum Preeclampsia
Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study
To determine if nifedipine and enalapril will have better blood pressure control in the postpartum setting compared to nifedipine and labetalol.
- Trial name
- NEPHRON (NCT07363343)
- Testing
- Nifedipine and Enalapril, Nifedipine and Labetalol
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Preeclampsia, Fullpairs
fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Preeclampsia
Apredictive formula, fullPIERS (Pre-eclampsia Integrated Estimate of Risk Score), can be used to estimate the risk of suffering an adverse outcome using information obtained within 48 hours of admission with pre-eclampsia.
- Trial name
- Aprospective (NCT07316140)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Severe Preeclampsia
Role of Postpartum Furosemide in Recovery of Patients With Severe Preeclampsia
This randomized controlled trial will compare oral furosemide with placebo for improving blood pressure control in women with severe preeclampsia after delivery.
- Trial name
- NCT07861685
- Testing
- Furosemide and Potassium
- Where
- Pakistan
- Volunteers
- 434 people
- Sponsor
- Lady Reading Hospital, Pakistan
Pre-eclampsia
Pharmacokinetic Study to Evaluate Safety and Tolerability of EG-101 in Healthy Female Volunteers as a Safety Lead-In for Dosing in Pregnant Women With Severe Pre-eclampsia
Preeclampsia is one of the leading causes of maternal and fetal death. It is a syndrome of pregnant women and is usually characterized by new onset of hypertension and proteinuria after 20 weeks of gestation.
- Trial name
- NCT07327255
- Testing
- EG-101
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Evergreen Therapeutics, Inc.
Preeclampsia, Gestational Hypertension
The ACHIEVE Trial: Achieving Longer Gestation in Preeclampsia Via Antihypertensive Therapy.
The Achieve Trial is a randomized clinical trial to test whether lowering blood pressure to less than 140/90 mmHg in women with hypertensive disorders of pregnancy will prolong pregnancy.
- Conditions
- Preeclampsia, Gestational Hypertension, Hypertensive Disorder of Pregnancy
- Trial name
- Achieve (NCT05676476)
- Testing
- Antihypertensive treatment
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of Alabama at Birmingham
Cardiovascular (CV) Risk, Preeclampsia (PE)
Cardiovascular Risk Assessment in Young Women After Index Pregnancy With and Without Placental Complications
In this project, the investigators aim to study how all these factors determine the cardiovascular status of a total of 1,800 mothers, 3 to 6 years after delivery.
- Conditions
- Cardiovascular (CV) Risk, Preeclampsia (PE), Fetal Weight
- Trial name
- CARDIOMOM (NCT07356817)
- Where
- Spain
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau